Clinical trials: Circulatory Disorders
Type2diabetes
Use of AI in Cardiometabolic Risk Prediction in Asian Indians
The Investigators are recruiting T2DM patients (n, 500) from Fortis-CDOC Hospital. Patients' weight, BMI, lipid profile, liver and kidney function tests, EGG, glycemic parameters, blood pressure, etc.
- Trial name
- NCT05939869
- Testing
- Medical and Clinical History
- Where
- India
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Diabetic Foot, Diabetic Foot Ulcer
SkinTE™ in the Treatment of Diabetic Foot Wounds
This study is a prospective, multi-center, randomized controlled trial designed to collect patient outcome data on a commercially available human autologous homologous skin construct with SOC dressing compared to SOC dressings…
- Conditions
- Diabetic Foot, Diabetic Foot Ulcer, Ulcer Foot
- Trial name
- NCT03881254
- Testing
- Human Autologous Homologous Skin Construct, Additional Outer Dressing Applicaiton, Offloading
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- PolarityTE
Aortic Aneurysm, Aortic Aneurysm and Dissection
Multidisciplinary Analysis by Morphological and Mechanical Evaluation of the Aortic Wall in Patients Undergoing Cardiac Surgery.
Surgical indication in patients suffering from Ascending aorta aneurysm is currently based mainly on the maximum diameter of the aortic dilatation and on the yearly growth rate.
- Trial name
- NCT07422129
- Where
- Italy
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Cardiovascular Disease
Effects of Growth Hormone on the Nitric Oxide Pathway
The purpose of the study is to determine whether the treatment with growth hormone has an influence on the nitric oxide pathway in healthy males.
- Trial name
- NCT00470002
- Testing
- Somatropin
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Neurogenic Thoracic Outlet Syndrome
Surgical Thoracic Outlet Decompression for Neurogenic Thoracic Outlet Syndrome
This study will determine the value of TOD (first rib resection with partial scalenectomy and neurolysis) on functionality and quality of life for patients with neurogenic thoracic outlet syndrome.
- Trial name
- STOPNTOS (NCT03748602)
- Testing
- Thoracic outlet decompression
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Stroke
Neurobiological Principles Applied to the Rehabilitation of Stroke Patients
The purpose of this study is to use (Transcranial Magnetic Stimulation) TMS or drugs to improve learning of movement skills and the adaptation processes in patients after stroke.
- Trial name
- NCT00715520
- Testing
- Transcranial Magnetic Stimulation (TMS), Carbidopa-Levodopa, Methylphenidate
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Emory University
Stroke
Effect of Pilates Training on Cognitive Functions in Patients With Stroke
The purpose of the present study is to investigate the effect of pilates training on cognitive functions in patient with stroke
- Trial name
- NCT04157582
- Testing
- Pilates training, Conventional physical therapy
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- October 6 University
Orthostatic Hypotension, Spinal Cord Injury
Safety and Efficacy of L-NAME and Midodrine to Increase MAP
After a spinal cord injury the brain is no longer completely in control of the body below the level of injury. This affects many organs and systems in the body, we are interested in understanding how a spinal cord injury affects…
- Trial name
- NCT00835224
- Testing
- L-NAME, Midodrine
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
No Condition
Fast vs. Slow Pranayama for Breathing, Heart, Balance, and Well-Being in Students
The goal of this clinical trial is to compare the effects of slow and rapid pranayama techniques on respiratory, cardiovascular, balance, and psychosocial parameters in healthy adults aged 18-35 years.
- Trial name
- NCT07320742
- Testing
- Slow Pranayama, Fast Pranayama
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Cadasil
AusCADASIL: An Australian Cohort of CADASIL
The aim of this project is to establish an Australian cohort of patients diagnosed with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL).
- Trial name
- NCT06148051
- Where
- 5 sites in Australia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Perminder Sachdev
Cardiovascular Diseases
Impact of Rapeseed and Sunflower Oils on Proteomic Biomarkers of Diseases.
This study will test the impact of vegetable oils with contrasting fatty acids composition on biomarkers of health (cardiovascular, kidney diseases and diabetes) after twelve weeks supplementation.
- Trial name
- DOC (NCT04867629)
- Testing
- Rapeseed oil, Sunflower oil
- Where
- United Kingdom
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Fibromuscular Dysplasia, Early Onset CAD
CAUSE Trial: Patient Specific-Cellular Characterization of Fibromuscular Dysplasia and High-Risk Atherosclerotic Endothelium
The purpose of this project is to see if heritable alterations in the function, biology and vascular repair capacity of vascular cells make a major contribution to the burden of coronary artery disease (CAD), fibromuscular…
- Trial name
- NCT01808729
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Familial Hypercholesterolemia, Nutrition, Healthy
Unravelling the Impact of Diet on Cardiovascular Health in Heterozygous Familial Hypercholesterolemia.
The investigators will first conduct a fully controlled dietary randomized crossover trial (RCT) including 50 adults with HeFH to investigate the impact of a whole food plant-based (WFPB) diet low in red and processed meats and…
- Conditions
- Familial Hypercholesterolemia, Nutrition, Healthy, Cholesterol, Elevated, Cholesterol; Metabolic Disorder
- Trial name
- FH-Diet (NCT05181553)
- Testing
- Whole-food plant based diet (WFPB diet), Standard North American diet (SAD diet)
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Laval University
Diabetes Mellitus, Type 2, Coronary Artery Disease
Optimizing Audit and Feedback for Primary Care
There remains a large gap between ideal and actual care provided to patients with chronic diseases. Performance feedback reports are often used as a foundation for quality improvement interventions.
- Trial name
- NCT00996645
- Testing
- Worksheet to facilitate goal-setting and action plans
- Where
- Canada
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Diabetes Mellitus, Type 2, Obesity
Culturally Adapted Dietary Clinical Trial in PR
This project will determine whether a diet culturally adapted to adults in Puerto Rico can effectively decrease cardiometabolic risk factors.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Hypertension, Dyslipidemias
- Trial name
- PRECISION (NCT05962372)
- Testing
- Culturally tailored food and diet advice, Standard healthy eating advice
- Where
- Puerto Rico
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Diabetic Foot, Health Behavior
Manipulating Narrative Presentations of Information to Encourage Good Foot Care Practice in People With and Without Diabetes Mellitus
The study explores the role of health messages (narrative, non-narrative vs. control condition [no message]) to enhance good foot care practices among people with diabetes and the general population.
- Conditions
- Diabetic Foot, Health Behavior, Foot Diseases
- Trial name
- NCT04623151
- Testing
- Online leaflet about foot care
- Where
- United Kingdom
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- University of Chichester
Stroke, Sarcopenia
Evaluating and Monitoring Physical Fatigue While Performing Functional Activities
Fatigue is a critical health parameter in older adults and stroke patients and is associated with negative health outcomes. Current assessment tools predominantly focus on walking related fatigue, neglecting other activities of…
- Conditions
- Stroke, Sarcopenia, Fatigue
- Trial name
- NCT06513377
- Testing
- Performance test
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Rheumatoid Arthritis, Spondylitis, Ankylosing
Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases
Introduction: Patients with autoimmune rheumatic diseases (ARDs), rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), psoriatic arthritis (PAs), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), primary…
- Conditions
- Rheumatoid Arthritis, Spondylitis, Ankylosing, Spondyloarthritis, Systemic Lupus Erythematosus
- Trial name
- RZVRheum (NCT05879419)
- Testing
- Recombinant Herpes Zoster Vaccine (RZV), MTX Discontinuation, MMF Discontinuation
- Where
- Brazil
- Volunteers
- 2,005 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Thrombosis
The Single, Multiple Dose and Food Effect Study of SHR2285 Tablets on Pharmacokinetics and Pharmacodynamics in Healthy Subjects
The study is a randomized, doubled-blinded, placebo-controlled, Phase I trials. The study is divided into two parts. The first part is a single-dose escalated study (SAD,part 1A ) and food effect study (SAD, part 1B ) in healthy…
- Trial name
- NCT04472819
- Testing
- SHR2285 tablet
- Where
- 2 sites in China
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Williams-Beuren Syndrome, Micro-duplication 7q11.23 Syndrome
Quantification of Elastin Markers Synthesis in Williams-Beuren Syndrome and 7q11.23 Micro-duplication Syndrome
Introduction: Williams-Beuren syndrome is a rare genetic disorder caused by a 7q11.23 microdeletion. The phenotype associates vasculopathy (arterial stenosis, hypertension), dimorphism and intellectual disability.
- Conditions
- Williams-Beuren Syndrome, Micro-duplication 7q11.23 Syndrome, Vasculopathy
- Trial name
- ELAST7 (NCT04051086)
- Testing
- Physical examination and Urine and blood samples, Urine and blood samples
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
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