Clinical trials: Chronic Obstructive Pulmonary
COPD, COPD Exacerbation
Inhaled Amikacin in Preventing AECOPD
The underlying bacterial colonization in lower respiratory tract (LRT) of COPD patients may be related to acute exacerbation of COPD (AECOPD) and disease progression.
- Trial name
- NCT05213507
- Testing
- aerosol inhaled Amikacin Sulfate Injection, conventional therapy
- Where
- 5 sites in China
- Volunteers
- 136 people
- Sponsor
- Shanghai Zhongshan Hospital
COPD, Chronic Obstructive Pulmonary Disease
Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD
The dNerva Lung Denervation System is one-time treatment intended to improve breathing in Chronic Obstructive Pulmonary Disease (COPD) patients on standard medical care.
- Trial name
- AIRFLOW-4 (NCT07051707)
- Testing
- Targeted Lung Denervation (TLD)
- Where
- 10 sites in United States
- Volunteers
- 200 people
- Sponsor
- Nuvaira, Inc.
Pulmonary Emphysema
Study of the AeriSeal System for HyPerInflation Reduction in Emphysema (ASPIRE)
The purpose of this study is to demonstrate the safety and efficacy of AeriSeal System treatment plus optimal medical therapy compared in patients with advanced upper lobe predominant (ULP) heterogeneous emphysema.
- Trial name
- ASPIRE (NCT01449292)
- Testing
- Treatment plus Optimal Medical Therapy, Optimal Medical Therapy
- Where
- 40 sites in United States, France and 5 more
- Volunteers
- 300 people
- Sponsor
- Aeris Therapeutics
Chronic Obstructive Pulmonary Disease
Trial of Vitamin D Supplementation in Chronic Obstructive Pulmonary Disease
The study null hypothesis is that vitamin D supplementation will not influence time to upper respiratory tract infection or time to moderate/severe exacerbation of chronic obstructive pulmonary disease.
- Trial name
- ViDiCO (NCT00977873)
- Testing
- Cholecalciferol, Miglyol oil
- Where
- 4 sites in United Kingdom
- Volunteers
- 240 people
- Sponsor
- Barts & The London NHS Trust
Chronic Obstructive Pulmonary Disease
A Pilot- and Feasibility Trial of the EHealth Tool My COPD for People with COPD
The aim of this multi-center, randomized controlled pilot- and feasibility trial is to evaluate the user satisfaction, reach and safety of My COPD, a novel eHealth tool for remote delivery of evidence-based treatment targeting…
- Trial name
- My COPD (NCT05086341)
- Testing
- My COPD
- Where
- 2 sites in Sweden
- Volunteers
- 22 people
- Sponsor
- Umeå University
Chronic Obstructive Pulmonary Disease
Exacerbation Study
This study compares indacaterol with tiotropium in terms of bronchodilation over 52 weeks
- Trial name
- INVIGORATE (NCT00845728)
- Testing
- Indacaterol 150 µg, Tiotropium
- Where
- 423 sites in Argentina, Australia and 38 more
- Volunteers
- 3,439 people
- Sponsor
- Novartis Pharmaceuticals
COPD
Optimizing Maintenance for Patients with COPD Via a Web Platform - Case Study
Pulmonary rehabilitation (PR) has been shown to improve quality of life of people with COPD by decreasing their symptoms. However, the benefits obtained during PR tend to decrease within six months to one year after PR.
- Trial name
- NCT04284865
- Testing
- Web Platform
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Université de Sherbrooke
COPD
Effect of Neuromuscular Electrical Stimulation Versus Cycle Ergometer Training in a Pulmonary Rehabilitation Program
The aim of this study is to evaluate the effectiveness of quadriceps strengthening with neuromuscular electrical stimulation versus cycle ergometer as part of pulmonary rehabilitation program , in patients with severe or very…
- Trial name
- ESNM (NCT02656667)
- Testing
- neuromuscular electrical stimulation, cycle ergometer training, Conventional pulmonary rehabilitation
- Where
- 2 sites in France
- Volunteers
- 102 people
- Sponsor
- University Hospital, Brest
COPD
A Home-based Module to Promote Mindful Breathing Awareness for COPD Patients
The purpose of this study is to develop a mindful breathing module to an already effective and developed home based rehabilitation program for guiding COPD patients in a mindful breathing practice and further palliate…
- Trial name
- NCT04517500
- Testing
- Home-based pulmonary rehabilitation program, Mindful breathing module, Health coaching
- Where
- 2 sites in United States
- Volunteers
- 99 people
- Sponsor
- Mayo Clinic
Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease
Move With Air: Exercise Training Study
The purpose of this study is to explore the role of a stream of cool air to the face, through fan-to-face therapy, as a novel adjunct non-pharmacological therapy to enable symptomatic adults with cardiopulmonary disease to…
- Conditions
- Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease, Heart Failure
- Trial name
- NCT05646407
- Testing
- Honeywell HT-900 Turbo Force Air Circulator
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- McGill University
Pulmonary Disease, Chronic Obstructive
Advair® DISKUS® Versus Serevent® DISKUS® For Chronic Obstructive Pulmonary Disease Exacerbations
This study evaluates the effect of two medicines on COPD (Chronic Obstructive Pulmonary Disease) exacerbations. This study will last up to 56 weeks, and subjects will visit the clinic 10 times.
