Clinical trials: Closed Loop
Sleep, Healthy Vollunteer
Wearable Sleep EEG and Auditory Stimulation in Healthy Adults
The purpose of this single-site pilot study is to evaluate the feasibility, usability, and technical performance of a wearable sleep-monitoring system that records electroencephalography (EEG) and delivers brief, low-volume…
- Trial name
- NCT07808645
- Testing
- Wearable EEG-Based Sleep Monitoring and Closed-Loop Auditory Stimulation System
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Houston
Non-invasive Brain Stimulation, Methodologic Study
Closed-loop Non-invasive Brain Stiumlation
Transcranial magnetic stimulation (TMS) is a widely used tool for exploring brain function in humans (Siebner et al. et al., 2022), which has led to new therapeutics for various psychiatric and neurological disorders (Lefaucheur…
- Trial name
- CLOSEDLOOP (NCT06600217)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Premature, Premature Infant
Servo Controlled Oxygen Targeting (SCO2T) Study: Masimo vs. Nellcor
Most premature babies require oxygen therapy. There is uncertainty about what oxygen levels are the best. The oxygen levels in the blood are measured using a monitor called a saturation monitor and the oxygen the baby breathes is…
- Conditions
- Premature, Premature Infant, Oxygen Therapy, Hypoxia
- Trial name
- SCO2T (NCT04866342)
- Testing
- Servo control (closed-loop automatic control of the inspiratory fraction of oxygen (FiO2)) - IntellO2 OAM
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Drug Interaction Potentiation
Analysis of Cisatracurium Consumption in Balanced Anesthesia With 1% Sevoflurane, and With Only Sevoflurane, Using a Closed-loop Computer Controlled System Infusion.
The aim in this study was to quantify the difference in cisatracurium and sufentanil consumption, and its recovery period, when patients are under balanced general anesthesia with 1% sevoflurane and patients under only…
- Trial name
- NCT01736371
- Testing
- 1% Sevoflurane, Propofol, Sevoflurane
- Where
- China
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Healthy Volunteers
Closed-loop Control of Penicillin Delivery
This study is an in-house feasibility study of penicillin biosensor technology linked with closed-loop control for the automated delivery of penicillin antibiotics.
- Trial name
- CLCPD (NCT04053140)
- Testing
- Microneedle array, Microneedle array and closed-loop control of penicillin delivery, Penicillin G_1200mg
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Epilepsy
Stimulation of Sleep in Patients With Epilepsy
Sleep slow waves (SSW) and the pathophysiological mechanisms of spike generation in patients with epilepsy are tightly linked. SSW are cortically generated oscillations (~1 Hz) alternating between a hyperpolarized down-state…
- Trial name
- NCT04716673
- Testing
- Down-phase targeted auditory stimulation
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Hypotension
Closed-loop Double-vasopressor Automated System to Treat Hypotension During Spinal Anaesthesia for Caesarean Section
Hypotension occurs commonly during spinal anesthesia for caesarean section with maternal and fetal adverse effects. The investigators developed a double-vasopressor automated system incorporating continuous non-invasive arterial…
- Trial name
- NCT04025918
- Testing
- Vasopressor automated delivery system, Phenylephrine, Ephedrine
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Major Depressive Disorder, Healthy
Sleep Modulation to Treat Depression
Current first-line treatments for major depression (antidepressants and psychotherapy) show a long latency to response, and less than half of all patients experience full remission with optimized treatment, indicating the need…
- Trial name
- NCT06443216
- Testing
- Auditory closed-loop stimulation
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Christoph Nissen
Stroke
Assessment of Eye Movements in Stroke Patients and Closed-loop Intervention
The current study evaluates first the assumption that eye-movements during free viewing behavior are potential biomarkers of visuospatial deficits in stroke population.
- Trial name
- EMS (NCT06965673)
- Testing
- Visual exploration training, Standard neuropsychological rehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Premature Infant, Oxygen Therapy
SCO2T (Servo vs. Servo)
Most premature babies require oxygen therapy. There is uncertainty about what oxygen levels are the best. The oxygen levels in the blood are measured using a monitor called a saturation monitor and the oxygen the baby breathes is…
- Conditions
- Premature Infant, Oxygen Therapy, Hypoxia, Hyperoxia
- Trial name
- NCT04546568
- Testing
- Servo control (closed-loop automatic control of the inspiratory fraction of oxygen (FiO2)) - Leoni plus CLAC, Servo control (closed-loop automatic control of the inspiratory fraction of oxygen (FiO2)) - IntellO2 OAM
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh