Clinical trials: Circadian Timing
Overweight Adolescents, Sleep
Improving Sleep Health and Circadian Timing to Support Cardiometabolic Health in Adolescents
Many teenagers get too little and late timed sleep. High body weight and diabetes are increasing in teenagers as well. This study plans to learn more about whether improving sleep habits can help improve how the body regulates…
- Conditions
- Overweight Adolescents, Sleep, Insulin Sensitivity
- Trial name
- REST (NCT07618117)
- Testing
- Circadian/Sleep (C/S)
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Obesity
Sleep Timing and Insulin Resistance in Adolescents With Obesity
This study examines the relationship between sleep timing and insulin resistance in adolescents with obesity. The investigators also aim to develop a physiologically-based mathematical model of adolescent sleep/wake and circadian…
- Trial name
- NCT02585830
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Circadian Rhythm Sleep Disorder, Circadian Rhythm Disorder Caused by Drug
Changes in Circadian Rhythm After Anaesthesia in Children
In this study the investigators will examine the effect of general anesthesia and surgery on sleep duration and sleep quality in children, using questionnaires and a sleep diary.
- Conditions
- Circadian Rhythm Sleep Disorder, Circadian Rhythm Disorder Caused by Drug, Circadian Rhythm Sleep Disorder, Jet Lag Type, Jet Lag
- Trial name
- CLOCKSkids (NCT05618405)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cardiometabolic Syndrome, Type 2 Diabetes
Circadian Intervention to Improve Cardiometabolic Health
The overall goal is to examine the efficacy of a circadian intervention in people with overweight and obesity and habitual short sleep duration (HSSD).
- Conditions
- Cardiometabolic Syndrome, Type 2 Diabetes, Sleep, Time Restricted Feeding
- Trial name
- TOCS (NCT05943626)
- Testing
- Circadian Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Utah
Sleep Disorders, Circadian Rhythm
Efficacy of Ramelteon on Speeding Up Sleep in Subjects With Delayed Sleep Phase Syndrome
The purpose of this study is to evaluate the ability of ramelteon, once daily (QD), to advance the timing of sleep in individuals with delayed sleep phase syndrome.
- Trial name
- NCT00593736
- Testing
- Ramelteon
- Where
- 42 sites in United States
- Volunteers
- 132 people
- Sponsor
- Takeda
Sleep Deprivation, Obesity
Sleep and Metabolism
The goal of this study is to uncover sleep and circadian mechanisms contributing to adverse metabolic health. The protocol is a 21 day (7 outpatient days, 14 inpatient days) mechanistic randomized-crossover study designed to…
- Conditions
- Sleep Deprivation, Obesity, Glucose Intolerance, Weight Gain
- Trial name
- SAM (NCT05775627)
- Testing
- Sleep Restriction
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Multiple Sclerosis
Understanding the Impact of Meal Timing on Neurological Health in Adults With Multiple Sclerosis
The goal of this clinical trial is to learn if the time an individual eats each day impacts neurological health in people with multiple sclerosis. The main questions the investigators are asking are: 1.
- Trial name
- Meal Time MS (NCT07475377)
- Testing
- Time Restricted Eating, Unrestricted eating
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Alabama at Birmingham
Type 1 Diabetes
Timing of Resistance Exercise in Type 1 Diabetes
The aims of the current study are 1. to compare the effects of acute morning and afternoon resistance exercise on blood glucose levels in people with type 1 diabetes. 2.
- Trial name
- T-REX (NCT05884814)
- Testing
- Morning exercise, Afternoon exercise, Habitual physical activity levels
- Where
- Kuwait
- Volunteers
- 54 people
- Sponsor
- Dasman Diabetes Institute
Alcohol Use Disorder
Mechanisms of Risky Alcohol Use in Young Adults: Linking Sleep to Reward- and Stress-Related Brain Function
This research will use biobehavioral approaches to generate understanding about the linkages between stressful life events, sleep duration and timing, and alcohol use in young adults, with a long-term aim of developing effective…
- Trial name
- MoRA (NCT05684094)
- Testing
- Sleep extension and advance, Regular sleep duration and timing
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Oregon
Liver Cirrhosis
Sleep Timing and Circadian Preferences in A Sample of Egyptian Patients With Hepatic Cirrhosis
Individuals with hepatic cirrhosis (n=50) and healthy controls (n=30) were recruited. Sleep quality, sleep timing parameters and circadian preference were evaluated using the Pittsburgh Sleep Quality Index (PSQI), Sleep Timing…
- Trial name
- NCT02710227
- Testing
- (PSQI), (STQ).
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sherief Abd-Elsalam
ADHD
Impact of Short and Mistimed Sleep on Adolescents With ADHD: The Adolescent Attention and Circadian Timing Study
Many adolescents go to bed late and wake up early for school. Science is only beginning to understand how sleep schedules can affect them.
- Trial name
- AACT (NCT07684417)
- Testing
- Aligned sleep extension, Misaligned sleep extension
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Sleep Quality, Chronotype
Sleep, Chronotype, and Prosocial Allocation Decisions
This observational behavioural study examines whether individual differences in sleep quality, sleep timing, and chronotype are associated with prosocial allocation decisions in adults.
- Conditions
- Sleep Quality, Chronotype, Prosocial Decision-Making, Circadian Timing
- Trial name
- SCPAD (NCT07697092)
- Testing
- Sleep, Circadian, and Prosocial Allocation Assessment
- Where
- 2 sites in Hong Kong
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Personalized Meal Timing and Walking Based on Glucose Patterns in Adults With Prediabetes
This study will test whether glucose sensor data can be used to identify the time of day when adults with prediabetes are most likely to have high blood sugar after meals.
- Conditions
- Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Prediabetes or Diabetes
- Trial name
- CLOCK-PRIME (NCT07618663)
- Testing
- Phenotype-Guided Meal Timing and Postprandial Walking, Sleep Hygiene and Step-Count Advice
- Where
- Pakistan
- Volunteers
- 105 people
- Sponsor
- Shifa International Hospital
Brain Injuries, Traumatic, Sleep Initiation and Maintenance Disorders
The Feasibility of Home-Based Measurement of Circadian Timing for Veterans With TBI and Insomnia
Veterans with traumatic brain injury (TBI) frequently experience insomnia, which is linked with delayed TBI recovery, more severe functional impairment, and exacerbation of disabling TBI after-effects such as depression, chronic…
- Trial name
- Home DLMO (NCT05665764)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- VA Office of Research and Development
Meal Timing, Postprandial Glucose
Effect of Circadian Timing of a Standardized Meal on Postprandial Glucose Response in Healthy Adults
This randomized crossover study aims to investigate the effect of circadian timing of a standardized meal (morning versus evening consumption) on postprandial glucose response in healthy adults.
- Conditions
- Meal Timing, Postprandial Glucose, Glycemic Response to Feeding in Healthy Participants
- Trial name
- NCT07545330
- Testing
- Standardized Test Meal
- Where
- Saudi Arabia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King Faisal University
Dietary Intervention
Eating to Adjust the Timing System
The goal of this clinical trial is to test the effects of dietary composition on the rhythms of food intake, appetite regulation, and rhythms of energy expenditure.
- Trial name
- EATS (NCT05800990)
- Testing
- dietary intervention
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Overweight and Obesity
Circadian Timing, Information Processing and Energy Balance Study
This study design will test biological and behavioral mechanisms in the cross-sectional analyses and determine the prospective effects of circadian alignment and sleep on changes in cardiometabolic risk factors.
- Trial name
- TIME (NCT04759755)
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University of Utah
Circadian Dysregulation
Development of Countermeasures Against Adverse Metabolic Effects of Shift Work
The goal of this application is to determine whether changing the timing of food intake prevents the adverse metabolic effects of circadian misalignment.
- Trial name
- NCT02291952
- Testing
- Meal schedule
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep Restriction
Impact of a Sleep Debt in Middle-Aged and Older Adults
This project has 6 aims. 1. To examine the impact of recurrent partial sleep loss in young, middle-aged and older men and women. Sleep will be restricted to 4 hours. 2.
- Trial name
- PPG (NCT00817700)
- Testing
- Sleep restriction
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Sleep Disorders, Circadian Rhythm, Circadian Rhythm Disorders
Validation of Circadian Biomarkers in Patients With Sleep Disorders
Current methods for assessing circadian timing require sampling over hours (or even up to a day) while the patient is in controlled conditions.
- Conditions
- Sleep Disorders, Circadian Rhythm, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder, Advanced Sleep Phase Syndrome (ASPS)
- Trial name
- NCT04690504
- Testing
- dim light melatonin onset (DLMO)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital