Clinical trials: Circadian Rhythm
Diurnal
the Bispebjerg Study of Diurnal Variations
To evaluate the influence of time of day on the circulating concentrations of various biochemical markers in healthy men
- Trial name
- DIURNAL (NCT06166368)
- Testing
- Diurnal variation
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Major Depressive Disorder (MDD), Sleep Disorders
A Longitudinal Follow-Up Study on Predicting Major Depressive Disorder From Rest-Activity Rhythm Profiles
This proposed study will be a longitudinal follow-up study of a case-control study of 160 participants (CREC Ref: 2023.234). This study aims to follow up on the trajectory of depression and rest-activity rhythm (RAR) disruptions…
- Conditions
- Major Depressive Disorder (MDD), Sleep Disorders, Circadian Rhythm
- Trial name
- NCT07388849
- Where
- Hong Kong
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
10-13 Age, Inspiratory Muscle Training
Effects of Inspiratory Muscle Training Combined With Circadian Rhythm-based Running Programs in Children Male Football Players
In this study, a parallel two-group pre-test-post-test randomized controlled trial was conducted according to CONSORT guidelines.
- Conditions
- 10-13 Age, Inspiratory Muscle Training, Running, Circadian Rhythm
- Trial name
- Circadian IMT (NCT07170891)
- Testing
- Morning Running and IMT, Inspiratory muscle training and evening running, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Gümüşhane Universıty
Osteoporosis, Circadian Rhythm Sleep Disorder, Shift Work Type
Skeletal Effects of Chronic Night Shift
The specific aim of this observational study is to characterize changes in bone turnover makers (BTMs), bone mineral density (BMD), and bone microarchitecture in a cohort of nurses during their first year of night compared to day…
- Trial name
- ACORN (NCT05091021)
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Sleep Disorders, Circadian Rhythm
The Efficacy of Melatonin in the Burning Mouth Syndrome
Burning mouth ( BMS) syndrome is the oral disorder characterized by an intraoral burning sensation for which no medical or dental cause can be found.
- Trial name
- BMS (NCT03788733)
- Testing
- Melatonin 3 mg
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Diabetes Mellitus, Type 2, Insulin Resistance
Circadian Misalignment and Insulin Sensitivity
This study will evaluate the effect of circadian misalignment on insulin sensitivity in healthy lean subjects in a randomized cross-over design.
- Trial name
- NCT02580513
- Testing
- Circadian Misalignment
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Sleep Disorder, Shift Work, Fatigue
Effect of Night Float Call on Sleep and Activity Patterns Among Anesthesia Residents
With increasing awareness about physician fatigue and its effect on patient safety, residency programs are increasingly transitioning to a night float call system.
- Conditions
- Sleep Disorder, Shift Work, Fatigue, Sleep Disturbance
- Trial name
- NCT05043038
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Stanford University
Circadian Rhythm Sleep Disorder
Effects of Chronobiology-guided Lifestyle Interventions on Insomnia Severity, Cognitive Performance, and Sleepiness
Poor sleep is closely related to circadian misalignment; shift workers often experience shift work disorder characterized by excessive sleepiness and recurrent shift work schedules-associated insomnia.
- Trial name
- NCT05569603
- Testing
- Chronobiology-guided lifestyle interventions
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Shift-Work Sleep Disorder, Insomnia
Fire Fighter Fatigue Management Program: Operation Healthy Sleep
Firefighters work some of the most demanding schedules known under highly stressful and demanding conditions. The need to work frequent extended shifts and long work weeks leads to acute and chronic partial sleep deprivation as…
- Conditions
- Shift-Work Sleep Disorder, Insomnia, Restless Leg Syndrome, Obstructive Sleep Apnea
- Trial name
- NCT01988129
- Testing
- Sleep disorders education and screening
- Where
- United States
- Volunteers
- 1,189 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Dry Eye
Diurnal Variation of Tear Meniscus and Tear Osmolarity
This study is to determine the diurnal variation of tear meniscus and tear osmolarity in normal subjects and dry eye patients.
- Trial name
- NCT01206244
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Miami
Depression, Anxiety
Simulated Dawn Med Students
Medical students score higher than the general population on measures of depression, anxiety, fatigue, poor sleep and sleepiness. Data suggest that disparages in circadian phase might contribute to these problems.
- Conditions
- Depression, Anxiety, Fatigue, Sleepiness
- Trial name
- NCT02088593
- Testing
- Simulated Dawn Light Box, Sleep Hygiene instructions
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Diurnal Variations of Cerebral Metabolite
Diurnal Variations of Brain Metabolite Concentrations in 1H-MRS
Proton Magnetic Resonance Spectroscopy (1H-MRS) is a magnetic resonance imaging (MRI) technique. It allows the quantification of cerebral metabolite concentrations.
- Trial name
- Dyn24 (NCT03497832)
- Testing
- magnetic resonance spectroscopy (MRI)
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Sleep, Sleep Disorders
The BEST Study: The Efficacy of Brain Entrainment Sleep Technology in Military Healthcare Beneficiaries
Brain Entrainment Technology (BET), also known as Binaural Beat Technology (BBT); is an auditory-neurophysiologic technique which uses auditory tones (often embedded in music, nature sounds or white noise) dichotically via stereo…
- Conditions
- Sleep, Sleep Disorders, Sleep Deprivation, Sleep Disturbance
- Trial name
- BEST (NCT03169309)
- Testing
- Brain Entrainment Technology
- Where
- Germany
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Landstuhl Regional Medical Center
Cryopyrin Associated Periodic Syndrome, Familial Cold Urticaria
Circadian Rhythm Deregulation in Patients With CAPS
Circadian rhythms are characterized by the physiology's adaptation to the alternation of day and night, enabling to adapt to the environment. These rhythms are generated by a molecular clock within each cell.
- Conditions
- Cryopyrin Associated Periodic Syndrome, Familial Cold Urticaria, Muckle-Wells Syndrome, CINCA Syndrome
- Trial name
- ICARUS (NCT06544018)
- Testing
- Genetic analysis of NLRP3, Circadian rhythm measurement, Saliva sampling
- Where
- 6 sites in France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Breast Cancer, Fatigue
The Role of Circadian Rhythms in Cancer-Related Symptoms
Emerging evidence indicates that circadian rhythms may be disrupted following cancer and its treatment, and that circadian rhythm disruption may be an underlying pathophysiological mechanism of cancer- and cancer…
- Conditions
- Breast Cancer, Fatigue, Cognitive Impairment, Sleep
- Trial name
- CHRONO (NCT04401189)
- Where
- Denmark
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Dry Eye Disease
Diurnal Variation in Tear Osmolarity
The purpose of this study is to measure the change in Tear Osmolarity during the course of the day to support clinical diagnosis of aqueous deficiency or meibomian gland disease and differentiate between the two forms of dry eye.
- Trial name
- NCT01321424
- Where
- 6 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ophthalmic Consultants of Long Island
Shift-Work Sleep Disorder
Effects of Daytime Eszopiclone Administration in Shift Workers
The purpose of this study is to test the effects of eszopiclone on daytime sleep and overnight wakefulness in shift workers.
- Trial name
- NCT00900159
- Testing
- eszopiclone
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cardiovascular Diseases, Obesity Prevention
Mediterranean Diet Education in Shift Nurses: Effects on Sleep, Activity, and Health Parameters
This study aimed to evaluate the effects of Mediterranean diet education on sleep quality, physical activity levels, blood parameters, and anthropometric measurements among shift-working nurses.
- Conditions
- Cardiovascular Diseases, Obesity Prevention, Atheroscleroses, Hypertension
- Trial name
- NCT07123610
- Testing
- Mediterranean Diet Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Circadian Rhythm Sleep Disorder, Delayed Sleep Phase, Sleep
The Effects of a Blue Monochromatic Light Intervention on Evening-type Individuals' Sleep and Circadian Rhythms
The present project is aimed to contribute with new knowledge concerning how light conditions in the physical environment can be manipulated to alter the sleep and circadian rhythms of individuals with an evening-type circadian…
- Trial name
- NCT03758768
- Testing
- Blue light exposure, Full spectrum light exposure
- Where
- Norway
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Diurnal Variation of Paracetamol Excretion
Estimation of Paracetamol in Urine to Assess the Diurnal Variation
Paracetamol is an antipyretic drug that is taken orally at different times of the day in same dose. It is excreted mainly through renal route which may show diurnal variation.
- Trial name
- NCT03122561
- Testing
- Paracetamol 500 mg tablet at morning, Paracetamol 500 mg tablet at midday, Paracetamol 500 mg tablet at night
- Where
- Bangladesh
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh