Clinical trials: Cirrhosis Early
Liver Cirrhosis
Optimized Treatment and Regression of HBV-induced Early Cirrhosis
Patients with chronic hepatitis B histologically confirmed of early cirrhosis S4 (similar to metavir F4, Ishak 5/6) are randomly assigned in a 1:1 ratio.
- Trial name
- NCT01938820
- Testing
- entecavir, Thymosin-α
- Where
- 21 sites in China
- Volunteers
- 82 people
- Sponsor
- Beijing Friendship Hospital
Liver Cirrhosis
Improving Healthcare Outcomes With Early Detection of Liver Related Complications in Liver Cirrhosis Patients by Implementing a Telemedicine Care Pathway (myLIVERcoach)
The goal of this multicenter feasibility study is to investigate the feasibility of our telemedicine platform (myLIVERcoach) in liver cirrhosis patients, according to liver cirrhosis patients, caregivers and healthcare…
- Trial name
- myLiverCOACH (NCT07376967)
- Testing
- telemedicine pathway
- Where
- 2 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Maastricht University
Cirrhosis With Septic Shock
To Assess the Efficacy of Early Introduction of a Combination of Low Dose Vasopressin Analogue in Addition to Noradrenaline as a Vasopressor in Patients of Cirrhosis With Septic Shock
The consecutive patients admitted to Intensive care unit of Hepatology department of ILBS and full filling all the eligibility criteria will be enrolled in 1:1 ration by the process of randomization.- The study is an open level…
- Trial name
- NCT02468063
- Testing
- Low dose terlipressin, Noradrenaline
- Where
- India
- Volunteers
- 184 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cirrhosis
Early Primary Prophylaxis of Esophageal Varices
Patients of cirrhosis with portal hypertension aged 18 to 75 years who have small esophageal varices with or without red color signs and have not bled previously will be enrolled.
- Trial name
- NCT01196507
- Testing
- Carvedilol
- Where
- India
- Volunteers
- 140 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cirrhosis
Carvedilol and Midodrine Versus Carvedilol Alone in Preventing Early Rebleed in Patients With Cirrhosis.
Acute variceal bleeding (AVB) in cirrhosis occurs as a result of portal hypertension and carries a 6-week mortality rate of approximately 10-20%.
- Trial name
- NCT07465471
- Testing
- Carvedilol, Midodrine Oral Product
- Where
- India
- Volunteers
- 210 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Non-alcoholic Fatty Liver Disease, Liver Fibrosis
Early Detection of Advanced Fatty Liver Disease
Non-alcoholic fatty liver disease is the most common cause of chronic liver disease in the western world, affecting one in every three subjects.
- Trial name
- NCT03608748
- Where
- Israel
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Liver Cirrhoses
Early Use of TIPS With Polytetrafluoroethylene(PTFE) Covered Stents in Cirrhotic Patients With Refractory Ascites
This multicenter RCT is designed to investigate if TIPS with covered stents improves transplant-free survival for cirrhotic patients with early stage of refractory ascites compared to LVP+albumin during 1 year follow-up period.
- Trial name
- NCT03172273
- Testing
- TIPS, paracentesis
- Where
- 2 sites in China
- Volunteers
- 180 people
- Sponsor
- Air Force Military Medical University, China
Liver Cirrhosis, Esophageal and Gastric Varices
The Effects of Early Enteral Nutrition on Endoscopic Therapy of Esophagogastric Varices in Liver Cirrhosis
The purpose of this study was to evaluate the safety of early enteral nutrition on endoscopic therapy of esophagogastric varices in Liver Cirrhosis ,and to assess the impact of different eating times on patients, so as to…
- Trial name
- NCT04823780
- Testing
- nutrient solution
- Where
- China
- Volunteers
- 397 people
- Sponsor
- Qilu Hospital of Shandong University
Liver Cirrhosis, Portal Hypertension
Early TIPS for Ascites Study
The purpose of this study is to demonstrate that TIPS with the GORE® VIATORR® TIPS Endoprosthesis improves transplant-free survival compared to LVP alone in patients who have cirrhosis of the liver with portal hypertension and…
- Conditions
- Liver Cirrhosis, Portal Hypertension, Ascites
- Trial name
- NCT01236339
- Testing
- TIPS procedure with the GORE® VIATORR® TIPS Endoprosthesis, LVP, TIPS procedure with the GORE® VIATORR® TIPS Endoprosthesis for subjects who failed LVP and crossed over to TIPS per protocol
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- W.L.Gore & Associates
Liver Cirrhosis, Early Allograft Dysfunction
Intraoperative Assessment of Microcirculatory Function Using Vascular Occlusion Test During Liver Transplantation
Early allograft dysfunction (EAD) remains one of the most important complications following orthotopic liver transplantation (OLT).
- Trial name
- NCT07658794
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Ippokrateio General Hospital of Thessaloniki
Antifungal Agents, Invasive Fungal Infections
Anti-fungal Strategies in Acute-on-Chronic Liver Failure Patients
Early treatment of invasive fungal infections (IFI) may prevent undue mortality in acute on chronic liver failure (ACLF) patients.
- Conditions
- Antifungal Agents, Invasive Fungal Infections, Mycoses, Acute-On-Chronic Liver Failure
- Trial name
- NCT04157465
- Testing
- Treatment strategy trial
- Where
- India
- Volunteers
- 216 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Liver Cirrhosis
Dose-ranging Study of Rifaximin Soluble Solid Dispersion (SSD) Tablets for the Prevention of Complications of Early Decompensated Liver Cirrhosis
The primary objective of this study is to assess the efficacy of rifaximin SSD versus placebo in preventing complications of liver cirrhosis, such as all-cause mortality (death due to all causes) or hospitalization, in subjects…
- Trial name
- NCT01904409
- Testing
- Rifaximin SSD 40 mg IR tablet, Rifaximin SSD 80 mg IR tablet, Rifaximin SSD 40 mg SER tablet
- Where
- 120 sites in United States, Russia
- Volunteers
- 420 people
- Sponsor
- Bausch Health Americas, Inc.
Liver Fibrosis, NASH
Early Liver Disease Breath Detection
The Early Liver Disease Breath Detection Study is a cross-sectional study where subjects with advanced liver fibrosis will ingest a mixture of food-grade compounds (known as Exogenous Volatile Organic Compound or EVOCs) in the…
- Conditions
- Liver Fibrosis, NASH, Liver Diseases
- Trial name
- NCT05935488
- Testing
- EVOCs emulsion
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- Owlstone Ltd
Hepatic Encephalopathy, Minimal Hepatic Encephalopathy
A Study of MHE in Patients With Liver Diseases
The study analyzes the diagnostic efficacy of neurophysiological tests and blood biomarkers on MHE, predicts risk factors on the development of OHE and investigate the mortality of MHE in patients with cirrhosis and acute on…
- Conditions
- Hepatic Encephalopathy, Minimal Hepatic Encephalopathy, Overt Hepatic Encephalopathy
- Trial name
- NCT04058327
- Testing
- neurophysiological tests, blood biomarkers.
- Where
- China
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Qin Ning
Decompensated Cirrhosis
National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Single vs Repeated Cycle of Granulocyte Colony-Stimulating Factor (GCSF) & Darbepoetin in Early Decompensated Cirrhosis
Chronic liver disease is a growing health concern, with limited access to liver transplants. This study addresses the urgent need for alternatives by exploring regenerative therapies, like G-CSF, to boost the liver's natural…
- Trial name
- NC-CHRM (NCT07131280)
- Testing
- Gcsf, Darbepoetin, Standard Medical Treatment
- Where
- India
- Volunteers
- 110 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Variceal Bleeding, Cirrhosis
Comparison of Terlipressin, Somatostatin, and Octreotide for Control of Variceal Bleeding
This study is performed to compare the efficacy of terlipressin, somatostatin, and octreotide in patients with variceal bleeding for the control of variceal bleeding in combination with endoscopic therapy.
- Trial name
- NCT00966355
- Testing
- Terlipressin, Somatostatin, Octreotide
- Where
- South Korea
- Volunteers
- 1,034 people
- Sponsor
- Korea University
Liver Cirrhosis, Hepatoencephalopathy, Early Fatal Progressive
Randomised Controlled Trial of Mechanistic Effects of Rifaximin in Cirrhosis and Chronic Hepatic Encephalopathy
Patients with cirrhosis are particularly prone to infection which is frequently a precipitant of hepatic encephalopathy, renal failure and circulatory collapse.
- Trial name
- RIFSYS (NCT02019784)
- Testing
- Rifaximin-α
- Where
- United Kingdom
- Volunteers
- 38 people
- Sponsor
- King's College Hospital NHS Trust
Decompensated Liver Cirrhosis
Effect of Single vs Repeated Cycles of a Combination of Granulocyte Colony Stimulating Factor and Darbepoetin vs Standard Medical Treatment on Immunometabolic Profile in Patient With Early Decompensated Cirrhosis.
Exogenous growth factor-mobilized bone marrow (BM) stem cells(G-CSF) and DARBEPOETIN use have shown a differential response in the management of decompensated cirrhosis (DC) with improved survival, CTP and MELD scores.
- Trial name
- NCT07002827
- Testing
- Darbepoetin, G-CSF, Lactulose
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Gall Bladder Cancer, Intrahepatic Cholangiocarcinoma (Icc)
A Cell-free DNA Methylation Blood-Based Test for Biliary Tract Cancers Screening
Biliary tract carcinoma (BTC), including gallbladder cancer, intrahepatic cholangiocarcinoma, and extrahepatic cholangiocarcinoma, ranks sixth in incidence among gastrointestinal malignancies and tenth in cancer-related mortality…
- Conditions
- Gall Bladder Cancer, Intrahepatic Cholangiocarcinoma (Icc), Extrahepatic Cholangiocarcinoma, Hilar Cholangiocarcinoma
- Trial name
- NCT07176962
- Where
- China
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Yingbin Liu, MD, PhD, FACS
Cirrhosis
Beta-blockers for Prevention Of Growth Of Small Esophageal Varices In Cirrhosis: An Randomized Controlled Trial (RCT)
Background and Aims: The efficacy of portal pressure reduction by beta blockers for the management of small (≤5 mm) esophageal varices in patients of cirrhosis is not clear.
- Trial name
- NCT00772057
- Testing
- Propranolol
- Where
- India
- Volunteers
- 164 people
- Sponsor
- Govind Ballabh Pant Hospital