Clinical trials: Cocaine
Cocaine Use Disorders, HIV
Project IMPACT: Improving Memory Performance by Applying Cognitive Training
The purpose of this study is to examine the effects of a cognitive training program in persons with Human Immunodeficiency Virus (HIV) infection who have used cocaine.
- Trial name
- NCT02909101
- Testing
- Active Cognitive Training (ACT), Control Training (CON)
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Duke University
Cocaine Use Disorder, Cocaine Dependence
Theta-Burst Stimulation as a Treatment for Reducing Cocaine Use
Objective: The goal of this clinical trial is to assess the tolerability of an accelerated intermittent theta burst stimulation (iTBS), a form of transcranial magnetic stimulation, intervention in participants with cocaine use…
- Trial name
- NCT02927236
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Investigation of Cocaine Addiction Using mGluR5 PET and fMRI
The proposed research program will investigate the changes in brain chemistry and circuitry that 're-wire' the brain during chronic cocaine use, promote relapse, and complicate treatment efforts.
- Trial name
- NCT03471182
- Testing
- Psychiatric and Cognitive Testing, Cocaine Self-adminstration, Positron Emission Tomography
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Yale University
Bipolar Disorder, Cocaine Dependence
Citicoline for Bipolar 1 Disorder and Cocaine Dependence
A 12-week, randomized, double-blind, parallel-group, placebo-controlled trial of citicoline as an add-on therapy will be conducted in 200 outpatients with bipolar I disorder and cocaine dependence.
- Trial name
- NCT00619723
- Testing
- Citicoline, Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Alcohol Abuse, Cocaine Abuse
Therapeutic Substance Abuse Treatment in Pregnancy - 1
The purpose of this study is... To assess whether a behavioral treatment that combines motivational enhancement and cognitive skills training therapy (MET-CBT) is more effective than brief advice in: 1) decreasing use of a full…
- Conditions
- Alcohol Abuse, Cocaine Abuse, Marijuana Abuse
- Trial name
- PRIDE-P (NCT00227903)
- Testing
- MI-CBT, Brief Advice
- Where
- 2 sites in United States
- Volunteers
- 168 people
- Sponsor
- Yale University
Alcohol Use, Drug Use
Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 1
This application is a competing continuation of a grant in which we developed and pilot tested a computerized Therapeutic Workplace designed to train and employ adults as data entry operators.
- Conditions
- Alcohol Use, Drug Use, Risk Behavior, Sexual Behavior
- Trial name
- NCT00249496
- Testing
- Contingency management, Employment Only
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Johns Hopkins University
Cocaine Use Disorder
Trial Of NS2359 For The Treatment of Cocaine Dependence
NS2359 attenuates the euphoria associated with cocaine use. In a manner parallel to cocaine, NS2359 blocks the reuptake of dopamine (DA), norepinephrine (NE), and serotonin (5HT) with nanomolar affinities at the 3 transporters.
- Trial name
- NCT02798627
- Testing
- NS2359
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence, Cocaine Withdrawal
Carvedilol for Psychostimulant Dependence
This study examines whether carvedilol prolongs abstinence in recently abstinent cocaine dependent participants.
- Trial name
- NCT01171183
- Testing
- controlled release carvedilol
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Arkansas
Cocaine-Related Disorders, Opioid-Related Disorders
The Therapeutic Workplace Initiation Study
The primary purpose of the study is to determine if the central feature of the Therapeutic Workplace, the abstinence reinforcement contingency, is critical to initiate cocaine abstinence in injection drug using methadone patients…
- Conditions
- Cocaine-Related Disorders, Opioid-Related Disorders, Heroin Dependence, Substance Abuse, Intravenous
- Trial name
- NCT00249470
- Testing
- Abstinence & Work, Work Only
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Johns Hopkins University
Cocaine Use Disorder, Contingency Management
Extending Long-term Outcomes Through an Adaptive Aftercare Intervention
Reinforcement interventions have pronounced effects on reducing cocaine use. This study will evaluate a novel approach in which reinforcement frequency varies by patient performance.
