Clinical trials: Claudication, active
Peripheral Artery Disease
BEETroot Juice to Reverse Functional Impairment in PAD
The BEET PAD Trial is a multi-centered double-blind randomized clinical trial designed to determine whether beetroot juice, compared to placebo, improves six-minute walk distance at four month follow-up in people with lower…
- Trial name
- BEET PAD (NCT05624125)
- Testing
- Beetroot juice
- Where
- 4 sites in United States
- Volunteers
- 210 people
- Sponsor
- Northwestern University
Peripheral Vascular Disease
Observing the Role of Inflammation in Peripheral Artery Disease and Its Impact on Heart and Mobility Health: PANACEA-O.
This registry aims to collect detailed information about people in Canada who have Peripheral Artery Disease (PAD) and are receiving care in heart clinics while still able to walk and live in the community.
- Trial name
- PANACEA-O (NCT07500610)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Cardiology Research UBC
Peripheral Arterial Disease, Critical Limb Ischemia
Swedish Drug-elution Trial in Peripheral Arterial Disease
Peripheral arterial disease (PAD) causes reduced blood flow to the lower limb(s) due to stenosis or occlusion in the supplying arteries.
- Conditions
- Peripheral Arterial Disease, Critical Limb Ischemia, Intermittent Claudication
- Trial name
- SWEDEPAD (NCT02051088)
- Testing
- Revascularization with drug-eluting technology, Revascularization without drug-eluting technology, drug-coated balloons and/or drug-eluting stents
- Where
- Sweden
- Volunteers
- 3,556 people
- Sponsor
- Sahlgrenska University Hospital
Peripheral Arterial Disease, Aging
Fisetin to Reduce Senescence and Mobility Impairment in PAD
The investigators propose a pilot randomized trial to gather preliminary data to test the hypothesis that Fisetin will reduce abundance of senescent cells in blood, skeletal muscle, and both subcutaneous and inter muscular…
- Conditions
- Peripheral Arterial Disease, Aging, Peripheral Vascular Diseases, Walking, Difficulty
- Trial name
- FIRST (NCT06399809)
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Northwestern University
Peripheral Artery Disease, Claudication, Intermittent
Red Light Treatment in Peripheral Artery Disease
Subjects with a known diagnosis of peripheral artery disease as measured by an abnormal ankle brachial index (<.9 or >1.1) will undergo a single 5 min exposure of 670 nm light, 1 cm above the gastrocnemius muscle.
- Conditions
- Peripheral Artery Disease, Claudication, Intermittent, Vasodilation
- Trial name
- NCT03203239
- Testing
- Red Light (670 nm energy), Octafluoropropane
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Peripheral Arterial Occlusive Disease, Femoropopliteal Artery Occlusion
FRAMED Infrainguinal Venous Bypass Versus Conventional Autologous Bypass Trial
The purpose of this clinical trial is to analyze patency after autologous infrainguinal bypass surgery in patients receiving a venous conduit versus a covered venous conduit.
- Conditions
- Peripheral Arterial Occlusive Disease, Femoropopliteal Artery Occlusion, Femoropopliteal Stenosis, Critical Limb-Threatening Ischemia
- Trial name
- Framed IVB (NCT06082466)
- Testing
- FRAMED Infrainguinal Venous Bypass, Conventional Autologous Bypass
- Where
- Austria
- Volunteers
- 110 people
- Sponsor
- Paracelsus Medical University
Sarcopenia, Body Composition
CT Body Composition as Predictor of Exercise Therapy Outcome in Peripheral Arterial Disease
Supervised exercise therapy (SET) is the recommended first treatment for patients with leg artery disease (peripheral arterial disease, PAD) causing pain when walking.
- Conditions
- Sarcopenia, Body Composition, Sarcopenic Obesity, Peripheral Arterial Disease
- Trial name
- COMPOSE-PAD (NCT07433309)
- Testing
- SET physiotherapy, CT scan
- Volunteers
- 128 people
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.
Diabetes Mellitus, Claudication, Intermittent
Additional Hyperbaric Oxygen After Lower Extremity Amputation
This study evaluates the effect of additional hyperbaric oxygen therapy after lower extremity amputation. The patients will be randomized after amputation to either a treatment group receiving hyperbaric oxygen therapy, or…
- Conditions
- Diabetes Mellitus, Claudication, Intermittent, Critical Limb Ischemia, Osteomyelitis
- Trial name
- AHOLEA (NCT03594344)
- Testing
- Hyperbaric oxygen therapy
- Where
- 2 sites in Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
Peripheral Artery Disease (PAD)
The NICE-PAD II Trial
Among people with peripheral artery disease (PAD) age 50 and older, the investigators will test the hypothesis that PAD participants randomized to nicotinamide riboside (NR) will have greater improvement or less decline in…
- Trial name
- NICE (NCT07782671)
- Testing
- Nicotinamide Riboside (NR)
- Volunteers
- 250 people
- Sponsor
- Northwestern University
Peripheral Artery Disease
Community-based Exercise Following Revascularization for PAD
The primary goal of this clinical trial is to evaluate whether a community-based structured exercise therapy (CB-SET) intervention, which could be accessible and easily disseminated, adds benefit to peripheral artery disease…
- Trial name
- NCT04252950
- Testing
- CB-SET, Revascularization
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
COPD, PAD
Effect of Breather in COPD Patients With Intermittent Claudication
The aim of this study To show the effect of breather on ventilatory and vascular function in COPD patient with intermittent claudication.
- Trial name
- NCT06529185
- Testing
- The BREATHER, pharmacological treatment
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Superficial Femoral Artery Stenosis, Claudication
Contribution of Optical Coherence Tomography in the Endovascular Treatment of Femoral Occlusions
This is a common care study. A study for evaluating the quality of balloon inflation and stent application will be performed in 2D angiography alone in the control group and then by 2D and OCT angiography for the experimental…
- Conditions
- Superficial Femoral Artery Stenosis, Claudication, Ischemic Leg
- Trial name
- TOCAF (NCT04434586)
- Testing
- femoropopliteal revascularization for TASC C or TASC D lesion
- Where
- France
- Volunteers
- 166 people
- Sponsor
- University Hospital, Lille
Lumbar Spinal Stenosis, Numerical Rating Scale
Presence of Dural Pulsation in Patients Diagnosed With Lumbar Spinal Stenosis
Lumbar spinal stenosis is defined as the narrowing of the spinal canal resulting from degenerative changes in the spinal joints, intervertebral discs, and the ligamentum flavum.
- Conditions
- Lumbar Spinal Stenosis, Numerical Rating Scale, Disability Physical, Magnetic Resonance
- Trial name
- NCT07233798
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Marmara University
Peripheral Arterial Disease
MitoQ Treatment of Claudication: Myofiber and Micro-vessel Pathology
In our research, we are delving into whether taking MitoQ for six months can improve the symptoms and function of people diagnosed with peripheral artery disease, especially those who suffer from leg pain while walking, known as…
- Trial name
- NCT06409949
- Testing
- Walking assessment, QOL Survey, Ankle pressure at rest and after stress
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Nebraska
Peripheral Arterial Disease
Evaluation of the Effectiveness of Hybrid Cardiac Rehabilitation in Peripheral Artery Disease
Peripheral artery disease (PAD) is a common atherosclerotic condition characterized by reduced blood flow to the lower extremities, leading to intermittent claudication, decreased walking capacity, and impaired quality of life.
- Trial name
- NCT07550959
- Testing
- Hybrid Cardiac Rehabilitation, Supervised Exercise Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Biruni University
Peripheral Arterial Disease, Intermittent Claudication
Personalised Multicomponent Exercise Programme in Peripheral Arterial Disease
Peripheral arterial disease (PAD) is characterised as an atherosclerotic disease, most common in the lower limbs (aortoiliac, femoropopliteal, and infrapopliteal arterial segments), which causes a decrease in blood flow to the…
- Trial name
- NCT06410521
- Testing
- Exercise, Usual care
- Where
- 3 sites in Portugal
- Volunteers
- 40 people
- Sponsor
- University of Trás-os-Montes and Alto Douro
Lumbar Spinal Stenosis, Lumbar Spondylolisthesis
Effectiveness and Safety of Korean Medicine for Low Back Pain or Sciatica Due to Lumbar Stenosis/Spondylolisthesis
A prospective observational study investigating the effectiveness and safety of integrative Korean medicine treatment in lumbar stenosis or spondylolisthesis patients with low back pain or sciatica at 3 locations of Jaseng…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Spondylolisthesis, Low Back Pain, Sciatica
- Trial name
- NCT03879447
- Testing
- Herbal medicine, Chuna manual medicine, Bee venom pharmacopuncture
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- Jaseng Medical Foundation
Intermittent Claudication
Home-based Exercice Therapy for Patients With Intermittent Claudication Using a New Smartphone Application
The main characteristic of PAD is to limit physical activity by the appearance of claudication of the lower limbs which limits the walking distance, or the maximum distance traveled by the patient before the pain forces to stop.
- Trial name
- APAISE (NCT05457738)
- Testing
- E-REVA® app, No E-REVA® app
- Where
- France
- Volunteers
- 52 people
- Sponsor
- CHU de Reims
Peripheral Arterial Disease
Evaluation of Safety, Tolerability and Preliminary Efficacy of Etrinabdione in Patients With Peripheral Arterial Disease
The goal of this clinical trial is to study the safety and tolerability of Etrinabdione in adult patients with peripheral arterial disease. It will also learn about the preliminary efficacy of Etrinabdione.
- Trial name
- CLAUDIA (NCT06774040)
- Testing
- Etribnabdione 25 mg BID, Etribnabdione 50 mg BID
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- VivaCell Biotechnology España
Peripheral Arterial Disease, Atherosclerotic Lesion
Study of the R3 Vascular Drug-Eluting Bioresorbable Scaffold in Treating Below the Knee Arterial Disease
This first-in-human clinical feasibility study will evaluate the safety and performance of the R3 Vascular MAGNITUDE® Bioresorbable Drug-Eluting Scaffold and Delivery System in patients undergoing treatment for peripheral…
- Conditions
- Peripheral Arterial Disease, Atherosclerotic Lesion, Lower Extremity Ischemia, Lower Extremity Claudication
- Trial name
- RESOLV I (NCT04912323)
- Testing
- Percutaneous Implantation of the MAGNITUDE® Bioresorbable Arterial Scaffold
- Where
- 7 sites in Austria, Canada and 1 more
- Volunteers
- 30 people
- Sponsor
- R3 Vascular Inc.