Clinical trials: Chronic Pulmonary Disease
Chronic Obstructive Pulmonary Disease, Asthma
A Cohort for Inflammatory Respiratory Diseases: From Phenotyping to Personalised Medicine
Chronic inflammatory pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and interstitial lung diseases (ILD) are…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Bronchiectasis, Cystic Fibrosis
- Trial name
- PALMIRE (NCT07274631)
- Testing
- Non applicable
- Where
- France
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Nonspecific Chronic Neck Pain
GPR vs Manual PT for Chronic Neck Pain
Effective treatment for nonspecific chronic neck pain is a clinical challenge. Patients will be randomized into two groups to compare the outcomes of Global Postural Re-education (GPR) with standard manual physical therapy on…
- Trial name
- NCT01947231
- Testing
- Global Postural Re-education, Standard manual physical therapy
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Bologna
Alpha 1-Antitrypsin Deficiency, Emphysema or COPD
PiMZ Longitudinal Cohort (PiMZ Logic)
Alpha-1 Anti-trypsin Deficiency (AATD) is a genetic disease with lung and liver disease presentations. Presentations are variable in the heterozygous population, the most predominant genotype being PiMZ.
- Trial name
- NCT06505603
- Where
- 5 sites in United States
- Volunteers
- 80 people
- Sponsor
- Columbia University
Opioid-Induced Constipation
The Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation
The purpose of this study is to evaluate the safety and efficacy of CB-5945 for the treatment of opioid-induced constipation (OIC) in adults taking opioid therapy for chronic non-cancer pain.
- Trial name
- NCT01901341
- Testing
- CB-5945
- Volunteers
- 44 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Pulmonary Disease, Chronic Obstructive
A Prescription-Event Monitoring (PEM) Study of Tiotropium
This prescription-event monitoring study was based upon 'event' monitoring and so capable of identifying signals of events that might be associated with the use of tiotropium, which none of the participating general practitioners…
- Trial name
- NCT02196194
- Testing
- Tiotropium
- Volunteers
- 13,891 people
- Sponsor
- Boehringer Ingelheim
Chronic Low Back Pain
A Pilot Study Examining the Efficacy of Biomodulator Treatment for Chronic Low Back Pain
The purpose of this study is to determine the efficacy of self treatment with the Biomodulator device to decrease chronic low back pain (LBP) in active duty service members.
- Trial name
- NCT02707094
- Testing
- Biomodulator, Usual Care (Medication + Exercise)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Brooke Army Medical Center
COPD, Obesity &Amp; Overweight
The Impact of a Weight Reduction Intervention on Clinical Outcomes in Patients With Obesity and COPD
Obesity and COPD are increasingly common and often coexist, worsening health outcomes such as reduced lung function, exercise capacity, and increased systemic inflammation.
- Trial name
- NCT07159594
- Testing
- Energy restriction
- Volunteers
- 70 people
- Sponsor
- Sahlgrenska University Hospital
Pulmonary Vascular Disease, Pulmonary Artery Hypertension
HA Residents With PVD, 6MWD Assessed at HA (2840m) vs LA (Sea Level)
To study the effect of relocation from 2840m (Quito) to sea level (Pedernales) in patients with pulmonary vascular diseases (PVD) defined as pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension (PH)…
- Conditions
- Pulmonary Vascular Disease, Pulmonary Artery Hypertension, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT05996302
- Testing
- Relocation to sea level
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease
pCO2 Oscillations During Exercise: Relation to Cerebral Blood Flow and to Cognitive Dysfunction in COPD
Investigators wish to identify a relationship between substantial changes in carbon dioxide partial-pressure (pCO2), which frequently occur during the transitions from rest to exercise (ΔpCO2 >4 millimeters of mercury [mmHg] from…
- Trial name
- NCT02660437
- Testing
- Pulmonary Rehabilitation program
- Where
- Germany
- Volunteers
- 91 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE)
This multicenter clinical trial tested whether minimal ventilation decreases death or BPD. Infants with birth weight 501g to 1000g and mechanically ventilated before 12 hours were randomly assigned to minimal ventilation (partial…
- Conditions
- Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Infant, Newborn, Infant, Low Birth Weight
- Trial name
- SAVE (NCT00005777)
- Testing
- Minimal mechanical ventilation management, Routine mechanical ventilation management, Dexamethasone
- Where
- 13 sites in United States
- Volunteers
- 220 people
- Sponsor
- NICHD Neonatal Research Network
Chronic Obstructive Pulmonary Disease
Comparison Between Symbicort® and Prednisolone in COPD
To assess if Symbicort forte Turbuhaler (during two weeks) is as effective as an oral course of prednisolone + Oxis Turbuhaler (during two weeks) for the treatment of an acute exacerbation of Chronic Obstructive Pulmonary Disease…
- Trial name
- SPACE (NCT00259779)
- Testing
- budesonide/formoterol, Prednisolone
- Where
- 37 sites in Denmark, Finland and 3 more
- Volunteers
- 120 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Efficacy and Safety of Aclidinium Bromide for Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) (LAS-MD-33)
The purpose of this study is to assess the efficacy (effectiveness) and safety of aclidinium bromide doses as compared to placebo in the treatment of moderate to severe chronic obstructive pulmonary disease.
- Trial name
- NCT00891462
- Testing
- Aclidinium bromide
- Where
- 112 sites in United States, Canada
- Volunteers
- 561 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive
A Comparison Study Between the Fixed Dose Triple Combination of Fluticasone Furoate/ Umeclidinium/ Vilanterol Trifenatate (FF/UMEC/VI) With Budesonide/Formoterol in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
This is a phase IIIa, randomised, double-blind, double-dummy, parallel group multicenter study evaluating once daily FF/UMEC/VI (100 microgram [mcg]/62.5 mcg/25 mcg) inhalation powder versus twice daily budesonide/formoterol (400…
- Trial name
- NCT02345161
- Testing
- Triple FF/UMEC/VI, Budesonide/Formoterol, Albuterol/salbutamol
- Where
- 159 sites in Bulgaria, China and 13 more
- Volunteers
- 1,811 people
- Sponsor
- GlaxoSmithKline
Cholecystitis, Chronic
A Scoring System for Difficult Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy is the treatment of choice for gall bladder stone disease. Difficult laparoscopic cholecystectomy (LC) is the most common "difficult" surgical procedure performed today, which possesses the potential…
- Trial name
- NCT04569370
- Testing
- Laparoscopic Cholecystectomy
- Volunteers
- 100 people
- Sponsor
- Assiut University
COPD - Chronic Obstructive Pulmonary Disease, Forward Head Posture
Combined Posture Correction and Resistive Respiratory Muscles Training in COPD With FHP
Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation, often exacerbated by postural abnormalities such as forward head posture (FHP).
- Trial name
- NCT07293429
- Testing
- Resistive inspiratory muscles training, Resistive expiratory muscles training:, Combined resistive inspiratory and expiratory muscles training
- Where
- Pakistan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Respiratory Insufficiency, Respiratory Distress Syndrome, Adult
Continuous Positive Airway Pressure (CPAP) Ventilation Using a Novel Full-Face Mask Versus Conventional Helmet
The aim of this study is to compare two methods of delivery of noninvasive mechanical ventilation (NIV). Since patient compliance and mechanical characteristics of the delivery devices are two fundamental variables in the success…
- Conditions
- Respiratory Insufficiency, Respiratory Distress Syndrome, Adult, Chronic Obstructive Pulmonary Disease, Pulmonary Edema
- Trial name
- NCT00944437
- Testing
- Helmet, Full-face mask
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- University of Parma
COPD, COPD-like
Breathing Performance of Healthy Young Adult
The study will recruit subject of healthy adult, COPD-like patient and patient with COPD to investigate the difference of respiratory performance.
- Trial name
- NCT04857541
- Where
- Taiwan
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Post-COVID Condition, Long COVID
Long-Term Health Effects of Previous Coronavirus Disease 2019 (COVID-19) in Patients Undergoing Preoperative Anesthesia Evaluation
The Coronavirus Disease 2019 (COVID-19) pandemic has resulted in persistent health problems in a significant proportion of individuals after recovery from the acute infection.
- Conditions
- Post-COVID Condition, Long COVID, Sequelae of COVID-19
- Trial name
- NCT07435805
- Testing
- Post-COVID Clinical Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Copd, Assessment, Self
Selfcare MAnagement InteRvenTion in COPD (SMART COPD)
To evaluate whether a digital support and communication platform for COPD patients after 6 months provides: 1. Decreased breathlessness on the basis of modified medical research council dyspnea scale [mMRC] 2.
- Conditions
- Copd, Assessment, Self, Hospitalization
- Trial name
- NCT04416295
- Testing
- LifePod
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Lund University
COPD, Chronic Obstructive Pulmonary Disease
Strategy for Early Treatment of Exacerbations in COPD: Standing Prescriptions of Advair With a Written Action Plan in the Event of an Exacerbation
The purpose of this pilot study is to determine whether early treatment of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) with a combination therapy, Salmeterol + Fluticasone Propionate (SFP - Advair) will…
- Trial name
- NCT02136875
- Testing
- Double dose of Salmeterol + Fluticasone Propionate, Self-management education on the use of a self-administered prescription for exacerbation., Self-administered prescription
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
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