Clinical trials: Citrate
Healthy
68Ga-Citrate PET of Healthy Volunteers
This study investigates whole-body distribution kinetics of intravenously administered Gallium-69 (68Ga) citrate by positron emission tomography (PET)/computed tomography (CT).
- Trial name
- SITRAT (NCT01951300)
- Testing
- Gallium-68 citrate
- Where
- Finland
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Colon Cleansing
PMC Split Preparation for Colon Cleansing
This is an endoscopist-blinded, prospective, multicenter study involving adult outpatients aiming at evaluating whether sodium picosulphate/magnesium citrate split dosing is associated to higher efficacy and acceptability in…
- Trial name
- MAGIC-P (NCT01909219)
- Testing
- Sodium picosulphate/magnesium Citrate
- Where
- 2 sites in Italy
- Volunteers
- 862 people, healthy volunteers welcome
- Sponsor
- Luigi Sacco University Hospital
Pharmacokinetics and Pharmacodynamics
Fentanyl Sublingual Spray and Fentanyl Citrate Intravenous (IV) in Opioid Naive Subjects
The primary objective of this study is to determine the pharmacokinetic and pharmacodynamic relationship of a single dose of fentanyl sublingual spray in opioid naive subjects.
- Trial name
- NCT02576353
- Testing
- Fentanyl, Fentanyl Citrate
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- INSYS Therapeutics Inc
Acute Kidney Failure With or Without:, MODS
Citrate Pharmacokinetics and Regional Citrate Anticoagulation in CRRT
1. To compare the differences of citrate pharmacokinetics in healthy individuals and critically ill patients as well as the influential factors. 2. To validate a pharmacokinetic model which has been established in a formal paper.
- Conditions
- Acute Kidney Failure With or Without:, MODS, Sepsis, Hepatic Insufficiency
- Trial name
- NCT00948558
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Bone Diseases, Metabolic, Osteoporosis, Postmenopausal
The Effects of Potassium Citrate on Bone Metabolism
Skeletal buffering of chronic acid loads may contribute to a significant amount of bone loss over time. Evidence from a few small short-term studies suggests that basic compounds, namely potassium citrate and potassium…
- Trial name
- NCT00357331
- Testing
- potassium citrate
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Liver Diseases, Hepatic Encephalopathy
Effects of Branched-Chain Amino Acids on Muscle Ammonia Metabolism in Patients With Cirrhosis and Healthy Subjects
The purpose of this study is to determine whether Branched chain Amino Acids enhances the uptake of ammonia in muscle tissue.
- Conditions
- Liver Diseases, Hepatic Encephalopathy, Hepatic Insufficiency
- Trial name
- NCT00931060
- Testing
- Branched chain amino acids
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Infertility, Anovulation
Efficacy Study of the OV-Watch™ Personal Fertility Monitor for Women Using Clomiphene Citrate.
The purpose of this study is to evaluate the effectiveness of the OV-Watch to predict ovulation while women are taking clomiphene citrate.
- Conditions
- Infertility, Anovulation, Polycystic Ovary Syndrome
- Trial name
- NCT00239603
- Testing
- OV-Watch
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emory University
Bowel Preparation, Sodium Picosulfate and Magnesium Citrate
Combination Method Using Sodium Picosulfate and Magnesium Citrate and PEG With Ascorbic Acid for Bowel Preparation
The aim of this study is to compare the efficacy depending on the order of the sequential combination method using sodium picosulfate and magnesium citrate (PMC) and PEG with ascorbic acid for bowel preparation.
- Conditions
- Bowel Preparation, Sodium Picosulfate and Magnesium Citrate, Polyethylene Glycol With Ascorbic Acid
- Trial name
- NCT02979223
- Testing
- sodium picosulfate and magnesium citrate, polyethylene glycol with ascorbic acid
- Where
- South Korea
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Kidney Stones, Nephrolithiasis
Effect of Diet Orange Soda on Urinary Lithogenicity
Beverages containing citrate may be useful in increasing urine citrate content and urine pH. Such changes in urine chemistry could help prevent kidney stones. Diet orange soda has more citrate than other similar beverages.
- Conditions
- Kidney Stones, Nephrolithiasis, Urolithiasis
- Trial name
- NCT01330940
- Testing
- Orange soda
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- VA New York Harbor Healthcare System
Bowel Preparation Solutions, Colonoscopy
Efficacy, Tolerance and Safety of Split Dose Bowel Preparation for Colonoscopy: 4L Polyethylene Glycol (PEG) Versus 1L Polyethylene Glycol Plus Sodium Picosulfate-magnesium Citrate (SPMC)
4L split dose PEG is the gold standard for bowel preparation, however it comes with poor tolerability and poor compliance. Combination of PEG with different agent is useful in reducing total volume, improving compliance and…
- Trial name
- NCT04474002
- Testing
- 4L Klean Prep®, 1L Klean prep® and 2 sachets Picoprep®
- Where
- Hong Kong
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Queen Elizabeth Hospital, Hong Kong
Healthy Subjects
Tofacitinib Citrate Topical Gel 3.2% FDA BA Bridging Study
This is a Phase 1, single center, open-label, fixed sequence, two-period pharmacokinetic (PK) study to evaluate the safety and relative systemic bioavailability of topical and oral tofacitinib formulations in approximately 14…
- Trial name
- NCT04468425
- Testing
- Tofacitinib Citrate
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- TWi Biotechnology, Inc.
Polycystic Ovary Syndrome
PCOSMIC Trial - PolyCystic Ovary Syndrome, Metformin for Infertility With Clomiphene
1. Metformin increases the pregnancy rate when added to the standard treatment of anovulatory polycystic ovary syndrome (PCOS). 2.
- Trial name
- PCOSMIC (NCT00795808)
- Testing
- Metformin, Metformin + Clomiphene, Clomiphene
- Where
- New Zealand
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Poly Cystic Ovary Syndrome
The Effect Of Polycystic Ovarian Syndrome Treatment On Ocular Surface.
This is a Descriptive prospective cohort study conducted at the Ophthalmology Department in Kasr-Alaini Hospital. A total of 90 subjects, 30 control females with no relevant medical, gynecological or ophthalmic history, and 60…
- Trial name
- NCT07419776
- Testing
- dry eye diagnostic system of Mediworks, Optical coherence tomography angiography, Contraceptives, Oral, Combined
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cairo University
Anovulatory Infertility Related to Polycystic Ovary Syndrome
Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS
Anovulatory infertility is a common feature of the polycystic ovary syndrome (PCOS). Even if several first-step treatments have been proposed for anovulatory infertile PCOS patients, very few data are available in literature…
- Trial name
- NCT00461643
- Testing
- Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
- Where
- 3 sites in Italy
- Volunteers
- 552 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Dyspnea
Inhaled Fentanyl Citrate & Dyspnea
"Dyspnea" refers to the awareness of breathing discomfort that is typically experienced during exercise in health and disease. In various participant populations, dyspnea is a predictor of disability and death; and contributes to…
- Trial name
- NCT01853449
- Testing
- Fentanyl Citrate, CWS
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- McGill University
Mood
Differential Effects of Clomiphene Citrate in Women Undergoing Superovulation
Clomiphene citrate is commonly used for ovulation induction in women with anovulation, correction of luteal phase deficiency or for superovulation as empiric therapy for unexplained infertility.
- Trial name
- NCT01291056
- Testing
- Clomiphene
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Utah
Anesthesia
A Study to Determine if Caffeine Accelerates Emergence From Propofol Anesthesia
At present clinicians have no way to reverse anesthesia. Patients wake when their bodies clear the anesthetic. Most people wake quickly, but some do not.
- Trial name
- NCT03360903
- Testing
- Caffeine
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Chicago
PCO, Induction of Ovulation
Parameters Declaring PCO Infertile Patients Either Sensitive or Resistant to Different Doses of Clomiphene Citrate.
Polycystic ovary syndrome (PCOS) is a common endocrinological disorder seen in 6%-10% of women (Human Reproduction, 2004). It is characterized by polycystic ovaries, anovulatory cycles, and hyperandrogenism.
- Conditions
- PCO, Induction of Ovulation, Clomiphene Citrate
- Trial name
- NCT04887402
- Testing
- Clomiphene Citrate
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Labor Preterm Requiring Hospitalization
Management of Acute Preterm Labor: Nifedipen Alone or Combined With Cildenafil Citrate
The aim of this study is to assess whether or not the emergency tocolytic effect of combined nifedipine and sildenafil citrate will have a superior effect over nifedipine alone in terms of inhibiting eminent preterm labor and…
- Trial name
- NCT02337881
- Testing
- nifedipen, Sildenafil
- Where
- 2 sites in Egypt, Saudi Arabia
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Al Hayat National Hospital
Polycystic Ovarian Syndrome
Effect of Ubiquinol Supplementation on Ovulation Induction in Clomiphene Citrate Resistance
Objective: To evaluate potential benefits of adding the active form of Coenzyme Q10 (Ubiquinol) to Clomiphene Citrate compared with Human Menopausal Gonadotropins (hMG) in Clomiphene Citrate resistant PCOS patients.
- Trial name
- NCT04870502
- Testing
- Controlled ovarian stimulation by Combined Clomiphene Citrate and Ubiquinol Versus hMG
- Where
- Saudi Arabia
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Saudi German Hospital - Madinah