Clinical trials: Circumcision
HIV, Adolescent Behavior
Gender-Specific Combination HIV Prevention for Youth in High Burden Settings (MP3-Youth)
MP3 Youth is a pilot study to evaluate the feasibility and acceptability of a gender-specific combination HIV prevention package for youth (aged 15-24) in high burden settings.
- Conditions
- HIV, Adolescent Behavior, Gender
- Trial name
- MP3-Youth (NCT01571128)
- Testing
- Male-Specific Intervention Package, Female-Specific Intervention Package, Pre-Exposure Prophylaxis (Females)
- Where
- 3 sites in United States, Kenya
- Volunteers
- 1,215 people, healthy volunteers welcome
- Sponsor
- New York University
Procedural Pain Relief, Virtual Reality
AI-Generated Video Distraction Via Virtual Reality for Fear and Pain During Pediatric Circumcision
This randomized controlled trial evaluated the effect of artificial intelligence-generated video distraction delivered via virtual reality on procedural fear and pain in children undergoing circumcision.
- Conditions
- Procedural Pain Relief, Virtual Reality, Fear, Child
- Trial name
- NCT07824427
- Testing
- AI-Generated Video Distraction via Virtual Reality
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Pain, Postoperative
Low Dose Caudal VS Dorsal Penile Nerve Block for Postoperative Analgesia After Circumcision
in order to eliminate fear and anxiety. Regional techniques are more effective than systemic opioids, non steroidal anti-inflammatory drugs, and acetaminophen for postoperative analgesia in circumcision, The most preferred…
- Trial name
- NCT05342259
- Testing
- Caudal nerve block /neuroaxial, Dorsal penile nerve block, Combined caudal and dorsal penile nerve block
- Where
- Egypt
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
HIV Prevention
Safety and Acceptability Study of PrePex Device When Removing the Foreskin Shortly After Placement of Device
To assess the safety and acceptability of the non-surgical PrePex device among healthy adult male participants scheduled for voluntary medical male circumcision when removing the foreskin shortly after device placement.
- Trial name
- NCT03132285
- Testing
- PrePex
- Where
- 2 sites in Zambia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Zambia
Circumcision, Male
Examination of Short and Long Term Complications of Thermocautery, Plastic Clamping and Surgical Circumcision Techniques
Since circumcision is a significant workload for surgeons working at the rural state hospitals in Turkey, the use of circumcision techniques that are easy to implement and have low complications is becoming widespread.
- Trial name
- NCT03136224
- Testing
- Thermocautery, Plastic Clamping, Surgical Circumcision
- Volunteers
- 2,062 people, healthy volunteers welcome
- Sponsor
- Kocatepe University
Male Circumcision
Randomized Trial Comparing PrePex Day 7 Foreskin Removal Procedure (FRP) to a Day 0 PrePex FRP .
A Prospective, Randomized, Open Label Trial Comparing PrePex™ Day 7 (FRP) to a PrePex Day 0 FRP of Male Circumcision in Resource Limited Settings.
- Trial name
- NCT03223532
- Testing
- PrePex Day 7 FRP, PrePex Day 0 FRP
- Where
- Kenya
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Nyanza Reproductive Health Society
HIV
Observational Study of Male Circumcision Using PrePex Device
The study will measure the incidence of moderate and severe adverse events (AEs) associated with PrePex procedures, including both procedural and post-procedure events, and all device-related incidents such as dislodgment.
- Trial name
- NCT01711411
- Testing
- PrePex device for male circumcision
- Where
- Kenya
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- FHI 360
Surgical Technique
A Randomized Controlled Trial of Open Surgical vs. Minimally-invasive Voluntary Adult Male Circumcision
This proposed randomized controlled trial will provide important data which will inform and enable the Mozambican government and global health programs to more effectively scale-up circumcision services.
- Trial name
- NCT01688310
- Testing
- Gomco Clamp with Tissue Adhesive, Open surgical circumcision
- Where
- Mozambique
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universidade Católica de Moçambique
Male Circumcision, HIV Prevention
Follow Up Study to Evaluate a Non-Surgical Device for Adult Male Circumcision for Screen Failure Subjects
It is well known from a range of observational and epidemiological studies that the lifetime risk of acquiring HIV among males can be significantly reduced via circumcision by 53%-60% and by up to 73% in post-trial observation.
- Conditions
- Male Circumcision, HIV Prevention, Screen Failure Subjects, Narrow Foreskin
- Trial name
- RMC-05 (NCT02281435)
- Testing
- PrePex™ device
- Where
- Rwanda
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Rwanda
Male Circumcision
From Obstacles to Opportunities for Male Circumcision in Tanzania
Male circumcision has been demonstrated by three randomized trials to be a highly effective method of HIV prevention, leading the World Health Organization to recommend its widespread implementation.
- Trial name
- NCT02167776
- Testing
- Church-based teaching
- Where
- Tanzania
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Voluntary Medical Male Circumcision
Assessing the Impact of a Digital VMMC Platform
VMMC has been identified as a crucial intervention by UNAIDS to achieve the 2030 global target of a 90% reduction in new HIV infections compared with 2010 levels.
- Trial name
- VMMC NEXUS (NCT06364891)
- Testing
- VMMC NEXUS Digital application
- Where
- Zambia
- Volunteers
- 150,383 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
to Have a Circumcision Operation
THE EFFECT OF VIRTUAL REALITY ON CHILDREN'S ANXIETY, FEAR, AND PAIN LEVELS BEFORE CIRCUMCISION IN TURKEY
Background: Circumcision is one of the most common surgical interventions in boys, and boys undergoing this procedure experience anxiety and fear during the preoperative period.
- Trial name
- NCT04778683
- Testing
- Virtual Reality
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Pain, Anxiety
Distraction Method on Pain and Anxiety During Circumcision
Circumcision is a common procedure in infants, children and young people around the world for cultural, religious or medical reasons.
- Conditions
- Pain, Anxiety, Urological Nursing
- Trial name
- NCT04220346
- Testing
- Tablet group
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
Medical Device Complication
Feasibility Study of PrePex Device When Performed on Early Infants & Children Male Population by Physicians
The PrePex is a WHO prequalified medical device for adult male circumcision for HIV prevention. The Government of Rwanda was the first country to implement the PrePex and acts as the leading Center of Excellence providing…
- Trial name
- RMC-06 (NCT02281461)
- Testing
- Male circumcision using a non-surgical device
- Where
- Rwanda
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Rwanda
Anxiety, Pain, Postoperative
Nursing Intervention Program in the Management of Parental Anxiety and Infant Pain in the Surgical Process of Children to be Circumcised
Entering the hospital and waiting for surgery is a very stressful time for people. According to some studies, surgical interventions in children generate in family members concerns related to: anesthesia, fear of being harmed…
- Conditions
- Anxiety, Pain, Postoperative, Child Development
- Trial name
- NCT05387291
- Testing
- Intervention group, Control group
- Where
- Spain
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Universitat de Girona
Voluntary Medical Male Circumcision
Text-based Follow-up in Zimbabwe's Voluntary Medical Male Circumcision Program
Voluntary medical male circumcision (VMMC) in sub-Saharan Africa is safe: the average rate of moderate and severe adverse events (AEs) at the country level is 0.8%, corresponding to 99% of men healing without incident.
- Trial name
- 2WT (NCT03119337)
- Testing
- Text-based follow-up
- Where
- 5 sites in Zimbabwe
- Volunteers
- 780 people, healthy volunteers welcome
- Sponsor
- University of Washington
Phimosis
Does Neurostimulation Improve Efficacy for Ultrasound-Guided Transperineal Pudendal Nerve Block In Children
This study aim to compare efficacy of transperineal pudendal nerve block between 2 techniques, by dual guidance (ultrasound and neurostimulation) vs by ultrasound-guided only, in pediatric patients who undergo circumcision.
- Trial name
- NCT03931850
- Testing
- Pudendal nerve block
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ramathibodi Hospital
Anesthesia, Pediatric Circumcision
Analgesia for Pediatric Circumcision : Comparison of the Effectiveness of Pudendal Nerve Block to Penile Nerve Block
Medical or ritual circumcisions are frequent interventions in children. To provide the best comfort to the patients, the anesthetists use regional anesthesia.
- Trial name
- NCT04227561
- Testing
- Pudendal nerve block, Penile nerve block
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Fear, Anxiety
Immersive Virtual Reality and Music During Circumcision in Children
The goal of this randomized controlled trial is to examine the effectiveness of immersive virtual reality (IVR) and music on children's anxiety, fear, and pain levels during circumcision surgery.
- Conditions
- Fear, Anxiety, Child
- Trial name
- NCT06255548
- Testing
- Immersive virtual reality group, Music group
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Postoperative Pain
Two Different Surgical Techniques on Postoperative Circumcision Pain
To compare the effect of two different surgical techniques, the dorsal slit and double incision technique, on postoperative pain.
- Trial name
- NCT01909765
- Testing
- Dorsal slit, Double incision
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital