Clinical trials: Clinical Efficacy
Spine Disease, Spinal Fractures
Evaluation of the Safety and Efficacy of Smart Orthopedic Minimally Invasive Surgical Systems for Spinal Surgery
To evaluate the safety and effectiveness of the intelligent orthopedic minimally invasive surgery system developed by Shenzhen Xinjunte Intelligent Medical Equipment Co., Ltd. in spinal surgery.
- Trial name
- NCT04956588
- Testing
- surgical robot, controlled approach
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Dental Plaque, Gingivitis
A Clinical Study Investigating the Efficacy of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival Health
The aim of this study is to evaluate the ability of an experimental toothpaste, containing 0.454 percent (%) Stannous Fluoride (SnF2) to improve gingival health and reduce plaque accumulation compared to a regular fluoride…
- Trial name
- NCT07169188
- Testing
- Test Fluoride Toothpaste, Colgate Cavity Protection Toothpaste
- Where
- Canada
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- HALEON
Skin Aging
Clinical Trial to Assess Efficacy, Safety and Tolerability of Botulinum Toxin A (Xeomin®) in Treatment of Expression Wrinkles in the Upper Third of the Face
The purpose of this study is to determinate whether Xeomin® (Botulinum toxin Type A) is safe, effective and tolerable in woman aged 30 to 50 years old for treatment of mild, moderate or severe expression lines (wrinkles) in the…
- Trial name
- XEO-001/07 (NCT00986570)
- Testing
- Botulinum Toxin A
- Where
- Brazil
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Biolab Sanus Farmaceutica
Dental Anxiety in Children
Effectiveness of Puppet Modeling During Dental Emergency Visits on Dental Anxiety and Behavior of Children in a Subsequent Visit
The goal of this clinical trial is to learn if using a puppet in dental visits for children is an effective behavior guidance tool.
- Trial name
- NCT07736170
- Testing
- Puppet Play Therapy, Tell-Show-Do (TSD)
- Where
- Saudi Arabia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Melanoma
HL-085 in NRAS-mutated Advanced Melanoma
This was an open-label, single-arm, multi-center phase II clinical study, aimed at investigating the efficacy and safety of HL-085 capsule in the treatment of advanced melanoma patients with NRAS mutation.
- Trial name
- NCT05217303
- Testing
- HL-085
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Shanghai Kechow Pharma, Inc.
Grade 1 Follicular Lymphoma, Grade 2 Follicular Lymphoma
Pirtobrutinib and Mosunetuzumab for the Treatment of Relapsed/Refractory Grades 1-3A Follicular Lymphoma, PROMOTE-FL Trial
This phase II trial tests how well pirtobrutinib and mosunetuzumab work in treating patients with grade 1-3a follicular lymphoma (FL) that has come back after a period of improvement (relapsed) or that has not responded to…
- Conditions
- Grade 1 Follicular Lymphoma, Grade 2 Follicular Lymphoma, Grade 3a Follicular Lymphoma, Recurrent Follicular Lymphoma
- Trial name
- NCT06948786
- Testing
- Pirtobrutinib, Mosunetuzumab, Biospecimen Collection
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Washington
Acne Vulgaris
Cold Atmospheric Plasma for Moderate-to-severe Acne Vulgaris Study
Acne vulgaris is a common, chronic inflammatory skin disease with complex pathogenesis and limited therapeutic options, especially for moderate-to-severe cases.
- Trial name
- NCT07056673
- Testing
- Active CAP therapy, standard care based on the JAAD acne guidelines
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Shenyang Medical College
Cholesterolemia
Study To Evaluate The Efficacy And Safety Of A Nutritional Supplement Based On Bergamot, Artichoke And Other Ingredients For Reducing Cholesterol Levels In Patients With Hypercholesterolemia (Metachol+)
The goal of this clinical trial with food supplement is to evaluate the effectiveness of a nutritional supplement based on bergamot, artichoke and other ingredients through low-density lipoprotein (LDL) values after four months…
- Trial name
- METACHOL+ (NCT07178769)
- Testing
- ARKOSTEROL
- Where
- 7 sites in Spain
- Volunteers
- 207 people
- Sponsor
- Laboratoires Arkopharma
Diarrhea-predominant Irritable Bowel Syndrome, Irritable Bowel Syndrome of Diarrhea Type (IBS-D)
Evaluation of the Efficacy and Safety of Gelsectan in the Treatment of Diarrhea-predominant Irritable Bowel Syndrome
This clinical study aims to investigate the effectiveness and safety of Gelsectan, a treatment containing xyloglucan, in adults diagnosed with diarrhea-predominant irritable bowel syndrome (IBS-D) in Vietnam.
- Trial name
- GELIBS (NCT07000383)
- Testing
- Gelsectan, Antispasmodic Agent
- Where
- Vietnam
- Volunteers
- 90 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Type 2 Diabetes
Electrical Vestibular Nerve Stimulation (VeNS) Compared to Sham Control As a Means of Improving Glycemic Control in Adults with Type 2 Diabetes Mellitus
Trial Title A randomized, double blind sham controlled clinical trial to evaluate the efficacy of vestibular nerve stimulation (VeNS), together with a lifestyle modification program, compared to a sham control with a lifestyle…
- Trial name
- NCT04595968
- Testing
- Vestal DM Active device, Lifestyle modification
- Where
- 16 sites in United States, Ireland
- Volunteers
- 267 people
- Sponsor
- Neurovalens Ltd.
Parkinson's Disease (PD), Parkinsonian Disorders
ZR001 Chemogenetics Gene Therapy Study in Patients With Parkinson's Disease
This study aims to evaluate the safety, tolerability, and preliminary efficacy of ZR001, a novel chemogenetic gene therapy product, in patients with moderately advanced Parkinson's disease (PD).
- Trial name
- NCT07718659
- Testing
- ZR001
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Qianfoshan Hospital
Optic Atrophy
Study the Safety and Efficacy of Bone Marrow Derived Autologous Cells for the Treatment of Optic Nerve Disease
This is a Single arm, Single centre trial to check the safety and efficacy of bone marrow derived autologous mono nuclear cell(100 millions per dose )clinical trial to be conducted for 36 months in patients with optic nerve…
- Trial name
- OND (NCT01834079)
- Testing
- STEM CELL THERAPY
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chaitanya Hospital, Pune
Seasonal Allergic Rhinitis
Rupatifen Fumarate Capsules in Patients With Seasonal Allergic Rhinitis
This Phase Ⅲ randomized, double-blind, active- and placebo-controlled trial aims to assess the efficacy and safety of Rupatifen Fumarate Capsules for seasonal allergic rhinitis.
- Trial name
- NCT07711262
- Testing
- Rupatifen Fumarate Capsules, Rupatadine Fumarate Tablets
- Where
- 18 sites in China
- Volunteers
- 550 people
- Sponsor
- Fujian Mindong Rejuvenation Pharmaceutical Co., Ltd.
Nonalcoholic Steatohepatitis
Pentoxifylline in Patients With Nonalcoholic Steatohepatitis
One third of the population in the United States has nonalcoholic fatty liver disease (NAFLD). Nonalcoholic steatohepatitis (NASH), the progressive form of NAFLD, can lead to cirrhosis.Currently, there is no proven therapy for…
- Trial name
- NCT00590161
- Testing
- pentoxifylline (PTX)
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- Case Western Reserve University
Advanced Solid Cancers
A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially Beneficial for People With Advanced Solid Tumors Known to Express the Tumor Marker CA19-9
The main goal of this study is to evaluate the safety of BNT329 and to identify the best dose of BNT329. This will be done by measuring the number of side effects that participants experience and how severe they are.
- Trial name
- NCT07186842
- Testing
- BNT329, CA19-9-targeting monoclonal antibody
- Where
- 18 sites in United States, Australia and 3 more
- Volunteers
- 245 people
- Sponsor
- BioNTech SE
Diabetes Mellitus, Type 2
Regulatory Post Marketing Surveillance (rPMS) Study of Rybelsus (Oral Semaglutide) to Evaluate Safety and Effectiveness in Patients With Type 2 Diabetes Mellitus in Routine Clinical Practice in Korea
The aim of this study is to assess the safety and effectiveness of Rybelsus initiated according to label in adults with Type 2 Diabetes Mellitus (T2DM) under routine clinical practice conditions.
- Trial name
- NCT05714683
- Testing
- Semaglutide
- Volunteers
- 600 people
- Sponsor
- Novo Nordisk A/S
Rheumatoid Arthritis
99mTc-3PRGD2 SPECT/CT in Rheumatoid Arthritis Patients
This is an open-label SPECT/CT (single photon emission computed tomography/computed tomography) study to investigate the diagnosis and efficacy evaluation performance of 99mTc-3PRGD2 in rheumatoid arthritis patients.
- Trial name
- TRGDRA (NCT02723760)
- Testing
- 99mTc-3PRGD2
- Where
- China
- Volunteers
- 4 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Rheumatoid Arthritis
The Study of Abatacept in Combination With Etanercept
The Study was designed to look at the safety and efficacy of abatacept in combination with etanercept.
- Trial name
- NCT00162279
- Testing
- Abatacept
- Where
- 35 sites in United States
- Volunteers
- 141 people
- Sponsor
- Bristol-Myers Squibb
Takayasu Arteritis
Takayasu Arteritis Clinical Trial in China
To investigate the efficacy and safety of Leflunomide (LEF) versus placebo combined with prednisone for active Takayasu arteritis (TAK) in Chinese population.
- Trial name
- TACTIC (NCT02981979)
- Testing
- Leflunomide(LEF), Prednisone Acetate Tablets
- Where
- 6 sites in China
- Volunteers
- 116 people
- Sponsor
- Jiang lindi
Multiple Sclerosis, Neurogenic Bladder
Clinical Study of Solifenacin Succinate in Patients With Bladder Symptoms Due to Spinal Cord Injury or Multiple Sclerosis
A clinical study to evaluate the efficacy and safety of solifenacin in patients with bladder symptoms due to spinal cord injury or multiple sclerosis
- Conditions
- Multiple Sclerosis, Neurogenic Bladder, Spinal Cord Diseases
- Trial name
- SONIC (NCT00629642)
- Testing
- Solifenacin Succinate, Oxybutynin Hydrochloride
- Where
- 39 sites in Australia, Belgium and 9 more
- Volunteers
- 249 people
- Sponsor
- Astellas Pharma Inc
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