Clinical trials: Chronic Obstructive Pulmonary
Pulmonary Disease, Chronic Obstructive
A Study To Evaluate The Safety And Tolerability Of SB-656933-AAA Following Repeated Doses In Healthy Adult Subjects
To assess safety of SB-656933 following repeat dosing for 14 days.
- Trial name
- NCT00504439
- Testing
- SB-656933-AAA, Simvastatin
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency
Сohort Study to Evaluate Exacerbations, Respiratory Symptoms, Physical Exercise Intolerance and Lung Functions Among Participants Who Use IQOS With Heatsticks Compared to Smokers of Conventional Cigarettes
This study evaluates frequency of exacerbations, respiratory symptoms, physical exercise intolerance and abnormal lung functions among participants who use IQOS with heatsticks compared to smokers of conventional cigarettes
- Conditions
- Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency, Physical Disability, Respiratory Disease
- Trial name
- NCT03383601
- Testing
- Heated Tobacco product IQOS/heatstick, Smoking combustible cigarettes
- Where
- Kazakhstan
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Kazakhstan Academy of Preventive Medicine
COPD
Mechanisms and Impact of Bacterial Colonisation in COPD
COPD is a leading cause of lung disease and a common cause of hospitalisation, time off work and death. Smoking is the major factor associated with development of COPD.
- Trial name
- NCT03161561
- Testing
- capacity of primary phagocytes
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Pulmonary Disease, Chronic Obstructive
A Study to Determine the Excretion Balance and Pharmacokinetics of 14C-GSK573719
This will be a two-period, open-label study conducted at a single site. Six healthy male subjects will participate in the study to ensure at least four fully evaluable subjects.
- Trial name
- NCT01362257
- Testing
- Treatment Period 1 - IV dose of GSK573719, Treatment Period 2 - Oral dose of GSK573719
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Respiratory Disorders
Study to Assess the Immunogenicity and Safety of GSK's Investigational Vaccine (GSK3277511A) When Given to Healthy Smokers and Ex-smokers After Administration of Shingrix Vaccine
This study will provide information regarding the sequential administration of two vaccines adjuvanted with AS01. The aim of this study is to understand immunogenicity and safety of NTHi-Mcat vaccine when administered…
- Trial name
- NCT03894969
- Testing
- GSK's investigational non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) multi-antigen vaccine (GSK3277511A) adjuvanted with AS01E, Shingrix GSK's lyophilized formulation of the herpes zoster (HZ) vaccine (GSK1437173A)
- Where
- 14 sites in Estonia, Finland and 3 more
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pulmonary Disease, Chronic Obstructive (COPD)
E-nose Utility in the Diagnosis of Bacterial Infection in COPD
Hypothesis: A commercial e-nose (Cyranose 320) is able to detect specific breathprints from patients with COPD and bacterial infection
- Trial name
- NCT01976117
- Testing
- enose
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Lung Cancer, Lung Infection
Identification of Multiple Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled Breath
The goal of this observational study is to develop an advanced expiratory algorithm model utilizing exhaled breath volatile organic compound (VOC) marker molecules.
- Conditions
- Lung Cancer, Lung Infection, COPD, Bronchitis
- Trial name
- NCT06528418
- Testing
- Gas chromatography-mass spectrometry(GC-MS) and micro Gas Chromatography-photoionisation detector (μGC-PID) system
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- ChromX Health
COPD
Effect of Self Management Program on Clinical Status of COPD Patients
This study evaluates the effectiveness of self management programs based on 5A model on the lung function status, dyspnea and exercise tolerance in Chronic Obstructive Pulmonary Disease patients.
- Trial name
- NCT02567474
- Testing
- 5 A model
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ahvaz Jundishapur University of Medical Sciences
Smoking Cessation, Chronic Obstructive Pulmonary Disease (COPD)
SAW Lung Microbiome Study in Smokers and Never-smokers
The trial aims to analyse changes in the microbiome of the lower airways after smoking cessation. Microbiome analyses (upper airway swabs, bronchoalveolar lavage, transbronchial brushing) are conducted in smokers before and 6…
- Conditions
- Smoking Cessation, Chronic Obstructive Pulmonary Disease (COPD), Healthy, Microbial Colonization
- Trial name
- NCT03562442
- Testing
- Smoking cessation
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Research Center Borstel
COPD, Weaning Failure
VentFree: A Novel Abdominal Stimulator to Assist With Ventilator Weaning
Background: Over one million patients in the US are estimated to undergo mechanical ventilation every year, and approximately 300,000 of them fail attempts at weaning.
- Trial name
- NCT02224352
- Testing
- Functional neuromuscular electrical stimulation
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Edward Hines Jr. VA Hospital
Chronic Obstructive Pulmonary Disease, COPD
Incorporation of Genetic Expression of Airway Epithelium With CT Screening for Lung Cancer
Lung cancer, largely the result of cigarette smoking, is the leading cause of cancer death in the United States, killing over 160,000 people in 2010, more than breast, colorectal, and prostate cancer combined.
- Trial name
- NCT01982149
- Testing
- Group 1, Group 2, Group 3
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
COPD
Determinants of Onset and Progression of COPD in Young Adults
COPD (Chronic Obstructive Pulmonary Disease) is a Public Health problem due to its impact in the patient's quality of life, high prevalence, growing incidence and socioeconomic implication.
- Trial name
- EARLY COPD (NCT02352220)
- Where
- Spain
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Borja Cosio
Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease
Lung Tissue Research Consortium
The LTRC will facilitate histopathological research of pulmonary diseases by collecting lung tissues from donors and preparing and distributing collections of tissue specimens to researchers within and outside the LTRC.
- Trial name
- LTRC (NCT02988388)
- Testing
- Lung biopsy/lobectomy
- Where
- 4 sites in United States
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pain, Chronic, Obstructive Pulmonary Disease
Comparison of Respiratory Muscle, Pain, Functional Performance and Cognitive Status in Obstructive Lung Diseases
In the literature, there are a limited number of studies evaluating postural awareness, cognitive status, respiratory muscle strength and endurance, functional capacity, and pain in people with obstructive pulmonary disease, and…
- Conditions
- Pain, Chronic, Obstructive Pulmonary Disease, Cognitive Impairment, Functional Disturbance
- Trial name
- NCT04048408
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Copd, Muscle Weakness
Mechanical Muscle Proprieties in Patient with COPD
This study aims to determine if patients with Chronic Obstructive Pulmonary Disease (COPD) exhibit altered muscle properties (specifically changes in tone and stiffness) in both their respiratory muscles and skeletal muscles when…
- Conditions
- Copd, Muscle Weakness, Muscle Weakness Condition
- Trial name
- NCT06410950
- Testing
- MyotonPRO Assessment of Muscle Biomechanical Properties
- Where
- Romania
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Spitalul Clinic de Boli Infecțioase și Pneumoftiziologie Dr. Victor Babeș Timișoara
Pulmonary Disease, Chronic Obstructive
A Healthy Volunteer Study With Inhaled GSK573719 and Placebo
This study is to look at a new formulation of GSK573719 to see if it is safe and tolerated in healthy volunteers
- Trial name
- NCT00803673
- Testing
- 100mcg, 500mcg, 1000mcg
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COPD, Asthma
Imaging Lung Function Using Oxygen Enhanced MRI
The goal of this study is to perform a pilot study to evaluate the utilization of oxygen as an inhaled contrast agent to image the airway spaces in normal and diseased human lungs to allow an effect size estimate to power future…
- Conditions
- COPD, Asthma, Cystic Fibrosis, Emphysema
- Trial name
- NCT01731015
- Testing
- Medical Grade Oxygen
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hal C Charles
COPD, Healthy
Study of Airflow in the Lungs Using Helium MRI
Computer simulations are being developed to predict air flow abnormalities in the airways of patients with lung disease. The purpose of this study is to obtain actual gas flow measurements in the lungs of healthy patients and…
- Conditions
- COPD, Healthy, Constrictive Bronchitis
- Trial name
- NCT02154568
- Testing
- hyperpolarized helium-3 gas with MRI of the chest
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Pulmonary Disease, Chronic Obstructive, Pain
Abnormal Pain Processing in COPD Patients
Dyspnea, cough, and fatigue are the symptoms characteristic of moderate-severe COPD. Within the progression of disease was also reported a prevalence of 34-77% of pain symptoms in these patients.
- Trial name
- NCT04319523
- Where
- Spain
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Asthma, COPD
A Bioequivalence Pivotal Study of SYN010 HFA Inhaler and Symbicort® 160/4.5 in Healthy Volunteers Without Charcoal Block
The objective of this pivotal study is to evaluate the relative bioavailability of SYN010 HFA Inhaler and Symbicort 160/4.5μg in healthy volunteers without charcoal block.
- Trial name
- NCT04494321
- Testing
- Budesonide, Formoterol
- Where
- Taiwan
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Intech Biopharm Ltd.
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