Clinical trials: Chronic Obstructive Pulmonary
Chronic Obstructive Pulmonary Disease
Comparison of Repetitive Magnetic Stimulation and Exercise on Quadriceps Function in COPD
Background Chronic Obstructive Pulmonary Disease (COPD) patients develop leg weakness and a reduced walking capacity, due to reduced leg muscle oxygen-utilising capacity (OUC).
- Trial name
- NCT00737698
- Testing
- Exercise, Repetitive magnetic stimulation
- Where
- United Kingdom
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Chronic Obstructive Pulmonary Disease
Innate Immune Responses in Chronic Obstructive Pulmonary Disease (COPD) Patients
We hypothesize that ongoing and more severe airway inflammation in COPD may result from the impairment in activation of innate immune response
- Trial name
- NCT00826163
- Testing
- Budesonide
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Mahidol University
Diabetes Type 2, COPD
Effectiveness of a Team-based Follow-up Program in General Practice Among People With Chronic Conditions
The study will develop and evaluate the effectiveness of a team-based follow-up program in general practice (GP) among people with chronic conditions.
- Trial name
- NCT04076384
- Testing
- Guided Self-Determination, Standard care
- Where
- Norway
- Volunteers
- 228 people
- Sponsor
- Bergen University College
CKD Stage 3/4
Identification of Markers for Determining the Efficacy of Vitamin D Receptor Activator Therapy in Stage 3/4 CKD Patients
The purpose of this study is to identify genes that are responsive to paricalcitol (active vitamin D) therapy. Scientists have found that over 30 different types of cells in the body respond to vitamin D therapy, including blood…
- Trial name
- NCT02018133
- Testing
- Vitamin D 2mg daily for 2 weeks oral paricalcitol
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Illinois Chicago
COPD
Efficacy and Safety of ICS/LABA vs. LAMA/LABA in Patients With Different COPD Phenotypes.
This is a randomized, blinded, controlled clinical trial for mexican COPD patients. Biomass smoke associated COPD (BS-COPD) clinical spectrum is different to the one seen in tobacco smoke associated COPD (TS-COPD).
- Trial name
- NCT05342558
- Testing
- Fluticasone Furoate/Vilanterol 100/25 mcgs, Umeclidinium/Vilanterol 62.5/25 mcgs
- Where
- Mexico
- Volunteers
- 133 people
- Sponsor
- National Institute of Respiratory Diseases, Mexico
Respiratory Disorders
Infectious Pathogens in Acute Respiratory Illness in Adults and Elderly
The aim of this study is to generate epidemiological data to further explore determinants of Chronic Obstructive Pulmonary Disease (COPD) and the contribution of bacterial and viral pathogens to Acute Exacerbation of COPD…
- Trial name
- NCT01360398
- Testing
- Blood sample, Sputum sample, Nasopharyngeal swab
- Where
- United Kingdom
- Volunteers
- 127 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
Inhaled Mannitol and Ciliary Beat Frequency in COPD Patients
The main purpose of the study is to evaluate the effect of mannitol on the cilia's beat frequency (ciliary beat frequency) in COPD patients.
- Trial name
- NCT00446121
- Where
- United Kingdom
- Sponsor
- Imperial College London
Pulmonary Disease, Chronic Obstructive
Evaluation of COPD (Chronic Obstructive Pulmonary Disease) to Longitudinally Identify Predictive Surrogate Endpoints
This is a 3 year longitudinal study to identify novel endpoints and compare these with standard measures such as forced expiratory volume in 1 second (FEV1) for their ability to measure and predict COPD (Chronic Obstructive…
- Trial name
- ECLIPSE (NCT00292552)
- Testing
- Novel endpoint determination
- Where
- 44 sites in United States, Bulgaria and 10 more
- Volunteers
- 2,747 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
Home-Based Health Management of COPD Patients
Minnesota HealthSolutions Corporation (MHS) proposes to develop and evaluate a program to motivate and monitor people with chronic obstructive pulmonary disease (COPD) to complete home exercise as part of pulmonary rehabilitation…
- Trial name
- NCT02557178
- Testing
- health coaching
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Sara Seifert
Chronic Obstructive Pulmonary Disease
Can Airflow Limitation in Chronic Obstructive Pulmonary Disease (COPD) be Reversible by Drugs?
Critical combination of various approved drugs in management for patients suffering with COPD.
- Trial name
- NCT01010178
- Testing
- Macrolid, Theophylline, Inhaler Corticosteroids
- Where
- Iran
- Volunteers
- 64 people
- Sponsor
- Baqiyatallah Medical Sciences University
Chronic Obstructive Pulmonary Disease (COPD)
Physical Activity Versus Pulmonary Rehabilitation in COPD
The primary aim of this study is to assess the feasibility of conducting a trial to investigate the effectiveness of a physical activity intervention (physical activity consultation and a pedometer-based walking programme) versus…
- Trial name
- LIVELY (NCT02161393)
- Testing
- Physical Activity Intervention, Pulmonary Rehabilitation Programme
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Ulster
Chronic Obstructive Pulmonary Disease
Regulatory T Cells in COPD
Lymphoid follicles, consisting of T-and B cells, are involved in the chronic inflammatory response in COPD. Foxp3 positive regulatory T cells (Tregs) are present in these follicles and may be involved in the suppression of this…
- Trial name
- NCT00452764
- Testing
- Withdrawal of medication
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Groningen Research Institute for Asthma and COPD
Chronic Obstructive Pulmonary Disease
Efficacy and Safety Study of Beclometasone/Formoterol Single Inhaler in Patients With COPD
To evaluate the 1-year efficacy and safety of the fixed combination beclometasone/formoterol pMDI in a twice daily regimen in patients with stable severe COPD.
- Trial name
- NCT00476099
- Testing
- Beclomethasone 100 µg plus formoterol 6 µg (CHF1535) pMDI, Budesonide 200 µg plus formoterol 6 µg DPI, Formoterol 12 µg DPI
- Where
- France
- Volunteers
- 828 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Chronic Obstructive Lung Disease, Acute Exacerbation of COPD
Are Comorbidities Related to Frequent Severe Exacerbations of AECOPD
INTRODUCTION: Relationship between comorbidities and COPD is two-sided. While the number of comorbidities increasing, the frequency of acute exacerbations of COPD (AECOPD) is increasing, too.
- Conditions
- Chronic Obstructive Lung Disease, Acute Exacerbation of COPD, Comorbidities and Coexisting Conditions
- Trial name
- NCT05504993
- Testing
- Frequency of AECOPD
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people
- Sponsor
- Ankara University
Hepatitis C, Chronic
Addition of ISIS 14803 to Therapy With Peginterferon and Ribavirin for Chronic Hepatitis C (HCV) Patients Not Responding Adequately to the Two Drugs
The purposes of this Phase 1/2 study are to examine the safety, tolerability, and antiviral activity of ISIS 14803, when given in combination with peginterferon alfa and ribavirin, to patients who either failed to have at least a…
- Trial name
- NCT00062816
- Testing
- ISIS 14803, peginterferon alfa, ribavirin
- Where
- 25 sites in United States
- Volunteers
- 22 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
COPD (Chronic Obstructive Pulmonary Disease), Hypoxemia
Inhaled Treprostinil (Tyvaso Nebulizer) For COPD Patients With Hypoxemia
The goal of this clinical trial is to evaluate whether inhaled Treprostinil (Tyvaso) can improve oxygen delivery and blood flow in the lungs in adults (age ≥40) with chronic obstructive pulmonary disease (COPD) and hypoxemia who…
- Trial name
- Tyvaso (NCT07037836)
- Testing
- Inhaled Treprostinil (Tyvaso Nebulizer)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Bastiaan Driehuys
Chronic Obstructive Pulmonary Disease, COPD
Sunovion Brovana Versus Serevent Inspiratory Capacity High Resolution Computed Tomography
This is a PI-initiated study taking place only at UCLA, sponsored by Sunovion. The investigators plan to enroll about 20 subjects who are at least 40 years old and have Chronic Obstructive Pulmonary Disease (COPD).
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD, Emphysema, Chronic Bronchitis
- Trial name
- NCT01361984
- Testing
- Nebulized arformoterol, Salmeterol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
COPD
Advanced Telemonitoring of Patients With COPD in Home Environment
Chronic obstructive pulmonary disease (COPD) is one of the leading and rising causes of morbidity and mortality worldwide. The most important etiopathogenetic agent is smoking.
- Trial name
- NCT05269043
- Testing
- Medimonitor
- Where
- Czechia
- Volunteers
- 25 people
- Sponsor
- University Hospital Olomouc
Pulmonary Disease, Chronic Obstructive
Tiotropium+Olodaterol Fixed Dose Combination (FDC) in Chronic Obstructive Pulmonary Disease (OTEMTO 2)
The objective of this study is to assess the efficacy and safety of 12 weeks once daily treatment with orally inhaled tiotropium + olodaterol FDC (delivered by the Respimat inhaler) compared with tiotropium and placebo in…
- Trial name
- NCT02006732
- Testing
- olodaterol, tiotropium
- Where
- 78 sites in United States, Australia and 9 more
- Volunteers
- 809 people
- Sponsor
- Boehringer Ingelheim
Heart Failure, Chronic Obstructive Pulmonary Disease
Program Evaluation of Telehomecare: TeLeCare Study
This study will evaluate the Telehomecare (THC) Program offered to patients with heart failure or chronic obstructive pulmonary disease across the Central West, Toronto Central and North East Local Health Integration Networks in…
- Trial name
- TLC (NCT02311114)
- Testing
- In Depth interview, Observational fieldwork, Survey
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Toronto
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