Clinical trials: Circulating Markers
Circulating Markers, Metastatic Colorectal Cancer
Correlation Between Circulating Tumour Markers Early Variations and Clinical Response in First Line Treatment of Metastatic Colorectal Cancer
The chemotherapy monitoring is currently based on radiological (RECIST 1.1 guideline) and clinical evaluation every 3 months. Circulating markers as Carcino Embryonic Antigen (CEA), circulating tumour DNA and total cell free DNA…
- Trial name
- COCA-MACS (NCT02872779)
- Testing
- Blood sampling for free mutant DNA analysis
- Where
- France
- Volunteers
- 74 people
- Sponsor
- University Hospital, Rouen
Lung Neoplasms
Functional Image and Molecular Markers to Predict Treatment Outcomes in Lung Cancer
This study is designed to apply various scans such as functional imaging, Fluorodeoxyglucose_Positron Emission Tomography (FDG-PET), 62Cu-ETS (Copper) PET, Ventilation/Perfusion Single Photon Emission Computerized Tomography (V/Q…
- Trial name
- NCT02117440
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Indiana University
Metastatic Breast Cancer, Mutation, Point
Genetic Markers of Circulating Tumor DNA for Monitoring Breast Cancer Patients in Costa Rica
The use of circulating tumor DNA (ctDNA) as a noninvasive test for breast cancer monitoring throughout the course of the disease
- Trial name
- NCT04163159
- Where
- Costa Rica
- Volunteers
- 25 people
- Sponsor
- Universidad de Costa Rica
Breast Cancer, Ovarian Cancer
Phenotypic Spectrum of CTCs in Tumors of the Female Reproductive System
The study evaluates the level and molecular profiles of different CTC populations as markers for predicting the risk of developing hematogenous metastases and the effectiveness of treatment in patients with tumors of the female…
- Conditions
- Breast Cancer, Ovarian Cancer, Endometrial Cancer
- Trial name
- CTCs (NCT04817501)
- Testing
- Taking 5 ml of venous blood at different time intervals, Taking 5 ml EDTA-stabilized ascitic fluid sampled during laparoscopy if any
- Where
- Russia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Breast Cancer, Breast Neoplasms
Genomic Markers for Measuring Breast Cancer Response to Neoadjuvant Chemotherapy
The primary aim of the study is to identify genomic markers (circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), transcriptomic markers) as biomarkers of response to neoadjuvant chemotherapy (NAC) among patients with…
- Conditions
- Breast Cancer, Breast Neoplasms, Cancer, Breast
- Trial name
- NCT03709134
- Testing
- Genomic Markers (CTC/ctDNA)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Sunnybrook Health Sciences Centre
Glioblastoma Multiforme, Healthy Volunteers
Laboratory Study of Early Tumor Markers in the Peripheral Blood of Glioblastoma Multiforme Patients
The purpose of this study is to determine if tumor cells can be detected in the blood of patients diagnosed with a brain tumor.
- Trial name
- NCT01135875
- Testing
- GBM Patients, Normal Controls
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Florida
Pancreatic Neoplasms, Adenocarcinoma
Perioperative Cancer Cell Dissemination and Systemic Immune Suppression in Resectable Ductal Pancreatic Adenocarcinoma
The purpose of this study is to determine whether early recurrence after curative resection of ductal pancreatic adenocarcinoma can be explained by either dissemination of cancer cells during intraoperative tumour manipulation…
- Conditions
- Pancreatic Neoplasms, Adenocarcinoma, Neoplasm Circulating Cells, Tumor Markers, Biological
- Trial name
- NCT00495924
- Testing
- Pancreatic resection (PD)
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Cancer, Breast Cancer
Analysis of Circulating Tumor Markers in Blood
The circulating tumoral biomarkers in the blood are the object of numerous researches for several decades. The potential clinical interests of these circulating biomarkers are diagnostic, prognostic, predictive of the efficiency…
- Conditions
- Cancer, Breast Cancer, Sarcoma, Lung Cancers
- Trial name
- ALCINA2 (NCT04025541)
- Testing
- Blood sampling, Blood sampling C3, Blood sampling C4/7/10/13
- Where
- 2 sites in France
- Volunteers
- 992 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Coronary Artery Disease
Effect of Cilostazol on Endothelial Progenitor Cells and Endothelial Function in Coronary Artery Disease
1. The number and function of circulating endothelial progenitor cells (EPCs) are inversely associated with coronary risk factors and atherosclerotic diseases such as coronary artery disease (CAD) and cardiovascular high risk. 2.
- Trial name
- NCT02174939
- Testing
- Cilostazol
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Cheng-Kung University Hospital
Ischemic Stroke
Potential Prognostic Markers of Recovery in Post-stroke Rehabilitation
Despite increasingly effective early treatment strategies for ischemic stroke, post-stroke recovery is often incomplete and depend on spontaneous and therapeutic-induced processes related to neuroplasticity, angiogenesis and…
- Trial name
- NCT05750303
- Where
- Poland
- Volunteers
- 32 people
- Sponsor
- Medical University of Lodz
Healthy Adult Participants, Osteopathic Manipulative Treatment (OMT)
Effect of Osteopathic Manipulation on Circulating Immune Markers
The goal of this clinical trial is to learn if osteopathic manipulative treatment (OMT) changes levels of immune markers in healthy volunteers.
