Clinical trials: Chronic Illnesses
Chronic Fatigue Syndrome
Noradrenergic and Stress-Related Etiologies of Chronic Fatigue Syndrome
The objective of this study is to measure sympathetic nervous system function and stress responses in patients with clinically documented and self-reported chronic fatigue that is worsened by stress, compared to healthy controls.
- Trial name
- NCT03029377
- Testing
- Posture Study, Autonomic Function Tests, and a Stress Test
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Idiopathic Pulmonary Fibrosis (IPF), Idiopathic Pulmonary Fibrosis
PET Study of PIPE-791 in Healthy Volunteers and Volunteers With PrMS and IPF
This is a study of PIPE-791, an investigational study drug to treat progressive multiple sclerosis (MS) and idiopathic pulmonary fibrosis (IPF).
- Conditions
- Idiopathic Pulmonary Fibrosis (IPF), Idiopathic Pulmonary Fibrosis, Multiple Sclerosis, Multiple Sclerosis, MS
- Trial name
- NCT06683612
- Testing
- PIPE-791
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Contineum Therapeutics
Chronic Obstructive Pulmonary Disease
How Smoking Causes COPD: Examination of Immune System Changes
A breathing condition known as "chronic obstructive pulmonary disease" (COPD) caused by cigarette smoking is a major health problem. The way by which smoking leads to lung disease is uncertain.
- Trial name
- NCT00186719
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
COPD, One Lung Ventilation
Effects of Dexmedetomidine on Respiratory Mechanics and Oxygenation During One Lung Ventilation With Chronic Obstructive Lung Disease
COPD is often associated with the airflow limitation and the pulmonary hyperinflation. During the one-lung ventilation (OLV), COPD patients' physiologic dead space increases and hypercapnia may develop.
- Trial name
- NCT02185430
- Testing
- saline infusion, dexmedetomidine infusion
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Yonsei University
COPD
Effects of Breathing Exercises With and Without Inspiratory Muscle Training in COPD Patients
Chronic Obstructive Pulmonary Disease (COPD) is a major health issue that affects a large proportion of the population, especially those over 50 years old. It is characterized by breathlessness and reduced lung function.
- Trial name
- NCT06555445
- Testing
- BREATHING EXERCISE, BREATHING EXERCISE REGIMEN COUPLED WITH BREATHER DEVICE
- Where
- Pakistan
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Riphah International University
End-stage Renal Disease
Functional Reserve Estimation of Donor Kidney
The purpose of the study: To estimate the role of morphological, clinical, biochemical and imaging studies at stages of kidney transplantation (medical therapy, explantation, preservation, transplantation).
- Trial name
- NCT01689272
- Testing
- Kidney Transplantation from alive relative donor
- Where
- Kazakhstan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nazarbayev University
Philadelphia Chromosome Positive (Ph+) Chronic Myeloid Leukemia (CML)
Bioequivalence And Food Effect Study Of Bosutinib In Healthy Subjects
The purpose of this study is to demonstrate the bioequivalence of the clinical tablet formulation (100 mg x 5) to the clinical capsule formulation (100 mg x 5) in healthy subjects under fed condition (Cohort 1) and to investigate…
- Trial name
- NCT01374139
- Testing
- Bosutinib
- Where
- Singapore
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Pfizer
Chronic Kidney Disease, Cardiovascular Complications
Omega-3 Acids and Cardio - Vascular Complications in Patients With Chronic Kidney Disease in Stage 1-3
The National Register of Nephrology in 2007 shows, similarly to the European data, a problem of a high mortality rate among Polish dialysis patients.
- Trial name
- Omega-3 acids (NCT02147002)
- Testing
- Gold omega 3
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Collegium Medicum w Bydgoszczy
Chronic Kidney Disease, Sleep Loss
Sleep Disturbances as a Non-traditional Risk Factor in CKD-Actigraphy
To test if usual at home night time sleep duration as measured with activity monitors and questionnaires will predict changes in kidney function as measured by kidney filtration rate and of cardiovascular function as measured by…
- Trial name
- CRIC (NCT00817674)
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Obesity, Heart Disease
Helping People to Exercise Regularly
This study tests two different incentive mechanisms to induce members of a particular urban senior center to attend more exercise classes.
