Clinical trials: Closed Head Trauma
Insomnia, Concussion Post Syndrome
Post-Concussion Sleep and Brain-heart Functions
This project is designed as a randomized controlled trial (RCT), with an active control group. Sleep and heart rate will be monitored at home for 1 week before and after the intervention.
- Trial name
- CBT-pI (NCT07636408)
- Testing
- CBT-pI, Sleep Hygiene
- Volunteers
- 70 people
- Sponsor
- University of Ottawa
Concussion, mTBI
Neurofeedback Impact on Veterans With mTBI
This study will evaluate neurofeedback (NFB) training as a low risk, non-invasive, effective treatment for Veterans diagnosed with mild traumatic brain injury (mTBI) and experiencing chronic post-concussive symptoms (PCSs).
- Conditions
- Concussion, mTBI, Post-Concussive Symptoms, Chronic Headache
- Trial name
- NFBVETmTBI (NCT04195685)
- Testing
- Neurofeedback (NFB)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- VA Office of Research and Development
Epilepsy, Functional Neurological Disorder
EXercise-induced PhysioLogical Adaptations In Neurological Disorders
The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers.
- Conditions
- Epilepsy, Functional Neurological Disorder, Mild Cognitive Impairment, Dementia
- Trial name
- EXPLAIN (NCT07883720)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Brain Injury Traumatic Mild, Post-traumatic Stress Disorder
Brain Health & Wellness Classes for Veterans With Traumatic Brain Injury
This study is testing the usefulness of two types of Brain Health \& Wellness classes for Veterans with a history of concussion to improve mental health.
- Trial name
- NCT06150196
- Testing
- Mindfulness-based Stress Reduction class, Brain Health Education class
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- East Bay Institute for Research and Education
Brain Injuries, Traumatic, Concussion, Mild
Objective Brain Function Assessment of mTBI/Concussion
This study (Part 3) is designed to build a database including EEG, neurocognitive performance, clinical symptoms, history and other relevant data, which will be used to derive a multimodal EEG based algorithm for the…
- Conditions
- Brain Injuries, Traumatic, Concussion, Mild, Concussion, Intermediate, Concussion, Severe
- Trial name
- CAS13-25 (NCT03963804)
- Testing
- BrainScope Ahead 300iP
- Where
- 4 sites in United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- BrainScope Company, Inc.
Traumatic Brain Injury
Growth Hormone or Sildenafil as Therapies for Fatigue in Mild- Traumatic-brain-injury (MTBI)
The overall goal is to determine whether perceptual or performance fatigue can be reduced in MTBI patients with and without growth hormone (GH) deficiency by treating them in a crossover fashion based upon GH status.
- Trial name
- NCT02114775
- Testing
- Growth Hormone, Sildenafil
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Concussion, Mild Traumatic Brain Injury
Impact of a Paced Breathing Exercise Intervention on Autonomic Nervous System Function After Pediatric Concussion (Acute Phase)
The goal of this pilot clinical trial is to assess the feasibility of administering a paced breathing exercise intervention program to children and adolescents in the acute period after concussion.
- Trial name
- Breathe - PED (NCT07572734)
- Testing
- Paced breathing exercises
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Concussion, Mild, Concussion, Brain
The Exercise and Concussion Health Study
This study aims to investigate the effect of two different physical exercise interventions on the brain, cognition and patient reported outcomes following a mild traumatic brain injury (mTBI) in community-dwelling adults.
- Conditions
- Concussion, Mild, Concussion, Brain, TBI (Traumatic Brain Injury), TBI
- Trial name
- TECHS (NCT06494592)
- Testing
- Aerobic Exercise, Balance Exercise
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Northeastern University
Concussion
Concussion Texting Study
This will be a prospective study of the implementation of a real-time assessment and intervention of a text messaging tool in mild traumatic brain injury (mTBI) patients post-discharge from the emergency department.
- Trial name
- texting (NCT03099733)
- Testing
- text message
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
Autonomic Nervous System Disease, Concussive Injury
Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms
Many combat veterans (c-Vs), service members (SMs) and civilians with mild traumatic brain injury (mTBI, also termed concussion) suffer from persistent post-concussion symptoms (PPCS) that degrade physical and cognitive…
- Conditions
- Autonomic Nervous System Disease, Concussive Injury, Mild Traumatic Brain Injury, Post Traumatic Stress Disorder
- Trial name
- NCT07071350
- Testing
- HRV Coherence Ratio, NSI, Pittsburgh Sleep Quality Index (PSQI)
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Virginia Commonwealth University
Physiological Post-Concussion Disorder, Post-Concussion Syndrome
Sub-maximal Exercise Prescription in Adolescents With Physiological Post-concussion Disorder
Although the vast majority of individuals sustaining a sport-related concussion (SRC) will receive medical clearance to return to sport within 7-10 days, approximately 30% of children and adolescents reporting to the emergency…
- Conditions
- Physiological Post-Concussion Disorder, Post-Concussion Syndrome, Traumatic Brain Injury, Rehabilitation
- Trial name
- NCT03367507
- Testing
- Sub-symptom aerobic exercise
- Where
- 2 sites in Canada
- Volunteers
- 136 people
- Sponsor
- Sport Injury Prevention Research Centre
Concussion
Protection Against Potential Brain Injury During Competitive Football
Significant morbidity, mortality, and related costs are caused by traumatic brain injury (TBI). An externally-worn medical device that applies mild jugular compression according to the principle of the Queckenstedt Maneuver (the…
- Trial name
- NCT02696200
- Testing
- Q Collar
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Concussion, Mild Traumatic Brain Injury, Brain Injury
Expanding Access to mTBI Treatment for Veterans and Service Members With Co-occurring Substance Use
The purpose of this research is to determine whether military veterans and service members with mild traumatic brain injury with and without co-occurring substance use can complete and benefit from integrated interdisciplinary…
- Conditions
- Concussion, Mild Traumatic Brain Injury, Brain Injury, Traumatic Brain Injury, Substance Use
- Trial name
- ExpandAccess (NCT06620900)
- Testing
- Integrated Model of Care
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Shepherd Center, Atlanta GA
Brain Concussion, Brain Trauma
Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)
The proposed study will evaluate a new approach to cognitive rehabilitation of mTBI using a brain stimulation technique called "Remotely Supervised Transcranial Direct Current Stimulation combined with Cognitive Training"…
- Conditions
- Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries
- Trial name
- COGNETRIC (NCT06413173)
- Testing
- Active tDCS and Cognitive Training Intervention
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- United States Naval Medical Center, San Diego
Concussion, Dizziness
Physical Therapy Intervention for Extended Physical Symptoms After a Sports-related Concussion
The purpose of this study is to investigate if skilled physical therapy treatment for dizziness after sports-related concussion, delivered after greater than 30 days post-concussion is effective to remediate physical symptoms.
- Trial name
- NCT02344446
- Testing
- Skilled Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Walsh University
Post Concussive Symptoms
Chasing Biomarkers in Post-concussion Syndrome
The goal of this study was to investigate the biomarkers, neurofilament light chain, inflammatory markers, calcitonin-gene-related peptide, and metabolites from the kynurenine pathway in patients with severe post-concussive…
- Trial name
- NCT05812742
- Testing
- Early intervention programme, Enhanced usual care
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Concussion, Brain, Mild Traumatic Brain Injury
Oculogica Portable EyeBOX Study
The objective of this study is to assess the accuracy of a portable version of the EyeBOX device, an eye-tracking based diagnostic, in comparison to a clinical reference standard of concussion.
- Trial name
- RESTLESS (NCT05047003)
- Testing
- EyeBOX Model EBX-4 (Portable version)
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Oculogica, Inc.
Mild Traumatic Brain Injury
Enhancing Brain Training With Virtual Reality
The purpose of this study is to evaluate the effectiveness of brain training in a Virtual Reality set up in neurotypical populations as well as in the traumatic brain injury population.
- Trial name
- NCT03582579
- Testing
- Training in Virtual Reality, Training on a computer screen
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Mild Traumatic Brain Injury, Acute Brain Injury
Aerobic Exercise for Concussion
The use of aerobic exercise treatment in the chronic phase of concussion recovery is well-described in the literature but there are limited existing data on the effect of exercise treatment in the acute phase after sport-related…
- Conditions
- Mild Traumatic Brain Injury, Acute Brain Injury, Brain Concussion
- Trial name
- NCT02959216
- Testing
- Aerobic Exercise, Stretching Exercise
- Where
- 3 sites in United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Brain Concussion, Mild Traumatic Brain Injury
Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches
This study aims to examine the long-term effect of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, on chronic headaches following mild traumatic brain injury (mTBI).
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Headache, Post-Concussion Symptoms
- Trial name
- NCT06112093
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University