Clinical trials: Clinical
Diabetic Neuropathy Peripheral
Empagliflozin in Treatment of Peripheral Diabetic Neuropathy
The aim of the study is to investigate the possible protective effect of empagliflozin in patients with type 2 diabetes mellitus with diabetic peripheral neuropathy and not on SGLT2 inhibitors treatment.
- Trial name
- NCT05977465
- Testing
- Empagliflozin 25 MG
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tanta University
Nasal Deformity, Revision Rhinoplasty
Effect of Costal Harvesting Technique on Postoperative Donor-site Morbidity: Does Muscle Sparing Technique Cause Less Postoperative Pain ? A Clinical Trial
The purpose of this study was to investigate the effect of 'muscle sparing technique' while harvesting costal/rib cartilage on postoperative donor-site morbidity -namely postoperative pain.
- Conditions
- Nasal Deformity, Revision Rhinoplasty, Autogenous Rib Graft, Costal Cartilage
- Trial name
- COSTA (NCT02818634)
- Testing
- Harvesting rib cartilage
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Obesity, Adult
Efficacy of Mindful Tai Chi on Obese or Overweight Adults: A Randomized Controlled Clinical Trial
Background: New weight-loss intervention programs are being studied to determine their effectiveness in helping overweight and obese individuals reach a healthy weight.
- Conditions
- Obesity, Adult, Healthy
- Trial name
- NCT01264029
- Testing
- Mindful Tai Chi Intervention, Mindfulness Meditation, Mall Walking
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Healthy
Validation of the Stability of Diagnostic Biomarkers on Healthy Volunteers
Stability studies on the peripheral biomarkers (lncRNAs, sncRNAs, mRNAs, proteins, lipids/metabolites) measured by Firalis IVD test candidates and effect of gender, age, nutrition on their expression level
- Trial name
- NCT05160337
- Testing
- Biomarker based IVD tests
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Firalis SA
COVID-19 Pneumonia
Evaluation of Immunogenicity, Safety and Antibody Persistence of COVID-19 Booster Vaccine (Produced in Wuhan) in Patients With Hypertension and/or Diabetes
To evaluate the post-marketing immunogenicity, safety and antibody persistence of the third dose (booster) of Covid-19 vaccine in patients aged 60 years or older with hypertension and/or diabetes.
- Trial name
- NCT05104437
- Testing
- Covid-19 vaccine (0-1-4 schedule), Covid-19 vaccine (0-1-6 schedule)
- Where
- 3 sites in China
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- China National Biotec Group Company Limited
Metacognitive Awareness and Self-Regulated Learning in Nursing Students
ChatGPT-Supported Metacognitive Feedback in Nursing Students
This randomized controlled study aims to evaluate the effects of ChatGPT-supported metacognitive feedback on nursing students' metacognitive awareness and self-regulated learning during clinical nursing practice.
- Trial name
- NCT07767695
- Testing
- ChatGPT-Supported Metacognitive Feedback, Routine Clinical Education and Traditional Feedback
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Elderly
A Clinical Study to Evaluate PK, PD, and PG of Rosuvastatin in the Elderly
A clinical study to evaluate pharmacokinetic, pharmacodynamic, and pharmacogenomic characteristics of Rosuvastatin in the elderly after multiple administration of Rosuvastatin
- Trial name
- NCT03715101
- Testing
- Rosuvastatin
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Coenzyme Q Deficiency
Comparative Single-dose Bioavailability Clinical Study of Different Coenzyme Q10 Products
The randomized, open-label, three period crossover single-dose bioavailability study with three coenzyme Q10 products
- Trial name
- NCT05272228
- Testing
- Dietary supplement - standard product, Dietary supplement - Investigational product IP1, Dietary supplement - Investigational product IP2
- Where
- Slovenia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Low Back Pain
Does Intrathecal Morphine Affect Outcomes in Spine Deformity Surgery
This study aims to compare the effects of intrathecal morphine to traditional pain management strategies on post-operative recovery for deformity surgery.
- Trial name
- NCT05092828
- Testing
- Intrathecal Morphine Injection, Pain Relieving
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sonoran Spine Research and Education Foundation
Virtual Reality
Virtual Reality-Supported Relaxation Before Objective Structured Clinical Examination
Accurate and objective assessment of clinical competencies is essential in nursing education to ensure that students acquire professional skills and contribute to the quality of patient care.
