Clinical trials: Chronic Subdural Hematomas, open to volunteers
Subdural Hematoma, Subdural Hematoma, Chronic
Study On Histoacryl Used For Embolization Of Middle Meningeal Artery (MMA) In Chronic Subdural Hematoma (CSDH) (HARMONY)
The aim of the study is to proof the effectiveness of Histoacryl® on preventing recurrence or progression of subdural hematoma after embolization of the middle meningeal artery.
- Trial name
- HARMONY (NCT07258069)
- Testing
- Histoacryl®
- Where
- 6 sites in Japan
- Volunteers
- 178 people
- Sponsor
- Aesculap AG
Subdural Hematoma
MMA Embolization With NeoCast for Subacute and Chronic Subdural Hematoma
The purpose of this study is to evaluate the safety and efficacy of embolization of the middle meningeal artery (MMA) using the NeoCast Embolic System for treatment of symptomatic subacute or chronic subdural hematoma (SDH)…
- Trial name
- RADIANT (NCT07541404)
- Testing
- NeoCast Embolic System, Onyx LES, an FDA-Approved Commercial Liquid Embolic
- Where
- 2 sites in United States
- Volunteers
- 360 people
- Sponsor
- Arsenal Medical, Inc.
Chronic Subdural Hemorrhage (cSDH)
Chronic Subdural Hematoma Embolization With Detachable Coils
This is a prospective, multi-center, post market registry study designed to evaluate the safety and efficacy of treatment with Balt coils in patients with chronic subdural hematoma (cSDH).
- Trial name
- SEED (NCT07291427)
- Testing
- Balt coils: (Balt USA, LLC), MMA embolization
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Subdural Hematoma
Middle Meningeal Artery Embolization (MMAE) Outcomes for Chronic Subdural Hematoma (cSDH)
This multi-center retrospective cohort study aims to investigate the real-world outcomes of chronic subdural hematoma treated with MMAE, including clinical effectiveness, recurrence rates, and safety profile.
- Trial name
- MESH (NCT06181994)
- Where
- 22 sites in United States, Australia and 1 more
- Volunteers
- 5,000 people
- Sponsor
- Montefiore Medical Center
Acute Ischemic Stroke, Intracranial Arterial Stenosis
Post-Market Active Surveillance and Health Economic Evaluation of Cerebrovascular Diagnostic and Therapeutic Devices
The research focuses on "post-market active surveillance and health economic evaluation of non-pharmacological therapies and innovative cerebrovascular diagnostic and therapeutic devices".
- Conditions
- Acute Ischemic Stroke, Intracranial Arterial Stenosis, Extracranial Arterial Stenosis, Intracranial Aneurysms
- Trial name
- NCT07828379
- Testing
- Endovascular Treatment for Acute Ischemic Stroke
- Volunteers
- 2,000 people
- Sponsor
- Changhai Hospital
Middle Meningeal Artery Embolization, Chronic Subdural Hematomas
Middle Meningeal Artery Embolization in Patients With Chronic Subdural Hematoma
Primary : to evaluate the efficacy of MMAE on resolution and recurrence of hematoma in patients with CSDH. Secondary : evaluate the effect of MMAE on functional outcome, radiological changes, the need to repeat surgery, duration…
- Trial name
- NCT07806552
- Testing
- middle meningeal artery embolization
- Volunteers
- 35 people
- Sponsor
- Assiut University
Chronic Subdural Hematoma, Stroke
Comparative Study of Embolic Agents in Patients With Subdural Hemorrhage Undergoing Middle Meningeal Artery (MMA) Embolization
Single site, prospective, comparative effectiveness pilot trial comparing efficacy and safety outcomes of three embolic materials (particles, liquid embolics, and Wallaby Phenox coils) in MMA embolication for cSDH.
- Conditions
- Chronic Subdural Hematoma, Stroke, Middle Meningeal Artery Embolization
- Trial name
- NCT07757113
- Testing
- Particles (polyvinyl alcohol or similar microspheres), Liquid Embolics (Onyx, n-BCA, or equivalent), Phenox Coils (Avenir UNO Helical Coil)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sanford Health
Chronic Subdural Hematomas
Middle Meningeal Artery Coagulation During Burr-Hole Drainage for Chronic Subdural Haematoma (BURR-MMA)
Chronic subdural haematoma (cSDH) is a common condition in older adults, usually treated by burr-hole surgery to drain the collection.
- Trial name
- BURR-MMA (NCT07549893)
- Testing
- CT-Guided Intra-Operative Middle Meningeal Artery Interruption
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Pelvic Fracture, Prostate Cancer
A COhort Study on Factors Leading to Vulnerability in Adult Patients With Serious Medical cOnditionS: the COSMOS-I Trial
The objective of this prospective multicentre study that recruits altogether 1500 older patients from the university hospitals of Tampere, Kuopio, and Oulu is to explore the clinical significance and detection of causes of…
- Conditions
- Pelvic Fracture, Prostate Cancer, Lung Cancer, Brain Metastasis
- Trial name
- COSMOS-I (NCT07740239)
- Testing
- Test set to determine vulnerability
- Where
- Finland
- Volunteers
- 2,050 people
- Sponsor
- Tampere University Hospital
Chronic Subdural Hematoma
The CHALLENGER Registry
The study is a multi-center prospective, single-arm, post-market study evaluating the efficacy and radiologic and functional outcomes associated use of the Numen SILK coils for Middle Meningeal Artery (MMA) embolization following…
- Trial name
- CHALLENGER (NCT07197840)
- Testing
- Numen SILK coil embolization system
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Subdural Hematoma
Frontal vs Parietal Eminence Drainage for Chronic Subdural Hematoma
This clinical trial aims to find out whether the puncture site used during minimally invasive surgery with twist-drill puncture and closed-system drainage affects the treatment of chronic subdural hematoma (cSDH).
