Clinical trials: Clinical
Hand, Foot, and Mouth Disease (HFMD), Enterovirus 71 Infection
Bridging Clinical Trial of EV71 Vaccine in Vietnamese Children
The purpose of this study is to evaluate the immunogenicity and safety of an inactivated Enterovirus Type 71 (EV71) vaccine, manufactured by Sinovac, in healthy Vietnamese children aged 6 to 71 months.
- Trial name
- NCT07793175
- Testing
- EV71 vaccine
- Where
- Vietnam
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd
Healthy
A Clinical Study to Assess the Effect of Increasing Intake Amounts of Two Novel Glycans on the Gut Microbiota of Healthy Subjects
This exploratory, randomized, open label study aims to explore the safety, tolerability, pharmacokinetics, and effects of increasing intake amounts of two novel glycans on the gut microbiota of healthy subjects.
- Trial name
- NCT04619875
- Testing
- KB5, SG1, Lactulose
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Kaleido Biosciences
Dental Caries
Comparison of Clinical and Radiographic Outcomes of SMART Technique vs ART in Primary Molars
This study conducted on thirty children aged 3-6 years old of both genders, have bilateral carious lower first primary molars. Pre-operative periapical x- ray were taken for both sides.
- Trial name
- NCT05438381
- Testing
- Atraumatic Restorative Technique (ART), SMART Technique
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Healthy
Clinical Trial of Comparing DA-5222 Single-administration and Co-administration of DA-5222-R1, DA-5222-R2 and DA-5222-R3 in Healthy Adult Subjects
This study is to compare pharmacokinetics and safety profiles of DA-5222 single-administration and co-administration of DA-5222-R1, DA-5222-R2 and DA-5222-R3 in healthy adult subjects
- Trial name
- NCT06993181
- Testing
- DA-5222, DA-5222-R1, DA-5222-R2
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dong-A ST Co., Ltd.
Decayed Primary Molars
Partial Versus Complete Pulpotomy Using Three Different Materials in Primary Molars: a Clinical Study
The purposes of the study to compare partial pulpotomy versus complete pulpotomy in primary molars using three different materials (Formocresol, MTA, Theracal LC) .
- Trial name
- NCT05190783
- Testing
- Formocresol, MTA, TheraCal
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Age-related Changes in Skin Appearance and Physiology
Effect of Collagen Peptides on Skin Health: A Clinical Trial
The goal of this clinical trial is to evaluate whether daily oral supplementation with 2.5 g of specific bioactive collagen peptides (SCP) can improve skin physiology in healthy adult women aged 35-55 years.
- Trial name
- BCP-Skin (NCT07516756)
- Testing
- Specific Collagen Peptides
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Collagen Research Institute
Crowding of Anterior Mandibular Teeth
Evaluation of the Effectiveness of Piezocision and Micro-osteoperforation in Alleviating Mandibular Anterior Crowding
In recent times, many patients want their treatment duration to be reduced, because lengthy orthodontic treatment duration is associated with negative sequelae such as discomfort, pain, white spot lesions, and decreased patient's…
- Trial name
- NCT04940351
- Testing
- GROUP - A: PIEZOCISION GROUP, GROUP- B: MICRO-OSTEOPERFORATION GROUP
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Influenza
A Clinical Trial of Split-virion Influenza A/H1N1 Vaccines
A single center, Open-Label phase IV clinical trial is to be conducted in healthy elders (equal to or more than 61 years to evaluate the immunogenicity and safety of Sinovac's 15μg H1N1 influenza A Vaccine (Split virion)…
- Trial name
- NCT01004653
- Testing
- H1N1 influenza A Vaccine (Split virion), Inactivated
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd
Aging, Pain
RHA® 4 With New Anesthetic - Nasolabial Folds
This is a randomized, controlled, double-blinded, within-subject (split-face), multicenter, prospective study to investigate whether RHA® 4 with New Anesthetic Agent is non-inferior to RHA® 4 (with lidocaine) in terms of…
- Trial name
- NCT04087395
- Testing
- RHA®4 with new anesthetic agent, RHA®4-Lidocaine
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Myocardial Infarction, Stroke
Women's Health Initiative Strong and Healthy Study
The WHISH trial applies state-of-the science behavioral principles and currently available technologies to deliver a physical activity intervention without face-to-face contact to ~25,000 older U.S. women expected to consent.
- Conditions
- Myocardial Infarction, Stroke, Cardiovascular Mortality, Hip Fractures
- Trial name
- WHISH (NCT02425345)
- Testing
- Physical Activity
- Volunteers
- 49,331 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Peri-Implantitis
Ozone Therapy as an Adjunct to the Surgical Treatment of Peri-implantitis
Decontamination procedure is a challenging factor that affects the success of surgical regenerative therapy (SRT) of peri-implantitis.
- Trial name
- NCT03018795
- Testing
- Decontamination of implant surfaces
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Gazi University
Pain, Postoperative
External Oblique Intercostal Plane Block Versus Subcostal Transversus Abdominis Plane Block in Supra-umbilical Surgical Incisions
Various newer techniques have been proposed to enhance analgesia in upper abdominal region. The subcostal transverse abdominis plane (SCTAP) block is the deposition of local anesthetic in the transverse abdominis plane inferior…
- Trial name
- NCT05432557
- Testing
- external oblique intercostal plain block (EOIP), subcostal transversus abdominis plane block (SCTAP), control group
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Benha University
Accuracy of 3D Printed Titanium Plates Versus 3D Milled Titanium Plates in Genioplasty Orthognathic Surgery, Patient Specific Genioplasty
Accuracy of Patient Specific 3D Printed Titanium Plates Versus Milled Titanium Plates in Genioplasty Orthognathic Surgeries.
To assess accuracy of patient specific 3D printed titanium plates versus 3D milled titanium plates in genioplasty orthognathic surgery
- Conditions
- Accuracy of 3D Printed Titanium Plates Versus 3D Milled Titanium Plates in Genioplasty Orthognathic Surgery, Patient Specific Genioplasty, Accuracy of 3D Printed Titanium Plates Versus 3D Milled Titanium Plates in Genioplasty
- Trial name
- NCT07344441
- Testing
- genioplasty using 3D printed patient specific titanium plates (study group), genioplasty using 3D milled patient specific titanium plates (control group)
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Microbiota
Descriptive Study of the Gene Count in Faecal Microbiota
The hypothesis of METARICH Study is that it is possible to draw up a profile of the faecal microbiota, which could contribute in the future to the characterisation of certain chronic pathologies.
- Trial name
- METARICH (NCT06955572)
- Testing
- Patients with colorectal cancer, Patients with Parkinson's disease, Patients with non-alcoholic steatohepatitis
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Type 2 Diabetes Mellitus
A Clinical Trial to Investigate Safety/Tolerability and Pharmacokinetics of DA-1229_01(Evogliptin/Metformin XR 2.5/500 mg x 2 Tablets) Compared to Co-administration of Evogliptin 5 mg and Metformin XR 1000 mg in Healthy Male Volunteers
This Phase I clinical study is to evaluate the safety/tolerability and pharmacokinetics of DA-1229_01(Evogliptin/Metformin XR 2.5/500 mg x 2 tablets).
- Trial name
- NCT02375139
- Testing
- DA-1229_01, E+M
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Dong-A ST Co., Ltd.
Maxillary Sinus Floor Elevation
Implant Placement With Corticocancellous Bone Block vs Mineralized Plasmatic Matrix in Maxillary Sinus Lifting
Maxillary sinus floor elevation is a predictable and effective procedure for increasing the height of the residual bone in the posterior maxilla.
- Trial name
- NCT06073912
- Testing
- Open sinus lifting, Collecting blood sample, Bone graft harvesting
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Stage IV Non-small Cell Lung Cancer
Randomized Controlled Clinical Study of Drug Therapy Combined With Thoracic Radiotherapy for Non-oligometastatic NSCLC
To investigate whether radiotherapy combined with drug therapy is beneficial to non- oligometastatic stage IV NSCLC
- Trial name
- NCT05176067
- Testing
- Thoracic Three-dimensional Radiotherapy
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Guizhou Medical University
Oily Skin
Evaluation of Dermal Acceptability and Comedogenic and Acnegenic Potential of a Cosmetic Product
This is a single-center, single-blind clinical study designed to evaluate the dermatological safety of a cosmetic product and to demonstrate the absence of comedogenic and acnegenic potential.
- Trial name
- NCT07768800
- Testing
- Blancy Pro
- Where
- Brazil
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Pharmacogenetics, Healthy
Typical Versus Atypical Antipsychotics; Occupation of Striatal Receptors and the Appearance of Extrapyramidal Symptomatology, in Healthy Volunteers
The purpose of this study is to determine in healthy volunteers treated with typical or atypical antipsychotics -AP-, the relationship between genetic polymorphisms in cytochrome genes CYP2D6 (*3, *4, *5, *6 and Nxn) and CYP3A5…
- Trial name
- APSEP (NCT01259973)
- Testing
- Risperidone, Haloperidol
- Where
- 2 sites in Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Multiple Sclerosis, Clinically Isolated Syndrome
AT RISK FOR MS - Clinical Conversion of Female Monozygotic Twins Discordant for CIS/MS
The definition of the most 'at-risk' population within highly susceptible groups would provide an opportunity for preemptive therapeutics.
- Trial name
- ARMS (NCT00617383)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
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