Clinical trials: Circulatory Collapse and Shock
Trauma
Pragmatic, Randomized Optimal Platelet and Plasma Ratios
Pragmatic, Randomized, Optimal Platelet and Plasma Ratios (PROPPR)is a Phase III trial designed to evaluate the difference in 24-hour and 30-day mortality among subjects predicted to receive massive transfusion ([MT] (defined as…
- Trial name
- PROPPR (NCT01545232)
- Testing
- 1:1:1 Blood Transfusion Ratio, 1:1:2 Blood Transfusion Ratio
- Where
- 12 sites in United States, Canada
- Volunteers
- 680 people
- Sponsor
- The University of Texas Health Science Center, Houston
Shock, Cardiogenic
Abciximab in Patients Undergoing Percutaneous Coronary Intervention for Cardiogenic Shock
Outcome of patients with myocardial infarction complicated with cardiogenic shock is very poor. Although early mechanical revascularization has been demonstrated superior to conservative medical treatment, mortality range remains…
- Trial name
- NCT00420030
- Testing
- Abciximab
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- Charles University, Czech Republic
Preload-responsiveness
Is Mitral Velocity Time-integral a Marker of Preload-responsiveness in Patients With Acute Circulatory Failure?
The aim of this is to assess the reliability of the variability of the mitral velocity time-integral with passive leg raising to predict the fluid responsiveness in patients with acute circulatory failure in intensive care.
- Trial name
- NCT05538637
- Testing
- Echocardiography
- Where
- Morocco
- Volunteers
- 50 people
- Sponsor
- Avicenna Military Hospital
Sepsis
Infraclavicular Axillary Vein Collapsibility Index as a Predictor of Fluid Responsiveness
Fluid responsiveness refers to the ability of the left ventricle to significantly increase stroke volume following fluid administration, and its assessment is critical in managing acute circulatory failure while avoiding fluid…
- Trial name
- NCT07507877
- Testing
- Infraclavicular axillary vein collapsibility index
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Cardiogenic Shock
Testing the Value of Novel Strategy and Its Cost Efficacy in Order to Improve the Poor Outcomes in Cardiogenic Shock
Cardiogenic shock (CGS) affects up to 10% of patients suffering acute coronary syndrome. It has a 30 day mortality of 45-50%. No pharmacological nor intervention/device trials have had any impact on this mortality in the last 20…
- Trial name
- EUROSHOCK (NCT03813134)
- Testing
- Percutaneous coronary intervention (PCI), Pharmacological Support, VA-ECMO
- Where
- 47 sites in Austria, Belgium and 6 more
- Volunteers
- 428 people
- Sponsor
- University of Leicester
Shock Circulatory
Interest of Urinary Oxygen Partial Pressure (PO2u) in Predicting the Onset or Recovery of Acute Renal Failure During Shock States - OXYpi Study
Shock state is defined as an acute, life-threatening, circulatory failure with impaired tissue oxygenation (or tissue hypoxia). The cause of the shock state can be septic, anaphylactic, hypovolemic or cardiogenic.
- Trial name
- OXYpi (NCT06320509)
- Testing
- Continuous measurement of uPO2 (both groups)
- Where
- 2 sites in France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Angers
Osteonecrosis
Use of Adipose Derived Regenerative Cells in Bilateral Femoral Head Osteonecrosis
This randomized clinical trial aims to determine if cells from a patient's own adipose tissue is safe and capable of helping regenerate the femoral head in patients with osteonecrosis.
- Trial name
- NCT03269409
- Testing
- Lactated Ringers, The Celution 800/GP System (Cytori Therapeutics), Adipose Derived Regenerative Cells (ADRC)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Septic Shock, Cardiomyopathy
Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock
The aim of this study is to investigate the effects milrinon and levosimandan on n heart function in septic cardiomyopathy and how norepinephrine affects the left and right ventricular function in patients with septick shock…
- Trial name
- SCLM (NCT02640846)
- Testing
- Norepinephrine, Milrinone, Levosimendan
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Sahlgrenska University Hospital
Cardiogenic Shock, Cardiac Arrest
China Extracorporeal Life Support Registry
Extracorporeal life support (ECLS), also known as extracorporeal membrane oxygenation (ECMO), is an extracorporeal technique of providing effective cardiac and respiratory support to patients with lungs and/or heart failure.
- Conditions
- Cardiogenic Shock, Cardiac Arrest, Heart Failure, Acute Respiratory Distress Syndrome
- Trial name
- NCT04158479
- Testing
- ECMO
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- Beijing Anzhen Hospital
Septic Shock, Sepsis
Effects of Paroxetine on Cardiovascular Function in Septic Patients
It is known that septic shock is characterized by arterial hypotension, decreased peripheral vascular resistance and hyporeactivity to vasoconstrictor agents, with NO being an important mediator of this organ dysfunction.
- Trial name
- NCT05725837
- Testing
- Paroxetine
- Where
- 2 sites in Brazil
- Volunteers
- 130 people
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Sepsis, Septic Shock
Control Versus Liberal Cardiac Frequency in Patients in Sepse With Atrial Fibrillation of High Ventricular Response
Amiodarone is considered the medicine of choice in heart rate control in critically ill patients with atrial fibrillation with high ventricular response.
- Conditions
- Sepsis, Septic Shock, Atrial Fibrillation, Ventricular Fibrillation
- Trial name
- FAARV (NCT03715556)
- Testing
- Amiodarone, 0.9% physiological solution
- Where
- Brazil
- Volunteers
- 126 people
- Sponsor
- University of Sao Paulo General Hospital
Oesophageal Atresia With Tracheo-Oesophageal Fistula, Tracheomalacia
Primary Posterior Tracheopexy Prevents Tracheal Collapse
Introduction: Children born with a blind-ending gullet (oesophagus), or Oesophageal Atresia (OA), need to undergo surgical correction in the first week of life.
- Conditions
- Oesophageal Atresia With Tracheo-Oesophageal Fistula, Tracheomalacia, Oesophageal Atresia
- Trial name
- PORTRAIT (NCT06335862)
- Testing
- Randomisation between the PPT- and no-PPT-group, Primary Posterior Tracheopexy, Preoperative tracheobronchoscopy
- Where
- 3 sites in Netherlands, United Kingdom
- Volunteers
- 78 people
- Sponsor
- UMC Utrecht
Cardiogenic Shock
An Interventional Left Ventricular Assist System for Cardiogenic Shock
Imported Impella The price is relatively expensive and difficult for ordinary patients to afford. In order to better meet the growing clinical needs in China, Anhui Tongling Bionic Technology Co., Ltd.
- Trial name
- NCT06127927
- Testing
- Interventional Left Ventricular Assist System
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Fujian Medical University
Hypotension
Use of Ultrasonography to Determine Fluid-responsiveness for Shock in a Population of Intensive Care Unit Patients
The objective of our study is to determine the correlation of transthoracic ultrasonographic indices of fluid responsiveness to changes in direct measures of cardiac output and to compare them to other established predictors of…
- Trial name
- NCT01680770
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- University of Chicago
Acute Kidney Injury, Septic Shock
Macro and Micro Haemodynamic Responses to Shock in the Renal and Systemic - MICROSHOCK - RENAL
An observational study of the state of the renal and systemic circulations in patients with early septic shock. Both macro and microvascular parameters will be assessed using echocardiography, sublingual incident dark field…
- Trial name
- NCT03713307
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- King's College London
Cardiogenic Shock
A Study on the Effects of Left Ventricular Unloading in the Setting of VA ECMO Support
REMAP ECMO is a registry based platform in which multiple response adaptive randomized clinical trials (trial domains) will be embedded.
- Trial name
- REMAP ECMO (NCT05913622)
- Testing
- Intra-aortic balloon pump
- Where
- 14 sites in Belgium, Netherlands
- Volunteers
- 430 people
- Sponsor
- Erasmus Medical Center
Sepsis, Circulatory Failure
Respiratory Variations For Predicting Fluid Responsiveness 2
Objectives: To investigate whether respiratory variations of inferior vena cava diameters (cIVC) predict fluid responsiveness in spontaneously breathing patients with septic acute circulatory failure and irregular heartbeats.
- Conditions
- Sepsis, Circulatory Failure, Respiratory Physiological Phenomena
- Trial name
- ReVaPreF2 (NCT03066375)
- Testing
- Echocardiography-Doppler
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Lille
Post Operative Cardiac Surgery, ARDS
PEEP Levels Selected by PEEP Titration and PEEP Levels Routinely Used in Post-operative Cardiac Patients With Hypoxemic Respiratory Failure
The purpose of this study is to: Compare PEEP level selected by individualized PEEP titration by electrical impedance tomography and PEEP level routinely used in post-operative cardiac patients with Hypoxemic Respiratory Failure…
- Conditions
- Post Operative Cardiac Surgery, ARDS, Hypoxemic Respiratory Failure
- Trial name
- NCT02056977
- Testing
- Titration, control
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- University of Sao Paulo General Hospital
Stroke Gait Rehabilitation
The Effectiveness of Laser and Extracorporeal Shock Wave Therapy in Resolving Ankle Muscle Spasm in Stroke Patients.
Stroke is one of the leading causes of long-term disability worldwide. Spasticity (muscle spasm) is a common and disabling consequence of stroke.
- Trial name
- spasticity (NCT07364110)
- Testing
- Rehabilitation Protocol, Extracorporeal Shock Wave Therapy (ESWT), High-Intensity Laser Therapy (HILT)
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Necmettin Erbakan University
Decompensated Chronic Heart Failure, Heart Failure NYHA Class III
Epidemiology and Prognostic of the Acute Heart Failure
EPICAL 2 (Epidemiology and prognostic of the Acute Heart Failure) is an epidemiological, observational, prospective and multicenter study.
- Conditions
- Decompensated Chronic Heart Failure, Heart Failure NYHA Class III, Acute Pulmonary Edema, Cardiogenic Shock
- Trial name
- EPICAL2 (NCT02880358)
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Central Hospital, Nancy, France