Clinical trials: Chronic Obstructive Pulmonary
COPD
Bronchial Obstruction in Dairy Farmers
Chronic Obstructive Pulmonary Disease (COPD) is a major public health problem and is expected to become the 3rd leading cause of death globally by 2020. The main risk factor is tobacco.
- Trial name
- BPCO Airbag (NCT03654469)
- Testing
- questionnaires and electronic mini-spirometry
- Where
- France
- Volunteers
- 1,247 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Healthy Volunteers
Assessment of Exercise Capacity in Virtual Reality
The 20th century brought a dynamic development of new technologies, including virtual reality (VR). VR is an artificial image generated by IT technologies.
- Trial name
- NCT04197024
- Testing
- Exercise capacity test, Exercise capacity test in virtual reality
- Where
- Poland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- The Opole University of Technology
Asthma, Chronic Obstructive Pulmonary Disease
EXhaled Hydrogen Peroxide As a Marker of Lung diseasE (EXHALE) Pilot Study.
This Pilot study evaluates the use of a new device called Inflammacheck and whether it can consistently measure hydrogen peroxide levels in exhaled breath condensate.
- Trial name
- EXHALE Pilot (NCT03055923)
- Testing
- The Inflammacheck Device
- Where
- United Kingdom
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Chronic Obstructive Pulmonary Disease (COPD)
Temple Health Chest Initiative (THCI 2.0)
Chronic obstructive pulmonary disease is highly prevalent globally, with considerable morbidity and mortality associated. In the US, it is the 4th leading cause of death, as well as contributing to significant costs on healthcare…
- Trial name
- NCT06933758
- Testing
- Determine COPD prevalence utilizing spirometry along with CT scans and symptom assessments in the THCI lung cancer screening populatio
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Temple University
Asthma, Cough
Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol
The objectives of this study are to determine the sensory-mechanical responses to Eucapneic Voluntary Hyperventilation (EVH) and Mannitol in individuals with cough variant asthma (CVA) and methacholine-induced cough with normal…
- Conditions
- Asthma, Cough, Cough Variant Asthma
- Trial name
- NCT03105843
- Testing
- Methacholine (MCh) Challenge Testing, Eucapneic Voluntary Hyperventilation (EVH), Mannitol Inhalation Kit
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Dr. Diane Lougheed
Chronic Obstructive Pulmonary Disease
Effects of Chest Physiotherapy and Lungs Squeezing Technique in Patients With Chronic Obstructive Pulmonary Disease.
Chronic pulmonary obstructive disease refers to a group of lungs problems that includes blockage of airway and difficulty in breathing. It includes mostly emphysema, asthma and chronic bronchitis.
- Trial name
- NCT06480435
- Testing
- Chest physical Therapy, Lungs squeezing technique
- Where
- Pakistan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Pulmonary Disease, Chronic Obstructive
Study to Evaluate the Safety, Tolerability and Pharmacokinetics of GSK2269557 Administered Via the ELLIPTA Dry Powder Inhaler to Healthy Subjects
GSK2269557 is a potent and highly selective inhaled Phosphoinositide 3-Kinase delta inhibitor being developed as an anti-inflammatory and anti-infective agent for the treatment of inflammatory airway diseases.
- Trial name
- NCT02691325
- Testing
- GSK2269557 ELLIPTA DPI, Activated charcoal
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pulmonary Disease, Chronic Obstructive
Study to Determine the Pharmacokinetics of GSK961081 and Fluticasone Furoate When Administered Alone or in Combination
GSK961081 is a novel bifunctional molecule that combines muscarinic antagonism and beta2-agonism in a single molecule and is in development for the treatment of chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT02064504
- Testing
- GSK961081, Fluticasone furoate
- Where
- Australia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
A Trial to Assess the Bioequivalence of Generic Tiotropium Bromide Inhalation Powder and Reference Product in Healthy Adult Participants Under Fasting Conditions (Pilot)
Primary Objective: To evaluate the pharmacokinetics of Tiotropium Bromide Inhalation Powder (Strength:18 mcg; manufactured by Chia Tai Tianqing Pharmaceutical Group Co.
- Trial name
- NCT06326671
- Testing
- Tiotropium Bromide Inhalation Powder, Spiriva HandiHaler
- Where
- China
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Chronic Obstructive Pulmonary Disease (COPD), Asthma (Diagnosis)
Construction and Validation of an Impulse Oscillometry (IOS)-Based Platform for Screening, Diagnosis, and Management of Chronic Airway Diseases
This is a multicenter, observational study aiming to construct and validate an Impulse Oscillometry (IOS)-based platform for the screening, diagnosis, and management of chronic airway diseases (COPD and asthma).
