Clinical trials: Chronic Leg Pain
Ankle Sprains, Chronic Pain
Effects of Closed Chain Exercise Versus Neuromuscular Training on Chronic Ankle Sprain in Football Players
A current study will be conducted to determine the effects of closed-chain exercise versus neuromuscular training on pain, range of motion, and functional performance in football players with a chronic ankle sprain.
- Trial name
- NCT05981560
- Testing
- Group A - Closed Chain Exercise, Group B - Neuromuscular Training Exercise
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Venous Leg Ulcer
Randomized Controlled Trial for Treatment of Pain and Assessment of Wound Healing in Chronic Venous Leg Ulcers Using Near Infrared Laser Therapy
The laser emits an infrared light that heats the skin and underlying tissues with the purpose of temporary relief of minor muscle and joint pain, as well as stiffness associated with arthritis.
- Trial name
- NCT03716167
- Testing
- Summus Laser
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Pes Planus, Flatfoot
Central Sensitization and Nociplastic Pain in Pes Planus
Background: Pes planus, commonly known as flatfoot, is a condition characterized by the collapse of the medial longitudinal arch of the foot.
- Conditions
- Pes Planus, Flatfoot, Central Sensitization, Nociplastic Pain
- Trial name
- NCT07125781
- Where
- Turkey (Türkiye)
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Bozok University
Painful Diabetic Neuropathy
Study on the Role of Decompression of Lower Extremity Nerves for the Treatment of Patients With Symptomatic Diabetic Neuropathy With Chronic Nerve Compression
The UT Southwestern Medical Center at Dallas would like to give you information about a research study that is being done for patients with painful diabetic neuropathy and have not responded to medical treatment.
- Trial name
- DNND (NCT00703209)
- Testing
- Nerve Decompression
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Electromyography, Knee Injuries
Vastus Medialis Activation During McMurray's Test
This study will use electromyography to evaluate activation patterns of the vastus medialis and vastus lateralis muscles during the McMurray's knee examination test in different knee positions.
- Conditions
- Electromyography, Knee Injuries, Knee Pain Chronic
- Trial name
- NCT05965804
- Testing
- McMurray knee examination test
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ahram Canadian University
Compartment Syndrome of Leg
Chronic Exertional Compartment Syndrome (CECS) Treated With Abobotulinumtoxin A
Chronic Exertional Compartment Syndrome (CECS) is a painful condition affecting runners and it is caused by a reversible increase in pressure within a closed compartment in the leg.
- Trial name
- CECS (NCT05466539)
- Testing
- AbobotulinumtoxinA
- Where
- 2 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Emory University
Pain, Acute, Pain, Chronic
Evaluation of the Effect of a Food Supplement Based on Hydrolyzed Collagen on Joint Function.
This clinical study evaluates the effect of taking a hydrolyzed collagen-based supplement on pain, function and quality of life in a moderately physically active population.
- Conditions
- Pain, Acute, Pain, Chronic, Knee Osteoarthritis, Knee Injuries
- Trial name
- COLART (NCT05917925)
- Testing
- COLLAGEN (COL)
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera
Chronic Lower Limb Pain
Basic Assessment of Safety and Minimally Invasive Stimulation Via Injectrode
The objectives of this non-significant risk (NSR) study are to evaluate the safety of the short term placement of the Basmati Injectrode for up to 28 days and the efficacy of conducting electrical current to stimulate…
- Trial name
- BASMATI (NCT04672096)
- Testing
- Neuronoff BASMATI Injectrode
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Neuronoff, Inc
Chronic Pain
Aquatic Exercise for Veterans in Pain
This trial is to show the feasibility of administering a randomized clinical trial that determines the effectiveness of aquatic exercise compared to land-based exercise of military Veterans who have chronic pain.
- Trial name
- NCT05869617
- Testing
- Aquatic exercise, Land-based Exercise
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr. Nicholas Held
Back Pain, Back Pain With Radiation
Sub-Sensory Intraspinal Neurostimulation Therapy
To explore the optimal stimulation parameters and locations for sub-perception programming in patients with previously implanted spinal cord stimulation systems for the treatment of chronic back and/or leg pain.
- Conditions
- Back Pain, Back Pain With Radiation, Pain in Leg, Unspecified
- Trial name
- NCT01976598
- Testing
- Sub-Sensory Stimulation
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Algos Clinical Development Thomas L. Yearwood, MD, PhD
Sedentary Lifestyle, Knee Osteoarthritis
NEAT!2 Sedentary Behavior Reduction for Individuals With Past or Present Knee Symptoms, Injuries, or Surgeries
This study will evaluate the effectiveness of an mHealth sedentary reduction program over a 6-month period of time in adults with past or present knee symptoms, injuries, or surgeries.
- Conditions
- Sedentary Lifestyle, Knee Osteoarthritis, Knee Injuries, Knee Pain Chronic
- Trial name
- NCT03987932
- Testing
- NEAT!2, NEAT!2+Calls, Delayed NEAT!2
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Musculoskeletal Pain, Ankle Injuries
Video Aided Mindful Deep Breathing for Pain Management
Chronic ankle instability (CAI) is the most common musculoskeletal injury in sports and the rate of CAI accounts for 85% of ankle injuries.
- Conditions
- Musculoskeletal Pain, Ankle Injuries, Joint Instability
- Trial name
- NCT04812158
- Testing
- standard ankle physiotherapy or rehabilitation for chronic ankle instability
- Where
- Malaysia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universiti Tunku Abdul Rahman
Hallux Limitus, Movement, Abnormal
Foot Posture Index, Hallux Limitus in Patients With Chronic Low Back Pain. Gait With Optogait Sensor
Foot disorders have been recognized as being linked to chronic low back pain
- Conditions
- Hallux Limitus, Movement, Abnormal, Back Pain Lower Back Chronic
- Trial name
- NCT04607863
- Testing
- Case control
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Seville
Chronic Low Back Pain
A Comparative Study: Non-Surgical Spinal Decompression and Spinal Manipulative Therapy- Utilizing a Quantifiable Musculoskeletal Functional Assessment Risk Analysis Tool (MSDR®) in Patients With Chronic Low Back Pain
To administer the MSDR® (Musculoskeletal Disorder Reporting) instrument to document the musculoskeletal profile of patients with chronic low back pain, a prospective, non-randomized, multicenter treatment trial
- Trial name
- NCT00732394
- Testing
- MSDR
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- MedAppraise, Inc.
Chronic Low Back Pain, Pain in Leg, Unspecified
Effect of Spinal Cord Stimulation on Gait and Balance in Chronic Low Back Pain Patients
Spinal Cord Stimulation (SCS) uses electrical signals to disrupt noxious signals arising from painful areas, thereby reducing pain perception.
- Trial name
- NCT03586882
- Testing
- Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Texas Back Institute
Osteoarthritis of the Knee, Degenerative Osteoarthritis
Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis
The primary research purpose is to determine if the use of a drug therapy intervention (each study participant will be randomly assigned to receive one of 3 study medications which will be blinded from everyone, including the…
- Conditions
- Osteoarthritis of the Knee, Degenerative Osteoarthritis, Knee Pain Chronic
- Trial name
- PRPNSAIDsKOA (NCT05742763)
- Testing
- Ibuprofen and PRP, Acetaminophen and PRP
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- QC Kinetix LLC
Cerebral Palsy, Bilateral Cerebral Palsy
Effects of HABIT-ILE in Adults with Bilateral Cerebral Palsy
This randomized controlled trial (RCT) aims to evaluate the effects of intensive Hand and Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) in improving body structure, function, daily activities, and…
- Trial name
- NCT06767930
- Testing
- Hand and Arm Bimanual Intensive Therapy Including Lower Extremities, Conventional intervention
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Failed Back Surgery Syndrome, Complex Regional Pain Syndrome (CRPS)
A Study to Confirm the Safety of High Frequency DRG Stimulator in Patients With Chronic Lower Limb Pain
This study is a prospective, single-arm, open label, single center pilot study to confirm the safety of a ultrahigh frequency DRG stimulator in patients with chronic lower limb pain. The actual trial length is 5 days.
- Trial name
- NCT03285113
- Testing
- GiMer Medical MN 1000 External Stimulator
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- GiMer Medical
Knee Osteoarthritis, Knee Pain Chronic
Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis
The objective of the study is to explore the effects of arm exercise (UE, arm ergometer) vs. leg exercise (LE, cycling ergometer) on exercise-induced hypoalgesia (EIH), central pain mechanisms and knee pain in people with knee…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Central Pain Syndrome
- Trial name
- NCT06105788
- Testing
- Exercise
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Back Pain Lower Back Chronic
Caudal Epidural Injection of Dextrose For Low Back Pain
Objective: The purposes of the study are to 1. Explore the immediate and short term (to 48 hour) analgesic potential of epidural D5W in comparison to normal saline. 2.
- Trial name
- NCT01547364
- Testing
- Saline, Dextrose
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Smigel, Liza, M.D.