Clinical trials: Circadian Misalignment
Mood Disorders, Major Depressive Diorder
Validation of Wearable Core Body Temperature-Based Circadian Rhythm Digital Biomarkers
This single-site prospective observational study aims to validate wearable-derived circadian and behavioral rhythm biomarkers using continuous core body temperature and raw accelerometry measurements and to explore longitudinal…
- Conditions
- Mood Disorders, Major Depressive Diorder, Bipolar Disorders, Mental Disorder
- Trial name
- Calera (NCT07905378)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Shift Work Schedule, Circadian Rhythm
Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance
The purpose of this study is to examine the impact of timed cortisol release or differently timed cortisol rhythms on insulin resistance in both men and women undergoing sleep restriction.
- Conditions
- Shift Work Schedule, Circadian Rhythm, Insulin Resistance, Circadian Misalignment
- Trial name
- NCT07494084
- Testing
- Metyrapone And Hydrocortisone, Dextrose, insulin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Washington State University
Circadian Rhythm Sleep Disorder, Jet Lag Type
Factors Associated With Infant Circadian Rhythm, Growth, and Temperament
The goal of this observational study is to learn about the role of modifiable factors affecting infant circadian rhythm so that recommendations can be made for better health outcomes for the mother and infant.
- Trial name
- NCT05700136
- Testing
- MOMENT
- Where
- 10 sites in Malaysia
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- UCSI University
Cushing Syndrome, Adrenal Insufficiency
Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid Disorders
This is a multicentric, prospective, intervention study on circadian genes expression in peripheral blood mononuclear cells as biomarkers of circadian rhythm derangement in patients affected by alterations of endogenous…
- Conditions
- Cushing Syndrome, Adrenal Insufficiency, Cushing Disease, Addison Disease
- Trial name
- CHROnOS (NCT04374721)
- Testing
- circadian gene expression evaluation
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Depression; Major Depressive Disorder
Sleep/Wake Cycle and Depression: An Imaging and Treatment Study
16.2 million American adults are affected by depression each year. The investigators are studying the relationship between sleep/wake cycle and depression.
- Trial name
- NCT04350567
- Testing
- Sleep Deprivation
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Obesity
Circadian Misalignment and Energy Balance
Preliminary findings from the investigators' lab suggest that circadian misalignment, occurring when meals and sleep are mistimed from one another, alters resting state neuronal processing in areas relevant to food reward and…
- Trial name
- CM (NCT03663530)
- Testing
- Meal times
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Columbia University
Sleep, Circadian Rhythm
Sleep and Circadian Contributions to Nighttime Blood Pressure
Broadly, this study (SCN-BP) seeks to examine sleep and circadian factors that contribute to blood pressure levels at night.
- Conditions
- Sleep, Circadian Rhythm, Blood Pressure, Hypertension
- Trial name
- SCN-BP (NCT05656768)
- Testing
- Constant Routine Protocol
- Where
- United States
- Volunteers
- 1,427 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Chronobiology, Light
Teen Sleep and Light Study
Circadian clocks shift later (delay) with the progression of puberty; this shift contributes to late sleep onsets in older adolescents.
- Conditions
- Chronobiology, Light, Sleep, Circadian Rhythm
- Trial name
- NCT04921215
- Testing
- Morning bright light
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Sleep Deprivation
Cardiovascular Risk and Circadian Misalignment in Short Sleepers - Role of Extended Eating Period
Short sleep duration confers high cardiovascular and metabolic risk, but lifestyle factors and molecular mechanisms that contribute to increased blood pressure and poor glucose control during short sleep are not completely…
- Trial name
- CRISP (NCT06070194)
- Testing
- Time restricted eating (TRE)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Circadian Misalignment, Sex Differences
Does Circadian Misalignment Have Sex-Specific Effects on Metabolism?
This study will test whether biological sex influences how the body responds to circadian misalignment-a mismatch between the internal body clock and the timing of sleep and eating (as can occur with shift work or jet lag).
- Trial name
- NCT07441265
- Testing
- Day shift, Night shift
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Ulcerative Colitis
The Impact of Circadian Misalignment on Colonic Barrier Homeostasis in Ulcerative Colitis
The purpose of this study is to investigate if circadian malalignment (unusual sleeping patterns), such as night shifts (sleeping during the day and being awake during the night time), worsens the inflammation of the gut.
- Trial name
- NCT05180279
- Testing
- 7-day sleep lab
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Healthy
Interaction of Chronic Sleep Restriction and Circadian Misalignment on Sleep and Neuro-cognitive Performance
The primary objectives of the proposed experimental and modeling efforts are to quantify the influences of acute sleep deprivation (short-term homeostatic), chronic sleep restriction (long-term homeostatic), circadian…
- Trial name
- NCT00438438
- Testing
- forced desynchrony protocol with sleep restriction
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Night Shift Work, Obesity & Overweight
Shift Workers' Health Behavior Action Program Across Europe
This study evaluates the effects of a Combined Lifestyle Intervention Program (CLIP) on sleep, lifestyle behaviors, obesity risk and health in night-shift workers.
- Conditions
- Night Shift Work, Obesity & Overweight, Circadian Misalignment
- Trial name
- SHAPE (NCT07631767)
- Testing
- Combined Lifestyle Intervention
- Where
- 5 sites in Germany, Netherlands and 1 more
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Circadian Dysregulation
Development of Countermeasures Against Adverse Metabolic Effects of Shift Work
The goal of this application is to determine whether changing the timing of food intake prevents the adverse metabolic effects of circadian misalignment.
- Trial name
- NCT02291952
- Testing
- Meal schedule
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Circadian Rhythm, Time Perception
Circadian Timing and Time Perception in Healthy Adults
This study examines how a person's natural daily rhythm ("chronotype") affects the way time is experienced and judged. Healthy Danish-speaking adults (23-45 years) who are clearly morning-type or evening-type will complete two…
- Trial name
- ChronoTime (NCT07292597)
- Testing
- Session timing relative to chronotype
- Where
- Denmark
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Sleep, Metabolism Changes
Nighttime Synchrony of Your Nutrition and Circadian Health
Sleep is an important factor for overall health. This study will see how different light exposure patterns and food intake impact a person's metabolism (how the body breaks down food) when sleeping is reduced.
- Conditions
- Sleep, Metabolism Changes, Circadian Rhythm, Lifestyle Factors
- Trial name
- N-Sync (NCT07329283)
- Testing
- Central Clock Misalignment, Peripheral Misalignment
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Utah
Diabetes Mellitus, Type 2, Insulin Resistance
Circadian Misalignment and Insulin Sensitivity
This study will evaluate the effect of circadian misalignment on insulin sensitivity in healthy lean subjects in a randomized cross-over design.
- Trial name
- NCT02580513
- Testing
- Circadian Misalignment
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease
Countermeasures to Circadian Misalignment
Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable.
- Conditions
- Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease, Insulin Sensitivity
- Trial name
- C2CM (NCT04966351)
- Testing
- Time-restricted feeding, Circadian Misalignment
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Non-visual Effects of Light, Chronic Variable Sleep Deficiency
Sleep, Light, Circadian, Central Oxidative Stress
Irregular sleep timing and sleep deficiency are pervasive in society despite evidence that sleep deficiency impairs cognition and is linked to neurodegenerative disease.
- Trial name
- NCT07471126
- Testing
- Chronic Variable Sleep Deficiency, Sleep- and Circadian-Informed Lighting, Dim Light
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center