Clinical trials: Chronic Opioid Use
Opioid Use Disorder, Chronic Pain
An Adaptive Walking Intervention to Manage Chronic Pain in Veterans With Opioid Use Disorder Engaged in Opioid Agonist Treatment
Severe chronic pain and opioid use disorder (OUD) occur at significantly higher rates in Veterans compared to the general population.
- Trial name
- NCT05051644
- Testing
- Steps 2 Change (S2C), Control
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Chronic Low-back Pain
EaseVRx for the Reduction of Chronic Pain and Opioid Use
EaseVRx, a software-based virtual reality (VR) medical device, is intended to offer users a prescription pain management tool that manages the symptoms associated with chronic pain and reduces or eliminates the risk of opioid…
- Trial name
- NCT04139564
- Testing
- EaseVRx headset
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- AppliedVR Inc.
Opioid-use Disorder, Opioid Use
PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Current Opioid-User Population
The objective of this research is to assess the effects of electronic health record (EHR)-based decision support tools on primary care provider (PCP) decision-making around pain treatment and opioid prescribing.
- Conditions
- Opioid-use Disorder, Opioid Use, Opioid Abuse
- Trial name
- PRINCE (NCT04601480)
- Testing
- Choice Architecture Nudge, PMP Integration & Nudge
- Where
- United States
- Volunteers
- 309 people
- Sponsor
- University of Minnesota
Chronic Pain
Integrated Services for Pain: Interventions to Reduce Pain Effectively
Long-term pain -or pain that lasts for months or years-is one of the most common health problems in the United States. Clinicians often prescribe opioids which can help ease pain in the short term, but evidence does not support…
- Trial name
- INSPIRE (NCT03454555)
- Testing
- Shared Decision Making, Motivational Interviewing and Cognitive Behavioral Therapy for Chronic Pain
- Where
- 3 sites in United States
- Volunteers
- 543 people
- Sponsor
- RTI International
Opioid Use Disorder, Chronic Pain
Phase II Pharmacokinetics Study of CAM2038
Phase II, open label, partially randomized, three treatment group study designed to evaluate the steady state pharmacokinetics of buprenorphine and norbuprenorphine following repeated subcutaneous administrations of CAM2038.
- Trial name
- NCT02710526
- Testing
- CAM2038
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- Braeburn Pharmaceuticals
Chronic Pain, Depression, Anxiety
Cognitive Behavioral Therapy and Real-Time Pain Management Intervention for Sickle Cell Via Mobile Applications
The investigators are conducting a comparative effectiveness trial among adult patients with sickle cell disease (SCD) who report chronic pain (N = 350), randomized to receive either mobile phone-delivered computerized cognitive…
- Conditions
- Chronic Pain, Depression, Anxiety, Opioid Use
- Trial name
- CaRISMA (NCT04419168)
- Testing
- cCBT, m-Education
- Where
- 7 sites in United States
- Volunteers
- 359 people
- Sponsor
- University of Pittsburgh
Joint Disease, Pain, Acute
Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty
Post-discharge pain after total knee arthroplasty remains problematic; many patients have excessive pain at the 2 week time point (and often thereafter).
- Conditions
- Joint Disease, Pain, Acute, Pain, Chronic
- Trial name
- NCT03271151
- Testing
- Cymbalta
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Hospital for Special Surgery, New York
Chronic Pain, Opioid Use
Use of Xtampza ER to Overcome Difficulties in Swallowing Opioid Pills
This study will examine how the use of Xtampza ER, an opioid analgesic packaged in openable microsphere-containing capsules, affects swallowing satisfaction, pain, and physical and mental health outcomes in chronic pain patients.
- Conditions
- Chronic Pain, Opioid Use, Deglutition
- Trial name
- NCT03588806
- Testing
- Xtampza ER (oxycodone)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Ajay Wasan, MD, Msc
Obstetric Pain, Postpartum Depression
Ketamine to Improve Recovery After Cesarean Delivery - Part 1
The objective of this study is evaluate the breastmilk transfer and pharmacokinetics (Part 1) and effectiveness (Part 2) of a post-cesarean delivery intravenous ketamine bolus-and-infusion strategy, as a preventive analgesic…
- Conditions
- Obstetric Pain, Postpartum Depression, Breastfeeding, Pain, Acute
- Trial name
- KINETIC (NCT04037085)
- Testing
- Ketamine
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Alcohol Drinking, Pain
Personalized Feedback Intervention for Alcohol and Opioid Use Among Adults With Chronic Pain
Over one-quarter of American adults engage in hazardous drinking (i.e., a pattern of alcohol consumption that increases risk for harmful consequences), which is the third leading cause of preventable death in the U.S.
- Conditions
- Alcohol Drinking, Pain, Opioid Use, Feedback, Psychological
- Trial name
- NCT04592978
- Testing
- Pain-Alcohol Personalized Feeback Intervention, Control Personalized Feedback Intervention
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- Syracuse University
Chronic Pain, Opioid-use Disorder
Imaging the Effects of rTMS on Chronic Pain
Chronic pain is highly prevalent in patients with opioid use disorder on methadone maintenance therapy, and associated with problems related to psychosocial functioning, medical and psychiatric health, and substance craving and…
- Trial name
- NCT02687360
- Testing
- Active rTMS treatment
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- New York State Psychiatric Institute
Opioid Use, Chronic Pain
Optimization and Multi-Site Feasibility of Yoga for Chronic Pain in People in YOGAMAT-II - Phase I
Phase 1 - MOST Preparation Phase: 1. To conduct a pilot trial at two opioid use disorder clinic sites, enrolling n=10 at both sites, for a total n=20. 2.
- Trial name
- YOGAMAT-II (NCT04646148)
- Testing
- Yoga classes
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Butler Hospital
Chronic Pain, Traumatic Brain Injury
Establishing Efficacy of a Functional-Restoration Based CAM Pain Management Program in Post-9/11 Veterans
This is a research study of an interdisciplinary pain management program for U.S. military veterans who served during the post-9/11 combat eras (e.g., Operations Iraqi Freedom [OIF], Enduring Freedom [OEF], New Dawn [OND])…
- Conditions
- Chronic Pain, Traumatic Brain Injury, Posttraumatic Stress Disorder, Depression
- Trial name
- NCT02657317
- Testing
- FORT-A, VA Treatment as Usual
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Pain, Chronic, Communication Research
Improving Communication About Pain and Opioids
The overall goal of this protocol is to pilot test a clinician training intervention that uses standardized patients (trained actors playing patient roles) as instructors who impart communication skills to primary care…
- Conditions
- Pain, Chronic, Communication Research, Opioid Use
- Trial name
- NCT03629197
- Testing
- Clinicians - Communication skills training, Clinician Control, Patient seeing trained clinician
- Where
- 2 sites in United States
- Volunteers
- 95 people
- Sponsor
- University of California, Davis
Chronic Pain, Opioid Use
Empower Opioid Misuse & Chronic Pain
This study evaluates the effects of peripheral nerve stimulation on opioid craving and use and pain in participants with chronic non-cancer pain (NCP) and opioid misuse.
- Trial name
- RAP_EOM (NCT04184362)
- Testing
- Empower Neuromodulation System Transcutaneous Electrical Nerve Stimulation
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Chronic Pain, Opioid Use
Medical Cannabis as an Opiate Alternative
Medical Cannabis is very safe and a viable option for pain relief to improve patients and their family's quality of life. However, medical cannabis is not covered by insurance and is an out of pocket expense.
- Trial name
- NCT07194928
- Testing
- We will monitor patient's response to medical marijuana as alternative to opioid for chronic pain.
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Pennsylvania
Knee Osteoarthritis, Knee Pain Chronic
Gabapentin Regimens and Their Effects on Opioid Consumption
The purpose of this study is to determine the best strategy of administering gabapentin in connection with our current approach to perioperative pain management.
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Opioid Use, Opioid Dependence
- Trial name
- NCT03334903
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Drug Use Disorders, Drug Abuse
Evaluation of a Health Plan Initiative to Mitigate Chronic Opioid Therapy Risks
Background: Sixty million American adults suffer from moderate to severe chronic pain. Of these, 5 to 8 million currently use opioids long-term.
- Conditions
- Drug Use Disorders, Drug Abuse, Drug Addiction, Drug Dependence
- Trial name
- CARE (NCT02224508)
- Volunteers
- 1,588 people
- Sponsor
- Kaiser Permanente
Opioid Use, Chronic Pain
Mindfulness Oriented Recovery Enhancement for Chronic Pain and Opioid Relapse
The objective of this study is to rigorously examine the impact of online MORE, delivered through video conference, on opioid use and chronic pain among individuals receiving methadone maintenance treatment (MMT).
- Trial name
- NCT04491968
- Testing
- Mindfulness Oriented Recovery Enhancement, Methadone Treatment as Usual
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Rutgers, The State University of New Jersey
Opioid-use Disorder, Medication Assisted Treatment
Psychosocial Pain Management to Improve Opioid Use Disorder Treatment Outcomes
The purpose of this research study is to look at the effect of programs aimed at helping people manage chronic pain and medication treatment.
- Conditions
- Opioid-use Disorder, Medication Assisted Treatment, Chronic Pain
- Trial name
- Persist (NCT04433975)
- Testing
- Psychosocial Pain Management (PPMI), Enhanced Usual Care (EUC)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Michigan