Clinical trials: Chronic Obstructive Lung Disease
COPD, Pulmonary Hypertension
Vasoactive Intestinal Peptide in COPD
This study, a new immunomodulatory therapy of COPD with vasoactive intestinal peptide (VIP) was evaluated. Based on preliminary unpublished clinical and experimental results, the course of disease under VIP treatment and the…
- Trial name
- VIPCOPD (NCT00464932)
- Testing
- Vasoactive Intestinal Peptide (VIP)
- Volunteers
- 34 people
- Sponsor
- Medical University of Vienna
Cough, COPD
Cough Monitoring in COPD
This is an observational study designed to learn about symptoms of cough and how changes in cough may be associated with the beginning of a COPD exacerbation (acute worsening of symptoms.
- Conditions
- Cough, COPD, COPD Exacerbation
- Trial name
- NCT07098793
- Testing
- Cough monitoring
- Where
- United Kingdom
- Volunteers
- 39 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Hepatitis c
Feasibility of a Hepatitis C Virus (HCV) Decision-Making Intervention Among HIV-infected Adults
The purpose of the LEAP-C (learning, experiencing and preparing for hepatitis C treatment) study is to see if a brief (4-week) small group intervention will help people with HIV/HCV co-infection make an informed decision about…
- Trial name
- LEAP-C (NCT01472354)
- Testing
- Leap-c group intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Massachusetts, Worcester
Chronic Obstructive Pulmonary Disease
Phenotypes of COPD in Central and Eastern Europe
The purpose of this study is to assess the representation of COPD patients in terms of categories and phenotypes of the disease in selected countries in Central and Eastern Europe (CEE).
- Trial name
- POPE (NCT02119494)
- Where
- 81 sites in Austria, Bulgaria and 9 more
- Volunteers
- 3,504 people
- Sponsor
- Zuzana Zbožínková, M.Sc.
COPD (Chronic Obstructive Pulmonary Disease)
Compare the Effects of Nebulizer Versus Inhaler Based Therapy for COPD Using Long-acting Bronchodilators
The purpose of this study is to compare the effectiveness of inhaled bronchodilators delivered via nebulizers vs. dry powder inhalers (DPIs) in symptomatic participants with Chronic Obstructive Pulmonary Disease (COPD) who have…
- Trial name
- NCT07133880
- Testing
- umeclidinium 62.5 µg and vilanterol 25 µg, Revefenacin 175 µg, Formoterol 20 µg
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Tennessee Graduate School of Medicine
COPD
Determination of Factors Related With Daily Living Activities in Severe COPD
The main purpose of chronic obstructive pulmonary disease (COPD) rehabilitation applications is to increase the functional capacity of the patients and improve the quality of life in daily living activities (ADL).
- Trial name
- NCT04765969
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Halic University
COPD
Nitrate, Chronic Obstructive Pulmonary Disease (COPD) and Exercise
Patients with moderate chronic obstructive pulmonary disease (COPD) typically have reduced exercise capacity. This is because their lungs are damaged and because of increased work of breathing.
- Trial name
- NCT01712386
- Testing
- Beetroot
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- NIHR Exeter Clinical Research Facility
Pulmonary Disease, Chronic Obstructive
A Healthy Volunteer Study With Inhaled GSK573719 and Placebo
This study is to look at a new formulation of GSK573719 to see if it is safe and tolerated in healthy volunteers
- Trial name
- NCT00803673
- Testing
- 100mcg, 500mcg, 1000mcg
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
Combined Effects of ACBT and AUTOGENIC DRAINAGE in Patients With Chronic Obstructive Pulmonary Disease
A randomised controlled trial will be conducted with COPD patients as its target population. There will be 40 individuals for both the control group and the intervention group.
- Trial name
- NCT05922254
- Testing
- Active cycle of breathing technique, Autogenic drainage
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riphah International University
COPD
Immuno-inflammatory Response of Erdosteine in COPD
Chronic obstructive pulmonary disease (COPD) remains a major contributor to global morbidity and mortality, exposing healthcare systems to a significant economical and social load.
- Trial name
- NCT07329946
- Testing
- Erdosteine, Standard of Care (SOC)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Pierachille Santus, MD, PhD
Chronic Obstructive Pulmonary Disease
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Repeat Doses of RV1729 for 28 Days in Patients With COPD
RV1729 is a new medicine being developed for the potential treatment of asthma and smoking related lung disease (also known as chronic obstructive pulmonary disease - COPD).