- Trial name
- NCT02143063
- Testing
- prize contingency management on a traditional twice weekly schedule for cocaine abstinence, prize contingency management on a variable interval schedule for cocaine abstinence, standard care
- Where
- 4 sites in United States
- Volunteers
- 274 people
- Sponsor
- UConn Health
Cocaine Use Disorders
Glutamatergic Modulation of Motivation Enhancement: A Pilot Feasibility Trial
This study evaluates the feasibility of a treatment paradigm that involves naturalistic cocaine use opportunities in the context of psychotherapy aimed at utilizing these opportunities therapeutically.
- Trial name
- NCT02373124
- Testing
- infusion of NMDA antagonist
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence, Depression
Mirtazapine for Treating Cocaine Dependent Individuals Who Also Suffer From Depression
Many substance dependent individuals also suffer from depression. Past research suggests that antidepressant medication is helpful in treating such individuals.
- Trial name
- NCT00249444
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Progesterone Treatment for Cocaine-dependent Women: A Pilot Study
The purpose of this pilot treatment trial is to evaluate the efficacy of oral micronized PROG in cocaine-dependent women. Since we have shown (Evans \& Foltin, 2006) that oral micronized PROG attenuates the positive subjective…
- Trial name
- PROG (NCT00632099)
- Testing
- Oral micronized progesterone
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Oxytocin in Cocaine Dependence
Stress is likely involved in relapse to cocaine use. This project will investigate the role oxytocin may play in the stress response in cocaine-dependent men and women and examine how oxytocin may impact brain activity in…
- Trial name
- NCT01573273
- Testing
- Oxytocin, Saline
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Medical University of South Carolina
Cocaine Dependence
Glutamatergic Modulation of Cocaine-related Deficits
Cocaine dependence involves problematic neuroadaptations, such as heightened reactivity to cocaine cues, that may be responsive to pharmacological modulation of glutamatergic circuits.
- Trial name
- NCT01790490
- Testing
- Ketamine 0.41 mg/kg, Ketamine 0.71 mg/kg, Lorazepam 2 mg
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Use Disorder
Drug Interaction and Self Administration Studies of Compounds for Cocaine Use Disorder
The overall goal of this project is to develop initial human data on effects of novel compounds on safety (interactions with cocaine) and efficacy (subjective response to cocaine and self administration data) in non-treatment…
- Trial name
- NCT02537873
- Testing
- Lorcaserin, Cocaine Intravenous (IV)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Virginia Commonwealth University
Cocaine Use Disorder
Cocaine Use Reduction and Health
Reduced drug use is a clinically meaningful target for treatment development, but few studies have evaluated the positive impacts produced by this behavioral change, preventing adoption of this endpoint in clinical trials.
- Trial name
- RCT (04) (NCT03224546)
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- William Stoops
Substance Abuse, Intravenous
The Long-Term Treatment of Drug Addiction and Unemployment
The purpose of this clinical trial is to evaluate the effectiveness and economic benefits of a Wage Supplement Model of arranging long-term exposure to employment-based abstinence reinforcement.
- Trial name
- NCT02487745
- Testing
- Abstinence-contingent wage supplements, Individual Placement and Support (IPS) supported employment
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Johns Hopkins University
Cocaine Use Disorder
Cocaine and Zolmitriptan
Cocaine potently inhibits the reuptake of serotonin (5-HT). Increased synaptic 5-HT resulting from this reuptake inhibition activates multiple 5-HT receptor subtypes.
- Trial name
- NCT05019430
- Testing
- Cocaine, Zolmitriptan
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- William Stoops
Any Ear Nose or Throat Conditions, With Identified Need for a Diagnostic Procedure or Surgery on or Through the Mucous Membranes of the Nasal Cavities
Topical Application of Cocaine HCl 4%, or 10%, or Placebo Solution in Local (Topical) Anesthesia
Randomized, prospective, multi-center, double blind placebo-controlled parallel group study of a Placebo Topical Solution versus Cocaine HCl 4% Topical Solution for safety and efficacy, and Cocaine HCl 4% and 10% Topical Solution…
- Trial name
- NCT02500836
- Testing
- Cocaine HCl 4% Topical Solution, Cocaine HCl 10% Topical Solution
- Where
- United States
- Volunteers
- 646 people, healthy volunteers welcome
- Sponsor
- Lannett Company, Inc.