- Trial name
- NCT07622966
- Testing
- Osteopathic Manipulative Treatment (OMT)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Inflammation
Effects of Chronic Intake of Processed Foods on Circulating Inflammatory Markers in Healthy Men
This study aims to investigate the effects of diets enriched or depleted in foods at high risk of containing pro-inflammatory bacterial molecules, on markers of inflammation and cardiometabolic risk in healthy men.
- Trial name
- NCT02430064
- Testing
- Low PAMP diet
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Chronic Kidney Failure, Dialysis Related Complication
Effect of Mixed On-line Hemodiafiltration on Circulating Markers of Inflammation and Vascular Dysfunction
On line haemodiafiltration (OL-HDF) has been shown to improve intra-dialytic hemodynamics and cardiovascular outcomes. Several potential candidates of these beneficial effects have been explored.
- Trial name
- NCT03202212
- Testing
- mixed on-line hemodiafiltration, High flux bicarbonate dialysis
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Gut Epithelial Permeability, Gut Microbiota Composition and Diversity
Impact of Dairy Integration Into Canadian Food Guide on Gut Health
The primary objective is to investigate the impact of milk, fermented milk, and soy beverages, incorporated in a diet reflecting adherence to Canadian food guide recommendations on food choices on gut microbiota in middle-aged…
- Conditions
- Gut Epithelial Permeability, Gut Microbiota Composition and Diversity, Gut and Circulating Inflammatory Markers, Milk and Digestion
- Trial name
- GutMilk (NCT07257913)
- Testing
- Milk, Fermented milk, Soy beverage
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Laval University
Lung Cancer (Diagnosis), Biomarkers / Blood
Circulating Immune Markers for Prognostic Evaluation in Postoperative Lung Cancer Patients
Investigating the Clinical Value of Tumor Antigen-Specific T Cells and Immune Cell Balance in Peripheral Blood of Non-Small Cell Lung Cancer Patients for Prognostic Evaluation.
- Trial name
- NCT07242482
- Testing
- Preoperative Peripheral Blood Immune Marker Analysis.
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhao Jun
Non-Hodgkin Lymphoma
Biochemical Role of Circulating microRNAs Expression as Diagnostic Markers for Non-Hodgkin's Lymphoma Patients
Lymphomas are a fairly common malignancy accounting for approximately half of all newly diagnosed hematological neoplasms, and they comprise the sixth most common group of malignancies worldwide in both men and women, With marked…
- Trial name
- NCT05921812
- Testing
- real time pcr
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sohag University
Osteoporosis, Menopause
MicroRNA and Markers and Therapeutic Response to Romosozumab and Abaloparatide in Postmenopausal Osteoporosis
Osteoporosis is a systemic skeletal disorder affecting approximately 10% of individuals over 50 years of age. It is characterised by an increased risk of fragility fractures, which constitute a major source of morbidity…
- Trial name
- ROMIRNA (NCT07616401)
- Testing
- miRNA typing
- Where
- 2 sites in Italy
- Volunteers
- 42 people
- Sponsor
- Istituto Auxologico Italiano
Ischemic Stroke, Atherosclerosis
COlchicine iN Circulating Inflammatory Markers After StrokE (CONCISE)
The goal of this phase 2, before-and-after interventional study is to investigate the effect of colchicine treatment on serum biomarkers of inflammation in patients with a history of stroke and atherosclerosis.
- Trial name
- CONCISE (NCT06062277)
- Testing
- Colchicine 0.5 MG
- Where
- Ireland
- Volunteers
- 91 people
- Sponsor
- University College Dublin
Stroke, Rehabilitation
Extracellular Vesicles as Stroke Biomarkers
The combination of rehabilitation protocols and regenerative therapies offers the outstanding opportunity to promote and enhance the endogenous regenerative and repair processes occurring in tissues damaged or lost due to injury…
- Trial name
- EXO4STROKE (NCT05370105)
- Testing
- blood withdrawal
- Where
- 2 sites in Italy
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Ovarian Neoplasms
Evaluation of Multiple Biomarkers to Estimate Risk of Ovarian Cancer in Patients With a Pelvic Mass.
ANGLE has developed the Parsortix™ Cell Separation System (Parsortix), an automated system capable of harvesting rare circulating cells for analysis from a sample of peripheral blood based on cellular size and deformability.
- Trial name
- NCT02785731
- Testing
- Pelvic imaging, Blood draw, laparotomy or laparoscopy
- Where
- 5 sites in Austria, Germany
- Volunteers
- 204 people
- Sponsor
- Angle plc