Clinical trials: Chronic Lung Disease
Copd
Short Acting Agents Vs Long Acting in Frequent Excerbator COPD Patients
Chronic obstructive pulmonary disease is heterogeneous lung condition characterized by chronic respiratory symptoms (dyspnea, cough, sputum production, exacerbations) due to abnormalities of the airways (bronchitis…
- Trial name
- NCT05748977
- Testing
- SABA SAMA ICS Vs LABA LAMA ICs
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
COPD Exacerbation Acute
The Effect of Airway and Chest Wall Oscillation on Respiratory Functions in COPD Patients in Acute Exacerbation
Chronic obstructive pulmonary disease (COPD); It is a common, treatable and preventable disease characterized by progressive and irreversible airflow limitation and has systemic effects with respiratory system involvement.
- Trial name
- NCT06274957
- Testing
- CONTROL, PEP DEVICE, HFCWO DEVICE
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Saglik Bilimleri Universitesi
Asthma Chronic
Thoracic Spine Rotation Stretching and Scapular Retraction in Asthma Patients
Patients with asthma frequently experience upper back stiffness and rounded shoulders and tightness in the thoracic region. Rib cage stiffness occurs due to poor posture and muscle tightness, which leads to decreased chest…
- Trial name
- NCT07508267
- Testing
- Thoracic Spine Rotation Stretching, Scapular retraction
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
COPD
Daily Magnesium-treatment of Patients With Chronic Obstructive Pulmonary Disease
The present study is part of a project titled 'Magnesium in asthma and chronic obstructive pulmonary disease'. The hypothesis of the main project is that a daily magnesium supplement will benefit patients with asthma and chronic…
- Trial name
- NCT01118936
- Testing
- Magnesium supplement (magnesium hydroxide/ -oxide)
- Where
- Denmark
- Volunteers
- 11 people
- Sponsor
- University of Aarhus
Chronic Obstructive Pulmonary Disease (COPD)
Fractional Exhaled Nitric Oxide and Exacerbations of COPD
Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition with recurrent exacerbations despite guideline-based therapy.
- Trial name
- NCT07396311
- Testing
- No intervention assigned
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Pulmonary Disease, Chronic Obstructive
Safety and Efficacy of Two Different Doses of Ipratropium Bromide Versus ATROVENT® Inhalation Aerosol in Adults With Chronic Obstructive Pulmonary Disease
The objective of this study is to confirm that chronic dosing of 20 mcg and 40 mcg of ipratropium bromide, administered via the RESPIMAT device, demonstrates clinical comparability and similar safety profiles to the 36 mcg dose…
- Trial name
- NCT02177344
- Testing
- Low dose of Ipratropium bromide, High dose of Ipratropium bromide, Atrovent
- Volunteers
- 646 people
- Sponsor
- Boehringer Ingelheim
Chronic Obstructive Pulmonary Disease, COPD
Incorporation of Genetic Expression of Airway Epithelium With CT Screening for Lung Cancer
Lung cancer, largely the result of cigarette smoking, is the leading cause of cancer death in the United States, killing over 160,000 people in 2010, more than breast, colorectal, and prostate cancer combined.
- Trial name
- NCT01982149
- Testing
- Group 1, Group 2, Group 3
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Asthma, COPD
MUlti-nuclear MR Imaging Investigation of Respiratory Disease-associated CHanges in Lung Physiology
Lung magnetic resonance imaging (MRI) with proton and inhaled inert gases has demonstrated a clinical ability to provide valuable structural and functional information in lung disease.
