Clinical trials: Cocaine Dependency
Cocaine Dependence
Vouchers vs. Prizes for Cocaine-Dependent Methadone Patients - 2
The purpose of this study is to compare voucher-based contingency management (CM) procedures to a lower-cost CM system that provides opportunities to win prizes.
- Trial name
- NCT00249535
- Testing
- Contingency management
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- UConn Health
Cocaine-Related Disorders
Effectiveness of Topiramate in Treating Cocaine Dependent Individuals - 1
Although a great amount of research has been conducted to resolve cocaine dependence, an effective treatment has yet to be discovered. Topiramate is a drug that was found to be useful in treating alcohol dependence.
- Trial name
- NCT00249691
- Testing
- Topiramate + Cognitive Behavioral Therapy
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Bankole Johnson
Cocaine Dependence
Effect of HF rTMS on Serum BDNF in Cocaine Use Disorder
This study aims to explore the effect of 5-Hz rTMS over the left dorsolateral prefrontal cortex on the BDNF, craving and cognitive function.
- Trial name
- NCT06189690
- Testing
- rTMS
- Where
- Mexico
- Volunteers
- 102 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Cocaine-Related Disorders
Dose Response Trial of Pergolide for Cocaine Dependence - 1
The purpose of this study is to evaluate the efficacy and safety of pergolide for treatment of cocaine dependence.
- Trial name
- NCT00000248
- Testing
- Pergolide
- Where
- United States
- Sponsor
- Medical University of South Carolina
Cocaine-Related Disorders, Substance-Related Disorders
Prepulse Inhibition of Startle in Cocaine Dependence - 7
The purpose of this study is to assess the effects of chronic cocaine use on the acoustic startle response and on gating of this response in humans.
- Trial name
- NCT00015249
- Testing
- Amantadine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Behavior, Addictive, Cocaine Abuse
Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 2
The purpose of this study is to determine whether long-term exposure to the Therapeutic Workplace intervention could sustain drug abstinence over an extended period of time in heroin- and cocaine-dependent, unemployed…
- Conditions
- Behavior, Addictive, Cocaine Abuse, Cocaine Dependence, Heroin Dependence
- Trial name
- NCT00249457
- Testing
- Contingency management
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Imaging the Neurobiology of Behavioral and Medication Treatment for Cocaine Dependence
The proposed study will look at cocaine dependent individuals and will consist of three consecutive phases: 1) the 2-week outpatient lead-in phase during which behavioral therapy will be administered; 2) the 15-21 day inpatient…
- Trial name
- COST (NCT01468012)
- Testing
- levodopa carbidopa and entacapone (LCE)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Exercise as an Adjunctive Treatment for Cocaine Dependent Patients
The purpose of this study is to evaluate if exercise added to usual treatment improves cocaine dependence treatment. The primary objective of this study is to investigate if exercise can facilitate cocaine craving reduction.
- Trial name
- NCT01832649
- Testing
- Exercise, Health education
- Where
- Spain
- Volunteers
- 19 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cocaine-Related Disorders
Cocaine Abuse and ADHD - 10
The purpose of this study is to evaluate the safety and efficacy of buproprion in treating individuals with adult attention-deficit hyperactivity disorder (ADHD) and cocaine dependence.
- Trial name
- NCT00000275
- Testing
- Flupenthixol
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Abuse, Cocaine Dependence
n-Acetylcysteine and Cocaine
This study will determine the initial efficacy, safety and tolerability of n-acetylcysteine as a pharmacotherapy for cocaine dependence.
- Trial name
- NCT02141620
- Testing
- Cocaine, n-Acetylcysteine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Cocaine-Related Disorders
Gepirone vs Placebo in Treatment of Cocaine Dependence - 3
The purpose of this study is to test antidepressant medication, gepirone, as a pharmacotherapy for cocaine dependent subjects.
- Trial name
- NCT00000189
- Testing
- Gepirone
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence
Measuring Distress Tolerance With Functional MRI
Background: People who are in treatment for substance abuse often feel distress during the withdrawal period and afterward. Some individuals feel distress more acutely than others, and this distress has been linked to poor…
- Trial name
- NCT01038232
- Where
- 2 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Effectiveness of N-Acetylcysteine (NAC) in Treating Cocaine Dependent Individuals - 1
Currently, no effective drug treatment exists for cocaine dependence. Glutamate levels are disrupted with long-term cocaine use.
- Trial name
- NAC (NCT00218491)
- Testing
- N-Acetylcysteine
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Medical University of South Carolina
Cocaine-Related Disorders
Aripiprazole to Reduce Cocaine Relapse
Despite the many behavioral and cognitive treatment therapies that exist for cocaine addiction, individuals who complete cocaine abuse treatment are still at high risk for relapsing.
- Trial name
- NCT00276874
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Craig Rush
Cocaine Abuse or Dependence, Cocaine Related Disorders
Effects of N-acetylcysteine on Brain Chemistry and Behavior in Cocaine Abusers (NAC)
N-acetylcysteine (NAC) is a medication that the Food and Drug Administration (FDA) has approved for several medical uses, such as dissolving mucus in patients with breathing problems, treating overdose from acetaminophen…
- Trial name
- NAC (NCT01392092)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Wayne State University
Cocaine Dependence
Validation of a Remote Wireless Sensor Network (WSN) Approach to the Individualized Detection of Cocaine Use in Humans
This study looks to explore the feasibility, sensitivity, validity, and specificity of a Remote Wireless Sensor Network (RWSN) approach to the detection of cocaine use/intoxication in the inpatient human laboratory, as well as in…
- Trial name
- NCT02018263
- Testing
- Cocaine hydrochloride, Exercise, Nicotine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Yale University
Cocaine-Related Disorders
Tiagabine, Sertraline, or Donepezil for the Treatment of Cocaine Dependence - 9
The purpose of this CREST (Clinical Rapid Evaluation Screening Trial) study is the use of tiagabine, sertraline, or donepezil for the treatment of cocaine dependence using a modified placebo-controlled experimental design.
- Trial name
- NCT00015132
- Testing
- Sertraline
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Varenicline and the Blunting of Cocaine Cues
Assessing the Impact of Varenicline on Brain-Behavior Vulnerability
Our proposal will enable us to study cocaine patients to determine whether varenicline can weaken brain arousal to drug cues in an fMRI imaging setting, which is what we theorize.
- Trial name
- NCT00895557
- Testing
- chantix
- Where
- United States
- Sponsor
- University of Pennsylvania
Cocaine Use Disorder
Trial Of NS2359 For The Treatment of Cocaine Dependence
NS2359 attenuates the euphoria associated with cocaine use. In a manner parallel to cocaine, NS2359 blocks the reuptake of dopamine (DA), norepinephrine (NE), and serotonin (5HT) with nanomolar affinities at the 3 transporters.
- Trial name
- NCT02798627
- Testing
- NS2359
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Pennsylvania
Cocaine-Related Disorders
Effect of Nefazodone on Relapse in Females With Cocaine Abuse - 10
The purpose of this study is to determine the effect of nefazodone on relapse to cocaine use in depressed and non-depressed females with cocaine abuse/dependence.
- Trial name
- NCT00000293
- Testing
- Nefazodone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)