Clinical trials: Chronic Hypertension
Cardiovascular Diseases, Heart Diseases
Genetic Analysis of Human Hypertensive End Stage Renal Disease (H-ESRD)
To identify genes causing hypertensive end-stage renal disease (H-ESRD) in high risk African-American populations
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Kidney Failure, Chronic
- Trial name
- NCT00005536
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pulmonary Hypertension, COPD
Treatment of Pulmonary Hypertension Associated COPD With Inhaled Treprostinil-1
An Open Label, Pilot Study Testing the Safety and Efficacy of Inhaled Treprostinil (Tyvaso®) in the Treatment of Pulmonary Hypertension (PH) Associated with Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- TAPIT-1 (NCT01758744)
- Testing
- Inhaled Treprostinil Therapy
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Hypertension, Chronic Kidney Disease
Renal Denervation for Treatment of Resistant Hypertension in Patients With Chronic Kidney Disease
Recent clinical studies have demonstrated that catheter-based renal sympathetic nerve ablation is safe and effective in treating patients with resistant hypertension.
- Trial name
- NCT01747382
- Testing
- Renal denervation
- Where
- 2 sites in Singapore
- Sponsor
- Singapore General Hospital
Chronic Kidney Disease, Endothelial Dysfunction
Study of Protective Effects of Paricalcitol on Inner Layer of Vessels and Its Protective Effect on Inflammation
The study is about possible protective effects of paricalcitol (Zemplar) upon inflammation, blood pressure and kidney function. Kidney Inflammation occurs when white blood cells become abnormally stimulated and accumulate in the…
- Conditions
- Chronic Kidney Disease, Endothelial Dysfunction, Inflammation, Hypertension
- Trial name
- NCT00428246
- Testing
- paricalcitol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Indiana University
Diabetes, Hypertension
Implementation of an Integrated Primary Care Network for Prevention and Management of Cardiometabolic Risks
CONTEXTE: L'Agence de la santé et des services sociaux de Montréal (ASSS) invited our research team to evaluate the implementation of an integrated and interdisciplinary primary care network for prevention and management of…
- Trial name
- RCM (NCT01326130)
- Testing
- Chronic care management 1-6
- Where
- Canada
- Volunteers
- 3,000 people
- Sponsor
- Public Health Department, Montreal
Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease (COPD)
Tadalafil for Pulmonary Hypertension Due to Chronic Lung Disease
The functional, social, and economic burden of chronic obstructive lung disease (COPD) on the healthcare system is extraordinary.
- Trial name
- TADA-PHILD (NCT01862536)
- Testing
- Tadalafil
- Where
- 5 sites in United States
- Volunteers
- 44 people
- Sponsor
- VA Office of Research and Development
Chronic Thromboembolic Pulmonary Hypertension
Pilot Study to Evaluate Right Ventricular Function With Riociguat in CTEPH
Chronic thromboembolic Pulmonary hypertension(CTEPH) is characterized by obstruction of the pulmonary vasculature, leading to increased pulmonary vascular resistance, progressive pulmonary hypertension (PH) and right ventricular…
- Trial name
- NCT02094001
- Testing
- Cardiac PET imaging using F-18-FDG, N-13 ammonia( NH3)
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Portal Hypertension, Chronic Liver Disease
Non-invasive Diagnosis of Portal Hypertension With Acoustic Radiation Force Impulse (ARFI)
The aim of this diagnostic study is to evaluate the efficacy of ARFI imaging (a specific type of ultrasound) in assessing the pressure of the portal vein (the major vein passing through the liver) and the amount of liver fibrosis…
- Trial name
- NCT01644656
- Testing
- ARFI ultrasound
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- VA Connecticut Healthcare System
Treatment Resistant Hypertension, Chronic Hemodialysis
Effect of Renal Denervation on Bood Pressure in Patients on Hemodialysis
The RDN-HD Study is a prospective, single-center feasibility study. All patients included will undergo endovascular ultrasound-based RDN (no sham group, no blinding).
- Trial name
- RDN-HD (NCT06556407)
- Testing
- renal denervation
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Pulmonary Hypertension, End-Stage Renal Disease
Impact of Hemo-dialysis Therapy on Blood Levels of Treprostenil in End Stage Renal Disease Patients With Pulmonary Hypertension
Remodulin (Treprostenil sodium) is synthetic prostacyclin analog available as a solution for administration in the intravenous route.
