Clinical trials: Clinical Pain
Total Knee Arthroplasty
REST-Knee: A Pilot RCT of 72-Hour Knee Immobilization and Pain Outcomes
Postoperative pain following total knee arthroplasty (TKA) is often difficult to manage, particularly with the increasing use of outpatient surgery where patients recover at home.
- Trial name
- REST-Knee (NCT07511842)
- Testing
- Knee Extension Brace (Zimmer-type), Early Mobilization (Standard Care)
- Where
- Canada
- Volunteers
- 106 people
- Sponsor
- Université de Sherbrooke
Chronic Pain, Pain
A Study of Cebranopadol for Opioid Withdrawal Symptoms in Adults With Chronic Pain
This Phase 2 study will evaluate whether multiple doses of cebranopadol suppress opioid withdrawal signs and symptoms compared with placebo in adults with chronic pain who are physically dependent on prescribed opioids.
- Conditions
- Chronic Pain, Pain, Opioid Withdrawal (Disorder), Opioid Use Disorder
- Trial name
- NCT07874620
- Testing
- Cebranopadol
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Adneuris Therapeutics, Inc.
Urologic Diseases, Urodynamics
The Effect of Different Education Methods Before Invasive Urodynamics
Aim: This study was carried out to compare the effects of different education methods utilized before a urodynamic testing procedure on patients' pain, anxiety, readiness for the procedure, and satisfaction.
- Trial name
- NCT05522686
- Testing
- Patients in the Brochure Education Group, Patients in the Video Education Group, Patients in the Brochure-Supported Video Education Group
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Pain Relief
Oral Hyoscine Butyl Bromide With Cervical Lidocaine Cream in Reducing Pain During Hysterosalpingography
hysterosalpingography is a diagnosis procedure in the evaluation of infertile women and considered to be the traditional and the gold standard in the assessment of the patency of the fallopian tubes.
- Trial name
- HBTB (NCT02710305)
- Testing
- oral hyoscine butyl bromide tablets plus lidocaine cream
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Assiut University
Psychological Disorders, Hip Pain Chronic
The Differences in the Psychological States of Patients with Different Chronic Hip Pain
Nowadays, studies related to the psychological state of patients with chronic hip pain are still limited, and there is a lack of research on the characteristics of the psychological state of patients with chronic soreness from…
- Trial name
- NCT06611722
- Testing
- Psychological and Functional Assessment
- Where
- China
- Volunteers
- 70 people
- Sponsor
- ChunBao Li
Vulvodynia
A Randomized Clinical Trial for Women With Vulvodynia
This study will evaluate the relative effectiveness of cognitive-behavioral therapy and supportive psychotherapy for the treatment of women with vulvodynia.
- Trial name
- NCT00607490
- Testing
- Cognitive-Behavioral Therapy, Supportive Psychotherapy
- Volunteers
- 50 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Plantar Fascitis, Myofacial Pain Syndromes
A Comparative Study of Two Dry Needling Interventions for Plantar Heel Pain
This is a clinical trial that will be done in the state of Kuwait, at the physical rehabilitation medicine hospital. the participants will be recruited from all over Kuwait, there is a clinical registry upon the ethical committee…
- Conditions
- Plantar Fascitis, Myofacial Pain Syndromes, Trigger Point Pain, Myofascial
- Trial name
- NCT03236779
- Testing
- dry needling
- Where
- Kuwait
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Pain
Assess the Efficacy and Safety in Volunteers of DCF100, TIB200 and SPR300 vs. Placebo and Control(s) in a UV Pain Model
This is a randomised, double blind, cross over clinical study in healthy human volunteers (including pharmacokinetic [PK] sampling and laser Doppler assessment of local blood flow in a subset of up to 6 subjects per cohort of 20)…
- Trial name
- NCT02666846
- Testing
- Ibuprofen, Diclofenac, Methyl-salicylate / Menthol
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Futura Medical Developments Ltd.
Migraine, Dysmenorrhea
Discussion on the Mechanism of Acupuncture on Patients with Paroxysmal Migraine Without Aura : a Randomized Controlled Clinical Trial
Background: Migraine is common but poorly managed with drugs. Acupuncture, a non-pharmacological approach, has shown promise, yet its mechanisms remain unclear.
- Trial name
- NCT06676670
- Testing
- real acupuncture
- Where
- China
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Bo Huang
Cancers, Chronic Pain
The Clinical Evaluation of Implantable Pump System For Safety And Delivery Accuracy In Patients Requiring Intrathecal Administration Of Morphine Sulfate For Chronic Pain
The objectives of this study are to confirm the medication delivery accuracy of the Infusion System, LLC Implantable Drug Delivery System (IDDS) with Patient Controlled Analgesia for intrathecal delivery of morphine sulfate for…
- Trial name
- NCT01185470
- Testing
- Implantation of Morphine Sulfate delivering programmable pump
- Where
- 9 sites in United States
- Volunteers
- 75 people
- Sponsor
- Medallion Therapeutics, Inc.
Apical Periodontitis
N-acetylcysteine for Root Canal Treatment of Necrotic Teeth With Apical Periodontitis
A randomized controlled trial comparing the postoperative pain intensity, periapical biomarkers level, and periapical healing in patients with necrotic mature teeth and apical periodontitis treated with N-acetylcysteine (NAC), as…
- Trial name
- NAC (NCT07262554)
- Testing
- Calcium hydroxide (Ca(OH)₂), N-Acetylcysteine (NAC)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alexandria University
Post Operative Pain Control
Duloxetine and Dexamethasone for Improving Postoperative Pain
75 female patients were randomly allocated into one of three equal groups. Group I(GI) received Dulox 60 mg orally and 100 ml 0.9% sodium chloride solution (NS) intravenous infusion (IVI) over 15 min, group II(GII): received…
- Trial name
- NCT03250494
- Testing
- Dulox capsule (60mg), combined Dulox capsule (60 mg) orally and Dex 0.1mg/kg diluted in 100 ml 0.9% NS IVI
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Asthma Bronchiale, Breast Neoplasms
Digital Implementation of the German S3 Clinical Practice Guideline for Multimorbidity
The web application gp-multitool.de is a digital tool for implementing the German S3 clinical practice guideline for multimorbidity of the German Society of General Practitioners and Family Physicians in primary care.
- Conditions
- Asthma Bronchiale, Breast Neoplasms, Coronary Disease, Diabetes Mellitus, Type 2
- Trial name
- NCT06831994
- Testing
- gp-multitool.de
- Where
- Germany
- Volunteers
- 659 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Rotator Cuff Tendinosis, Rotator Cuff Injuries
Effectiveness of Non-surgical Management in Rotator Cuff Calcific Tendinopathy (THE EFFECT TRIAL)
The aim of this study will be to compare the effectiveness of an exercise therapy program with extracorporeal shockwave therapy, ultrasound-guided percutaneous irrigation and a wait and see approach in people with rotator cuff…
- Conditions
- Rotator Cuff Tendinosis, Rotator Cuff Injuries, Shoulder Tendinitis, Calcific Shoulder Tendinitis
- Trial name
- EFFECT (NCT05478902)
- Testing
- Exercise Therapy, Extracorporeal Shockwave Therapy, Ultrasound-Guided Percutaneous Irrigation
- Where
- 2 sites in Spain
- Volunteers
- 116 people
- Sponsor
- University of Valencia
Anxiety, Stress
Music Therapy and Pre-recorded Music on Patients and Caregivers in the Emergency Unit
Patients and caregivers attending emergency units often experience elevated levels of stress and anxiety. Music has been used in waiting rooms to reduce stress and anxiety, but existing studies on music in emergency unit waiting…
- Conditions
- Anxiety, Stress, Well-Being, Psychological
- Trial name
- NCT06510153
- Testing
- Environmental Music Therapy, Pre-recorded music, Standard care only
- Where
- 2 sites in Colombia
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Claudia Aristizábal
Pelvic Pain, Abdominal Pain
Female Chronic Pelvic Pain
The purpose of this study is to investigate the frequency and severity of chronic pelvic pain (CPP) in adult women living in Copenhagen Country and Zealand Country (total population 2,4 million), Denmark, in relation to selected…
- Conditions
- Pelvic Pain, Abdominal Pain, Painful Bladder Syndrome, Interstitial Cystitis
- Trial name
- Female CPP (NCT01255345)
- Testing
- Chronic pelvic pain
- Where
- Denmark
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital at Herlev
Total Knee Replacement
A Study to Compare Different Ways of Steroid Administration After Total Knee Implantation
We are going to evaluate the difference between perioperative intravenous steroid supplementation, perioperative periarticular steroid supplementation, and standard anaesthesia protocols.
- Trial name
- NCT04432012
- Testing
- Dexamethasone Sodium Phosphate 4 mg/ml intravenous, Dexamethasone Sodium Phosphate 4 mg/ml intra-articular
- Where
- Switzerland
- Volunteers
- 159 people
- Sponsor
- Christian Candrian
Post Operative Pain
Ultrasound vs. Surgical ESP Block With Bupivacaine-Dexmedetomidine in Lumbar Fusion Surgery
Lumbar spine surgery causes intense post-op pain, peaking within 12 hours and improving by day three. Traditional spinal procedures involve extensive tissue dissection, leading to severe pain and potential complications like…
- Trial name
- NCT06958718
- Testing
- Ultrasound Guided erector spinae plane block (UB), Surgical erector spinae plane block (SB), Dexmedetomidine
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Fayoum University Hospital
Posttraumatic Stress Disorder
Neurosteroids for Treatment of PTSD in Veterans
This study seeks to determine if pregnenolone can improve symptoms of PTSD and other symptoms that commonly occur with PTSD in Iraq/Afghanistan-era Veterans. The total study duration for each participant is 10 weeks.
- Trial name
- NCT03799562
- Testing
- Pregnenolone
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- VA Office of Research and Development
Osteoarthritis, Knee, Pain, Chronic
Management of Knee Pain by Cooled Radiofrequency in Classical Anatomical Targets and Revised Targets
Osteoarthritis (OA) is a chronic and progressive disease that results from characteristic pathological changes in the tissues of the entire joint, resulting in failure in the component parts.
- Conditions
- Osteoarthritis, Knee, Pain, Chronic, Analgesia
- Trial name
- NCT05363241
- Testing
- Cooled radiofrequency in classical targets (CRF-CT), Cooled radiofrequency in revised targets (CRF-RT)
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Universidade Federal de Alfenas
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