Clinical trials: Chronic Lung Allograft Dysfunction
Lung Transplantation, Antibody Mediated Rejection
Quantitative Parameters of HLA-DQ Antibodies in Lung Transplantation
The aim is to compare the quantitative parameters of de novo anti-HLA DQ Donor Specific Antibodies (DSA), determined at the time of their discovery by surface plasmon resonance (SPR), between recipients that developed a Chronic…
- Conditions
- Lung Transplantation, Antibody Mediated Rejection, Chronic Lung Allograft Dysfunction
- Trial name
- AFFIHLA-P (NCT03474536)
- Where
- 5 sites in France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Bordeaux
Bronchiolitis Obliterans Syndrome (BOS)
Extracorporeal Photopheresis for Medicare Recipients of Lung Allografts
The primary aims of this study is to determine the efficacy and tolerability of Extracorporeal Photopheresis (ECP) for the treatment of either Refractory Bronchiolitis Obliterans Syndrome (BOS) patients (258 at cessation of…
- Trial name
- ECP (NCT02181257)
- Testing
- Extracorporeal Photopheresis (ECP), No intervention in the SOC / Retrospective Chart review.
- Where
- 22 sites in United States
- Volunteers
- 280 people
- Sponsor
- Washington University School of Medicine
Chronic Lung Allograft Dysfunction (CLAD)
Breath Volatile Organic Compounds Patterns of Lung Transplant Patients With Chronic Lung Allograft Dysfunction
It's the aim of this study to clarify, whether the non-invasive assessment of breath can serve as a novel clinical tool to assist in the diagnosis of CLAD.
- Trial name
- NCT02836938
- Testing
- Collection of exhaled breath volatile organic compounds
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Prof. Dr. Jens Hohlfeld
Bronchiolitis Obliterans Syndrome
A Retrospective Chart Review Study of Patients With CLAD-BOS Post Lung Transplantation
The Primary Objective of this study was to evaluate the FEV1 trajectory of patients diagnosed with CLAD-BOS. The Secondary Objectives of this study were: To describe demographics of patients diagnosed with CLAD-BOS To describe…
- Trial name
- NCT06503770
- Where
- 6 sites in United States, Belgium and 1 more
- Volunteers
- 284 people
- Sponsor
- Zambon SpA
Lung Transplant Rejection
Macitentan in the Treatment of Organ Rejection After Lung Transplantation
Potential therapy with MACITENTAN in the treatment of Chronic Lung Allograft Dysfunction (CLAD) after Lung Transplantation. Pilot Study, Double-blind, "ADD-ON Therapy" with MACITENTAN to "usual standard of care immunosuppressive…
- Trial name
- NCT02893176
- Testing
- macitentan
- Where
- United States
- Sponsor
- University of California, Los Angeles
Transplantation, Heart-Lung, Chronic Lung Allograft Dysfunction
Evaluation of Electrical Impedance Tomography for the Diagnosis of Chronic Rejection in Lung Transplants Recipients
Electrical impedance tomography (EIT) is non-invasive and provides functional imaging of the lung and it could be a useful tool to diagnose chronic lung allograft dysfunction (CLAD) and specially Bronchiolitis Obliterans Syndrome…
- Conditions
- Transplantation, Heart-Lung, Chronic Lung Allograft Dysfunction, Bronchiolitis Obliterans Syndrome
- Trial name
- CLAD (NCT02863835)
- Testing
- EIT, Salbutamol nebulisation and with CPAP
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Lung Transplant Infection, Lung Transplant Rejection
Clinical Significance of Community-acquired Respiratory Virus Infection and Longitudinal Analysis of the Lung Microbiome in Lung Transplantation
The purpose of this study is to evaluate the clinical significance of community-acquired respiratory virus (CARV) infection in patients with lung transplantation;Explore the lung microbiome dynamics within one year after lung…
- Trial name
- NCT03545919
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Capital Medical University
Bronchiolitis Obliterans, Chronic Rejection of Lung Transplant
Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Double Lung Transplant (BOSTON-2)
The objective of this trial was to assess the efficacy and safety of aerosolized liposomal cyclosporine A (L-CsA) as add-on therapy to standard of care (SoC) as compared to SoC alone in double lung transplant (DLT) recipients…
- Conditions
- Bronchiolitis Obliterans, Chronic Rejection of Lung Transplant, Lung Transplant Rejection, Lung Transplant; Complications
- Trial name
- BOSTON-2 (NCT03656926)
- Testing
- Liposomal Cyclosporine A, Standard of Care
- Where
- 40 sites in United States, Austria and 7 more
- Volunteers
- 169 people
- Sponsor
- Zambon SpA
Lung Transplant Rejection
Assessment of Chronic Lung Allograft Dysfunction Using Single-breath & Multi-breath Hyperpolarized Xenon-129 MRI
This study will use Magnetic Resonance Imaging (MRI) to study the lungs of 90 volunteers using the inhaled contrast agent, hyperpolarized xenon-129.
