Clinical trials: Clinical Study - RCT, open to volunteers
Pain After Surgery, Anxiety After Surgery
Using Mindfulness in an Enhanced Recovery After Surgery Protocol to Support Recovery After Colorectal Surgery
This study teaches participants who are having colorectal surgery how to use mindfulness to feel calmer and manage pain better. Participants will be randomized (like a flip of a coin) into one of two groups: Mindfulness…
- Trial name
- NCT07026786
- Testing
- Mindfulness Intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University Hospitals Cleveland Medical Center
Poor Ovarian Response, PRP Injection
A RCT Study on Autologous PRP Injection in Patients With POR
Poor ovarian response (POR) is a pathological condition where the ovaries do not respond well to the stimulation of gonadotropins.
- Trial name
- NCT07282314
- Testing
- PRP injection
- Volunteers
- 142 people
- Sponsor
- Peking University Third Hospital
MCRC
"Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer"
This is a multicenter, open-label, prospective, randomized controlled Phase II clinical study. All eligible subjects will be randomly assigned in a 1:1 ratio to either the triple therapy group or the double therapy group.
- Trial name
- THYMI (NCT06829355)
- Testing
- Thymalfasin (Thymosin alpha 1, Ta1), Regorafenib (BAY 73-4506), Tislelizumab (BGB-A317)
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Beijing Friendship Hospital
Preterm Birth, Caffeine
Caffeine for Infants Born at 28 to 34 Weeks Receiving Respiratory Support
The goal of this pilot clinical trial is to test if it is possible to conduct a larger study on the use of caffeine in preterm infants who need help with their breathing.
- Conditions
- Preterm Birth, Caffeine, Neonatal Outcomes
- Trial name
- CARES-Pilot (NCT07456670)
- Testing
- Caffeine
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- Queen's University
Essential Tremor, Deep Brain Stimulation
Multicentre RCT of Awake Versus Asleep Tractography Based DBS for ET
Rationale: Deep brain stimulation (DBS) of the thalamus is an effective surgical treatment for patients with disabling essential tremor, despite optimal pharmacological treatment.
- Conditions
- Essential Tremor, Deep Brain Stimulation, Diffusion Tensor Imaging, Magnetic Resonance
- Trial name
- TREMBLE (NCT05968976)
- Testing
- Awake DBS, Asleep DBS
- Where
- Netherlands
- Volunteers
- 110 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Elderly Patients, Polypathology
Personalized Digital Remote Monitoring for Elderly Patients
Objective This clinical investigation aims to evaluate whether the EPOCA Remote Monitoring System (RMS) enhances care for elderly patients with multiple chronic conditions and reduces unplanned hospitalizations.
- Conditions
- Elderly Patients, Polypathology, Multiple Chronic Conditions
- Trial name
- EPOCARE (NCT06845917)
- Testing
- Remote Patient Monitoring system
- Volunteers
- 700 people
- Sponsor
- EPOCA U&I
Fatty Liver Disease
Synbiotics Impact on Insulin and TNF-α in MAFLD: a Gut Microbiota Profile Analysis
Primary Objective: To analyze the effect of synbiotic supplementation on metabolic profile, insulin and TNF-α and gut microbiota changes in patients with Metabolic dysfunction-Associated Fatty Liver Disease (MAFLD).
- Trial name
- NCT06585982
- Testing
- Treatment, Control
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Diponegoro
Frequent Episodic Tension-Type Headache
Treatment of Tension-type Headache by Zhixuan Analgesic Tablets
The goal of this clinical trial is to learn if Zhixuan Analgesic Tablet works to treat frequent episodic tension-type headache in adults aged 18-60 years. It will also learn about the safety of Zhixuan Analgesic Tablet.
- Trial name
- NCT07872943
- Testing
- Zhixuan Analgesic Tablet
- Where
- China
- Volunteers
- 212 people
- Sponsor
- Tongji Hospital
Personality Disorder, Borderline, Personality Trait
Bridging Affect Consciousness, Mentalization and Trauma- Exploring an Integrative Treatment Approach for Personality Disorder (PD).
Study background: Specialized Group Outpatient Clinic within specialist mental health services, tailoring two year group treatment programmes for severe Avoidant PD (AvPD) and Borderline PD (BPD) with Affect Consciousness (AC)…
- Conditions
- Personality Disorder, Borderline, Personality Trait, Personality Disorder, Personality Type
- Trial name
- NCT06983002
- Testing
- Experimental group: AC-group therapy intervention., Control group 1: Body Awareness Group., Control group 2: Art Psychotherapy group.
- Where
- Norway
- Volunteers
- 300 people
- Sponsor
- Helse Stavanger HF
Breast Cancer Screening, Breast Carcinoma in Situ
Women Informed to Screen Depending on Measures of Risk (Wisdom Study)
Most physicians still use a one-size-fits-all approach to breast screening in which all women, regardless of their personal history, family history or genetics (except BReast CAncer gene (BRCA) carriers) are recommended to have…
- Conditions
- Breast Cancer Screening, Breast Carcinoma in Situ, Breast Cancer
- Trial name
- WISDOM (NCT02620852)
- Testing
- Complete a health questionnaire, Provide a saliva sample for genetic testing, Screening advice based on a comprehensive risk assessment
- Where
- 11 sites in United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Inflammatory Bowel Diseases, Ulcerative Colitis
Personalized B-fructan Diet in Inflammatory Bowel Disease Patients
This study aims to examine patient tolerability of personalized dietary fibre consumption recommendations (high-pectin diet versus high-B-fructan diet based on personalized responses), provided by an IBD dietician, based on our…
- Trial name
- NCT05615779
- Testing
- Randomized B-fructan diet, Personalized pectin diet, Personalized B-fructan diet
- Where
- 2 sites in Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Perinatal Mental Health, Gestational Weight Gain
Healthy Adaptation to Pregnancy, Postpartum and Parenthood
Healthy Adaptation to Pregnancy, Postpartum and Parenthood (HAP3) The HAP3 study is evaluating a new digital support program for pregnant women and their partners.
- Conditions
- Perinatal Mental Health, Gestational Weight Gain, Postpartum Weight Retention, Child Development
- Trial name
- HAP3 (NCT07837193)
- Testing
- HAP3 Family App
- Where
- Belgium
- Volunteers
- 572 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Neck Pain
Neck Movement Training in a Virtual Reality Headset for People with Neck Pain - a Feasibility Study
The goal of this clinical trial is to learn if a virtual reality (VR) intervention for people with chronic neck pain is feasible.
- Trial name
- NCT06832748
- Testing
- VR neck training, Endurance neck training
- Volunteers
- 20 people
- Sponsor
- Luleå Tekniska Universitet
Nicotine Use Disorder
Real-time eCounselling for Nicotine Addiction
The goal of this clinical trial is to pilot an eHealth intervention (real-time telecounselling) in nicotine addiction. The main questions it aims to answer are: Is the intervention likely to be efficacious in preventing an…
- Trial name
- NCT06544057
- Testing
- CBT-MI
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Overcome
Type 2 Diabetic Patients
A Study Comparing Degu Insulin Liraglutide Injection With Premixed Insulin on the Prognosis of Diabetes Mellitus
A randomized open, positive parallel controlled clinical study design was adopted. Participants were randomly assigned 1:1 according to inclusion criteria and exclusion criteria into two treatment regiments: Delu insulin…
- Trial name
- TLI vs PMI (NCT06925334)
- Testing
- Degludec insulin
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Thumb Osteoarthritis, Thumb Carpometacarpal Joint Osteoarthritis
Surgery for Thumb Base Osteoarthritis: Joint Replacement vs. Trapeziectomy
The goal of this clinical trial is to learn if the surgical method with total joint arthroplasty, (TOUCH joint prosthesis), is as good as or better than the traditional surgical method, trapezectomy, to treat thumb base joint…
- Conditions
- Thumb Osteoarthritis, Thumb Carpometacarpal Joint Osteoarthritis, Carpometacarpal (CMC) Joint Arthritis, Basal Thumb Osteoartrithis
- Trial name
- BASTION (NCT07569549)
- Testing
- Implantation of trapeziometacarpal prosthesis, Trapeziectomy with Capsuloplasty
- Where
- Sweden
- Volunteers
- 84 people
- Sponsor
- Uppsala University
Lung Cancer, Small Cell
A Study on the Efficacy of Atezolizumab Combined with Chemotherapy
This is a multicenter phase III simulated RCT study aimed to compare the efficacy and safety of atezolizumab combined with chemotherapy versus placebo combined with chemotherapy in small cell lung cancer.
- Trial name
- NCT06780826
- Testing
- Atezolizumab, Etoposide, Carboplatin
- Where
- China
- Volunteers
- 1,430 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Cartilage Defects, Talus Osteochondral Defect
A RCT of Collagen Scaffold for the Repair of Talus Cartilage Injury
The goal of this clinical trial is to test whether adding a collagen protein scaffold can improve cartilage repair of talus injury, compared to standard surgery alone.
- Trial name
- NCT07917806
- Testing
- Collagen Scaffold (Colla-Plug), microfracture
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Jishuitan Hospital
Knee Osteoarthritis
Allogenic Mesenchymal Stem Cell Intraarticular Injection for Knee Osteoarthritis Therapy
This phase I and II double blinded randomized clinical controlled trial investigates the safety and efficacy of intraarticular knee injection with allogenic adipose derived mesenchymal stem cells (AD-MSC), in patients suffering…
- Trial name
- STEMJOINT (NCT05933434)
- Testing
- Allogenic adipose derived mesenchymal stem cells (AD-MSC), Saline
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Aarhus University Hospital
Severe Emphysema
A Multi-center RCT to Evaluate Subsegmental BTVA Treatment for Severe Emphysema
To compare the efficacy and safety of subsegmental treatment and segmental treatment with InterVapor in patients with severe emphysema
- Trial name
- BTVA (NCT06152107)
- Testing
- BTVA treatment plus optimal medical therapy (GOLD guidelines)
- Where
- 9 sites in China
- Volunteers
- 100 people
- Sponsor
- Shanghai Chest Hospital