- Conditions
- Pulmonary Hypertension, End-Stage Renal Disease, Hemo-dialysis Therapy
- Trial name
- NCT01234571
- Volunteers
- 5 people
- Sponsor
- Rambam Health Care Campus
Heart Failure, Chronic Obstructive Pulmonary Disease
Primary Care-Hospital Embedding: a Prospective, Multicentric, Observational Study
This is a multicentric, prospective, observational study with two cohorts and adjunctive procedure. It aims at collecting and analyzing data about the function of an innovative hospital-territory integration health service for…
- Conditions
- Heart Failure, Chronic Obstructive Pulmonary Disease, Diabetes Mellitus, Pneumonia
- Trial name
- PRIME (NCT05723185)
- Testing
- Outpatient visit
- Where
- Italy
- Volunteers
- 246 people
- Sponsor
- Rovere Querini Patrizia
Sleep-Disordered Breathing, Pulmonary Arterial Hypertension
Sleep Disordered Breathing in Precapillary Pulmonary Hypertension: Effect of CPAP Treatment
Evaluation of the effect of CPAP (continuous positive airway pressure ) treatment in PAH (pulmonary arterial hypertension) and CTEPH (chronic thromboembolic pulmonary hypertension) patients suffering from sleep disordered…
- Conditions
- Sleep-Disordered Breathing, Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT02583906
- Testing
- CPAP
- Where
- Belgium
- Volunteers
- 8 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hypertension, Diabetes
Using Health Information Technology (HIT) to Improve Ambulatory Chronic Disease Care: Smart Device Substudy
In-home health monitoring devices have the potential to increase the speed and ease of modifying treatment for ambulatory patients living with chronic conditions.
- Trial name
- NCT00802152
- Testing
- Home monitoring
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Missouri-Columbia
Chronic Pain, Hypertension
Improving Pain Management Via Spinal Cord Stimulation and Blood Pressure Reduction
The purpose of this study (PASSION study) is to monitor symptoms of chronic pain before and after 2 weeks of a standard drug commonly used to treat elevated blood pressure compared with 2 weeks of placebo (crossover design) so…
- Conditions
- Chronic Pain, Hypertension, Diuretics Drug Reactions, SCS
- Trial name
- PASSION (NCT04676399)
- Testing
- Hydrochlorothiazide 12.5mg
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Kansas Medical Center
Chronic Kidney Disease
Pulmonary Hypertension Prevention in Hemodialysis
Pulmonary hypertension is a new complication described in hemodialysis patients. in the last year these patients were treated by calcium carbonate orally to control serum phosphor.
- Trial name
- NCT01350687
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- The Baruch Padeh Medical Center, Poriya
CTEPH
Feasibility and Influence of Exercise Therapy on Oxygen Uptake and Right Heart Function in CTEPH Patients After PEA
Purpose of this study is to investigate whether and to what extent a cautious respiratory and movement therapy can complement medical treatment and the condition, oxygen uptake, quality of life, the pulmonary vascular pressures…
- Trial name
- NCT01393327
- Testing
- respiratory and exercise therapy
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- Heidelberg University
Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension, Chronic Cardiorespiratory Disease
Effect of Short-term Oxygen During CPET in Pulmonary Hypertension
In a randomized, sham-controlled trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with…
- Trial name
- ExOx-CPET (NCT01748474)
- Testing
- Supplemental oxygen via a mask
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Obesity, Hypertension
The Mobile Health Platform
This study develops and pilots the initial interface of our mobile health platform that will allow for intra-individual tailoring and personalization of health interventions.
- Conditions
- Obesity, Hypertension, Diabetes
- Trial name
- mHealth (NCT02099513)
- Testing
- The Mobile Health Platform
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Duke University
Chronic Venous Hypertension With Ulcer
Standard Compression Therapy With/Without Application of Skin Allograft (Theraskin) for Venous Leg Ulcer Treatment
This study will compare the efficacy of using standard compression therapy for treatment of chronic venous leg ulcers vs. the standard compression therapy with the additional use of the application of a human allograft (Theraskin)
- Trial name
- NCT03935386
- Testing
- Standard Multi-layered Compression dressing, Standard Multi-layered Compression dressing with a cryopreserved skin allograft (TheraSkin)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Solsys Medical LLC
Dyspnea, Lung Diseases
Effects of Automated Oxygen Titration Alone or With High Flow Nasal Therapy on Dyspnea and Exercise Tolerance
The main purpose of this study is to evaluate the effects of automated oxygen administration (FreeO2 system) alone or with high-flow oxygen on dyspnea and exercise tolerance in people with desaturating chronic lung disease…
- Conditions
- Dyspnea, Lung Diseases, Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT05267418
- Testing
- Automated nasal O2 titration with FreeO2
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
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