- Trial name
- NCT04941573
- Testing
- Hyperpolarized 129-Xenon (MagniXene) MRI of the lung
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Xemed LLC
Lung Transplantation, Chronic Lung Allograft Dysfunction
Lung Clearance Index and Lung Allograft Dysfunction
The aim of this project is to evaluate the ability of the lung clearance index (LCI) to detect early chronic lung allograft failure (CLAD) in adult lung transplant recipients over a period of 3 years.
- Conditions
- Lung Transplantation, Chronic Lung Allograft Dysfunction, Rejection Lung Transplant
- Trial name
- NCT03850002
- Testing
- Early detection of CLAD by Lung Clearance Index (LCI)
- Sponsor
- University of Zurich
Granulomatous Disease, Chronic
Use of Busulfan as Conditioning Agent for a Second Stem Cell Transplant
This protocol is designed for a single specific patient. It uses busulfan as a conditioning agent in a second stem cell transplant procedure for a patient with chronic granulomatous disease (CGD), a disorder in which a certain…
- Trial name
- NCT00092937
- Testing
- Busulfan
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lung Transplant
Belumosudil to Block Chronic Lung Allograft Dysfunction (CLAD) in High Risk Lung Transplant Recipients
The purpose of this study is to see if taking the study drug, Belumosudil, for 52 weeks in addition to your usual care and medication, will prevent Chronic Lung Allograft Dysfunction (CLAD) in participants who have a lung biopsy…
- Trial name
- CLAD (NCT06476132)
- Testing
- Belumosudil
- Where
- 12 sites in United States, Canada
- Volunteers
- 234 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lung Transplant Failure and Rejection, Chronic Lung Allograft Dysfunction
Trajectories of FEV1 After Lung Transplantation
For individuals with ESLD, lung transplantation is the best, or only treatment option with increased pulmonary function and quality of life.
- Trial name
- TRAJLUNG (NCT05934617)
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Disorder Related to Lung Transplantation, Chronic Lung Allograft Dysfunction
Studying the Treatment Effect of Pirfenidone in Chronic Lung Allograft Dysfunction (STOP-CLAD)
Greater than 50% of lung transplant recipients show signs of chronic lung allograft dysfunction (CLAD) by 5 years post-transplantation.Therapies to prevent or slow CLAD are lacking.
- Trial name
- NCT03473340
- Testing
- Pirfenidone Capsule
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Michigan
Lung Transplant, Post Lung Transplantation
CLAD Phenotype Specific Risk Factors and Mechanisms
While many patients experience benefits from transplant, complications such as infections and lung rejection may affect long term survival and quality of life.
- Trial name
- NCT02631720
- Testing
- Blood Draw, Bronchoscopy
- Where
- 5 sites in United States, Canada
- Volunteers
- 884 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lung Transplant Rejection
A Study to Test How Effective Belumosudil Tablets Are for Treating Adult Participants With Chronic Lung Allograft Dysfunction
This double-blind, randomized, placebo-controlled, multinational, multicenter, parallel-group, Phase 3, 2-arm, study will investigate the efficacy and safety of belumosudil compared with placebo, both administered on top of…
- Trial name
- ROCKaspire (NCT06082037)
- Testing
- Belumosudil, Azithromycin
- Where
- 85 sites in United States, Australia and 18 more
- Volunteers
- 180 people
- Sponsor
- Sanofi
Graft Rejection, Kidney Transplantation
TRAnscriptional Profile of Peripheral Blood Cells in Patient With Chronic Kidney and Lung Rejection: Correlation With Response to Extracorporeal Photo-aphereSiS
With this project, the research team aims to identify the molecular pathways associated with the response to extracorporeal photonchemioapheresis (ECP) in kidney or lung transplant patients suffering from chronic rejection, by…
- Conditions
- Graft Rejection, Kidney Transplantation, Lung Transplantation, Antibody-Mediated Rejection
- Trial name
- TRACKLESS (NCT07316829)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Chronic Rejection of Lung Transplant
Noninvasive Early Detection of Lung Allograft Dysfunction After Lung Transplantation With Multiple Breath Washout Test
Chronic rejection, more commonly called bronchiolitis obliterans syndrome (BOS), is the leading cause of death beyond the first year post lung transplantation.
- Trial name
- NCT05586906
- Testing
- Multiple Breath Washout (MBW) tests
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- University of Zurich
Kidney Transplant
A Study of Factors That Affect Long-Term Kidney Transplant Function
The causes of deterioration of transplanted kidney function are poorly understood. The purpose of this study is to determine the disease processes that cause transplanted kidney dysfunction and loss in patients who received a…
- Trial name
- DeKAF (NCT00270712)
- Where
- 7 sites in United States, Canada
- Volunteers
- 3,175 people
- Sponsor
- University of Minnesota
Lung Transplant Rejection
The Role of Immune Checkpoints in Lung Transplant (ILTRA)
The goal of this observational study is to learn about rejection in lung transplantation. The main question it aims to answer is: what is the role of immune checkpoints in lung transplantation? Participants will describe pathways…
- Trial name
- ILTRA (NCT06302556)
- Testing
- Immune checkpoints analysis, Gene expression analysis
- Where
- 4 sites in Italy
- Volunteers
- 280 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico