Clinical trials: Clinical Pain
Degenerative Disc Disease, Low Back Pain
VIA Disc NP Pilot for Patients With Symptomatic Degenerated Discs
VIA Disc NP is an allograft intended to supplement the nucleus pulposus tissue in degenerated intervertebral discs.
- Conditions
- Degenerative Disc Disease, Low Back Pain, Disc Degeneration
- Trial name
- NCT05201287
- Testing
- VIA Disc NP
- Where
- 6 sites in United States
- Volunteers
- 35 people
- Sponsor
- VIVEX Biologics, Inc.
Knee Pain, Chronic Osteoarthritis
ROSA Total Knee Post Market Study EMEA
This is a prospective, multicenter clinical study designed to facilitate the collection and evaluation of surgical workflow efficiency, patient pain and function outcome and adverse events data.
- Conditions
- Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities
- Trial name
- NCT04338893
- Testing
- Device: Persona Total Knee, Device: NexGen Total Knee, Device: Vanguard Total Knee
- Where
- 6 sites in Belgium, Germany and 3 more
- Volunteers
- 252 people
- Sponsor
- Zimmer Biomet
Pain, Acute Pain
A Clinical Study in Healthy Adults Who Sometimes Take Drugs for Pleasure to Investigate the Safety and Tolerability of GRT0151Y and to Find Out Which Single Dose of the Compound is Maximally Tolerated
The purpose of this study is to determine the maximum dose of GRT0151Y that is tolerable and to explore the safety profile of the drug. For each Treatment Period (Visits 2-5), dosing will be separated by at least one week.
- Conditions
- Pain, Acute Pain, Chronic Pain
- Trial name
- NCT03765658
- Testing
- GRT0151Y dose escalation
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Pain
A Phase Ⅲ Clinical Study Trial of Felbinac Trometamol Injection in China
A multi-center, randomized, double-blind, placebo parallel controlled phase Ⅲ clinical trial on the efficacy and safety of felbinac trometamol Injection in the treatment of moderate and severe postoperative pain.main purpose is…
- Trial name
- NCT04526132
- Testing
- Felbinac Trometamol Injection
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Shijiazhuang Yiling Pharmaceutical Co. Ltd
Pain, Acute, Pain, Chronic
Evaluation of the Effect of the AI500™ SINGLE-DOSE GEL Medical Device in Patients With Reduced Knee Function
Evaluation of the effect of the AI500™ SINGLE-DOSE GEL medical device in patients with reduced knee function
- Conditions
- Pain, Acute, Pain, Chronic, Knee Injuries, Knee Osteoarthritis
- Trial name
- NCT05886608
- Testing
- AI 500™ SINGLE-DOSE GEL
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Contrad Swiss SA
Diseases [C] - Musculoskeletal Diseases [C05
PRGF-ENDORET® Infiltrations in the Treatment of Low Back Pain.
The goal of this clinical trial is to evaluate the efficacy of PRGF in reducing pain and improving patients' quality of life. Researchers will compare an experimental drug (Plasma Rich in Growth Factors) to a control…
- Trial name
- NCT06715085
- Testing
- Plasma Rich in Growth Factors (PRGF), Corticosteroid solution (Celestone Cronodose suspension for injection) in saline solution.
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Biotechnology Institute IMASD
Acute Pain, Surgery
Prospective Observational Clinical Study to Evaluate Patient Outcomes Following Pharmacogenetic Testing of Patients Undergoing Elective Surgical Procedures
The purpose of this study is to evaluate the effect of pharmacogenetics (PGx) guided treatment when implemented into the pre-operative process for patients undergoing bowel surgery, major urologic procedure, or major ventral…
- Trial name
- NCT02605343
- Testing
- NeuroIDgenetix Test Panel
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- AltheaDx
Joint Diseases
Post Market Clinical Follow-Up Study for PROFEMUR® Preserve Classic Femoral Stem
Sponsor is conducting this post market clinical study to evaluate the safety and effectiveness of its PROFEMUR® Preserve Classic Femoral Stem.
- Trial name
- NCT04147559
- Testing
- Total Hip Arthroplasty Implant
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- MicroPort Orthopedics Inc.
Intestinal Stricture, Crohn Disease
NaviCam Patency Capsule to Verify Gastrointestinal Patency
Participants included in this study will first swallow a patency capsule and then undergo an abdominal X-ray scan within 30 hours after swallowing the capsule to confirm weather the capsule is still in the body.
- Conditions
- Intestinal Stricture, Crohn Disease, NSAID (Non-Steroidal Anti-Inflammatory Drug) Induced Enteropathy, Abdominal Pain
- Trial name
- PATENCY (NCT07649720)
- Testing
- NaviCam Patency Capsule
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- AnX Robotica Corp.
Pain, Postoperative
Phase II Clinical Trial to Evaluate the Efficacy and Safety of LPM3480392 Injection for Moderate to Severe Pain After Abdominal Surgery
A randomized, double-blind, placebo/positive drug parallel controlled design was used to evaluate the preliminary efficacy and safety of intravenous infusion of LPM3480392 injection using different dosing regimens in subjects…
- Trial name
- NCT06204120
- Testing
- LPM3480392 Injection, morphine hydrochloride injection
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Luye Pharma Group Ltd.
