Clinical trials: Chronic Illness
Mental Health, Depression and Burden in Caregivers
SOS for Caregiver Wellbeing
Parents and caregivers of children who have a chronic condition carry a large care burden and are at higher risk of having mental health symptoms.
- Conditions
- Mental Health, Depression and Burden in Caregivers, Anxiety Depression, Stress
- Trial name
- SOS (NCT07136584)
- Testing
- Screening, Outcomes and Referral Pathways
- Where
- Australia
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Murdoch Childrens Research Institute
Chronic Illness, Heart Failure - NYHA II - IV
An Optimization Pilot to Optimize An Early Palliative Care Intervention for Advanced Heart Failure
Using a highly innovative methodology, the Multiphase Optimization Strategy (MOST), the purpose of this randomized factorial pilot trial is to identify feasibility, acceptability, and preliminary efficacy of components of an…
- Trial name
- UPHOLDS (NCT05879887)
- Testing
- UPHOLDS (Utilizing Palliative Care for Heart Failure Optimized using Lay Navigators to Decrease Suffering)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Advance Care Planning, Advance Directives
Project Talk Trial: Engaging Underserved Communities in End-of-life Conversations
Compared to the general population, individuals from underserved communities are more likely to receive low quality end-of-life care and unwanted, costly and burdensome treatments due in part to a lack of advance care planning…
- Conditions
- Advance Care Planning, Advance Directives, Terminal Illness, Chronic Illness
- Trial name
- NCT04612738
- Testing
- Hello (serious game), The Conversation Project (CP) Starter Kit, Table Topics (general conversation game)
- Where
- 79 sites in United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Depression and/or Anxiety in the Mild-to-moderate Range, Stress (Psychology)
SanaMente: A Peer-Led Program to Reduce Health Disparities in Rural Latino/a Communities
The goal of this clinical trial is to evaluate the feasibility, acceptability, and preliminary effectiveness of the SanaMente peer-led mental health and lifestyle program for rural Latino/a adults with chronic medical conditions…
- Conditions
- Depression and/or Anxiety in the Mild-to-moderate Range, Stress (Psychology), Chronic Medical Illness
- Trial name
- SanaMente (NCT07705776)
- Testing
- SanaMente
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Caregiver Stress, Caregiver Stress Syndrome
ACT Group for Family Caregivers of Stroke Survivors
The goal of this study is to evaluate the efficacy of group-based ACT intervention in improving the levels of psychological distress in caregivers of stroke survivors. The main questions it aims to answer are: 1.
- Conditions
- Caregiver Stress, Caregiver Stress Syndrome, Caregiver Burnout, Caregiver Distress
- Trial name
- NCT07528261
- Testing
- Group-based ACT Intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Wright Institute
Chronic Illness
Virtual ACT for Adolescent Stress
This study aims to test the effectiveness of a 6-week long virtual Acceptance Commitment group therapy as a non-pharmaceutical intervention to improving other functional outcomes for adolescents with a chronic medical condition…
- Trial name
- NCT04978610
- Testing
- Virtual Acceptance Commitment Therapy
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Caregiver Stress in Chronic Mental Illness, Psychosocial Burden in Psychiatric Caregivers
Effect of a Mindfulness-Based Stress Reduction Program on Caregivers
This study is designed to investigate the effects of a Mindfulness-Based Stress Reduction (MBSR) program on cognitive control and flexibility, psychological well-being, and self-compassion among primary caregivers of individuals…
- Conditions
- Caregiver Stress in Chronic Mental Illness, Psychosocial Burden in Psychiatric Caregivers, Chronic Mental Illness Caregiving, Cognitive and Emotional Outcomes in Caregivers
- Trial name
- MBSR-CG (NCT07322081)
- Testing
- The Mindfulness-Based Stress Reduction program consists of structured mindfulness practices, psychoeducation, and experiential exercises delivered to caregivers., Usual Care Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Healthy, Chronic Stable Illness
COVID-19 Study to Assess Immunogenicity, Safety, and Tolerability of Moderna mRNA-1273 Vaccine Administered With Casirivimab+Imdevimab in Healthy Adult Volunteers
The primary objectives of the study are: To evaluate the extent of effect, if any, of REGN10933+REGN10987 administration on vaccine-induced neutralizing antibody responses to SARS-CoV-2 by Moderna mRNA-1273 To evaluate the time…
- Trial name
- NCT04852978
- Testing
- casirivimab+imdevimab, Moderna mRNA-1273 vaccine
- Where
- 6 sites in United States
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Healthy, Chronic Stable Illness
COVID-19 Study Assessing the Safety and Tolerability of Co-Formulated Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies (Casirivimab+Imdevimab) in Adult Volunteers
The primary objective of the study is to assess the safety and tolerability of co-formulated subcutaneous (SC) and intravenous (IV) casirivimab+imdevimab The secondary objectives of the study are to: Explore variability in the…
- Trial name
- NCT05181683
- Testing
- Casirivimab+Imdevimab
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Siblings of Children With Chronic Illness
SIBS-Intervention for Siblings and Parents of Children With Chronic Illness
SIBS-RCT is a randomized controlled trial comparing the effect of a 5-session group intervention for siblings and parents of children with chronic illness to 12-week waitlist.
- Trial name
- SIBS-RCT (NCT04056884)
- Testing
- SIBS intervention
- Where
- Norway
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Depression, Anxiety
The Mental Health Experiences of Sexual and Gender Minorities Living With Cancer and Their Care Partners
The purpose of this study is to examine relationships between contextual stressors and stress moderators, depression symptom experience, resilience, frailty, and quality of life among older sexual gender minorities cancer…
- Conditions
- Depression, Anxiety, Caregiver Burden, Stress
- Trial name
- SGMC (NCT05866705)
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Depression, Family Dynamics
The Mental Health Effects of a Mindfulness App in Parents of a Child With Medical Complexity
The number of children with special health care needs (CSHCN) in the US is nearly 20% of children representing approximately 14.6 million children nationally.
- Conditions
- Depression, Family Dynamics, Stress, Psychological, Chronic Illness
- Trial name
- NCT05925868
- Testing
- mindfulness app
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Boise State University
Chronic Illness
You.Mind! | Boosting First-line Mental Health Care for Youngsters Suffering From Chronic Conditions With Mindfulness
Adolescents with chronic conditions often experience high levels of stress, anxiety and depression and reduced quality of life. Mindfulness-Based Interventions (MBI) have been found to improve emotional distress in clinical and…
- Trial name
- NCT04359563
- Testing
- Mindfulness-Based Intervention
- Where
- Belgium
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Healthy, Chronic Stable Illness
Study Assessing the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Repeated Subcutaneous Doses of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies (REGN10933+REGN10987) in Adult Volunteers as Related to COVID-19
The primary objectives are: To assess the occurrence of adverse events of special interest (AESIs) in participants treated with repeated subcutaneous (SC) doses of REGN10933+REGN10987 compared to placebo To assess the…
- Trial name
- NCT04519437
- Testing
- REGN10933+REGN10987
- Where
- 7 sites in United States
- Volunteers
- 974 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Chronic Disease, Aging
Student-delivered Telehealth Program for COVID-19 Education and Health Promotion
The purpose of this study is to ensure effective health management among community-living older adults during unprecedented times, such as the current COVID-19 pandemic.
- Conditions
- Chronic Disease, Aging, Aging Problems, Health Behavior
- Trial name
- NCT04492527
- Testing
- Telehealth coaching sessions
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Chronic Illness
Promoting Medication Reimbursement Policy (PAPMed)
Rationale: Chronic non-communicable diseases (NCDs) have become the leading cause of morbidity and mortality in China. Rural NCDs patients are more likely to suffer from poverty.
- Trial name
- PAPMed (NCT04731194)
- Testing
- Performance-based financial incentive program
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke Kunshan University
Critical Illness, Chronic Obstructive Lung Disease
Advance Care Planning Evaluation in Hospitalized Elderly Patients
The purpose of the study is to inform decision-makers of the best strategies to implement advanced care planning (ACP). An advanced care plan (ACP) is a verbal or written instruction describing what kind of care an individual…
- Conditions
- Critical Illness, Chronic Obstructive Lung Disease, Congestive Heart Failure, Cirrhosis
- Trial name
- ACCEPT (NCT01362855)
- Where
- 9 sites in Canada
- Volunteers
- 503 people, healthy volunteers welcome
- Sponsor
- Daren K. Heyland
Narrative Medicine, Chronic Disease
Impact of Early Implementation of Narrative Medicine Techniques on Patient Centered Attitudes of Medical Students
A qualitative study assessing the impact of early narrative medicine practice on Medical Honors Program (MHP) students' attitudes regarding patient-centered interactions, through interviewing patients with chronic or…
- Conditions
- Narrative Medicine, Chronic Disease, Terminal Illness, Cancer
- Trial name
- NCT03041571
- Testing
- Patient Provider Orientation Scale, Interview performed by MHP student
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Caregiver, Mindfulness
Resourcefulness Training and Decentering on Self-Management in Caregivers of Technology Dependent Children
The investigators will conduct a randomized clinical trial pilot study to examine the effectiveness of a theoretically based intervention (called ReMind) encompassing two key components: (a) Resourcefulness Training for parent…
- Conditions
- Caregiver, Mindfulness, Mechanical Ventilation Pressure High, Gastrostomy
- Trial name
- NCT02993887
- Testing
- Resourcefulness Training, Mindfulness
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Chronic Illness, Comorbidities
Advance Care Planning & Goals of Care Randomized Controlled Trial in Primary Care
Sometimes people with health conditions become ill suddenly and can no longer speak for themselves and another person (such as a family member) will make health care decisions for them.
- Trial name
- NCT03434626
- Testing
- ACP Education, Usual care
- Where
- 2 sites in Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- McMaster University