- Trial name
- NCT02140346
- Testing
- RV1729 28 day repeat dose
- Where
- 2 sites in United Kingdom
- Volunteers
- 48 people
- Sponsor
- Respivert Ltd
COPD
Feedback on the New Profession of Care Manager in Maintenance Pulmonary Rehabilitation Programmes
Pulmonary rehabilitation (PR) is one of the main treatments for COPD, but its benefits are transient. The care manager's mission is to help the patient maintain the long-term benefits of their stay by adopting health-promoting…
- Trial name
- RECOORDS (NCT06448559)
- Testing
- Semi-directive interview
- Where
- France
- Volunteers
- 16 people
- Sponsor
- GCS CIPS
Chronic Obstructive Pulmonary Disease (COPD)
Dyspnea Self-Management: Internet or Face-to-Face
Chronic obstructive pulmonary disease, including emphysema and chronic bronchitis, is the fourth most common cause of death and the second leading cause of disability in the United States.
- Trial name
- NCT00461162
- Testing
- Internet DSMP, Face-to-Face Dyspnea Self-management, Attention Control
- Where
- 2 sites in United States
- Volunteers
- 125 people
- Sponsor
- University of California, San Francisco
Asthma, Copd
Inhaler Trainer Efficacy Study
This will be a randomized, controlled, clinical trial. The investigators aim to determine the feasibility of and efficacy of the Inhaler Trainer Device for ongoing inhaler skill training.
- Conditions
- Asthma, Copd, Acute Exacerbation of COPD
- Trial name
- NCT06461403
- Testing
- Inhaler Trainer System, Initial Inhaler Use Assessment, Inhaler Use Instruction
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Koronis Biomedical Technologies
Breathing Technique
Effects of BBT Versus Diaphragmatic Breathing on Exercise Capacity and Quality of Life in Patients With COPD
Group A will be treated with manual chest physical therapy and Buteyko breathing technique Group-B will be treated with manual chest physical therapy and Diaphragmatic breathing technique.
- Trial name
- NCT05947227
- Testing
- Buteyko breathing technique, Diaphragmatic breathing technique.
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Riphah International University
Chronic Obstructive Pulmonary Disease, Hypercapnic Respiratory Failure
Non-invasive Positive Pressure (NPPV ) for Severe Stable Chronic Obstructive Pulmonary Disease
Assessment of the effect and safety of noninvasive positive pressure ventilation for severe stable chronic obstructive pulmonary disease
- Trial name
- NCT02499718
- Testing
- BiPAP mode
- Where
- China
- Volunteers
- 368 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Chronic Obstructive Pulmonary Disease, Asthma
Systematic Approach for the Diagnosis and Treatment of Obstructive Lung Diseases
The differential diagnosis of asthma and COPD is sometimes difficult. Recently, an overlap syndrome has been defined based on the concurrence of asthma and COPD characteristics.
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Overlap Syndrome
- Trial name
- ACOS (NCT02488590)
- Testing
- LABA + LAMA, ICS, LABA + LAMA + ICS
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- KU Leuven
Lung, Hyperlucent, Positive-Pressure Respiration, Intrinsic
Non Invasive Mechanical Ventilation Versus Respiratory Rehabilitation in Hypercapnic COPD
Objective: To analyze the additional benefits of exercise training application by the non-invasive home mechanical ventilation in patients with stable COPD and hypercapnic respiratory failure.
- Trial name
- COPD (NCT01377818)
- Testing
- ventilation, excecise training, Both
- Volunteers
- 45 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Pulmonary Disease, Chronic Obstructive
Morphine for Treatment of Dyspnea in Patients With COPD
Dyspnea is the most reported symptom of patients with advanced Chronic Obstructive Pulmonary Disease (COPD) and is undertreated.
- Trial name
- MORDYC (NCT02429050)
- Testing
- sustained release morphine
- Where
- Netherlands
- Volunteers
- 124 people
- Sponsor
- Maastricht University Medical Center
Chronic Obstructive Pulmonary Disease
Comparative Effects of Different Noninvasive Ventilation Mode on Neural Respiratory Drive in Recovering AECOPD Patients
Background: The efficiency of Neural respiratory drive (NRD)expressed by a ratio of ventilation to the diaphragm electromyogram (EMGdi) decreases in patients with COPD .Improving the neural respiratory drive efficiency of COPD…
- Trial name
- NCT01782768
- Testing
- noninvasive positive pressure ventilation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University