- Trial name
- NCT07910409
- Where
- China
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
Hypertension, Diabetes Mellitus
The Study of CCTM and Common Diseases
This study aimed to explore the associations between constitutions of traditional Chinese medicine (TCM) and common disease (CD).
- Conditions
- Hypertension, Diabetes Mellitus, Chronic Obstructive Pulmonary Disease Moderate, Coronary Artery Disease
- Trial name
- NCT02998944
- Volunteers
- 3,748 people, healthy volunteers welcome
- Sponsor
- Shanghai Tongji Hospital, Tongji University School of Medicine
Chronic Obstructive Pulmonary Disease
Muscle Atrophy In Patients With Chronic Obstructive Pulmonary Disease
Limb muscle dysfunction, characterized by atrophy and weakness, is amongst the most troublesome systemic consequences of chronic obstructive pulmonary disease (COPD) leading to poor functional status and premature mortality.
- Trial name
- NCT02284932
- Testing
- No specific intervention for this study
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Laval University
Tuberculosis, Chronic Obstructive Pulmonary Disease
Biologic Basis Of Increased Susceptibility Of Smokers To Pulmonary Infection With Mycobacterium Tuberculosis
Identify a biologic (molecular) basis for the increased susceptibility of cigarette smokers to pulmonary TB (Mtb) by testing the hypothesis that smoking reprograms AM polarization towards a distinct phenotype associated with…
- Trial name
- NCT02021747
- Where
- Qatar
- Volunteers
- healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Chronic Obstructive Pulmonary Disease
Combined Effects of Blow Bottle Device and Postural Drainage in Moderate to Severe Elderly COPD Patients
It will be a randomized clinical trial. Age of selected subjects will be between 40 to 70 years. Data will be collected from Wazirabad institute of cardiology. There will be 2 groups i.e.
- Trial name
- NCT06476769
- Testing
- blow bottle technique, percussion
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Diseases and Proprioceptive Neuromuscular Facilitation
To investigate the effects of resistant proprioceptive neuromuscular facilitation exercises on physical fitness, respiratory muscle strength, walking distance and quality of life in chronic obstructive pulmonary patients.
- Trial name
- NCT05723302
- Testing
- MIP/MEP
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Chronic Obstructive Pulmonary Disease
Staccato Loxapine Pulmonary Safety in Patients With COPD
The purpose of this study is to assess the pulmonary safety of 2 doses of Staccato Loxapine within a day in patients with COPD.
- Trial name
- NCT00889837
- Testing
- Inhaled Loxapine
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Alexza Pharmaceuticals, Inc.
Chronic Obstructive Pulmonary Disease
Education-Based İntervention Program for Persons With Chronic Obstructive Pulmonary Disease (EBIPCOPD)
Obstructive Pulmonary Disease(COPD) treatment, leading to the role of nurses to become more and more important. An Education-Based Intervention Program(EBIP) consists of several steps that aim to achieve better health outcomes…
- Trial name
- NCT04260178
- Testing
- An Education-Based Intervention Program and handbook (EBIP, hospital and home), PFT, BMI, BDI, SCMP-G
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gönül GÖKÇAY
Pulmonary Disease, Chronic Obstructive, E-cigarettes
Ventilation and Pulmonary Endothelium Toxicities of E-cigarettes: A Randomized Crossover Pilot Study
Determination of the acute pulmonary toxicities of e-cigarettes in young adults is of major public health importance, as e-cigarette vapor contains established toxicants that as hypothesized cause acute damage to the airways and…
- Trial name
- VaPE-Tox (NCT02783768)
- Testing
- E-cigarette, Hyperpolarized 3-Helium, Gadolinium
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Columbia University
Chronic Obstructive Pulmonary Disease
Muscle Dysfunction in Patients With Chronic Obstructive Lung Disease (COPD): the Role of Sympathetic Activation
The objective of the project is to better understand the causes of exercise limitation, dyspnea and neurohumoral activation in patients with COPD.
- Trial name
- NCT01750489
- Testing
- non-invasive ventilation (NIV)
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Chronic Obstructive Pulmonary Disease
Combined Effects of ACBT and AUTOGENIC DRAINAGE in Patients With Chronic Obstructive Pulmonary Disease
A randomised controlled trial will be conducted with COPD patients as its target population. There will be 40 individuals for both the control group and the intervention group.
- Trial name
- NCT05922254
- Testing
- Active cycle of breathing technique, Autogenic drainage
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riphah International University