Knee Osteoarthritis
Post Marketing Clinical Follow up Study of HyaleXo
Hyaluronic acid is a polysaccharide naturally present in several human tissues such as cartilage. It is the major constituent of synovial fluid and provides its viscosity and elasticity.
- Trial name
- PMCF (NCT07096050)
- Testing
- HyaleXo
- Where
- Romania
- Volunteers
- 101 people
- Sponsor
- Yooyoung Pharmaceutical Co., Ltd.
Back Pain Lower Back Chronic
An Open Label Extension Study of Duloxetine (LY248686) in Participants With Chronic Low Back Pain
The purpose of the study is to assess the long term safety of duloxetine in participants with Chronic Low Back Pain (CLBP).
- Trial name
- NCT01914666
- Testing
- Duloxetine
- Where
- Japan
- Volunteers
- 151 people
- Sponsor
- Eli Lilly and Company
Pain, Postoperative
Dose-Escalation, Single Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GB-6002 Local Infiltration in Healthy Male Adults
This study is to evaluate the safety and tolerability of single dose of GB-6002 (Ropivacaine) Local Infiltration in healthy male Adults.
- Trial name
- NCT06095973
- Testing
- GB-6002, Naropin injection
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- G2GBio, Inc.
Pain, Pharmacokinetics
Clinical Study in Healthy Men to Investigate the Uptake of Buprenorphine and Its Elimination From the Body After Dermal Application as Patches for 96 Hours and for 72 Hours
The purpose of the study was to investigate the pharmacokinetics (i.e. the uptake, distribution and elimination from the body) of dermally applied buprenorphine during and after different application periods, i.e., a 96-hour and…
- Trial name
- NCT03770234
- Testing
- Transtec 35 µg/hour transdermal patch
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Diabetic Neuropathy, Neuropathic Pain
Extended-release Pregabalin for the Treatment of Neuropathic Pain in Patients With Diabetic Peripheral Neuropathy and Postherpetic Neuralgia
Extended-release Pregabalin for the Treatment of Neuropathic Pain in Patients With Diabetic Peripheral Neuropathy and Postherpetic Neuralgia
- Conditions
- Diabetic Neuropathy, Neuropathic Pain, Neuralgia, Postherpetic
- Trial name
- PRISE (NCT07712913)
- Testing
- Experimental: Pregabalin XR, Comparator: Dorene Tabs
- Where
- 15 sites in Brazil
- Volunteers
- 348 people
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Pain, Chronic
Efficacy and Safety of Canadá Association in the Treatment of Chronic Pain
The purpose of this study is to evaluate the efficacy and safety of Canadá association in the treatment of chronic pain
- Trial name
- CANADÁ (NCT05125978)
- Testing
- Canadá, Dipyrone, Tramadol hydrochloride
- Sponsor
- EMS
Primary Dysmenorrhea
Efficacy and Safety of DEH113 in the Treatment of Menstrual Cramp Pain in Primary Dysmenorrhea: a Pilot Study
This study aims to evaluate the preliminary efficacy and safety of DEH113 in the Treatment of Menstrual Cramps Pain Associated with Primary Dysmenorrhea.
- Trial name
- NCT06555549
- Testing
- DEH113
- Volunteers
- 60 people
- Sponsor
- EMS
Pain, Pain, Chronic
Establishing Clinical Utility of a New Diagnostic Test for Patients Suffering From Pain: A CPV® Randomized Controlled Trial
This study will collect high-quality data on how practicing primary care physicians across the U.S. currently manage patients experiencing chronic pain and how the results of Ethos Laboratories' test change clinical decision…
- Trial name
- NCT04266821
- Testing
- Experimental Arm
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Qure Healthcare, LLC
Muscle Soreness, Pain
Recovery and Muscle Function After Supplementation With Turmeric
The objective of the study is to test the capacity of a five-day supplementation of Turmipure Gold® to improve exercise-induced muscle pain and function recovery in moderately active adults after exercise-induced muscle damage
- Conditions
- Muscle Soreness, Pain, Muscle Damage
- Trial name
- RECOFAST (NCT04946981)
- Testing
- Turmipure Gold®
- Where
- Ireland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Givaudan France Naturals
Postural Low Back Pain, Mechanical Low Back Pain
To Evaluate the Superiority of Fixed Combination (Orfenadrine 35mg, Acetaminophen 325mg, Caffeine 65mg and Diclofenac Sodium 50mg) Compared to Voltaren® (Diclofenac Sodium 50mg) in the Treatment of Acute Postural Low Back Pain.
The purpose of this study is to determine whether the fixed combination of orphenadrine, acetaminophen, caffeine and diclofenac sodium is more effective in the treatment of an acute episode of mechanical postural low back pain…
- Trial name
- Eiffel (NCT02985671)
- Testing
- orphenadrine, acetaminophen, caffeine and diclofenac sodium, Diclofenac Sodium 50 MG
- Volunteers
- 110 people
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.