Clinical trials: Circadian Rhythms
Inflammatory Response
The Effects of Surgery Performed At Different Times of the Day on Inflammation and Recovery
To evaluate the inflammatory response of participants who will undergo unilateral inguinal hernia surgery at two different times of the day (08.00-12.00 during the day and 18.00-22.00 at night).
- Trial name
- NCT06345313
- Testing
- Day Group, Night Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Healthy
Circadian Brown Adipose Tissue Metabolism
Brown adipose tissue is poorly understood fat that can metabolize glucose in order to generate heat. Since activated brown fat has a high metabolic rate, it is of great interest as a potential target to combat obesity.
- Trial name
- NCT02285270
- Testing
- FDG PET/CT
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Physiological Stress, Cognitive Dysfunction
DEEPTIME: Human Adaptation in Time Underground Isolation
The objectives of this scientific expedition are: a/ Evaluation of temporal cognitive perception and collective synchronization in a temporally anomalous universe (underground environment), b/ Influence of group living on the…
- Conditions
- Physiological Stress, Cognitive Dysfunction, Sleep
- Trial name
- DEEPTIME (NCT05603780)
- Testing
- exploratory protocol
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Shift-Work Sleep Disorder
The Effects of Lemborexant on the Ability to Sleep During Daytime
This study aim to evaluate whether a dose of 5 mg of lemborexant, as compared to a placebo, may improve daytime recovery sleep, without producing lingering sleepiness during wakefulness, using a 3-day simulated night shift…
- Trial name
- NCT06231641
- Testing
- Lemborexant 5 MG [Dayvigo]
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Sleep Disorders, Circadian Rhythm
Effect of Melatonin on Sleep Patterns of Resident Trainees During Night Float Shift
Anesthesiology residency requires extended and overnight shifts, which may negatively impact the quantity and quality of sleep. Previous studies have investigated the effect of night float shift work on anesthesiology resident…
- Trial name
- NCT05701969
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Circadian Dysregulation
Body Clocks - Coordination of Peripheral and Central Oscillators
The investigators are conducting an observational trial examining young women over the course of 28 days in which we are monitoring movement, sleep, heart rate, oxygen saturation, gut physiology, light, and menstrual cycle.
- Trial name
- NCT07459764
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Stanford University
Sleep, Circadian Rhythm
Examining the Biological Factors That Affect Sleep Duration
Sleep is necessary for healthy functioning, and people who sleep too little or too much may have an increased risk of developing health problems.
- Conditions
- Sleep, Circadian Rhythm, Cognitive Performance
- Trial name
- NCT00607204
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Caffeine, Caffeine Withdrawal
Influence of Caffeine Consumption on the Human Circadian System
Surveys indicate that 85% of the adult population consume caffeine on a daily basis. Caffeine acts on sleep homeostatic mechanisms by antagonizing the sleep factor adenosine.
- Conditions
- Caffeine, Caffeine Withdrawal, Sleep, Circadian Rhythm
- Trial name
- CICAFF (NCT05409339)
- Testing
- Caffeine
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Psychiatric Hospital of the University of Basel
Obesity
Daytime vs. Delayed Eating Among Obese Individuals
The randomized, cross-over design study is designed to determine how timing of eating affects weight, adiposity, energy metabolism, and gene expression.
- Trial name
- NCT03354169
- Testing
- Eating Condition, No Intervention; withdrawn before randomization
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Sleep Disorders, Circadian Rhythm
Nursing Activity and Quality of Hospitalized Patients' Sleep
This study is to determine the impact of night shift nurse's activity on patients' sleeping patterns in medical services including individual, clinical and environmental factors.
- Trial name
- SOMACTIV (NCT03370354)
- Testing
- Observational
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Phenylketonuria (PKU)
A Pilot Study on Diurnal Variation
This self-controlled, prospective, pilot study is designed to gather information regarding the diurnal variation (changes that occur each day) in the levels of plasma phenylalanine (Phe) and tyrosine in patients with…
- Trial name
- NCT01806051
- Testing
- Kuvan
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Dr. Linda Randolph
Rheumatoid Arthritis
Cortisol Circadian Rhythm in Patients With RA
The European League Against Rheumatism (EULAR), acknowledging the critical issue of the complications, of long term treatment with glucocorticoids in the most recent update of the management guidelines for Rheumatoid arthritis…
- Trial name
- CortRyRA (NCT05671627)
- Testing
- DMARDs
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Exercise Induced Hypoalgesia, Circadian Rhythm
Pain Perception and Exercise-Induced Hypoalgesia Across Circadian Rhythms
The goal of this randomized crossover clinical trial is to investigate whether exercise-induced hypoalgesia (EIH) is influenced by circadian rhythm in healthy adults aged 18-40 years.
- Conditions
- Exercise Induced Hypoalgesia, Circadian Rhythm, Pain Perception, Healthy Participants
- Trial name
- NCT07290465
- Testing
- High-Intensity Functional Training (HIFT), Supervised Deep Breathing
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Medipol University
Sleep Disorders, Circadian Rhythm
The Impact of Night Float on Anesthesiology Resident Sleep Patterns
Residency training requires hospital presence twenty-four hours a day. At times this necessitates working extended shifts, including night shifts, resulting in altered sleep patterns and sleep deprivation.
- Trial name
- NCT03325244
- Testing
- EEG monitor, FitBit
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Sleep, Inadequate, Overweight and Obesity
Improving Metabolic & Mental Health in Female Healthcare Shift Workers
Circadian rhythm disruption caused by shift work alters metabolic and hormonal pathways, which accelerates chronic disease onset, leading to decreased quality and quantity of life.
- Conditions
- Sleep, Inadequate, Overweight and Obesity, Work Related Stress, Healthy Lifestyle
- Trial name
- NCT06158204
- Testing
- Lifestyle Intervention
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Auburn University
Type 2 Diabetes, Circadian Rhythm
Determining Circadian Metabolic and Behavioural Rhythms in Patients with and Without Type 2 Diabetes
The goal of the present clinical descriptive study is to characterize and quantify the potential hormonal chronobiological differences between individuals with type 2 diabetes (T2D) and healthy age and weight-matched controls as…
- Trial name
- Cir-D-Brain (NCT06243172)
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Obesity
Randomized Study of Daytime vs. Delayed Eating: Effect on Weight and Metabolism
The purpose of this study is to determine if, controlling for eating and sleep timing, caloric intake, and exercise, daytime vs. delayed eating affects body mass, adiposity, and energy metabolism in healthy adults.
- Trial name
- NCT04414644
- Testing
- Eating Condition
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Circadian Rhythm Sleep Disorders
Safety and Efficacy of VEC-162 on Circadian Rhythm in Healthy Adult Volunteers
The purpose of this study is to assess the safety and efficacy of VEC-162 compared to matching placebo on circadian phase shift and sleep parameters.
- Trial name
- NCT00490945
- Testing
- VEC-162
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Shift Work Type Circadian Rhythm Sleep Disorder, Eating Behavior
Eating Behaviors in Shift Workers
This study will compare eating behaviors and measures of hunger and fullness between day and night workers in order to better understand why night workers are at increased risk for obesity and related diseases.
- Trial name
- NCT04468672
- Testing
- Portion size
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Columbia University
Healthy, Psoriasis
Sleep, Circadian Rhythm & Skin Health
The purpose of this study is to explore the mechanisms behind how sleep quality may affect skin aging, skin integrity and skin disease.
- Conditions
- Healthy, Psoriasis, Eczema, Acne
- Trial name
- NCT02457000
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center