Clinical trials: Chronic Hand Eczema
Chronic Hand Eczema
PPDTM CorEvitasTM Chronic Hand Eczema (CHE) Drug Safety and Effectiveness Registry
The design is a prospective, observational registry for subjects with CHE under the care of dermatology or other qualified healthcare provider.
- Trial name
- NCT07598058
- Testing
- Observational (Non-Interventional) Registry
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- CorEvitas
Eczema
Alitretinoin in the Treatment of Chronic Hand Eczema
The purpose of the study is to investigate the safety and efficacy of alitretinoin in chronic hand eczema that is refractory to topical corticosteroids.
- Trial name
- NCT00519675
- Testing
- alitretinoin
- Where
- 4 sites in France, Germany
- Volunteers
- 150 people
- Sponsor
- Basilea Pharmaceutica
Chronic Hand Eczema
Phase 2b Dose-ranging Trial to Evaluate Delgocitinib Cream 1, 3, 8, and 20 mg/g Compared to Delgocitinib Cream Vehicle Over a 16-week Treatment Period in Adult Subjects With Chronic Hand Eczema
The purpose of this research trial was to test different strengths of a new trial medication, delgocitinib cream 1, 3, 8, and 20 mg/g, and to investigate how treatment with delgocitinib cream affects chronic hand eczema.
- Trial name
- NCT03683719
- Testing
- Delgocitinib cream, Delgocitinib cream vehicle
- Where
- 28 sites in United States, Denmark and 1 more
- Volunteers
- 258 people
- Sponsor
- LEO Pharma
Hand Dermatoses
Follow-up Efficacy and Safety of Alitretinoin in Severe Chronic Hand Dermatitis
Patients who have been treated in study protocol BAP089 may have responded to treatment, and subsequently relapsed to >75% of the baseline disease severity, will be investigated for response to further treatment with…
- Trial name
- NCT00124436
- Testing
- alitretinoin
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Basilea Pharmaceutica
Chronic Hand Eczema
Safety and Efficacy of ARQ-252 Cream in Subjects With Chronic Hand Eczema
This study will assess the safety and efficacy of ARQ-252 cream in subjects with chronic hand eczema
- Trial name
- NCT04378569
- Testing
- ARQ-252 cream 0.3%, ARQ-252 cream 0.1%, ARQ-252 Vehicle Cream
- Where
- 37 sites in United States, Australia and 1 more
- Volunteers
- 230 people
- Sponsor
- Arcutis Biotherapeutics, Inc.
Chronic Hand Dermatitis
Comparison Study With E-DO in Chronic Hand Dermatitis
The objective of this study is to evaluate the topical E-DO in patients with Chronic Hand Dermatitis (fu kuei shou).
- Trial name
- NCT00556855
- Testing
- E-DO
- Where
- Taiwan
- Volunteers
- 67 people
- Sponsor
- HenKan Pharmaceutical Co., Ltd.
Chronic Hand Eczema
Pharmacokinetics of Delgocitinib 20 mg/g Cream in Subjects With Chronic Hand Eczema
The purpose of the trial is to test how much delgocitinib enters the body over a given time period after application of delgocitinib cream in patients with moderate to severe hand eczema.
- Trial name
- NCT05486117
- Testing
- Delgocitinib
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- LEO Pharma
Chronic Hand Dermatitis
Pimecrolimus Cream 1% in Patients (18 Years of Age and Over) With Mild to Moderate Chronic Hand Dermatitis
Topical steroids are standard of care for Chronic Hand Dermatitis, but long-term use is associated with adverse effects. This study will assess the efficacy and safety of pimecrolimus cream 1% in patients with mild-to-moderate…
- Trial name
- NCT00226707
- Testing
- Pimecrolimus Cream 1%
- Volunteers
- 652 people
- Sponsor
- Novartis
Hand Eczema
Topical Ruxolitinib Evaluation in Chronic Hand Eczema
The purpose of this study is to evaluate the efficacy and safety of ruxolitinib cream in adult participants with diagnosis of chronic hand eczema (CHE) and moderate to severe disease activity (Investigator's Global Assessement…
- Trial name
- NCT05906628
- Testing
- Ruxolitinib cream, Vehicle
- Where
- 36 sites in United States, Canada and 2 more
- Volunteers
- 186 people
- Sponsor
- Incyte Corporation
Chronic Hand Eczema
A 24 Week Trial to Compare the Efficacy and Safety of Delgocitinib Cream 20 mg/g Twice-daily With Alitretinoin Capsules Once-daily in Adult Participants With Severe Chronic Hand Eczema
This is a 24-week study in adult participants with severe chronic hand eczema (CHE) and with a documented inadequate response to treatment with topical corticosteroids (TCS) or for whom TCS are documented to be otherwise…
- Trial name
- DELTA FORCE (NCT05259722)
- Testing
- Delgocitinib, Toctino
- Where
- 102 sites in Austria, Canada and 8 more
- Volunteers
- 513 people
- Sponsor
- LEO Pharma
Hand Eczema
Dupilumab in Severe Chronic Hand Eczema
The purpose of this study is to investigate the efficacy of dupilumab in hand eczema patients with an inadequate response or intolerance to alitretinoin.
- Trial name
- DUPSHE (NCT04512339)
- Testing
- Dupilumab
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Chronic Hand Eczema
Open-label Multi-site Extension Trial in Subjects Who Completed the DELTA 1 or DELTA 2 Trials
The purpose of this extension trial is to evaluate the long-term safety of delgocitinib. Subjects will visit the clinic every 4 week to assess the safety and efficacy of the treatment, until Week 36.
- Trial name
- DELTA 3 (NCT04949841)
- Testing
- Delgocitinib
- Where
- 95 sites in Belgium, Canada and 8 more
- Volunteers
- 801 people
- Sponsor
- LEO Pharma
Chronic Hand Dermatitis
Study to Evaluate ASN002 in Subjects With Moderate To Severe Chronic Hand Eczema
Randomized double-blind/placebo study to evaluate the efficacy of ASN002 in subjects with severe chronic hand eczema.
- Trial name
- NCT03728504
- Testing
- ASN002
- Where
- 23 sites in United States, Canada
- Volunteers
- 97 people
- Sponsor
- Asana BioSciences
Hand Eczema
Immune Signature of Chronic Hand Eczema Unveiled by Spatial Transcriptomics and Single-Cell Proteomics
The study explores the immune landscape of chronic hand eczema using spatial transcriptomics and single-cell proteomics, offering new insights into disease mechanisms and potential therapeutic targets.
- Trial name
- ECMANDO (NCT06884163)
- Testing
- comprhensive spatial transcriptomic profile on lesional skin biopsies
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Chronic Hand Eczema
Efficacy and Safety of Delgocitinib Cream in Adolescents 12-17 Years of Age With Moderate to Severe Chronic Hand Eczema
The purpose of this trial is to test if delgocitinib cream is effective in treating chronic hand eczema (CHE) and to find out what side effects it may have compared with a cream vehicle with no active medical ingredient in…
- Trial name
- DELTA TEEN (NCT05355818)
- Testing
- Delgocitinib, Cream vehicle
- Where
- 37 sites in Australia, Belgium and 5 more
- Volunteers
- 98 people
- Sponsor
- LEO Pharma
Chronic Hand Eczema
Efficacy and Safety of Dupilumab Chronic Hands Eczema Refractory to Highly Potent Topical Corticosteroids
Dupilumab has recently demonstrated high efficacy and good safety profile in the treatment of moderate-to-severe atopic dermatitis.
- Trial name
- DUPECZEMAIN (NCT03861455)
- Testing
- Dupilumab
- Where
- 4 sites in France
- Volunteers
- 94 people
- Sponsor
- University Hospital, Toulouse
Hand Dermatoses
Safety and Efficacy of a Retinoid for the Treatment of Severe Chronic Hand Dermatitis
Patients with severe chronic hand dermatitis, that has not responded to topical treatment, including topical steroids and the avoidance of aggravating factors, will be treated with the oral medication alitretinoin.
- Trial name
- NCT00309621
- Testing
- alitretinoin
- Where
- 33 sites in Canada, Germany and 1 more
- Volunteers
- 250 people
- Sponsor
- Basilea Pharmaceutica
Chronic Hand Eczema
Prospective Real-World Clinical Investigation on Dexyane Med® in Adults With Chronic Hand Eczema
Prospective, descriptive, multicenter, real-world, international clinical investigation. Data collection is based on current clinical practice over a 6-month follow-up period using both electronic Case Report Form (eCRF) and…
- Trial name
- CARING (NCT05545215)
- Testing
- Dexyane Med
- Sponsor
- Pierre Fabre Medicament
Acne, Atopic Dermatitis
Collection of Samples From Subjects With Various Skin Conditions and Healthy Volunteers
The purpose of the study is to collect different samples for molecular characterization of inflammatory skin diseases.
- Conditions
- Acne, Atopic Dermatitis, Chronic Hand Eczema, Hidradenitis Suppurativa
- Trial name
- NCT05994976
- Testing
- Blood samples collection, Oral samples collection, Hair samples collection
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Innovaderm Research Inc.
Chronic Hand Eczema
Treatment of Chronic Hand Eczema With Oral Roflumilast (HERO)
This study is a multicentre, double-blinded, randomized, placebo-controlled, clinical trial with open-label extension. The purpose and aim of this study is to investigate the efficacy and safety of roflumilast (PDE4-inhibitor) in…
- Trial name
- NCT05682859
- Testing
- Roflumilast 500 Mcg Oral Tablet
- Where
- Denmark
- Volunteers
- 41 people
- Sponsor
- Jacob Pontoppidan Thyssen