Clinical trials: Clinical High-risk
Non-Muscle-Invasive Bladder Cancer (NMIBC)
Disitamab Vedotin Plus Intravesical Mitomycin C in HER2-Expressing Intermediate- to High-Risk Non-Muscle-Invasive Bladder Cancer
This study aims to evaluate the efficacy and safety of intravenous administration of vedacitinib combined with intravesical instillation of mitomycin in treating patients with high-risk NMIBC with HER2 expression.
- Trial name
- NCT07646145
- Testing
- Disitamab Vedotin, Mitomycin C (MMC)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanxi Province Cancer Hospital
Anemia Postoperative
A Clinical Trial Assessing the Efficacy of Intravenous Iron for the Treatment of Anemia Following Cardiac Surgery
BACKGROUND Anemia and iron deficiency are highly prevalent in cardiac surgery patients. Both conditions may adversely affect postoperative rehabilitation.
- Trial name
- PICS (NCT04608539)
- Testing
- Ferric Derisomaltose, Ferrous sulfate, normal saline
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Michael Kremke
Brain and Central Nervous System Tumors
High Light and Low Light Dose PDT in Glioma
RATIONALE: Photodynamic therapy uses a drug, such as porfimer sodium, that becomes active when it is exposed to a certain kind of light. When the drug is active, tumor cells are killed.
- Trial name
- NCT00118222
- Testing
- porfimer sodium, adjuvant therapy, conventional surgery
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Case Comprehensive Cancer Center
Depressive Disorder
Augmentation of Interpersonal Psychotherapy With High-Definition Transcranial Direct Current Stimulation for Adolescent Depression
Depression is among the most prevalent psychiatric disorders, with an upward trend in its manifestation in younger individuals. In contrast to adult depression, adolescent depression often presents with longer attack durations…
- Trial name
- NCT06061653
- Testing
- IPT plus HD-tDCS
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Weight Gain
Growth of Preterm Infants Fed a Infant Milk Formula Containing High Versus Low Amounts of Beta-palmitate
The aim of this study is to assess weight gain of preterm infants (gestational age lower than 32 weeks) fed infant milk formula with about 60% beta-palmitate (EX_IMF) vs infant milk formula with similar macronutrient, mineral and…
- Trial name
- NCT04541095
- Testing
- EX_IMF, ST_IMF
- Where
- 2 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Ospedali Riuniti Ancona
Coronary Artery Disease, Myocardial Infarction
Mi-RNAs and Specificity of Hs-TnT in Symptomatic ED Patients
Biomarkers play a key role in the diagnostic workup of patients presenting to an emergency department (ED). European and American guidelines recommend cardiac Troponin (T or I) as the biomarker gold standard for the diagnosis of…
- Trial name
- NCT02116153
- Sponsor
- University Hospital Heidelberg
Breast Cancer
Indole-3-Carbinol in Preventing Breast Cancer in Nonsmoking Women Who Are at High Risk For Breast Cancer
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. Indole-3-carbinol may be effective in preventing breast cancer.
- Trial name
- NCT00033345
- Testing
- Indole-3-carbinol
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Kansas Medical Center
Breast Cancer, Chemotherapy Effect
Efficacy of Supplement Adjuvant Capecitabine in HR+/HER2- Breast Cancer Patients With High Risks
According to the latest data from the World Health Organization's International Agency for Research on Cancer (IARC) for 2020, breast cancer has been the most prevalent cancer with 2.26 million new cases.
- Trial name
- NCT05212454
- Testing
- Capecitabine
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Psychotic Disorders, Personality Disorders
The Staged Treatment in Early Psychosis Study
A sequential multistage randomised clinical trial (SMART) to produce evidence to guide a step-wise clinical approach for the treatment of ultra high risk patients and reduction of risk for psychosis and other deleterious clinical…
- Conditions
- Psychotic Disorders, Personality Disorders, Clinical High Risk
- Trial name
- STEP (NCT02751632)
- Testing
- Support and Problem Solving Therapy, Cognitive Behavioural Case Management, Fluoxetine
- Where
- 5 sites in Australia
- Volunteers
- 342 people
- Sponsor
- Orygen
Decision Support System, Outcome
Assisted Fluid Management (AFM) System and Postoperative Outcome After High-risk Abdominal Surgery
Goal directed fluid therapy (GDFT) or "Personalized fluid therapy" may benefit high-risk surgical patients but these strategies are infrequently implemented.
- Trial name
- PEFLA (NCT06011187)
- Testing
- Routine care, AFM
- Where
- 17 sites in United States, Belgium and 3 more
- Volunteers
- 2,007 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma
Measuring Small-Airways Disease Improvement After Step-up to Extrafine TRIple or High-dose ICS/LABA in Patients Uncontrolled on Medium Dose ICS/LABA eXploring T2 Inflammation
The goal of this observational study is to investigate the change in small airway function through the R5-R19 index in oscillometry at 12 weeks in adults with asthma.
- Trial name
- MATRIX (NCT07372521)
- Volunteers
- 130 people
- Sponsor
- University Hospital, Ioannina
Fibromyalgia (FM)
Exercise and Neuromodulation in Fibromyalgia
Exercise is recommended for people with fibromyalgia because it can reduce symptoms and improve quality of life. Some studies show that high-intensity exercises like running or cycling (also called high-intensity interval…
- Trial name
- NCT07323199
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION, Neuromodulators
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- Universidad Nacional Andres Bello
First Episode Psychosis (FEP), At Risk Mental State (ARMS)
Reducing the Duration of Untreated Psychosis in the United States
The goal of this project is to investigate whether a systematic screening approach for individuals with first episode psychosis (FEP) can substantially reduce Duration of Untreated Psychosis (DUP).
- Trial name
- NCT03369730
- Where
- 3 sites in United States
- Volunteers
- 94 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Respiratory Complication, Obstructive Sleep Apnea
Applying Best Clinical Practices to Patients at High Risk of Respiratory Complications
The purpose of this study is to: 1. Perform a retrospective analysis on data contained in the UCLA Perioperative Data Warehouse on the incidence of respiratory dysfunction in the post-operative care unit (PACU) before and after…
- Trial name
- NCT04263363
- Testing
- Sugammadex 100 MG/ML [Bridion]
- Where
- United States
- Volunteers
- 12,248 people
- Sponsor
- University of California, Los Angeles
Adjuvant Therapy in Patients With Hepatocellular Carcinoma (HCC) at High Risk of Recurrence After Curative Resection or Ablation
A Study to Evaluate Camrelizumab Plus Rivoceranib (Apatinib) Versus Camrelizumab as Adjuvant Therapy in Patients With Hepatocellular Carcinoma (HCC) at High Risk of Recurrence After Curative Resection or Ablation
A Trial to Evaluate the Efficacy and Safety of Camrelizumab Plus Rivoceranib (Apatinib) Versus Camrelizumab as Adjuvant Therapy in Patients with Hepatocellular Carcinoma (HCC) at High Risk of Recurrence After Curative Resection…
- Trial name
- NCT05367687
- Testing
- Camrelizumab、Rivoceranib, Camrelizumab
- Where
- China
- Volunteers
- 251 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Anesthesia, Intraocular Pressure
Intraocular Pressure, Optic Nerve Sheath Diameter and Optic Perfusion Pressure of Minimal Low and High-Flow Anesthesia
The aim of this clinical trial is to determine the effect of minimal low-flow versus high-flow anesthesia on intraocular pressure (IOP) by non-contact tonometry, optic nerve sheath diameter (ONSD) by USG and optic perfusion…
- Conditions
- Anesthesia, Intraocular Pressure, Nephrolithiasis
- Trial name
- NCT06684704
- Testing
- minimal and high flow anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Endocarditis
Early Valve Surgery Versus Conventional Treatment in Infective Endocarditis Patients With High Risk of Embolism
Infective endocarditis (IE) is associated with an overall in-hospital mortality rate of 15-25% and a high incidence of embolic events (20-50%).
- Trial name
- CHIRURGENDO (NCT03718052)
- Testing
- Early valve surgery (EVS), Conventional Care
- Where
- France
- Volunteers
- 73 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Migraine
Efficacy of Individualized Homeopathic Remedies on Migraine: a Randomized, Triple-blind, Placebo Controlled Study.
Migraine, a chronic and often lifelong neurological disorder, is the second leading cause of years lived with disability worldwide.
- Trial name
- HOMEOMIG (NCT05468801)
- Testing
- Individualized Homeopathic Remedy
- Where
- Argentina
- Volunteers
- 72 people
- Sponsor
- Hospital General de Agudos Bernardino Rivadavia
Cardiovascular Risk Factors
Clinical Intervention Study in the Primary Care Setting of Patients With High Plasma Fibrinogen (EFAP)
Objectives: To study the possible effects of an intensive lifestyle change program on, the plasma fibrinogen levels in patients with no cardiovascular disease, with a high fibrinogen and normal cholesterol levels, and moderate…
- Trial name
- EFAP (NCT01089530)
- Testing
- Lifestyle intensive group
- Where
- Spain
- Volunteers
- 436 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Various Advanced Cancer
An Investigational Immuno-therapy Study of Nivolumab, Compared to Placebo, in Patients With Bladder or Upper Urinary Tract Cancer, Following Surgery to Remove the Cancer
The purpose of this study is to determine the effectiveness and safety of Nivolumab compared to placebo in participants who have undergone radical surgery for invasive urothelial cancer.
- Trial name
- CheckMate 274 (NCT02632409)
- Testing
- Nivolumab
- Where
- 188 sites in United States, Argentina and 28 more
- Volunteers
- 709 people
- Sponsor
- Bristol-Myers Squibb
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