Clinical trials: Circulatory; Change
Diabetes Mellitus, Cardiovascular Diseases
Pharmacist-led Group Medical Visits to Help With Diabetes Management
This is a multi-site open label randomized controlled study of patients with type 2 diabetes undergoing pharmacist-led group medical visits that include education by a multi-disciplinary personnel, behavioral modification and…
- Trial name
- MEDIC-1 (NCT00554671)
- Testing
- Algorithm driven medication titration, Monitoring, Group support
- Where
- 3 sites in United States
- Volunteers
- 250 people
- Sponsor
- VA Office of Research and Development
Stroke
Zambia Stroke Unit Study
The goal of this clinical trial is to evaluate the impact of a locally adapted stroke unit on outcomes of adults with stroke in Zambia.
- Trial name
- ZASUS (NCT06457048)
- Testing
- Stroke Unit
- Where
- Zambia
- Volunteers
- 300 people
- Sponsor
- Johns Hopkins University
Brain Neoplasms, Surgery
Cerebral Blood Perfusion Changes After General Anesthesia for Craniotomy
Few studies look into cerebral blood flow (CBF) changes during emergence from general anesthesia for craniotomy. The purpose of this study is to demonstrate CBF changes during emergence from general anesthesia for craniotomy…
- Conditions
- Brain Neoplasms, Surgery, Hyperemia
- Trial name
- NCT01642147
- Testing
- Transcranial Doppler (TCD), jugular venous bulb catheterization, Tumor removal surgery under general anesthesia
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huashan Hospital
Hereditary Angioedema
Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Prevention of Acute Hereditary Angioedema (HAE) Attacks
The study objective was to evaluate the safety and efficacy of prophylactic use of C1INH-nf for the prevention of acute HAE attacks.
- Trial name
- CHANGE 3 (NCT00462709)
- Testing
- C1 esterase inhibitor [human] (C1INH-nf)
- Where
- 48 sites in United States
- Volunteers
- 146 people
- Sponsor
- Shire
Chronic Ischemic Stroke
Study of Modified Stem Cells (SB623) in Patients With Chronic Motor Deficit From Ischemic Stroke
Controlled study of stereotactic, intracranial injection of SB623 cells in patients with fixed motor deficits from ischemic stroke
- Trial name
- ACTIsSIMA (NCT02448641)
- Testing
- SB623 Implant (2.5M), SB623 Implant (5.0M)
- Where
- 65 sites in United States
- Volunteers
- 163 people
- Sponsor
- SanBio, Inc.
Acute Heart Failure
Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode.
The purpose of this study was to assess the effect of in-hospital initiation of sacubitril/valsartan (LCZ696) vs. enalapril on time averaged proportional change in NT-proBNP in patients who have been stabilized following…
- Trial name
- PIONEER-HF (NCT02554890)
- Testing
- sacubitril/valsartan (LCZ696), Enalapril
- Where
- 123 sites in United States
- Volunteers
- 887 people
- Sponsor
- Novartis Pharmaceuticals
Valvular Heart Disease, Aortic Valve Failure
NHLBI Transmural Electrosurgery LeafLet Traversal And Laceration Evaluation (TELLTALE) BASILICA-TAVR Trial
Background: Replacing a valve in the heart can save many people's lives. The procedure is called transcatheter aortic valve replacement (TAVR).
- Trial name
- NCT05666713
- Testing
- TELLTALE BASILICA procedure
- Where
- 10 sites in United States
- Volunteers
- 90 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Infection
The Effects of Modified Ultrafiltration on Vancomycin Levels During Cardiopulmonary Bypass in Cardiac Surgery
Antibiotics are routinely used to prevent surgical wound infection. Vancomycin is a widely used antibiotic for surgery in patients with an allergy to penicillin.
- Trial name
- NCT02051595
- Testing
- Vancomycin concentrations
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Cognitive Change
Transcranial Near-Infrared Light in Healthy Subjects: a Cerebral Blood Flow Study With Diffuse Correlation Spectroscopy
Transcranial Light Therapy involves non-invasive and invisible beams of light that increase energy metabolism in the brain. Transcranial light therapy has been found to promote brain metabolism.
- Trial name
- NIR-Flow (NCT03740152)
- Testing
- Transcranial Light Therapy
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Fever, Brain Hemorrhage
Temperature Control in Central Fever in the Neuro-ICU
There are few treatments for central fever (fever that is due to the central nervous system, as opposed to an infectious source).
- Trial name
- NCT00751634
- Testing
- Gaymar Rapr-Round (external cooling blanket)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Hemochromatosis, Cerebrovascular Accident
Stroke With Transfusions Changing to Hydroxyurea
The purpose of this study is to compare standard therapy (transfusions and chelation) with alternative therapy (hydroxyurea and phlebotomy) for the prevention of secondary stroke and management of iron overload in children with…
- Conditions
- Hemochromatosis, Cerebrovascular Accident, Anemia, Sickle Cell, Hematologic Diseases
- Trial name
- NCT00122980
- Testing
- Red Cell Transfusions, Iron Chelation, Hydroxyurea
- Where
- 28 sites in United States
- Volunteers
- 134 people
- Sponsor
- St. Jude Children's Research Hospital
Heart Failure, Congestive
Effect of Chronic Changes in Heart Rate on Congestive Heart Failure
This will be a double blind randomized crossover study of patients with congestive heart failure and a heart rate dependent upon a permanent pacemaker.
- Trial name
- NCT00389649
- Testing
- heart rate setting
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Maryland, Baltimore
Mild Cognitive Impairment, Alzheimer Disease
Cerebral Haemodynamic Changes During Cognitive Testing: A fTCD Study
850,000 people live with dementia in the UK, with that number expected to rise to more than 1 million within the next 5 years. The most common type of dementia (55%) is Alzheimer's dementia, and vascular dementia is the second…
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Vascular Dementia, Healthy Controls
- Trial name
- NCT03134963
- Testing
- Transcranial doppler ultrasonography, Blood pressure monitoring, Heart rate monitoring
- Where
- 2 sites in United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Fever, Ischemic Stroke
Impact of Fever Prevention in Brain Injured Patients
This study will assess the impact of fever prevention on fever burden and short- and long-term neurologic outcomes in brain injured patients.
- Conditions
- Fever, Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage
- Trial name
- INTREPID (NCT02996266)
- Testing
- Targeted Temperature Management, Standard Care
- Where
- 40 sites in United States, Australia and 4 more
- Volunteers
- 686 people
- Sponsor
- C. R. Bard
Heart Defects, Congenital
Comparison of Two Types of Shunts in Infants With Single Ventricle Defect Undergoing Staged Reconstruction--Pediatric Heart Network
This trial will evaluate the efficacy and safety of the modified Blalock-Taussig shunt (MBTS) compared to the right ventricle to pulmonary artery (RV-to-PA) shunt; compare the effect of the MBTS to that of the RV-to-PA shunt on…
- Trial name
- NCT00115934
- Testing
- Blalock-Taussig pulmonary artery shunt, Right ventricular to pulmonary artery shunt
- Where
- 13 sites in United States, Canada
- Volunteers
- 555 people
- Sponsor
- Carelon Research
Multiple Myeloma
Characterization of Corneal Epithelial Changes in Participants Treated With Belantamab Mafodotin
This study will be available to any participant who has received or is currently receiving belantamab mafodotin treatment through either a clinical trial, an access program, or a physician prescription.
- Trial name
- NCT04549363
- Testing
- Belantamab mafodotin
- Where
- 6 sites in United States
- Volunteers
- 16 people
- Sponsor
- GlaxoSmithKline
Metabolic Syndrome
Canadian Health Advanced By Nutrition and Graded Exercise
The overall objective of the CHANGE initiative is to change the delivery of care in primary care clinics to treat disease by reducing reliance on drugs and hospitals through the promotion of scientifically validated nutritional…
- Trial name
- CHANGE (NCT01616563)
- Testing
- Dietary Intervention, Exercise Prescription and Fitness Program
- Where
- 3 sites in Canada
- Volunteers
- 305 people
- Sponsor
- Daren K. Heyland
Coma, Heart Arrest
Amantadine to Speed Awakening After Cardiac Arrest
This study evaluates if amantadine will increase the rate of awakening in patients resuscitated from cardiac arrest but comatose (not following commands) after their resuscitation.
- Conditions
- Coma, Heart Arrest, Anoxia
- Trial name
- AWAKE (NCT02486211)
- Testing
- Amantadine
- Where
- 4 sites in United States
- Volunteers
- 14 people
- Sponsor
- Jon Rittenberger, MD
Coronary Artery Disease
A Clinical Evaluation of ST Changes in a Group of Patients Having Ventricular Arrhythmias
The purpose of this investigation is to determine the prevalence of device-recorded ST segment changes occurring before appropriate Implantable Cardiac Defibrillator (ICD) therapies (ATP or Shock) and to define their temporal…
- Trial name
- inSighT (NCT01685047)
- Where
- Germany
- Volunteers
- 481 people
- Sponsor
- Abbott Medical Devices
Acute Coronary Syndrome, Depression
Healthy Heart Habits
Approximately 350,000 Acute Coronary Syndrome (ACS) patients experience significant depression symptoms each year in the US. Post-ACS depressed mood interferes with patients making necessary changes to behavioral risk factors…
- Trial name
- H^3 (NCT04158219)
- Testing
- Behavioral activation for health and depression (BA-HD)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Hennepin Healthcare Research Institute