Clinical trials: Chronic Subdural Hematomas
Chronic Subdural Hematoma, Trendelenburg
Effect of the Postoperative Trendelenburg Position on Chronic Subdural Hematoma Recurrence
Objective: Determine the effect of the postoperative trendelenburg position on the recurrence of chronic subdural hematoma (CSH) in patients undergoing surgery.
- Conditions
- Chronic Subdural Hematoma, Trendelenburg, Recurrence, Mortality
- Trial name
- POTHeR (NCT06911736)
- Testing
- Trendelenburg position
- Where
- 3 sites in Colombia
- Volunteers
- 254 people
- Sponsor
- Universidad de Antioquia
Chronic Subdural Hematoma
Middle Meningeal Artery Embolization for the Treatment of Subdural Hematomas With TRUFILL® n-BCA
This is a prospective, multi-center, open-label, randomized controlled study in which subjects can receive standard of care (SOC) alone or SOC and TRUFILL n-BCA MMA embolization for the treatment of chronic subdural hematomas…
- Trial name
- MEMBRANE (NCT04816591)
- Testing
- Experimental: Interventional Cohort: TRUFILL n-Butyl Cyanoacrylate (n-BCA) Liquid Embolic System, Standard of Care Surgery, Experimental: Interventional Cohort: TRUFILL n-BCA Liquid Embolic System
- Where
- 33 sites in United States, China
- Volunteers
- 376 people
- Sponsor
- Cerenovus, Part of DePuy Synthes Products, Inc.
Chronic Subdural Hematoma
Bedside Versus Operating Room Burr-Hole Drainage of Chronic Subdural Hematoma (DECIDE)
DECIDE (Bedside versus Operating Room Burr-Hole DrainagE of ChronIc SubDural HEmatoma) CSDH is an abnormal collection of blood between the layers of the brain causing brain tissue compression leading to neurological…
- Trial name
- DECIDE (NCT03053895)
- Testing
- CSDH - Bedside twist drill technique, CSDH - Operating Room Burr-hole technique
- Volunteers
- 486 people
- Sponsor
- Hamilton Health Sciences Corporation
Chronic Subdural Hematoma
High Concentration Oxygen Therapy for Pneumocephalus in Chronic Subdural Haematoma: A Prospective Observational Study
Normobaric oxygen therapy was shown to be effective in reducing post craniotomy pneumocephalus. Theoretical assessment of normobaric oxygen therapy in treating pneumocephalus has shown that a higher level of oxygen concentration…
- Trial name
- NCT05143216
- Testing
- Low concentration oxygen group: Room air (0-2Litre Oxygen via Nasal Canula), High concentration oxygen group: Room air (12-15Litre Oxygen via Non-rebreather Mask)
- Where
- Hong Kong
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Dr. David Yuen Chung CHAN
Chronic Subdural Hematoma
Aspirin Continuation or Discontinuation in Conservative Treatment for Chronic Subdural Hematoma
This clinical study aims to learn about the efficacy and safety of aspirin continuation or discontinuation in conservative treatment for chronic subdural hematoma.
- Trial name
- NCT07240454
- Testing
- Aspirin Continuation, Aspirin Discontinuation
- Where
- 2 sites in China
- Volunteers
- 143 people
- Sponsor
- Tao Liu
Chronic Non-Traumatic Intracranial Subdural Haemorrhage
Non Traumatic Chronic Subdural Haematoma in Paediatric Age Groups, Management and Outcome
1-Review the management strategies and outcomes in cases of non traumatic chronic subdural haematoma in paediatric age group. 2- Review the underlying causes and risk factors in cases of non traumatic chronic subdural haematoma…
- Trial name
- NCT06743893
- Testing
- Diagnosis and outcome of non traumatic chronic subdural haematoma in pediatric age groups
- Volunteers
- 30 people
- Sponsor
- Assiut University
Chronic Subdural Hematomas
Middle Meningeal Artery Coagulation During Burr-Hole Drainage for Chronic Subdural Haematoma (BURR-MMA)
Chronic subdural haematoma (cSDH) is a common condition in older adults, usually treated by burr-hole surgery to drain the collection.
- Trial name
- BURR-MMA (NCT07549893)
- Testing
- CT-Guided Intra-Operative Middle Meningeal Artery Interruption
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Hematoma, Subdural, Fibrinolytic; Hemorrhage
Use of Tissue Plasminogen Activator in the Clearance of Chronic Subdural Hematomas
To determine the utility of tissue plasminogen activator (tPA) in the clearance of chronic subdural hematomas (CSDH). Intra-catheter tPA will be administered during surgical procedure and allowed to break down blood clot to…
- Trial name
- NCT05491356
- Testing
- Tissue Plasminogen Activator
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Hamilton Health Sciences Corporation
Chronic Subdural Hematoma
The CHALLENGER Registry
The study is a multi-center prospective, single-arm, post-market study evaluating the efficacy and radiologic and functional outcomes associated use of the Numen SILK coils for Middle Meningeal Artery (MMA) embolization following…
- Trial name
- CHALLENGER (NCT07197840)
- Testing
- Numen SILK coil embolization system
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Subdural Hematomas
Prospective Clinical Investigation on Infection as a Cause of Chronic Subdural Hematoma.
