Clinical trials: Citrate
Healthy
Effect of Neutralization of Endogenous Acid Production on BMD and Bone Microarchitectural
Hypothesis: Neutralization of acid production induced by the Western diet with oral administration of potassium citrate increases bone mineral density and bone mass as well as skeletal muscle mass and strength in elderly people…
- Trial name
- NCT00509405
- Testing
- potassium citrate
- Where
- Switzerland
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Kantonsspital Baselland Bruderholz
Labor Preterm Requiring Hospitalization
Management of Acute Preterm Labor: Nifedipen Alone or Combined With Cildenafil Citrate
The aim of this study is to assess whether or not the emergency tocolytic effect of combined nifedipine and sildenafil citrate will have a superior effect over nifedipine alone in terms of inhibiting eminent preterm labor and…
- Trial name
- NCT02337881
- Testing
- nifedipen, Sildenafil
- Where
- 2 sites in Egypt, Saudi Arabia
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Al Hayat National Hospital
Bone Density
Bone Density in Voluntary Apheresis Blood Donors
A longitudinal, randomized, controlled, single-center Phase IV clinical trial will be performed to assess changes in bone mineral density (BMD) among voluntary apheresis blood donors.
- Trial name
- ALTRUYST (NCT02655055)
- Testing
- high frequency voluntary apheresis blood donation
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Versiti Blood Health
Vitamin D Deficiency, Clomiphene Allergy
Effect of Vitamin D Oral Supplementation in Poly Csytic Ovarian Women Resistant to Clomiphene Citrate
effect of vitamin D oral supplementation in poly csytic ovarian women resistant to clomiphene citrate
- Conditions
- Vitamin D Deficiency, Clomiphene Allergy, Polycystic Ovary Syndrome
- Trial name
- NCT04916925
- Testing
- Vitamin D, Clomid
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- rana alaaeldin aly ibrahim nasr
Bowel Preparation
Compare Polyethylene Glycol and Sodium Picosulfate Alone or Combined
Sodium picosulfate/magnesium citrate (SPMC) is generally better tolerated than PEG, its cleansing effect remains uncertain. While most studies showed SPMC was non-inferior to PEG, some studies reported that SPMC was less…
- Trial name
- NCT03965182
- Testing
- PEG, PEG plus SPMC, SPMC
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Dalin Tzu Chi General Hospital
InFertility
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Three Dosage Strengths of Pulsatile GnRH
This study will be performed in approximately 132 women with anovulatory/oligoovulatory infertility.
- Trial name
- NCT00296465
- Testing
- Pulsatile gonadotropin-releasing hormone (GnRH), Clomiphene Citrate
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Pregnancy
Effect of Luteal Progesterone Support on Pregnancy Rates With Combined Clomid/ Gonadotropin & IUI
To determine the difference in clinical pregnancy rates with and without luteal progesterone support in a young reproductive aged population having undergone ovulation induction with combined clomiphene citrate and gonadotropin…
- Trial name
- NCT02510534
- Testing
- Menopur 150 international units, Endometrin 100 mg
- Where
- United States
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Northwest Center for Infertility and Reproductive Endocrinology
Bone Diseases, Metabolic, Osteoporosis, Postmenopausal
The Effects of Potassium Citrate on Bone Metabolism
Skeletal buffering of chronic acid loads may contribute to a significant amount of bone loss over time. Evidence from a few small short-term studies suggests that basic compounds, namely potassium citrate and potassium…
- Trial name
- NCT00357331
- Testing
- potassium citrate
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Acute Kidney Failure With or Without:, MODS
Citrate Pharmacokinetics and Regional Citrate Anticoagulation in CRRT
1. To compare the differences of citrate pharmacokinetics in healthy individuals and critically ill patients as well as the influential factors. 2. To validate a pharmacokinetic model which has been established in a formal paper.
- Conditions
- Acute Kidney Failure With or Without:, MODS, Sepsis, Hepatic Insufficiency
- Trial name
- NCT00948558
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Healthy Subjects
Tofacitinib Citrate Topical Gel 3.2% FDA BA Bridging Study
This is a Phase 1, single center, open-label, fixed sequence, two-period pharmacokinetic (PK) study to evaluate the safety and relative systemic bioavailability of topical and oral tofacitinib formulations in approximately 14…
- Trial name
- NCT04468425
- Testing
- Tofacitinib Citrate
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- TWi Biotechnology, Inc.
Liver Disease
Inhibition of VAP-1 by Caffeine in Healthy Human Volunteers Study
Worldwide, liver related morbidity and mortality continue to rise. It is the 5th commonest cause of death in the UK. Liver damage consists of two main components - a) damage to the cells of the liver, called hepatocytes, meaning…
- Trial name
- NOCTUA (NCT02098785)
- Testing
- Caffeine citrate
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Birmingham
Ovulation Disorder
Human Chorionic Gonadotrophin & Trigger
In women being treated with medicines to help eggs to grow (called ovulation induction), The investigators wish to know whether adding medicines (called ovulation triggers) that help to release the egg (ovulation) would lead to…
- Trial name
- NCT02264847
- Testing
- Human chorionic gonadotrophin, clomiphene citrate alone
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain
Bioequivalence of a Test Troche Formulation of Fentanyl Citrate (400 mcg) Compared to Actiq® 400 mcg, Cephalon, Inc.
The purpose of this study was to evaluate the oral bioequivalence of the Mallinckrodt test fentanyl citrate oral transmucosal 400 mcg troche compared to Actiq 400 mcg (Cephalon, Inc.) under fasting conditions.
- Trial name
- NCT01173627
- Testing
- Test fentanyl citrate 400 mcg troche, Actiq 400 mcg
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mallinckrodt
Healthy Volunteers, Patients
Drug Interaction Study on Linaprazan Glurate Capsules
This study is a drug-drug interaction (DDI) investigation involving Linaprazan Glurate capsules and a combination of clarithromycin tablets, amoxicillin capsules, and bismuth potassium citrate capsules.
- Trial name
- NCT07294846
- Testing
- Linaprazan Glurate Capsules, Bismuth Potassium Citrate Capsules, Amoxicillin Capsules
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Jiangsu Sinorda Biomedicine Co., Ltd
Mitochondrial Biogenesis
Examining The Effect of Blood Flow Restricted Aerobic Training on Mitochondrial Adaptations in Young Healthy Adults
This parallel-arm trial study investigates the effects of restricting arterial blood flow during cycling exercise on citrate synthase.
- Trial name
- NCT04151095
- Testing
- BFR Exercise Training, CTL Exercise Training
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Brendon Gurd, PhD
Dietary Supplements, Heart Rate/Drug Effects
Caffeine and Sodium Citrate Ingestion
A positive ergogenic effect of sodium citrate and caffeine ingestion in a short-term, high-intensity exercise task was shown by several studies. These studies were conducted with healthy, able-bodied subjects.
- Conditions
- Dietary Supplements, Heart Rate/Drug Effects, Lactic Acid/Metabolism, Physical Education and Training/Methods
- Trial name
- NCT01591226
- Testing
- Caffeine, Sodium Citrate, Mannitol
- Where
- Switzerland
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Healthy
Bioequivalence Study of Dr.Reddy's Ibuprofen and Diphenhydramine Citrate 200 mg/38 mg Caplets Under Fasting Condition
To determine the single-dose oral bioequivalence study of Ibuprofen and Diphenhydramine citrate 200 mg/38 mg caplets of Dr. Reddy's Laboratories Limited, India and Advil® PM, of Wyeth consumer health care, USA, in normal…
- Trial name
- NCT01053208
- Testing
- Ibuprofen and Diphenhydramine Citrate
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dr. Reddy's Laboratories Limited
Healthy
Magnesium Effects in Apheresis
This study will determine whether magnesium replacement during apheresis can decrease side effects that donors commonly experience.
- Trial name
- NCT00040235
- Testing
- magnesium
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Anovulatory Infertility Related to Polycystic Ovary Syndrome
Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS
Anovulatory infertility is a common feature of the polycystic ovary syndrome (PCOS). Even if several first-step treatments have been proposed for anovulatory infertile PCOS patients, very few data are available in literature…
- Trial name
- NCT00461643
- Testing
- Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
- Where
- 3 sites in Italy
- Volunteers
- 552 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Central Venous Pressure, Hepatectomy
Preoperative Sildenafil Administration for Hepatectomy
Hepatectomy is an important treatment for liver diseases, and bleeding is one of the most common complications during dissection of the liver parenchyma.
- Conditions
- Central Venous Pressure, Hepatectomy, Hemodynamics Instability, Sildenafil
- Trial name
- NCT06237751
- Testing
- Sildenafil 100 MG
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Chenzhou