- Conditions
- Asthma, COPD, Covid19, Long COVID
- Trial name
- MURDOCH (NCT04872309)
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Long COVID
Utilizing Novel Blood RNA Biomarkers as a Diagnostic Tool in the Identification of Long COVID-19
The Primary objective of this study is to determine, using unblinded samples, if it is possible to develop an algorithm for the classification of specific blood RNA from patients with long COVID together and separately from the…
- Trial name
- NCT06311435
- Testing
- RNA Biomarker Blood Test
- Where
- 3 sites in United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- MaxWell Clinic, PLC
Chronic Respiratory Disease, Chronic Obstructive Pulmonary Disease
High-Intensity Interval Alternating Concentric-Eccentric Training in Chronic Respiratory Disease
This randomized controlled trial aims to evaluate the effects of high-intensity interval training incorporating alternating concentric and eccentric cycling on functional performance in adults with chronic respiratory disease…
- Trial name
- Effects of Hig (NCT07867535)
- Testing
- Alternating Concentric-Eccentric High-Intensity Interval Training, Concentric High-Intensity Interval Training, Usual Care
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Fu Jen Catholic University Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Temple Health Chest Initiative (THCI 2.0)
Chronic obstructive pulmonary disease is highly prevalent globally, with considerable morbidity and mortality associated. In the US, it is the 4th leading cause of death, as well as contributing to significant costs on healthcare…
- Trial name
- NCT06933758
- Testing
- Determine COPD prevalence utilizing spirometry along with CT scans and symptom assessments in the THCI lung cancer screening populatio
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Temple University
COPD, Acute Respiratory Failure
Revefenacin in Acute Respiratory Insufficiency in COPD
RARICO is a pragmatic, randomized, controlled, double-blinded, multi-center trial evaluating the safety and feasibility of nebulized revefenacin in comparison to nebulized ipratropium in patients with COPD and acute respiratory…
- Trial name
- RARICO (NCT04315558)
- Testing
- Revefenacin Inhalation Solution [Yupelri], Ipratropium Bromide
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- University of California, Los Angeles
Chronic Obstructive Pulmonary Disease (COPD)
A Pragmatic Cluster Trial of a Tailored Intervention to Improve COPD Management
Background: Chronic Obstructive Pulmonary Disease (COPD) remains a major health problem, which is strongly related to smoking. Despite publication of guidelines on the prevention and treatment of COPD, not all COPD patients…
- Trial name
- TICD-COPD (NCT01893476)
- Testing
- Implementation educational programme
- Where
- Poland
- Volunteers
- 540 people
- Sponsor
- Medical University of Lodz
Chronic Obstructive Pulmonary Disease
Effects of Tiotropium on Walking Capacity in Patients With COPD
This study was designed to test the following hypothesis: A) The acute and long-term (3 weeks) bronchodilator-induced changes in exercise tolerance and in the physiological response during the endurance shuttle walk will be…
- Trial name
- NCT01307189
- Testing
- Tiotropium
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Laval University
Chronic Obstructive Pulmonary Disease (COPD)
Validation of Structured Light Plethysmography - Health and Disease
Validation of Structured Light Plethysmography (SLP) in patients with conditions such as Chronic Obstructive Pulmonary Disease (COPD) that effect breathing and in healthy participants.
- Trial name
- SLP-RespDis (NCT02626468)
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pneumacare Ltd
COPD
A Pilot Study of the Use of 129Xe and 1H MRI to Measure the Modulation of Eosinophil-Related Inflammation by Mepolizumab In COPD
The investigators aim to recruit 32 people with COPD who have frequent exacerbations and high eosinophil counts which indicates "asthmatic type" inflammation and treat them for a year with mepolizumab.
- Trial name
- SUMMER (NCT05138250)
- Testing
- Mepolizumab 100 MG
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Chronic Obstructive Pulmonary Disease (COPD)
A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
This Phase IIb dose-ranging study will evaluate the efficacy and safety of 2 different doses of AZD6793 compared with placebo tablets in participants with moderate to very severe chronic obstructive pulmonary disease.
- Trial name
- PRESTO (NCT07082738)
- Testing
- AZD6793
- Where
- 367 sites in United States, Argentina and 22 more
- Volunteers
- 987 people
- Sponsor
- AstraZeneca
Hypertension, Pulmonary, Pulmonary Disease, Chronic Obstructive
Single Dose Study in Patients With Chronic Obstructive Pulmonary Disease (COPD) Associated Pulmonary Hypertension.
This study is to demonstrate the safety, tolerability, pharmakokinetic and pharmacodynamic effect of a single oral dose of BAY63-2521 in patients with pulmonary hypertension due to chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00640315
- Testing
- Riociguat (Adempas, BAY63-2521) 1.0 mg, Riociguat (Adempas, BAY63-2521) 2.5 mg
- Where
- 7 sites in Germany
- Volunteers
- 23 people
- Sponsor
- Bayer
COPD, COPD (Chronic Obstructive Pulmonary Disease)
How Nocturnal Hypoventilation Predicts Long-term Response to Non-invasive Ventilation in Hypercapnic COPD Patients
The study is an observational, single-center, prospective cohort study aiming to evaluate respiratory mechanics data, as well as clinical and functional parameters commonly used in clinical practice in patients with COPD and…
- Conditions
- COPD, COPD (Chronic Obstructive Pulmonary Disease), Hypercapnia, Hypercapnic Respiratory Failure, COPD
- Trial name
- HYPONIV (NCT07414108)
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
COPD Patients
Comparing the Efficacy of Symbicort® pMDI and Formoterol Turbuhaler in Reducing Exacerbations in Patients With Cronic Obstructive Pulmonary Disease
Comparing the efficacy of Symbicort® pMDI and Formoterol Turbuhaler in reducing exacerbations in patients with Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- RISE (NCT02157935)
- Testing
- Symbicort, Formoterol turbohaler
- Where
- 371 sites in United States, Argentina and 9 more
- Volunteers
- 2,026 people
- Sponsor
- AstraZeneca
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.