- Trial name
- NCT00115492
- Testing
- Fluticasone Propionate/Salmeterol Combination Product, Salmeterol
- Where
- 110 sites in United States, Canada
- Volunteers
- 797 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
Exacerbations and Real-World Outcomes Among Patients With Chronic Obstructive Pulmonary Disease Following Severe Exacerbation
This real-world retrospective study will use de-identified administrative claims data and will examine patients with a diagnosis of COPD who have experienced a qualifying severe disease exacerbation and received subsequent…
- Trial name
- NCT07414134
- Testing
- BGF- BUDESONIDE/GLYCOPYRRONIUM/FORMOTEROL
- Where
- United States
- Volunteers
- 3,598 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
TOPIC Trial for COPD
The study is a randomized, double-blind, placebo-controlled, multiple-dose, pilot study of orally-administered ivacaftor in subjects with chronic obstructive pulmonary disease.
- Trial name
- NCT02135432
- Testing
- Ivacaftor
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Alabama at Birmingham
Chronic Obstructive Pulmonary Disease
Digital Therapeutics on Inhalation Medication Adherence in COPD
Digital Therapeutics (DTx) is an evidence-based，clinically evaluated software to treat，manage，and prevent a broad spectrum of diseases and disorders according to Digital Therapeutics Alliance，which may improve the adherence of…
- Trial name
- NCT05667363
- Testing
- Digital Intervention
- Where
- China
- Volunteers
- 582 people
- Sponsor
- China-Japan Friendship Hospital
Chronic Obstructive Pulmonary Disease
Safety Study to Evaluate MN-221 in Chronic Obstructive Pulmonary Disease (COPD) Patients
In MediciNova's clinical development plan for MN-221, it was recognized that treatment of COPD exacerbations may necessitate more than one single i.v.
- Trial name
- NCT01551316
- Testing
- MN-221
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- MediciNova
Emphysema, Pulmonary
Unilateral vs. Bilateral Lung Volume Reduction Surgery
This study compares two surgical approaches for patients with severe Chronic Obstructive Pulmonary Disease (COPD) and severe emphysema: unilateral (operating on one lung) versus bilateral (operating on both lungs) lung volume…
- Trial name
- NCT07731958
- Testing
- Unilateral LVRS, Bilateral LVRS
- Where
- Denmark
- Volunteers
- 146 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Obstructive Pulmonary Disease
Air as a Placebo: Increasing the Respiratory Performance of People With COPD Through Simple Expectations of Improvement
COPD (Chronic Obstructive Pulmonary Disease) is a disease of the respiratory system characterised by irreversible airway obstruction of varying severity.
- Trial name
- NCT05218564
- Testing
- Oxygen Therapy, Compressed Medical Air
- Where
- Italy
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Severe COPD
The Identification of Phenotypes in Patients With Severe Chronic Obstructive Pulmonary Disease (Groningen Severe COPD Cohort)
Rationale: Chronic Obstructive Pulmonary Disease (COPD) is defined by airway obstruction. However, the degree of airflow limitation does not adequately describe the complexity of COPD because significant heterogeneity exists…
- Trial name
- NCT04023409
- Testing
- NA: no intervention
- Volunteers
- 1,030 people
- Sponsor
- University Medical Center Groningen
Chronic Obstructive Pulmonary Disease
Comparison of Safety and Efficacy of the Combination Product QVA149A Against the Concurrent Administration of the Individual Components, QAB149 and NVA237, in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The study assessed the safety and efficacy of the fixed combination product QVA149 versus the component products QAB149 and NVA237, administered concurrently, in patients that have moderate to severe chronic obstructive pulmonary…
- Trial name
- BEACON (NCT01529632)
- Testing
- QVA149, NVA237, QAB149
- Where
- 26 sites in Austria, Denmark and 3 more
- Volunteers
- 193 people
- Sponsor
- Novartis Pharmaceuticals
Asthma
Study to Assess the Efficacy of a Single PBF-680 Oral Administration to Attenuate Adenosine 5'-Monophosphate Challenge-induced Airway Hyperresponsiveness in Mild-to-moderate Asthmatics
This is a single-center, double-blind, randomized trial utilizing a three-period, balanced block design, with each period comprising a unique study product administration.
- Trial name
- NCT01939587
- Testing
- PBF-680 5 mg, PBF-680 20 mg
- Where
- 2 sites in Spain
- Volunteers
- 21 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
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