- Trial name
- NCT07864428
- Testing
- Experimental
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Emine Arici Parlak
Postoperative Pain
Evaluation of Postoperative Pain in Children
Postoperative pain is a common symptom of a flare up after root canal treatments (RCTs). Insufficient instrumentation, extrusion of irrigation solutions and debris and existence of a periapical lesion are the factors affecting…
- Trial name
- NCT04510571
- Testing
- Evaluating Postoperative Pain After Root Canal Treatment with Protaper Next, Evaluating Postoperative Pain After Root Canal Treatment with Reciproc Blue Files
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ege University
Pharmacogenomics
Effectiveness of an Arabic CPIC-Based Pharmacogenomics Microlearning Program on Community Pharmacists' Clinical Decision-Making in Jordan
Pharmacogenomics (PGx) presents a vital opportunity to optimize medication safety, yet community pharmacists often lack the applied clinical training required to interpret and act upon genetic data.
- Trial name
- NCT07735572
- Testing
- immediate post-intervention clinical decision-making score
- Where
- Jordan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Petra
Healthy Adult Participants
Safety, Tolerability, and Pharmacokinetic Evaluation of ADB116 for Injection
A Phase I Study of ADB116 for Injection in Healthy Chinese Adults. This study aims as follows: Primary Objective: To evaluate the safety and tolerability of a single intravenous bolus dose of ADB116 for injection in healthy…
- Trial name
- NCT07729839
- Testing
- ADB116 for Injection
- Where
- China
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Jiangsu Aidea Pharmaceutical Group Co., Ltd.
Visual Disorder
A Clinical Trial to Evaluate Investigational Silicone Hydrogel Contact Lenses Worn Continuously for One Week
This study is a prospective, randomized, double-masked, bilateral, dispensing, parallel-group clinical trial design. All subjects will participate in a 2-week daily disposable contact lens adaptation period prior to being…
- Trial name
- NCT02543528
- Testing
- Investigational Lens 1, Investigational Lens 2, Investigational Lens 3
- Where
- India
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
mHealth, Mindfulness
The Effectiveness of a Mindfulness Application on Perceived Stess
Mindfulness has become increasingly popular and positive outcomes have been reported for mindfulness-based interventions (MBIs) in reducing stress.
- Conditions
- mHealth, Mindfulness, Stress, Burnout
- Trial name
- NCT05246800
- Testing
- Structured 8-week mHealth mindfulness program
- Where
- Netherlands
- Volunteers
- 587 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Overweight or Obesity
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HRS-4729 Injection in Healthy Subjects
The study is being conducted to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of HRS-4729 injection in healthy subjects.
- Trial name
- NCT06762600
- Testing
- HRS-4729 injection, HRS9531 injection, Acetaminophen
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Safety
Evaluation of Allergenicity by HRIPT and Phototest
This clinical study will evaluate the dermatological safety and allergenic potential of a cosmetic product. The study will use the Human Repeat Insult Patch Test (HRIPT) and phototest procedures to assess whether the product may…
- Trial name
- HRIPT + FOTO (NCT07797192)
- Testing
- Blancy Pro
- Where
- Brazil
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Hemophilia A, Hemophilia B
Pre-clinical Models for Mesenchymal Stem Cell Therapy in Hemophilic Arthropathy
Hemophilia is a constitutional coagulation disorder responsible for a hemorrhagic phenotype in patients from an early age. Hemarthrosis is one of the most frequent complications in hemophiliacs and leads to the development of…
- Conditions
- Hemophilia A, Hemophilia B, Arthropathy
- Trial name
- NCT05187936
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Infectious Endocarditis
Evaluation of an Antibiotic Regimen Pharmacokinetic Applicable to Enterococcus Faecalis Infective Endocarditis
The clinical trial is designed as a phase II, crossover clinical trial. It will be carried out in healthy volunteers, who will receive two different antibiotic regimen based on ceftriaxone.
- Trial name
- NCT03681431
- Testing
- Ceftriaxone 4g/ 24h, Ceftriaxone 2g/ 12h
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Jaw, Edentulous, Partially
The Effect of Immediate Implant Placement and Provisionalization in the Esthetic Zone
The purpose of this study is to compare two different techniques of placing dental implants: 1) removing the tooth and placing the implant immediately and 2) removing the tooth and placing both the implant and a temporary crown…
- Trial name
- 3i (NCT02021331)
- Testing
- immediate implant placement without provisionalization, immediate implant placement with immediate provisionalization
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Michigan
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