- Trial name
- NCT07731620
- Testing
- Frontal-region puncture drainage, Parietal Eminence region puncture drainage
- Where
- 3 sites in China
- Volunteers
- 440 people
- Sponsor
- The Second Hospital of Anhui Medical University
Chronic Subdural Hematoma
Intra-Arterial Bevacizumab as an Adjunct to Middle Meningeal Artery Embolization for Chronic Subdural Hematoma
This is a Phase 1, open-label, single-center, dose-escalation study evaluating the safety and tolerability of intra-arterial bevacizumab (IA-BEV) given as an adjunct to middle meningeal artery embolization (MMAE) in adults with…
- Trial name
- SAFER-MMAE (NCT07729098)
- Testing
- Bevacizumab (intra-arterial)
- Volunteers
- 18 people
- Sponsor
- Dheeraj Gandhi
Chronic Subdural Hematoma
Template-Guided Burr-Hole Drainage With Middle Meningeal Artery Coagulation for Chronic Subdural Hematoma
Chronic subdural hematoma is a collection of blood and fluid on the surface of the brain that is common in older adults. Burr-hole drainage is a standard surgical treatment, but the hematoma may come back in some patients and…
- Trial name
- 3D-MMA-cSDH Tr (NCT07720687)
- Testing
- Standard Burr-Hole Drainage Group, 3D-Printed Template-Guided Burr-Hole Drainage With Attempted MMA Coagulation Group
- Where
- China
- Volunteers
- 440 people
- Sponsor
- The Second Hospital of Anhui Medical University
Chronic Subdural Hematoma
Assessing Outcomes of Coil Embolization for Unilateral vs Bilateral Chronic Subdural Hematomas
This is a pragmatic, prospective, multicenter, randomized controlled trial with intention to treat analysis. In which subjects will receive either unilateral or bilateral middle meningeal artery (MMA) embolization using coils for…
- Trial name
- (COAST) (NCT07715656)
- Testing
- embolization therapy Bilateral, embolization therapy Unilateral
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Lahey Clinic
Endovascular Treatment, Chronic Subdural Hematoma
Middle Meningeal Artery Embolization for Patients With Chronic Subdural Hematoma
COMPLEMENT study (ChrOnic subdural hematoMa Patients suppLemented with Embolization of Middle mENingeal artery Trial) is a prospective, open label, blinded endpoint (PROBE), Japanese, two-arm, randomized, controlled, post-market…
- Trial name
- NCT06772740
- Testing
- Middle meningeal artery embolization
- Where
- Japan
- Volunteers
- 600 people
- Sponsor
- Kazutaka Uchida
Chronic Subdural Hematoma
Adjuvant Tranexamic Acid (TXA) Versus Surgery Alone for Adult Patients With Chronic Subdural Hematoma (CSDH)
This study is an open label randomized controlled trial. Patients with a symptomatic Chronic Subdural Hematoma (CSDH) confirmed on radiological imaging, planned for surgery, age over 18, free from other intracranial pathologies…
- Trial name
- RATATA (NCT07245264)
- Testing
- Tranexamic Acid (Cyklokapron)
- Where
- India
- Volunteers
- 274 people
- Sponsor
- St. Olavs Hospital
Chronic Subdural Hematoma
Efficacy of a Minimally Invasive Therapy Adjuvant to the Standards of Care by Cyanoacrylate Embolization
Chronic subdural hematomas (CSH) are collections of blood in the subdural space. CSH are becoming the most common cranial neurosurgical condition among adults, and a significant public health problem, due to an increasing use of…
- Trial name
- LEADH (NCT05374681)
- Testing
- Medical treatment, Surgical treatment, embolization of the MMA
- Where
- 11 sites in France
- Volunteers
- 550 people
- Sponsor
- University Hospital, Brest
Chronic Subdural Hematoma, Subdural Hematoma
Non-Thermal Plasma to Reduce Recurrence in Chronic Subdural Hematoma
The goal of this randomized controlled trial is to evaluate whether the adjuvant application of non-thermal plasma (NTP) during standard surgical drainage of chronic subdural hematoma (cSDH) can reduce the recurrence rate at 6…
- Conditions
- Chronic Subdural Hematoma, Subdural Hematoma, Recurrence, Postoperative Complications
- Trial name
- NCT07656818
- Testing
- Standard Surgery Protocol, Non-Thermal Plasma
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Benjamín Gonzalo Rodríguez Méndez
Chronic Subdural Hematomas
Prospective MMA Embolization Registry
Chronic subdural hematoma (cSDH) is a common condition, particularly in older adults, that can substantially impair patients' quality of life, functional independence, and neurological well-being.
- Trial name
- PRO-EMMA (NCT07626671)
- Testing
- Middle Meningeal Artery Embolization
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Chronic Subdural Hematoma
Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Study
The goal of this clinical trial is to test in moderately symptomatic chronic subdural hematoma (CSDH) patients if middle meningeal artery embolization (MMAE) can be used as an alternative to conventional open surgery.
- Trial name
- CHESS (NCT06347796)
- Testing
- Conventional Surgery, Middle Meningeal Artery Embolization (MMAE)
- Where
- 31 sites in United States
- Volunteers
- 520 people
- Sponsor
- The University of Texas Medical Branch, Galveston