Clinical trials: Cigarette Use
Nicotine Dependence, Tobacco Use Disorder
Effectiveness of Using Reduced Nicotine Cigarettes in Men and Women Smokers to Combat Nicotine Addiction
This is a 2-year study involving the progressive reduction in the nicotine content of cigarettes. The investigators believe that at the end of the study smokers of cigarettes with progressively reduced nicotine content will be…
- Trial name
- NCT00264342
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Use Disorder, Nicotine Dependence
Beta-Adrenergic Modulation of Drug Cue Reactivity
This study is designed to investigate the effects of a beta-adrenergic antagonist (Propranolol; 40 mg IR) and nicotine patch (14 mg) administered alone and in combination on neurobiological and behavioral responses to smoking…
- Conditions
- Tobacco Use Disorder, Nicotine Dependence, Cigarette Smoking
- Trial name
- NCT05587361
- Testing
- Propranolol, Nicotine Patch
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Anxiety Disorders, Anxiety
Personalized Feedback for Smokers With Elevated Anxiety Sensitivity
This project will develop and refine a computer-delivered integrated Personalized Feedback Intervention (PFI) that directly addresses smoking and anxiety sensitivity (AS).
- Conditions
- Anxiety Disorders, Anxiety, Tobacco Dependence, Smoking, Cigarette
- Trial name
- NCT03382093
- Testing
- Personalized Feedback Intervention, Smoking Information Control
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Houston
Smoking, Smoking Behaviors
CSD200907: A Study to Assess Elements of Abuse Liability for a Heated Tobacco Product With Four Non-Combusted Cigarette Variants
This is a single-center, open-label, randomized, 2-arm, within-arm cross-over study designed to evaluate elements of abuse liability (AL) including subjective effects and physiological measures (pharmacodynamics [PD]), and plasma…
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Trial name
- NCT05114863
- Testing
- Product A1, Product B, Product C
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Cigarette Smoking
Effects of Smoking Environments on Craving and Smoking (CameraCue2.0)
The goal of this study is to evaluate the effects of varenicline versus nicotine replacement versus placebo on personal smoking environment cue (PSE) reactivity.
- Trial name
- NCT02551692
- Testing
- Nicotine Patch, Varenicline
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Duke University
Electronic Cigarette Use, Endothelial Dysfunction
Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use
The use of electronic nicotine delivery systems, or e-cigarettes - colloquially referred to as "vaping" - in the United States has increased exponentially since their introduction to the US market in 2007.
- Conditions
- Electronic Cigarette Use, Endothelial Dysfunction, Inflammation
- Trial name
- NCT06489249
- Testing
- Salsalate 750 MG Oral Tablet [DISALCID]
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Tobacco Use, E-Cigarette Use
E-Cigarette Effects on Markers of Cardiovascular and Pulmonary Disease
This study is designed to enhance the understanding of the possible health effects of e-cigarette use by relating the acute and long-term use of e-cigarettes and conventional cigarettes ("products") to well-validated…
- Conditions
- Tobacco Use, E-Cigarette Use, Cardiovascular Diseases, Pulmonary Disease
- Trial name
- NCT03863509
- Testing
- Cigarettes, E-Cigarettes
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Nicotine Dependence, Smoking Cessation
Smoking Cessation and Reduction With an Electronic Nicotine Delivery Device (ENDD)
The study's major aim is to investigate the ability of a commercial Electronic Nicotine Delivery Device (ENDD) to induce long-term smoking reduction/abstinence in smokers unwilling to quit.
- Trial name
- NCT01195597
- Testing
- E-Cigarette 7.2 mg nicotine
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Catania
Smoking, Cigarette, Alveolar Bone Grafting
Wound Healing Following Extraction and Ridge Preservation in Smokers and Non-smokers
The goal of this study is to evaluate bone wound healing following extraction and alveolar ridge preservation (bone graft and membrane) clinically, histologically and in relation to gene expression in smokers and non-smokers.
- Conditions
- Smoking, Cigarette, Alveolar Bone Grafting, Wound Healing, Bone Healing
- Trial name
- NCT07372183
- Testing
- observational study
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Marquette University
Cigarette Smoking
Developing a Smartphone App With Mindfulness Training for Teen Smoking Cessation
The recent Surgeon General's Report calls for effective and readily available treatment approaches to help adolescent smokers interested in quitting.
- Trial name
- NCT02218281
- Testing
- C2Q-Teen app, NCI's QuitSTART app, Written smoking cessation materials only
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Cigarette Smoking, Coronary Heart Disease
Exercise and Coronary Heart Disease Risk Markers in Male Smokers and Non-Smokers
The present study will investigate the effect of acute exercise on fasting and postprandial risk markers for coronary heart disease (CHD) in healthy male cigarette smokers and non-smokers.
- Conditions
- Cigarette Smoking, Coronary Heart Disease, Cardiovascular Risk Factor, Insulin Resistance
- Trial name
- NCT03735186
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Vaping Behavior
High Impact E-cigarette Advertisement Features
This randomized controlled trial aims to examine the effects of high-impact e-cigarette advertisement features among young adults of various tobacco-use statuses.
- Trial name
- NCT06704295
- Testing
- Control ad with dark gray product with tobacco flavor name, Dark gray product with strawberry flavor name, Colorful (strawberry color) product with strawberry flavor name
- Where
- United States
- Volunteers
- 3,083 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Electronic Cigarette Use, Cigarette Smoking
Effects of e-Cigarettes on Perceptions and Behavior - Remote Substudy # 2
This study assess the ways in which e-cigarette product characteristics, such as flavors and nicotine salts, impact user experience to inform potential regulations.
- Conditions
- Electronic Cigarette Use, Cigarette Smoking, Cigarette Use, Electronic, Vaping
- Trial name
- NCT05958992
- Testing
- E-cigarette
- Where
- United States
- Volunteers
- 461 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Electronic Cigarette Use, Cigarette Use, Electronic
Evaluating Selected Constituents in the Exhaled Breath Samples
An Open-Label, Multi-Center Study to Evaluate Selected Constituents in the Exhaled Breath Samples From the Use of JUUL Nicotine Salt Pod System Product (5% and 3% Virginia Tobacco, Mint, Mango, Menthol) Users and Conventional…
- Conditions
- Electronic Cigarette Use, Cigarette Use, Electronic, Tobacco Use, Tobacco Smoking
- Trial name
- NCT04143256
- Testing
- JUUL ENDS 5% Virginia Tobacco, JUUL 3% Virginia Tobacco ENDS, JUUL 5% Mint ENDS
- Where
- 3 sites in United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Cigarette Smoking
Experimental Tobacco Marketplace in Regulating Flavored Tobacco Products in Menthol Cigarette Smokers
This trial uses an Experimental Tobacco Marketplace to study the purchase of tobacco products in menthol cigarette smokers. Determining the level of substitutability of both flavored and unflavored/tobacco flavored e-cigarettes…
- Trial name
- NCT03897530
- Testing
- Smoking Cessation Intervention, Functional Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Vascular Diseases
Vascular EffectS of regUlar Cigarettes Versus electronIc Cigarette USe
The purpose of this study is to assess the effects of electronic cigarettes-nicotine and electronic cigarette-nicotine free on endothelial function as compared to traditional cigarettes.
- Trial name
- VESUVIUS (NCT02878421)
- Testing
- electronic cigarette + 16mg nicotine & flavor, electronic cigarette + 0mg nicotine & flavor, Tobacco cigarette
- Where
- United Kingdom
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University of Dundee
Tobacco Use
Sugars in Cigarettes
The aim of this study is to investigate the impact of sugar levels in cigarette tobacco on cigarette abuse liability and appeal.
- Trial name
- NCT05308316
- Testing
- Cigarettes with added sucrose
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Nicotine Dependence
A Brain Imaging Study of Nicotine Release in Cigarette Smokers
Tobacco Smoking is the most prevalent addiction in society today causing directly major health hazards and sharing morbidity with other psychiatric disorders.
- Trial name
- NCT00254358
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Vaping, Adolescent
Nicotine and Cannabis Vape Labeling Experiment - Spring 2025
This study assesses how the ways in which nicotine and cannabis vaping devices are labeled impact use susceptibility, anticipated effects, and health harm.
- Conditions
- Vaping, Adolescent, Electronic Cigarette Use, Nicotine
- Trial name
- EPIC/ADVANCE (NCT06919276)
- Testing
- Vaping Device Labeling
- Where
- United States
- Volunteers
- 3,048 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Smoking, Cigarette
Compare the Pharmacokinetic Characteristics and the Safety Between Zeropix and Champix in Healthy Adult Male Subjects.
This study is a randomized, open-label, 2-way, 2-period, single-dose crossover clinical study to compare the pharmacokinetic characteristics and the safety between zeropix tablet 1 mg and champix® tablet 1 mg in healthy adult…
- Trial name
- NCT03362008
- Testing
- Zeropix, Champix®
- Where
- South Korea
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Jeil Pharmaceutical Co., Ltd.