Clinical trials: Circumcision Adult
Male Circumcision, HIV Prevention
Follow Up Study to Evaluate a Non-Surgical Device for Adult Male Circumcision for Screen Failure Subjects
It is well known from a range of observational and epidemiological studies that the lifetime risk of acquiring HIV among males can be significantly reduced via circumcision by 53%-60% and by up to 73% in post-trial observation.
- Conditions
- Male Circumcision, HIV Prevention, Screen Failure Subjects, Narrow Foreskin
- Trial name
- RMC-05 (NCT02281435)
- Testing
- PrePex™ device
- Where
- Rwanda
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Rwanda
Circumcision, Male
Unicirc vs Open Surgical Circumcision
RCT of Unicirc under topical anesthetic w/ cyanoacrylate wound sealing vs. open surgical circumcision under local anesthetic with suturing.
- Trial name
- Unicirc004 (NCT02443792)
- Testing
- Unicirc with tissue adhesive, Open Surgical
- Where
- South Africa
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Simunye Primary Health Care
Surgical Technique
A Randomized Controlled Trial of Open Surgical vs. Minimally-invasive Voluntary Adult Male Circumcision
This proposed randomized controlled trial will provide important data which will inform and enable the Mozambican government and global health programs to more effectively scale-up circumcision services.
- Trial name
- NCT01688310
- Testing
- Gomco Clamp with Tissue Adhesive, Open surgical circumcision
- Where
- Mozambique
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universidade Católica de Moçambique
HIV
Randomized Control Trial of Shang Ring Versus Forceps-guided Adult Male Circumcision in Southwestern Uganda.
Adult male circumcision (AMC) can reduce the incidence of HIV transmission by 40-60% in sub-Saharan Africa (SSA). The World Health Organisation and Joint United Nations Programme on HIV/AIDS advocate AMC for the reduction of HIV…
- Trial name
- NCT01757938
- Testing
- Shang Ring Guided Circumcision, Forceps Guided Circumcision
- Where
- Uganda
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Mbarara University of Science and Technology
HIV
Male Circumcision Against HIV Hukomboa
Tanzania launched a National Strategy for scaling-up voluntary medical male circumcision in 2010, and aims to circumcise 2.8 million males by 2015.
- Trial name
- NCT02376348
- Testing
- A targeted demand creation Activities
- Where
- 2 sites in Tanzania
- Volunteers
- 10,782 people, healthy volunteers welcome
- Sponsor
- National Institute for Medical Research, Tanzania
Circumcision
Rapid, Minimally-invasive Voluntary Adult Male Circumcision
This study will evaluate a new, minimally-invasive surgical circumcision technique for men, which is easy to learn and perform, is safe, and is associated with high patient satisfaction and excellent cosmetic results.
- Trial name
- NCT01998360
- Testing
- Surgical Control, Unicirc with tissue adhesive
- Where
- South Africa
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Simunye Primary Health Care
Male Circumcision
Evaluation of Healing at Three Time Intervals and Potential for Spontaneous Detachment
The objective of this research study is to evaluate the safety and acceptability of the Shang Ring method of medical male circumcision.
- Trial name
- NCT01247844
- Testing
- Shang Ring
- Where
- Kenya
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- FHI 360
HIV Infections, Herpesvirus 2, Human
Male Circumcision for HIV Prevention in Rakai, Uganda
Circumcision in HIV unifected men may reduce the likelihood of becoming infected with HIV, reduce sexually transmitted infections (STIs) in men, not engender increases in sexual risk behaviors, and be acceptable to men as a…
- Conditions
- HIV Infections, Herpesvirus 2, Human, Syphilis, Genital Diseases, Male
- Trial name
- NCT00425984
- Testing
- Adult male circumcision
- Where
- Uganda
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV
Comparing the PrePex™ Device to Surgical MC for Rapid Scale Up of MC in Resource Limited Setting
The protocol, approved by the Medical Research Council, was issued to assess the safety and efficacy of the non-surgical device for applying it to the national scale up of adult male circumcision in Zimbabwe
- Trial name
- NCT01956370
- Testing
- PrePex™ device for adult male circumcision, Surgical circumcision
- Where
- Zimbabwe
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Ministry of Health and Child Welfare, Zimbabwe
Phimosis, Paraphimosis
Evaluating the Efficacy of 2-Octyl Cyanoacrylate (2-OCA) With Four Interrupted Sutures in Adult Male Circumcision
This study aims to determine whether cyanoacrylate glue is a non-inferior alternative to continuous suturing for wound closure following adult circumcision.
- Trial name
- NCT06487494
- Testing
- Circumcision wound closure using 2-octyl cyanoacrylate glue with four interrupted sutures, Circumcision wound closure using continuous sutuing
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Circumcision Adult, HIV CDC Category B2
Evaluation of Safety and Efficacy of the PrePexTM Device for Rapid Scale up of Adult MC Programs in Zimbabwe
The protocol, approved by the Medical Research Council, was issued to assess the safety and efficacy of the non-surgical device for applying it to the national scale up of adult male circumcision in Zimbabwe
- Conditions
- Circumcision Adult, HIV CDC Category B2, HIV Infections
- Trial name
- ZW-01 (NCT01956396)
- Testing
- PrePex™ device
- Where
- Zimbabwe
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Ministry of Health and Child Welfare, Zimbabwe
Circumcision Adult, HIV CDC Category B2
Safety and Efficacy of the PrePex Device Circumcision When Performed by Nurses
The protocol, approved by the Medical Research Council, was issued to assess the safety and efficacy of the non-surgical device for applying it to the national scale up of adult male circumcision in Zimbabwe
- Trial name
- NCT01956383
- Testing
- PrePex™ device
- Where
- Zimbabwe
- Volunteers
- 603 people, healthy volunteers welcome
- Sponsor
- Ministry of Health and Child Welfare, Zimbabwe
HIV Seropositivity
Evaluation of the PrePex Device for Rapid Scale-up of VMMC, Phase 3 Field Implementation Trial With HIV + Adult Males
This study will assess the safety of the PrePex device as applied to HIV positive men by assessing the rate of clinical adverse events.
- Trial name
- NCT03218839
- Testing
- PrePex male circumcision device
- Where
- Zimbabwe
- Volunteers
- 430 people
- Sponsor
- University of Washington
Circumcision, Male
Comparison of the Shang Ring With Conventional Surgical Methods
This is a randomized control trial of 400 adult male circumcision procedures with a one to one ratio between Shang Ring and the in-country standard surgical technique (forceps guided in Kenya and dorsal slit in Zambia).
- Trial name
- NCT01300910
- Testing
- Shang Ring, Male circumcision
- Where
- 2 sites in Kenya, Zambia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- FHI 360
Male Circumcision
Safety Study of the PrePex Device for Non-Surgical Adult Male Circumcision During Phased in National Implementation in an Effort to Prevent the Spread of HIV
It is well known from a range of observational and epidemiological studies that the lifetime risk of acquiring HIV among males can be significantly reduced via circumcision.
- Trial name
- RMC-07 (NCT01921608)
- Testing
- PrePex™ device
- Where
- Rwanda
- Volunteers
- 1,001 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Rwanda
Male Circumcision
Safety and Effectiveness of Different ShangRing Device Sizes for Adult Male Circumcision in Lusaka, Zambia
The purpose of this study was to assess the safety, effectiveness and acceptability of providing a reduced number of ShangRing sizes for adult voluntary medical male circumcision (VMMC) within routine service delivery in Lusaka…
- Trial name
- NCT02242565
- Testing
- ShangRing
- Where
- 2 sites in Zambia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- FHI 360
Safe Circumcision
Pilot Trial of Novel Circumcision Device
The investigators are testing a novel surgical device to facilitate safe circumcision among adult males. The investigators hypothesize that this device will allow non-medical providers to perform safe surgical circumcision…
- Trial name
- NCT01885286
- Testing
- circumcision with simple circumcision device
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- VA Puget Sound Health Care System
Circumcision Adult, Circumcision, Male
Technological Devices in Circumcision
It aims to investigate the effect of circumcision on the pain and anxiety level of children who are circumcised by watching videos/playing games during the procedure.
- Conditions
- Circumcision Adult, Circumcision, Male, Circumcision
- Trial name
- NCT06793722
- Testing
- Technological device in circumcision
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Adiyaman University
HIV Prevention
Safety and Acceptability Study of PrePex Device When Removing the Foreskin Shortly After Placement of Device
To assess the safety and acceptability of the non-surgical PrePex device among healthy adult male participants scheduled for voluntary medical male circumcision when removing the foreskin shortly after device placement.
- Trial name
- NCT03132285
- Testing
- PrePex
- Where
- 2 sites in Zambia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Zambia
Post Operative Pain
The Use of Lignocaine and Bupivacaine Mix in Adult Safe Male Circumcision
Using routinely collected data to compare different concentrations of locally applied anaesthetic drugs and determine which concentrations give better pain control during voluntary medical Male circumcision.
- Trial name
- NCT02245126
- Testing
- 3-3-4 mix, 4-4-2
- Where
- Uganda
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- International Hospital Kampala