Clinical trials: Circadian Rhythms
Depression, Anxiety
Simulated Dawn Med Students
Medical students score higher than the general population on measures of depression, anxiety, fatigue, poor sleep and sleepiness. Data suggest that disparages in circadian phase might contribute to these problems.
- Conditions
- Depression, Anxiety, Fatigue, Sleepiness
- Trial name
- NCT02088593
- Testing
- Simulated Dawn Light Box, Sleep Hygiene instructions
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Hypertension, Cardiovascular Risk Factor
Sleep and Circadian Mechanisms of Non-dipping Blood Pressure
This study will be the first to distinguish the relative contributions of sleep, circadian and behavioral mechanisms to the non-dipping BP profile in Black adults and will lay the groundwork for optimizing therapies dependent on…
- Trial name
- NCT03558893
- Testing
- Forced Desynchrony
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Circadian Rhythm, Blood Pressure
Circadian Mechanisms Underlying Non-Dipping Blood Pressure in Blacks
This study seeks to examine central and peripheral circadian mechanisms in Blacks with appropriately dipping systolic blood pressure (blood pressure that dips by at least 10%) compared with non-dipping systolic blood pressure…
- Trial name
- NCT03934255
- Testing
- Constant Routine Protocol
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Circadian Rhythms, Time Perception
The Effect of a Continuous 1-Hour Time Delay on Circadian Rhythms
The purpose of this study is to investigate whether the experience of a daily time delay can affect our internal circadian rhythm.
- Conditions
- Circadian Rhythms, Time Perception, Sleep
- Trial name
- NCT07317349
- Testing
- Fixed daily routine, Daily time delay
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Sleep, Circadian Rhythm
Sleep and Circadian Contributions to Nighttime Blood Pressure
Broadly, this study (SCN-BP) seeks to examine sleep and circadian factors that contribute to blood pressure levels at night.
- Conditions
- Sleep, Circadian Rhythm, Blood Pressure, Hypertension
- Trial name
- SCN-BP (NCT05656768)
- Testing
- Constant Routine Protocol
- Where
- United States
- Volunteers
- 1,427 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Vaccine Response, Sleep
Melatonin and Vaccine Response, Immunity, and Chronobiology Study
This study will evaluate the impact of sleep, circadian health and melatonin on flu vaccine immunogenicity.
- Conditions
- Vaccine Response, Sleep, Circadian Rhythm Disorders
- Trial name
- MAVRICS (NCT04953754)
- Testing
- Melatonin, Phillips Actiwatch Spectrum Plus
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Sleep Disorders, Circadian Rhythm
Circadian Phase Adjustment and Improvement of Metabolic Control in Night Shift Workers
EuRhythDia II is a multicenter, randomized, double-blind controlled study. The rationale of EuRhythdia is to explore the effects of 12 weeks of timed melatonin treatment on circadian rhythm, metabolic control and cardiovascular…
- Trial name
- NCT02108353
- Testing
- Melatonin 2mg
- Where
- 3 sites in Germany, Italy
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Type 1 Diabetes, Overweight
Effect of Circadian Rhythm and Physical Exercise in Overweight Type 1 Diabetes Patients
Cardiometabolic risk in patients with abdominal obesity and type 1 diabetes can be moderated by life style modifications. There is an intimate link between gene regulation and circadian rhythm in mediating response to exercise in…
- Trial name
- NCT05277532
- Testing
- High intensity interval training (HIIT)
- Where
- Sweden
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Circadian Rhythm Disorders, Sepsis
Functionality of Endogenous Biological Clock in Sepsis
The aim of the current study is to demonstrate dysregulation of immune system΄s circadian rhythms as a consequence of sepsis, as well as marked malfunction of the central circadian clock in comparison with patients without sepsis…
- Trial name
- NCT04063332
- Where
- 2 sites in Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Athens
Behavioral Responses to Bright Light Therapy in Elders
Effect of Bright Light Treatment On Elders In a Long Term Care Environment
The investigators hypothesize that significant exposure to artificial morning bright light (approximately 200 lux of primarily blue light at eye level for thirty minutes daily) as compared to sham bright red light (placebo) will…
- Trial name
- BrightLights (NCT01042587)
- Testing
- exposure to bright light, low luminosity red light
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
PreDiabetes, Circadian Dysregulation
Morning Light Treatment to Improve Glucose Metabolism
The primary purpose of this pilot study is to test a novel head worn light device (Re-Timer®) as an intervention to improve glucose metabolism in people with prediabetes.
- Trial name
- ML (NCT03188263)
- Testing
- Bright Light, Dim Light
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Sleep Disorders, Circadian Rhythm, Craniopharyngioma
Sleep Wake and Melatonin Pattern in Craniopharyngioma
The hypothalamus is a part of the brain containing a number of nuclei with a variety of functions. It is central in the regulation of hormone secretion, sleep, and circadian functions.
- Trial name
- NCT01881854
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cancer
Health Status Evaluation for Cancer Survivors by Non-intrusive Sensing System
To improve quality of life of elderly cancer survivors 1. Using physical activity and environmental sensing technology 2. Monitoring physiological indicators of cancer recurrence Analyzing the patient's circadian rhythm, frailty…
- Trial name
- NCT02175823
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Diurnal Variation of Paracetamol Excretion
Estimation of Paracetamol in Urine to Assess the Diurnal Variation
Paracetamol is an antipyretic drug that is taken orally at different times of the day in same dose. It is excreted mainly through renal route which may show diurnal variation.
- Trial name
- NCT03122561
- Testing
- Paracetamol 500 mg tablet at morning, Paracetamol 500 mg tablet at midday, Paracetamol 500 mg tablet at night
- Where
- Bangladesh
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Inflammation, Sleep Deprivation
Circadian Rhythm Disruption Effects on Smoke Inhalation
Particulate matter exposure during smoke inhalation provokes inflammatory immune responses in people exposed to burning biomass including fire fighters and civilians.
- Conditions
- Inflammation, Sleep Deprivation, Circadian Rhythm Sleep Disorder, Shift Work Type, Smoke Inhalation
- Trial name
- NCT04955431
- Testing
- Sleep Restriction, Normal Sleep
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Montana
Aspirin, Circadian Rhythm
Aspirin AM or PM: Effect on Circadian Rhythm of Platelet Reactivity
Low-dose aspirin is a cornerstone in the secondary prevention of cardiovascular disease (CVD) and is usually taken on awakening, although evidence regarding optimal time of intake is lacking.
- Conditions
- Aspirin, Circadian Rhythm, Platelet Activation, Cardiovascular Diseases
- Trial name
- NCT01900639
- Testing
- change time of intake of aspirin
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Caffeine, Caffeine Withdrawal
Influence of Caffeine Consumption on the Human Circadian System
Surveys indicate that 85% of the adult population consume caffeine on a daily basis. Caffeine acts on sleep homeostatic mechanisms by antagonizing the sleep factor adenosine.
- Conditions
- Caffeine, Caffeine Withdrawal, Sleep, Circadian Rhythm
- Trial name
- CICAFF (NCT05409339)
- Testing
- Caffeine
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Psychiatric Hospital of the University of Basel
Sleep Disorders, Circadian Rhythm
Nursing Activity and Quality of Hospitalized Patients' Sleep
This study is to determine the impact of night shift nurse's activity on patients' sleeping patterns in medical services including individual, clinical and environmental factors.
- Trial name
- SOMACTIV (NCT03370354)
- Testing
- Observational
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Circadian Rhythm
Circadian Rhythm Monitoring Study
This will be a single-center, prospective observational study designed to evaluate the feasibility and accuracy of a new wearable device for non-invasive continuous monitoring of physiological signals to derive circadian rhythm.
- Trial name
- NCT07336654
- Testing
- Circadian monitoring device
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ResMed
Bipolar Disorder, Schizophrenia
Sleep, Obesity and Mental Disease - Biological Markers for the Evaluation of Circadian Rhythmicity
Introduction 16.8% of the Danish adult population are obese (Body Mass Index> 30 kg / m2). Obesity increases the risk of lifestyle diseases such as type-2 diabetes and non-alcoholic fatty liver.
- Conditions
- Bipolar Disorder, Schizophrenia, Obesity, Circadian Rhythm Disorders
- Trial name
- SOMBER (NCT05413486)
- Testing
- Observational
- Where
- Denmark
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark