Clinical trials: Chronic Total Coronary Occlusion
Chronic Total Occlusion of Coronary Artery
Safety and Efficacy Study of the SoundBite™ Crossing System With ACTIVE Wire in Coronary CTOs.
The objective of this study is to evaluate the safety and efficacy of the SoundBite™ Crossing System - Coronary (SCS-C) in a subject population with chronic coronary artery disease including Chronic Total Occlusion (CTO).
- Trial name
- ACTIVE (NCT03521804)
- Testing
- SoundBite™ Crossing System Active Wire 14
- Where
- 5 sites in United States, Canada
- Volunteers
- 35 people
- Sponsor
- SoundBite Medical Solutions, Inc.
Coronary Occlusion, Angioplasty, Balloon, Coronary
Functional Assessment-guided Angioplasty in Patients With Coronary Chronic Total Occlusion
The aim of this study is to investigate the role of functional evaluation for predicting clinical outcome in patients with coronary chronic total occlusion (CTO) undergoing percutaneous coronary intervention (PCI), and to…
- Trial name
- FAGA-CTO (NCT03522038)
- Testing
- percutaneous coronary intervention
- Volunteers
- 300 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Occlusion, Coronary Stenosis
STAR and Deferred Stenting Study
STAR is a minimal-risk pragmatic clinical trial of patients admitted for a CTO-PCI procedure. The overall objective of the STAR Study is to address the current gaps in knowledge regarding use of STAR during CTO-PCI, as a…
- Conditions
- Coronary Occlusion, Coronary Stenosis, Coronary Restenosis
- Trial name
- STAR (NCT05089864)
- Testing
- Stent Placement Timing - Early, Stent Placement Timing - Late
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Saint Luke's Health System
Coronary Artery Disease
68Ga-NODAGA-RGD PET in Patients With an Occluded Coronary Artery
Background: In patients with coronary artery disease, acute or chronic coronary artery occlusion is associated with various degrees of ischemic myocardial injury and left ventricle dysfunction.
- Trial name
- RGDHeart (NCT04871217)
- Testing
- 68Ga-NODAGA-RGD PET-imaging
- Where
- 3 sites in Finland, Netherlands and 1 more
- Volunteers
- 60 people
- Sponsor
- Turku University Hospital
Chronic Total Occlusion of Coronary Artery, Coronary Occlusion
ABSORB FIRST is a Registry Designed to Evaluate the Safety and Performance of Absorb Bioresorbable Vascular Scaffold (Absorb BVS) Used in Real-world Patients.
ABSORB FIRST is a prospective, multi-center registry. The objectives of the study are to: Provide ongoing post-market surveillance for documentation of safety, performance and clinical outcomes of the Absorb BVS (Bioresorbable…
- Conditions
- Chronic Total Occlusion of Coronary Artery, Coronary Occlusion, Coronary Artery Disease, Coronary Artery Restenosis
- Trial name
- NCT01759290
- Testing
- Absorb Bioresorbable Vascular Scaffold
- Where
- Belgium
- Volunteers
- 1,800 people
- Sponsor
- Abbott Medical Devices
Chronic Total Occlusion, Atherosclerosis
Registry Study to Evaluate the Performance and Safety of Roxwood Medical Catheters in Arteries of Participants With a Stenotic Lesion or Chronic Total Occlusion (CTO)
The purpose of this registry study is to gather real world standard of care (SOC) data on the safety and performance on the Roxwood Medical catheter devices in the treatment of stenotic lesions and CTO.
- Conditions
- Chronic Total Occlusion, Atherosclerosis, Coronary Artery Disease, Peripheral Artery Disease
- Trial name
- NCT04059536
- Testing
- Roxwood Anchoring Catheters, Acetylsalicylic Acid, Heparin
- Where
- 11 sites in United States
- Sponsor
- Boston Scientific Corporation
Coronary Artery Disease
Prospective Global Registry for the Study of Chronic Total Occlusion Intervention
Percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs) is increasingly being performed in patients with advanced coronary artery disease, but there is limited information on the techniques utilized and the…
- Trial name
- PROGRESS-CTO (NCT02061436)
- Where
- 48 sites in United States, Canada and 4 more
- Volunteers
- 2,000 people
- Sponsor
- Minneapolis Heart Institute Foundation
Chronic Total Occlusion of Coronary Artery
EvaLuAtion On the cHaracteristics of the True/False lUmen and Its Prognostic Value for cOronary CTO Patients Just Before Stent Implantation
IVUS will be used to evaluate the ratio of false lumen to occluded segment, the ratio of false lumen to stent length, the location characteristics of false lumen and its prognostic value for perioperative complications, 1-year…
- Trial name
- NCT04965207
- Volunteers
- 1,000 people
- Sponsor
- Shanghai 10th People's Hospital
Coronary Artery Disease, Angina Pectoris
Change in Exercise Capacity as Measured by Peak Oxygen Uptake After CTO PCI
The purpose of this project is to objectively assess the change (improvement) in exercise capacity in patients undergoing routine percutaneous coronary intervention (PCI) for chronic total occlusion (CTO)
- Trial name
- EXERTION (NCT02499666)
- Testing
- Percutaneous Coronary Intervention, Coronary stent, Clopidogrel
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Coronary Artery Disease, Chronic Total Occlusion
CTO-PCI in Heart Failure Patients
The study investigates wheather CTO-PCI improves survival and heart failure related rehospitalization compared to optimal medical therapy (OMT).
- Conditions
- Coronary Artery Disease, Chronic Total Occlusion, Heart Failure
- Trial name
- CTO-HF (NCT05632653)
- Testing
- CTO-PCI
- Volunteers
- 783 people
- Sponsor
- Universitätsmedizin Mannheim
Ventricular Tachycardia, Ischemic Cardiomyopathy
Impact of PREVENTIVE Substrate Ablation of Coronary Chronic Total Occlusion on Implantable cardioVerTer-Defibrillator Interventions
The aim of this study is to assess whether preventive substrate ablation of chronic total occlusion infarct-related artery (CTO-IRA) area in heart failure (HF) patients correlates with lower appropriate implantable cardiac…
- Trial name
- PREVENTIVE VT (NCT03421834)
- Testing
- Catheter ablation of ventricular tachycardia, Optimal medical treatment
- Where
- 5 sites in Croatia, Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Coronary Artery Disease (CAD), Chronic Total Occlusion (CTO)
EXPERT CTO: Evaluation of the XIENCE PRIME™ LL and XIENCE Nano™ Everolimus Eluting Coronary Stent Coronary Stents, Performance, and Technique in Chronic Total Occlusions
A prospective, multi-center, single-arm study to establish the safety and effectiveness of the XIENCE V® Everolimus Eluting Coronary Stent, XIENCE nano™ Everolimus Eluting Coronary Stent, XIENCE PRIME™ LL Everolimus Eluting…
- Trial name
- EXPERT CTO (NCT01435031)
- Testing
- CTO Treatment Device
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Abbott Medical Devices
Coronary Occlusion
Supplemental Study to Evaluate the Safety and Effectiveness of the NovaCross™ Micro-catheter
This study will include up to 60 eligible male and female subjects. The purpose of this trial is to evaluate the safety and effectiveness of the NovaCross™ micro-catheter when used to facilitate crossing of Chronic Total…
- Trial name
- NCT03717675
- Testing
- NovaCross™ Chronic Total Occlusion micro-catheter
- Where
- 3 sites in Israel, Poland and 1 more
- Volunteers
- 40 people
- Sponsor
- Nitiloop Ltd.
Chronic Total Occlusion of Coronary Artery, Heart Failure
The NOrdic-Baltic Randomized Registry Study for Evaluation of PCI in Chronic Total Coronary Occlusion
Randomized registry for the study of CTO PCI as adjunction to optimal medical therapy.
- Conditions
- Chronic Total Occlusion of Coronary Artery, Heart Failure, Angina Pectoris
- Trial name
- NOBLE-CTO (NCT03392415)
- Testing
- CTO PCI
- Where
- Denmark
- Volunteers
- 2,000 people
- Sponsor
- Leif Thuesen
Chronic Total Occlusion of Coronary Artery
Coronary Crossing System in Patients With Coronary Chronic Total Occlusions
This is a prospective and multicenter clinical investigation aiming to evaluate the safety and effectiveness of coronary crossing system for the treatment of patients with coronary chronic total occlusions.
- Trial name
- VITAL (NCT05813704)
- Testing
- Coronary Crossing System of Shanghai MicroPort Rhythm
- Where
- China
- Volunteers
- 159 people
- Sponsor
- Shanghai MicroPort Rhythm MedTech Co., Ltd.
Chronic Total Occlusion of Coronary Artery
Japanese CTO PCI Expert Registry
The purpose of this study is to establish a consensus of treatment strategy of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) through patient registry of PCI for CTO performed by Japanese certified…
- Trial name
- NCT01889459
- Where
- Japan
- Volunteers
- 19,000 people
- Sponsor
- Kurashiki Central Hospital
Coronary Artery Disease
Real-World Outcomes of Drug-Coated Balloon Angioplasty in Coronary Artery Disease
The Real-World Drug-Coated Balloon Registry (RW-DCB) is an investigator-initiated, multicenter, observational cohort study evaluating the use of drug-coated balloons (DCBs) during percutaneous coronary intervention (PCI) in…
- Trial name
- RW-DCB (NCT07875088)
- Testing
- Coronary Drug-Coated Balloon
- Where
- 5 sites in Mexico, Spain
- Volunteers
- 2,000 people
- Sponsor
- Kristian Rivera
Chronic Total Occlusion (CTO)
A Novel Scoring System for Predicting the Success of PCI in Patients With CTO
The investigators conducted a retrospective, single-center observational registry upon which one novel scoring system was formed and evaluated for their accuracy in predicting technical success.
- Trial name
- NCT06322914
- Where
- China
- Volunteers
- 493 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Coronary Occlusion, Coronary Artery Stenosis
Chronic Total Occlusion Registry
This study evaluated the long-term outcome of patients with chronic total occlusion treated with percutaneous coronary intervention, medical treatment or coronary artery bypass grafting.
- Conditions
- Coronary Occlusion, Coronary Artery Stenosis, Coronary Stenosis
- Trial name
- IRIS CTO (NCT04041921)
- Testing
- Percutaneous coronary intervention, Coronary Artery Bypass Grafting, Medical treatment
- Where
- 19 sites in South Korea
- Volunteers
- 4,006 people
- Sponsor
- Seung-Jung Park
Coronary Artery Disease, Chronic Total Occlusion
German Epicardial Collateral CTO Registry
The EPIC registry is an observational multicentre registry evaluating the technical feasibility of retrograde CTO-PCI using epicardial collateral connections.
- Conditions
- Coronary Artery Disease, Chronic Total Occlusion, Percutaneous Coronary Intervention
- Trial name
- EPIC (NCT04533633)
- Testing
- Retrograde Percutaneous Coronary Intervention of Chronic Total Occlusion
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Universitätsmedizin Mannheim