Clinical trials: Cleft Palate Lip
Cleft Lip and/or Palate, Speech Disorder
Neural Changes After Speech Therapy in Patients With Cleft Palate: A Brain Imaging Study
Cleft palate is one of the most common maxillofacial congenital malformations, which results in severe speech disorders. Compensatory articulation disorder, also known as non-oral articulation disorder (NOA), is considered as the…
- Conditions
- Cleft Lip and/or Palate, Speech Disorder, Speech Therapy, Brain
- Trial name
- fMRI-Speech-CP (NCT07330687)
- Testing
- Structured Speech Training for Decompensation
- Where
- China
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Shufan Zhao
Cleft Lip and Palate
The Effect of a Newly Designed Presurgical Orthopedic Appliance
A randomized clinical trial to compare the effectiveness of newly designed active type of presurgical orthopedic appliances on maxillary arch dimensions in infants with bilateral cleft lip and palate.
- Trial name
- NCT05535530
- Testing
- Active PSIO
- Where
- Iraq
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Nasoalveolar Fistula (Defect)
Clinical Assessment of Usage of Cleft Margin Flap With Anterior Palatal Closure in Closure of Naso-alveolar Defect.
During primary cleft lip repair in patients who were born with cleft lip and palate, usage of cleft margin flap with anterior palatal closure will be done in an attempt to close the Naso-alveolar fistula (defect) that usually…
- Trial name
- NCT03922438
- Testing
- usage of cleft margin flap with anterior palatal closure during primary cleft lip repair.
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cleft Palate
Sleep and Behavior in Children With Cleft Palate
The purpose of this study is to determine whether cleft palate repair increases the risk for obstructive sleep apnea in children and whether sleep apnea could explain learning and behavior difficulties that are often observed.
- Trial name
- NCT01046591
- Testing
- Polysomnography
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Relationship Between the Exposure of Glucocorticoids During Pregnancy and Orofacial Cleft Development
A Study to Learn More About the Relationship Between the Development of a Gap in the Upper Lip (Cleft Lip) or in the Roof of the Mouth (Cleft Palate) in Newborns and the Use of Glucocorticoids by the Mother During Pregnancy: a Meta-analysis
Glucocorticoids are drugs that have many effects on body metabolism, raise sugar level in the blood, and reduce inflammation. By applying a statistical technique for combining the findings from a systematic literature review…
- Trial name
- NCT03788863
- Testing
- Diflucortolone valerate (BAY866146)
- Where
- Germany
- Volunteers
- 99,999 people, healthy volunteers welcome
- Sponsor
- LEO Pharma
Surgically Repaired Unilateral Cleft Lip and Palate
Evaluation of Arch Dimensions of Children With Surgically Repaired Unilateral Cleft Lip and Palate
The aim of the study is to assess arch dimensions among children with surgically repaired unilateral cleft lip and palate.
- Trial name
- NCT03219021
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- Menna Allah Mohammed Awad
Craniofacial Abnormalities, Cleft Lip
FaceBase Biorepository
The purpose of this study is to find out if there are any genetic differences between people with and without disorders of the head, face, and eye.
- Conditions
- Craniofacial Abnormalities, Cleft Lip, Cleft Palate
- Trial name
- NCT01252264
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Jeff Murray
Cleft Lip and Palate
Two Methods of Lip Taping as a Presurgical Orthopedic Appliance
A randomized clinical trial to compare the effectiveness of two methods of lip taping as a presurgical orthopedic appliances on maxillary arch dimensions in infants with bilateral cleft lip and palate.
- Trial name
- NCT05796336
- Testing
- Lip taping
- Where
- Iraq
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Bilateral Cleft Lip and Palate, Maxillary Expansion
Efficiency of Two Maxillary Expanders for Maxillary Arch Expansion in Bilateral Cleft Lip and Palate Patients
This randomized controlled trial is designed to compare between Fan expander with palatal springs appliance vs three-way expander regarding the their effectiveness in maxillary expansion in patients with bilateral cleft
- Trial name
- NCT07056296
- Testing
- 3D Maxillary Expansion with 3 expansion screws, 3D Maxillary Expansion using modified Fan expander with springs
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Cleft Lip and Palate
The Effectiveness of Adhesive Versus Conventional Nasoalveolar Molding on Children With Unilateral Cleft Lip and Palate
The present study will compare the effectiveness of adhesive nasoalveolar molding (GS-NAM) and conventional nasoalveolar molding on the alveolar ridge, nasal, and labial growth in children with unilateral cleft lip and palate.
- Trial name
- NCT06451276
- Testing
- Nasoalveolar molding in unilateral cleft lip and palate
- Where
- 2 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Cleft Lip and Palate
Effectiveness of a Customized 3D Printed Nostril Retainer Combined With Taping Vs.Taping Only on Enhancing the Nasolabial Esthetics and Maxillary Arch Dimensions in Infants With Unilateral Complete Cleft Lip and Palate.
Lip taping was proven as simple, handy technique of PSIO for alveolar molding yielding enhanced maxillary arch dimensions in UCCLP infants.
- Trial name
- NCT06211205
- Testing
- Customized 3D printed nostril retainer combined with lip taping, Lip taping
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cleft Lip and Palate
Bone Tissue Engineering With Dental Pulp Stem Cells for Alveolar Cleft Repair
Iliac crest autogenous bone graft is accepted as the most effective method for secondary alveolar cleft repair. However this method is associated with complications.
- Trial name
- CLOSE (NCT03766217)
- Testing
- Mesenchymal stem cells associated with biomaterials, Iliac crest autogenous bone graft
- Where
- Brazil
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hospital Sirio-Libanes
Cleft Lip, Scarring
Botulinum Toxin to Improve Cosmesis of Primary Cleft Lip Repair
Objective: To determine if the use of botulinum toxin during primary cleft lip repair improves the cosmetic appearance of the cleft lip scar
- Conditions
- Cleft Lip, Scarring, Cleft Palate
- Trial name
- NCT02247193
- Testing
- Botulinum Toxin Type A, Normal Saline Injection
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Unilateral Cleft Lip and Palate
Effect of Using Two Different Construction Techniques of Nasoalveolar Molding Devices in Unilateral Cleft Lip and Palate Patients
This study includes Three Dimensional Evaluation of Maxillary Arch Changes After Using Two Different Construction Techniques of Nasoalveolar Molding Devices in Unilateral Cleft Lip and Palate Patients (Randomized Controlled…
- Trial name
- NCT05837780
- Testing
- Nasoalveolar molding device
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Minia University
Cleft Lip and Palate
The Effect of Bone Marrow Stem Cells Harvested from the Iliac Crest Versus Mandibular Ramus in Alveolar Cleft Regeneration
This comparative and prospective study was conducted on 10 patients with alveolar cleft defects. Patients with alveolar cleft defects were randomly selected and randomly divided into two equal groups: Group A: received Autologous…
- Trial name
- NCT06636643
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Evaluation
Prosthetic Rehabilitation of Lip and Palate Deformaties in Neonates Using Two Different Approaches
This study was conducted to compare the use of conventional nasoalveolar molding appliances and the use of digitally designed and produced nasoalveolar molding appliances in rehabilitating neonates born with unilateral complete…
- Trial name
- NCT06522217
- Testing
- nasoalveolar molding appliance, digital nasoalveolar molding appliance
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tanta University
Cleft Lip and Palate, Rhinoplasty
Single Stage Versus Multiple Staged Repair of Nasal & Alveolar Deformities in Patients With Cleft Lip and Palate
Cleft lip and palate patients are commonly seen among maxillofacial patients. Patients with cleft lip and palate have evident cosmetic nasal deformities.
- Trial name
- NCT06510881
- Testing
- Rhinoplasty with or without cleft alveolus repair
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cleft Lip, Cleft Lip and Palate
Effect of Different Nasal Stent Designs With Nasoalveolar Molding Appliance
This study is designed to compare 2 different designs of nasal stents in conjunction with nasoalveolar molding appliance regarding the changes in nose and lip esthetics in infants with cleft lip and palate.
- Trial name
- NCT06411444
- Testing
- Grape Design Nasal Stent
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cleft Lip and Cleft Palate
Detection of Single Nucleotide Polymorphism (SNP) Rs2235371 of IRF6 Gene in Egyptian Patients with Non-Syndromic Cleft Lip and Palate
The aim of this work is to study the relation between SNP rs2235371 of IRF 6 gene and Non-Syndromic Cleft Lip and Palate in Egyptian Patients in a prospective study
- Trial name
- NCT06730880
- Testing
- PCR
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cleft Lip and Palate, Bilateral Cleft Lip/Palate
Short Term Efficiency of Presurgical Vacuum Formed Nasoalveolar Molding Aligners in Infants With Bilateral Cleft Lip and Palate Compared With Grayson Acrylic Formed Nasoalveolar Molding Appliances.
Newborns with bilateral cleft lip/ palate will be treated pre-surgically by either presurgical vacuum-formed nasoalveolar molding aligners VF (NAM) or conventional Grayson acrylic formed nasoalveolar molding appliances in order…
- Trial name
- NCT04966572
- Testing
- Presurgical vacuum formed nasoalveolar molding aligners, Conventional Grayson acrylic formed nasoalveolar molding appliances
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University