- Trial name
- NCT01335880
- Testing
- Coupons for use within the next week, Coupons for use within the next 3 months
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Chronic Obstructive Pulmonary Disease
Identification of Volatile Organic Compounds in Exhaled Air During Exacerbation of Chronic Obstructive Pulmonary Disease
Exacerbations of the disease are a hallmark of Chronic Obstructive Pulmonary Disease (COPD), affecting the decline of pulmonary function, quality of life and increasing morbidity.
- Trial name
- LAVOLEX (NCT02529891)
- Testing
- Measurement of VOC in exhaled air
- Where
- France
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Pulmonary Hypertension, Chronic Kidney Disease
Association Between Biomarkers and Kidney Function Decline in Pulmonary Hypertension
The objective of this study is to examine the association between urinary and plasma biomarkers and change in estimated glomerular filtration rate (eGFR) among patients with pulmonary hypertension (PH).
- Trial name
- NCT06409624
- Testing
- No intervention is planned as part of the study
- Where
- 2 sites in Germany
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Chronic Periodontitis
Comparison of Autogenous Periosteal Pedicle Graft and Collagen Membrane in Management of Periodontal Intrabony Defects
A clinical and radiographic evaluation of autogenous periosteal pedicle graft in comparison with collagen membrane for management of periodontal intrabony defects.
- Trial name
- NCT02248103
- Testing
- Periosteal pedicle graft, Bioresorbable collagen membrane
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Exercise
The Effects of 'Functional' Inspiratory Muscle Training
This study was designed as a prospective and experimental study. Geriatric individuals (age ≥ 65 years) with COPD and non-COPD were included in the study.
- Trial name
- NCT04460261
- Testing
- Functional Inspiratory Muscle Training
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ismail OZSOY
Chronic Periodontitis, Aggressive Periodontitis
Smoking Influence on Apoptosis in Periodontitis
Apoptosis is an evolutionary form of physiological cell death. Studies suggest that apoptosis is involved in the pathogenesis of periodontal diseases.
- Trial name
- NCT02111005
- Where
- 2 sites in Syria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Damascus University
Chronic Periodontitis
Adjunctive Use of Salvadora Persica in Chronic Periodontitis
A randomized controlled triple blinded study to evaluate the effectiveness of Salvadora Persic (SP) as an adjunct to Scaling and Root Planing (SRP) in chronic periodontitis by comparing the basic parameters of periodontitis…
- Trial name
- NCT03749369
- Testing
- Salvadora Persica Root, Scaling and root planing
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- King Saud University
Chronic Disease
Barriers to Vegetarian Diets
The goal of this observational study is to learn what affects a person's openness to adopting a vegetarian diet in urban community members with chronic disease.
- Trial name
- NCT07075653
- Testing
- Survey using a questionnaire.
- Where
- 3 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Chronic Periodontitis
Comparison of Salivary Interleukin-1β and Matrix Metalloproteinase-8 Levels in Individuals With Chronic Periodontitis
Periodontitis is an infectious inflammatory disease affecting the periodontal tissue (Gingivae, alveolar bone, periodontal ligament and cementum).
- Trial name
- NCT03270280
- Testing
- Nigella Sativa Oil, Normal saline
- Where
- Pakistan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Lahore
Cancer, Cardiac Anomaly
Using NPT to Evaluate Providing PPC as ELNEC-PPC WBT for Nurses
The purpose of this study is to explain the provision of palliative care at the end of life by the implementation of the ELNEC course, as WBT Program using the Normalization Process Theory, that focus attention on how complex…
- Conditions
- Cancer, Cardiac Anomaly, Cystic Fibrosis, Muscular Dystrophy
- Trial name
- ELNEC-PPC (NCT04461561)
- Testing
- end-of-life nursing education consortium-pediatric palliative care as web based-training plus usual care
- Where
- Iraq
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Altoosi University College
Chronic Illness
Promoting Medication Reimbursement Policy (PAPMed)
Rationale: Chronic non-communicable diseases (NCDs) have become the leading cause of morbidity and mortality in China. Rural NCDs patients are more likely to suffer from poverty.
- Trial name
- PAPMed (NCT04731194)
- Testing
- Performance-based financial incentive program
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke Kunshan University
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