Clinical trials: Coagulation Defect; Bleeding
Purpura, Thrombocytopaenic, Idiopathic
Study In Healthy Subjects To Evaluate The Photo-Irritant Potential Of Eltrombopag
This study is designed to investigate the safety profile and the photoirritant potential of eltrombopag in healthy subjects. The study is placebo- and positive controlled, randomized, parallel group with three treatment arms…
- Trial name
- NCT00688272
- Testing
- Ciprofloxacin, Eltrombopag
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Congenital Bleeding Disorder, Healthy
Dose Response to Recombinant Factor VIIa When Administered for Bleed
This trial is conducted in the United States of America (USA). The purpose of this trial is to investigate the dose response to recombinant factor VIIa in healthy volunteers when administered for bleed.
- Trial name
- NCT00104455
- Testing
- activated recombinant human factor VII
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Unexplained Isolated Provoked Hemorrhages, Familial Bleeding Disorder
Markers of Defective Membrane Remodelling in Scott-like Syndromes
Purpose: Identification of the gene(s) involved in plasma membrane remodelling. Identification of the circulating markers affected by the defective membrane remodelling in a collection of families with unexplained provoked…
- Conditions
- Unexplained Isolated Provoked Hemorrhages, Familial Bleeding Disorder, Scott Syndrome
- Trial name
- NCT00617721
- Testing
- Blood withdrawal
- Where
- 5 sites in France, Martinique
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Preterm Birth, Coagulation Protein Disorders
Stratifying Risk for Intracerebral Haemorrhage
This study aims to investigates the role of gestational age on the prevalence of coagulation factors and components of the complement system in preterm- (≤32+0 weeks) and term neonates (≥37+0 weeks) and their role for the…
- Conditions
- Preterm Birth, Coagulation Protein Disorders, Coagulation Disorder Neonatal
- Trial name
- NEW_STRATEGI (NCT04140812)
- Testing
- mass spectrometry (LC-MS/MS)
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Hip Fractures, Anticoagulants and Bleeding Disorders
Caudal Block & Hip Fracture Surgery in Anticoagulated Patient
Hip fractures are common in elderly patients, and require surgery. Many elderly patients take anticoagulants for vasculopathy treatment.
- Trial name
- NCT05946863
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Salem Anaesthesia Pain Clinic
Immune Thrombocytopenic Purpura ( ITP ), Systemic Lupus Erythematosus (SLE)
Modeling the Early Stages of Autoimmunity Through the Study of Immunological Thrombocytopenic Purpura and Juvenile Lupus
Immunologic thrombocytopenic purpura (ITP) in children is a pre-lupus condition if associated with the presence of anti-nuclear antibodies (ANA), providing a unique model for understanding the natural history of autoimmunity…
- Trial name
- PRELUDE (NCT07680010)
- Testing
- Blood sampling baseline and M3, Monitoring for SLE, Procedure/Surgery: Blood sampling baseline and M3 then each 6 months until 48 months
- Where
- 2 sites in France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Immune Thrombocytopenic Purpura
Study of T Cells and Natural Killer Cells Expression in Patients With Immune Thrombocytopenic Purpura
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by bleeding due to isolated thrombocytopenia with platelet count less than 100 × 109/L.
- Trial name
- NCT05093257
- Testing
- Laboratory investigations for control, Laboratory investigations for patients
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sohag University
Idiopathic Thrombocytopenic Purpura
Role of CD11a in Pathogenesis of Primary ITP and Effect of Immunosuppressive Therapy on Its Level
1. The purpose of this study is to investigate the expression of CD11a on subpopulation of lymphocytes and compared its expression between ITP patients and healthy controls and explores its possible role in the pathogenesis of…
- Trial name
- NCT03864796
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Coagulation Disorder, Cirrhosis, Liver
Heparin Like Effect in Acute Variceal Bleeding
This study attempts to clarify the pathophysiology of haemostasis in relation to the evidence of sepsis in liver disease, and compares the accuracy of various available laboratory tests in assessment of these patients.
- Conditions
- Coagulation Disorder, Cirrhosis, Liver, Variceal Hemorrhage
- Trial name
- NCT04111120
- Testing
- SONOCLOT, coagulation factor assays for VIII/X, XIII, TPA/ PAI
- Where
- India
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Thrombotic Microangiopathy, Hemolytic Uremic Syndrome
International Registry and Biorepository for TMA(Thrombotic Microangiopathy)
This registry will collect clinical data and store biosamples (seru, plasma, urine, and DNA) annually from pediatric patients with thrombotic mcroangiopathy
- Conditions
- Thrombotic Microangiopathy, Hemolytic Uremic Syndrome, Thrombotic Thrombocytopenic Purpura
- Trial name
- NCT00593229
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Immune Thrombocytopenic Purpura
" Effect of Single-nucleotide Polymorphism of CD40 Gene rs1883832 C/T on the Risk of Immune Thrombocytopenic Purpura "
Immune thrombocytopenia is an acquired autoimmune disease, in which platelets are opsonized by auto-antibodies and destroyed by phagocytic cells .Genetic polymorphisms in the immune mediators have been suggested to play a pivotal…
- Trial name
- NCT05585944
- Testing
- Genotyping of rs1883832C/T related single-nucleotide polymorphism
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University
ITP - Immune Thrombocytopenia
"Cytotoxic T Lymphocyte-Associated Antigen-4 (CTLA-4) Gene Single-nucleotide Polymorphism in Primary Immune Thrombocytopenic Purpura in Children"
the investigators aim in this study to investigate the potential association of single gene polymorphisms of CTLA-4 (SNPs; rs: 3087243) using real-time PCR in children with primary ITP.
- Trial name
- ITP (NCT07014904)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University
Idiopathic Thrombocytopenic Purpura
Triple Therapy in Patients With Idiopathic Thrombocytopenic Purpura : What is Behind?
Idiopathic thrombocytopenic purpura (ITP) is a benign hematological disorder characterized by isolated thrombocytopenia. Development of antiplatelet autoantibodies is the main pathogenetic mechanism in patients with ITP.
- Trial name
- NCT04128358
- Testing
- Serological assay for blood born viral hepatitis, Quantitative microbiological test for HCV
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Assiut University
Senile Purpura
Factors Associated With Dermatoporosis
Dermatoporosis is a chronic syndrome of skin insufficiency or fragility. It is characterized by cutaneous atrophy, senile purpura and stellate pseudoscars. Dermatoporosis prevalence is 37% in ≥65 years.
- Trial name
- FAWD (NCT05037604)
- Testing
- Questionnaire about associated factors, Self questionnaire diagnostic tool, Physical Examination
- Where
- Mexico
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Clotting and Bleeding Disorders, Child Development
Determination of ClotPro Paediatric Reference Range Study
A new thromboelastometry analyser (ClotPro, Enicor GmbH, Munich, Germany) with improved technology was developed. This device has an improved new-generation viscoelastometric testing technique and enables the detection and…
- Conditions
- Clotting and Bleeding Disorders, Child Development, Infant Development, Coagulopathy
- Trial name
- NCT04190615
- Testing
- thromboelastometry test (TEM test)
- Where
- Slovakia
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- National Institute of Children's Diseases, Slovakia
Congenital Bleeding Disorder, Haemophilia A
Investigation of the Pharmacokinetics of NNC172-2021, at Two Different Dose Levels, in Healthy Japanese Subjects
This trial is conducted in Europe. The aim of this trial is to investigate the pharmacokinetics (how the trial drug is distributed in the body) of NNC172-2021 administered subcutaneously, at two different dose levels, in healthy…
- Conditions
- Congenital Bleeding Disorder, Haemophilia A, Haemophilia B, Healthy
- Trial name
- NCT01555749
- Testing
- NNC172-2021
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Edema, Ecchymosis; Eyelid
The Effect of Local Tranexamic Acid on Post-operative Edema and Ecchymosis in Eyelid Surgery
Tranexamic acid (TXA) is a synthetic inhibitor of plasminogen lysine receptor that has used to reduce intra-operative bleeding in a number of clinical scenarios.
- Trial name
- NCT04951128
- Testing
- Tranexamic acid injection, Local anesthetic control
- Where
- 4 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Consultants in Ophthalmic and Facial Plastics Surgery
Hemophilia
Motor Proficiency of People With Bleeding Disorders Using the BOT-2 (TM)
The purpose of this study is to find out if gross motor skills of children and young adults with bleeding disorders are different from those without bleeding disorders.
- Trial name
- NCT02279199
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University