Chronic subdural hematoma (cSDH) is a very common disease, primarily affecting older people, and is associated with significant morbidity and mortality.
- Trial name
- iSDH (NCT07556991)
- Testing
- Amoxicillin + clavulanic acid
- Where
- Germany
- Volunteers
- 164 people
- Sponsor
- University of Rostock
Chronic Subdural Hematoma
General Anesthesia Versus Locoregional Anesthesia for Evacuation of Chronic Subdural Hematoma
This study compare general anesthesia versus locoregional anesthesia for evacuation of chronic subdural hematoma. Half of participant will be operated under general anesthesia, while the other half will be operated under…
- Trial name
- NCT03666949
- Testing
- All General anesthesia, All Locoregional anesthesia
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Caen
Monitored Anaesthesia Care, Loco-regional Chronic Subdural Hematoma Evacuation
Oral Melatonin as Premedication During MAC for Patients Undergoing Loco-regional Chronic Subdural Hematoma Evacuation
investigators assume that administration of preoperative melatonin will reduce the required dose of propofol in participants undergoing loco-regional chronic subdural hematoma evacuation, it may as well provide better…
- Trial name
- NCT03732963
- Testing
- Melatonin (Group M)
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Middle Meningeal Artery Embolization, Chronic Subdural Hematomas
Middle Meningeal Artery Embolization in Patients With Chronic Subdural Hematoma
Primary : to evaluate the efficacy of MMAE on resolution and recurrence of hematoma in patients with CSDH. Secondary : evaluate the effect of MMAE on functional outcome, radiological changes, the need to repeat surgery, duration…
- Trial name
- NCT07806552
- Testing
- middle meningeal artery embolization
- Volunteers
- 35 people
- Sponsor
- Assiut University
Chronic Subdural Hematoma, Chronic Subdural Hematomas
Implementation of an Enhanced Recovery Pathway for Burr-hole Drainage in Patients With a Chronic Subdural Hematoma
A chronic subdural hematoma (cSDH) is a type of intracranial hematoma that primarily affects older adults. The rising incidence of this condition, coupled with the high healthcare burden of this disease, calls for an update of…
- Trial name
- ERP-cSDH (NCT07421453)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Subdural Hematoma
Embolization of Middle Meningeal Artery for Subdural Hematoma in Canada (EMMA Can)
EMMA-Can is a prospective cohort study to assess the safety and effectiveness of MMA-embolization for the treatment of CSDH. Hypothesis- EMMA reduces the recurrence rate of CSDH with or without concomitant surgical evacuation.
- Trial name
- EMMA-Can (NCT04923984)
- Testing
- Embolization of the middle meningeal artery
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- University of Manitoba
Hematoma, Subdural, Chronic
Curcumin/Turmeric as a Treatment for Patients With Subdural Hematomas Recurrence
Our long-term objective is to evaluate the efficacy of curcumin (CC) in preventing a recurrence of chronic subdural hematoma (cSDH) following surgical evacuation.
- Trial name
- CACTIS (NCT03845322)
- Testing
- Curcumin Pill
- Where
- United States
- Sponsor
- University of New Mexico
Chronic Subdural Hematoma
Targeting Spreading Depolarization After Chronic Subdural Hematoma Surgery (TASD)
Chronic Subdural Hematoma (cSDH) is an extremely common problem, particularly in the aging population, where fluid like collections compress the brain, frequently requiring surgical drainage.
- Trial name
- TASD (NCT04966546)
- Testing
- Memantine Hydrochloride
- Where
- United States
- Sponsor
- University of New Mexico
Chronic Subdural Hematoma
The Finnish Study of Intraoperative Irrigation Versus Drain Alone After Evacuation of Chronic Subdural Hematoma (FINISH)
FINISH-trial is a prospective, randomized, controlled, parallel group non-inferiority trial comparing single burr-hole evacuation of chronic subdural hematoma (CSDH) with intraoperative irrigation (IR) and evacuation of CSDH…
- Trial name
- FINISH (NCT04203550)
- Testing
- Intraoperative irrigation, No irrigation
- Where
- Finland
- Volunteers
- 587 people
- Sponsor
- Helsinki University Central Hospital
Chronic Subdural Hematoma
Middle Meningeal Artery Embolization for Treatment of Chronic Subdural Hematoma
Middle meningeal artery (MMA) embolization via a minimally invasive endovascular approach has been attempted with the goal of eliminating the arterial supply to the vascularized membrane.
- Trial name
- NCT03307395
- Testing
- Middel Meningeal Artery Embolization
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Weill Medical College of Cornell University
Chronic Subdural Hematomas, Cerebral Compression Due to Injury
Middle Meningeal Artery Embolization for Chronic Subdural Hematomas (STORMM)
Chronic Subdural Hematomas (cSHD) are common, and due to cerebral compression, often result in neurological impairment and reduced consciousness. Surgery is typically performed once neurological symptoms develop.
- Trial name
- STORMM (NCT06163547)
- Testing
- MMA embolization
- Where
- 2 sites in Switzerland
- Volunteers
- 180 people
- Sponsor
- University Hospital, Geneva