Clinical trials: Clinical Practice Guidelines
Hiv
Antiretroviral Therapy Selection: Comparing HIV Clinical Guidelines With HIV-ASSIST, an Online Decision-support Tool
HIV-ASSIST is an online decision support tool created by Johns Hopkins faculty that utilizes standard patient variables, and provides treatment recommendations and tailored educational content to assist providers learn HIV…
- Trial name
- NCT04080765
- Testing
- HIV-ASSIST, DHHS guidelines
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Johns Hopkins University
The Study Goal is to Assess the Introduction of Sustainable Family Planning/Reproductive Health Information and Services Through, Land O' Lakes-supported Dairy Cooperatives
Family Planning Through Dairy Cooperatives
This observational study will assess a model for providing family planning through quarterly events organized by dairy cooperatives supported by Land O'Lakes in Kenya.
- Trial name
- NCT01226433
- Where
- Kenya
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- FHI 360
Systemic Lupus Erythematosus
Multicomponent Strategy to Implement a Clinical Practice Guideline and Improve Health Outcomes in People With SLE
Principal objective: To produce scientific knowledge on the effectiveness and cost-effectiveness of a multicomponent intervention for knowledge transfer and implementing a Clinical Practice Guideline (CPG) for Systemic Lupus…
- Trial name
- NCT03537638
- Testing
- Multicomponent intervention
- Where
- Spain
- Volunteers
- 237 people
- Sponsor
- Servicio Canario de Salud
Depression
Controlled Study About Implementation of a Computerized Depression Guideline in Primary Care
The aim of this study is to evaluate the effects of an active multifactor implementation process of a Computerized Depression Guideline in Primary Care.
- Trial name
- GPC-DEPc (NCT02328833)
- Testing
- Experimental strategies of guidelines implementation
- Volunteers
- 10 people
- Sponsor
- Corporacion Parc Tauli
Diabetes, Prediabetes
Meta-analyses of Pasta as Part of Low Glycemic Index Diets and Adiposity
Pasta is an important example of a food which can lower the glycemic index (GI) of the diet, a property that has been exploited extensively in studies of low GI dietary patterns.
- Conditions
- Diabetes, Prediabetes, Overweight, Obesity
- Trial name
- NCT02961088
- Testing
- Pasta as part of a low GI/GL diet
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Head Injury Trauma, Traumatic Brain Injury, Mild
The PIONEER Comparative Effectiveness Study - Project 2
This is a pragmatic, open-label, multicenter, stepped-wedge, Type II hybrid effectiveness-implementation study. It is designed to evaluate both the comparative effectiveness and implementation feasibility of a…
- Trial name
- NCT07829107
- Testing
- Clinical pathway 1: Guidelines plus biomarkers, Clinical guidelines only
- Where
- 6 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- University of Michigan
Acute Pancreatitis, Acute Pancreatic Necrosis
coMpliAnce With evideNce-based cliniCal Guidelines in the managemenT of Acute biliaRy pancreAtitis
Acute pancreatitis (AP) is an inflammatory disease of the pancreas, most commonly caused by gallstones, or excessive use of alcohol. It represents a management challenge and a significant healthcare burden.
- Conditions
- Acute Pancreatitis, Acute Pancreatic Necrosis, Acute Pancreatitis Due to Gallstones, Acute Pancreatic Fluid Collection
- Trial name
- MANCTRA-1 (NCT04747990)
- Testing
- Early Definitive Treatment
- Where
- 3 sites in Italy, Spain
- Volunteers
- 600 people
- Sponsor
- University of Cagliari
Decision Support Techniques, GRADE Approach
Defining Decision Thresholds for Judgments on Health Benefits and Harms: Study Protocol
The objective of this study is an approach to derive and use decision-thresholds for judgments on health benefits and harms using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Evidence to Decision…
- Trial name
- NCT05237635
- Testing
- descriptive case-scenarios
- Where
- Canada
- Volunteers
- 1,406 people, healthy volunteers welcome
- Sponsor
- McMaster University
Evidence Based Practice, Stroke
Adherence to Stroke Rehabilitation Guidelines Among Physical Therapists and Internship Students
The goal of this observational study is to learn about adherence to the 2024 VA/DoD Clinical Practice Guidelines for Stroke Rehabilitation among Turkish physiotherapists and internship students treating post-stroke patients.
- Conditions
- Evidence Based Practice, Stroke, Physical Therapist
- Trial name
- NCT07044817
- Testing
- Stroke Rehabilitation Guideline Adherence Survey
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Medipol University
Infection Due to Indwelling Urinary Catheter, Asymptomatic Bacteriuria
Asymptomatic Bacteriuria Guideline Implementation Study
Overtreatment of asymptomatic bacteriuria (ABU) is a quality, safety, and cost issue, particularly as unnecessary antibiotics lead to emergence of resistant pathogens.
- Trial name
- ABU (NCT01052545)
- Testing
- Audit-Feedback
- Where
- United States
- Volunteers
- 1,598 people
- Sponsor
- VA Office of Research and Development
Diabetes Mellitus, Cardiovascular Disease
Evaluation of a Toolkit to Improve Cardiovascular Disease Screening and Treatment for People With Diabetes
Diabetes is a common and serious chronic disease. However, there is a large gap between the level of care that people should receive (based on research and guidelines) and the level of care they actually receive.
- Trial name
- NCT01411865
- Testing
- Toolkit, Control
- Where
- Canada
- Volunteers
- 933,789 people
- Sponsor
- Sunnybrook Health Sciences Centre
Clinical Decision Support, Clinical Practice Guidelines
Professional Development in Emergency Medical Services
The ProDEms-trial focuses on nurses and ambulance drivers working in prehospital care, taking care on the one hand of patients suffering from time-sensitive critical conditions like STEMI, acute stroke or severe traumatic brain…
- Conditions
- Clinical Decision Support, Clinical Practice Guidelines, Emergency Medical Services
- Trial name
- ProDEms (NCT02365792)
- Testing
- Clinical Decision Support Tool for Prehospital Care
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- KU Leuven
Heart Failure, Heart Failure With Reduced Ejection Fraction
Evaluating Strategies to Improve Guideline Directed Medical Therapy: The GDMT Research, Education & Assist Trial for Heart Failure Care
Heart failure with reduced ejection fraction (HFrEF) is associated with high mortality and adverse events (hospitalization or urgent outpatient visits for HF), along with diminished quality of life.
- Trial name
- GREAT-HF Care (NCT05990296)
- Testing
- Multiprong CDS with referral to pharmacist co-management, Multiprong CDS with GDMT order set, Focused education
- Where
- United States
- Volunteers
- 4,306 people
- Sponsor
- Geisinger Clinic
Atrial Fibrillation
Integrated Management Program Advancing Community Treatment of Atrial Fibrillation
Research Question: Among community-based patients with AF, does providing an integrated Clinical Decision Support System (CDSS) to providers and patients improve process of care and clinical outcomes, and decrease the healthcare…
- Trial name
- IMPACT-AF (NCT01927367)
- Testing
- Clinical Decision Support System for AF
- Where
- 2 sites in Canada
- Volunteers
- 1,145 people, healthy volunteers welcome
- Sponsor
- Jafna L Cox
Guidelines, Diabetes Mellitus Type 2
Adherence to Clinical Guidelines for Management of Patients With Type 2 Diabetes Mellitus and Obesity
Observational study in physicians regarding their adherence to clinical guidelines (by American Diabetes Association 2025) for the management of type 2 diabetes mellitus and obesity via questionnaire
- Conditions
- Guidelines, Diabetes Mellitus Type 2, Obesity Type 2 Diabetes Mellitus, Obesity (BMI > 35) and Diabetes Mellitus
- Trial name
- NCT07839546
- Testing
- Questionnaire regarding the adherence to American Diabetes Association
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Pit-and-Fissure Sealants
An Implementation Strategy for the Adoption of an Evidence-Based Guideline for Pit-and-Fissure Sealants
The purpose of this implementation science study is to determine whether Deliberative Loops are effective in increasing providers' adherence to the non-cavitated caries component of the American Dental Association's…
- Trial name
- DISGO (NCT04682730)
- Testing
- Deliberative Loop
- Where
- United States
- Volunteers
- 896 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Osteoporosis
Gaining Optimal Osteoporosis Assessments in Long-Term Care (GOAL)
The aim of this study is to disseminate the 2010 Osteoporosis Canada clinical practice guidelines, using a multi-faceted Knowledge Translation (KT) model, as KT aims to close the gap between knowledge generated from research and…
- Trial name
- GOAL (NCT01887392)
- Testing
- Knowledge Translation Education Sessions
- Where
- Canada
- Volunteers
- 6,800 people
- Sponsor
- McMaster University
Diabetes Mellitus, Cardiovascular Disease
Evaluation of a Toolkit to Improve Cardiovascular Disease Screening and Treatment for People With Type 2 Diabetes
Diabetes is a common and serious chronic disease. However, there is a large gap between the level of care that people should receive (based on research and guidelines) and the level of care they actually receive.
- Trial name
- NCT01026688
- Testing
- Toolkit, Control
- Where
- Canada
- Volunteers
- 1,592 people
- Sponsor
- Sunnybrook Health Sciences Centre
Relapsed and Refractory Multiple Myeloma
Retrospective Viability Study of the PETHEMA-POMCIDEX Clinical Practice Guidelines for the Treatment of Patients With Relapsed and Refractory Multiple Myeloma (RRMM)
Multiple myeloma (MM) is a plasma cell neoplasm representing the second most common type of hematologic tumor after lymphomas. The incorporation of novel agents such as bortezomib, lenalidomide, or thalidomide into first-line…
- Trial name
- NCT03477643
- Where
- 27 sites in Spain
- Volunteers
- 110 people
- Sponsor
- PETHEMA Foundation
Knee Osteoarthritis
Non-Surgical Management of Knee Osteoarthritis in the Military Health System (MHS)
This study will compare two different treatment approaches for the management of knee osteoarthritis (OA). All subjects will receive a standardized approach consistent with the core set of recommendation from the Department of…
- Trial name
- NCT03747393
- Testing
- DoD/VA CPG Core Set + PT, DoD/VA CPG Core Set
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Brooke Army Medical Center