Clinical trials: Cocaine Dependency
Cocaine-Related Disorders
Carbamazepine Treatment for Cocaine Dependence - 5
The purpose of this study is to assess carbamazepine as a pharmacotherapy for cocaine dependence.
- Trial name
- NCT00000191
- Testing
- Carbamazepine
- Where
- United States
- Sponsor
- University of Pennsylvania
Cocaine Dependence
Imaging the Neurobiology of a Behavioral Treatment for Cocaine Dependence
The purpose of this study is to determine whether patients with the greatest loss of dopamine transmission due to cocaine dependence at pre-treatment PET and MRI scans will be those who fail to respond to substance abuse…
- Trial name
- PET-CRA (NCT00376558)
- Testing
- Community Reinforcement Approach
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine-Related Disorders, Substance-Related Disorders
Pharmacotherapy and Intensive Treatment - 2
The purpose of this study is to evaluate desipramine and carbamazepine in reducing cocaine craving; increase outpatient treatment capacity and evaluate their incidence of psychiatric disorders.
- Trial name
- NCT00000218
- Testing
- Carbamazepine
- Where
- United States
- Volunteers
- 353 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Substance-Related Disorders
Pergolide Treatment for Substance Abusers - 4
The purpose of this study is to evaluate the safety and efficacy of pergolide for cocaine dependence.
- Trial name
- NCT00000269
- Testing
- Pergolide
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Impact of a Non-Drug Choice on Cocaine Reinforcement
Cocaine-use disorders continue to be a significant public health concern, yet no effective medications have been identified. The goal of this study is to establish a research platform for the development of medications for…
- Trial name
- NCT01906346
- Testing
- Cocaine
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Joshua A. Lile, Ph.D.
Cocaine Dependence
A Placebo-Controlled Study of Mixed Amphetamine Salts and Topiramate for the Treatment of Cocaine Dependence
The proposed protocol is a double-blind, placebo-controlled outpatient study of the safety and efficacy of Adderall-XR (ER-MAS) and topiramate in the treatment of cocaine dependence.
- Trial name
- TACT (NCT00421603)
- Testing
- Adderall-XR and Topiramate
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Disulfiram for Cocaine Abuse
This study examines the influence of dopamine beta-hydroxylase enzyme activity on the clinical efficacy of the novel pharmacotherapy, disulfiram, for treating cocaine dependence in cocaine-dependent patients, some of whom are…
- Trial name
- NCT00395850
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Cocaine Dependence, Opioid Dependence
FMRI of Stress and Addictive Disorders
The purpose of this study is to explore whether frontal brain activation in response to stress varies as a function of the presence or extent of early trauma and whether or not this effect is greater in women compared to men.
- Conditions
- Cocaine Dependence, Opioid Dependence, Alcoholism, Pathological Gamblers
- Trial name
- NCT01558973
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Yale University
Cocaine Dependence
New Medication Treatment for Stimulant Dependence
This study will evaluate the efficacy of ondansetron compared with placebo in the treatment of cocaine dependence.
- Trial name
- NCT00689572
- Testing
- Ondansetron
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of Virginia
Heroin Dependence, Opioid-Related Disorders
Sustained Release d-Amphetamine & Buprenorphine on Drug Seeking Behavior in Opioid & Cocaine Dependent Individuals
The purpose of this study is to determine whether maintenance on different oral doses of sustained release d-amphetamine (SR-AMP) combined with constant-dose sublingual buprenorphine (BUP) is safe and well tolerated and decreases…
- Conditions
- Heroin Dependence, Opioid-Related Disorders, Cocaine Abuse or Dependence
- Trial name
- NCT00429767
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Wayne State University
Cocaine-Related Disorders, Substance-Related Disorders
Quetiapine for Cocaine Use and Cravings
The purpose of this study was to collect pilot data on whether quetiapine may be effective in the reduction of cocaine use and cravings in cocaine dependent individuals.
- Trial name
- NCT00232336
- Testing
- quetiapine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Cocaine Dependence
Multisite Controlled Trial of Cocaine Vaccine
The purpose of this study is to test the efficacy of a newly developed active vaccine against cocaine (TA-CD).
- Trial name
- TA-CD (NCT00969878)
- Testing
- TA-CD Vaccination
- Where
- 6 sites in United States
- Volunteers
- 300 people
- Sponsor
- Baylor College of Medicine
Cocaine-Related Disorders, Drug Administration Schedule
Ondansetron for the Treatment of Cocaine Dependence - 1
The purpose of this study is to assess the efficacy and safety of ondansetron to reduce cocaine use in subjects with cocaine dependence.
- Trial name
- NCT00033085
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Related Disorders, Drug Addiction
Contingency Management for Cocaine Dependence: Cash Versus Vouchers
Contingency management (CM) is a demonstrably efficacious intervention for substance abuse and dependence. Although CM protocols have employed a variety of reinforcers, they have almost exclusively relied upon non-cash privileges…
- Conditions
- Substance Related Disorders, Drug Addiction, Substance Abuse
- Trial name
- NCT01366716
- Testing
- Cash CM, Voucher CM
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- Treatment Research Institute
Cocaine Dependence
A Study of Baclofen ER
This is a Phase II, randomized, double-blind, placebo-controlled study that will examine the efficacy of extended-release baclofen (Baclofen ER) for the treatment of cocaine dependence.
- Trial name
- CURE (NCT02003664)
- Testing
- Baclofen ER
- Where
- United States
- Sponsor
- University of Pennsylvania
Cocaine-Related Disorders
Assessment of Potential Interactions Between Cocaine and RPR 102681 - 1
The purpose of this study is to assess Potential Interactions Between iv Cocaine and RPR 102681
- Trial name
- NCT00067535
- Testing
- Cocaine-Related Disorders
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
An fMRI Study of SYN115 in Cocaine Dependent Subjects
The dopamine system is critical in modulation of reward and has been implicated in the initiation and maintenance of addiction (Volkow et al 2004).
- Trial name
- NCT00783276
- Testing
- SYN115
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence, Alcohol Dependence
HBPL Study of the Impact of the NK1 Antagonist Aprepitant
The proposed research will focus on investigating the determinants and consequences of CAD via measurement of physiological, behavioral and subjective effects of physiologic and psychologic stress cues in CAD volunteers in the…
- Trial name
- NCT01176591
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Pennsylvania
Cocaine Abuse, Cocaine Dependence
Progesterone for Postpartum Cocaine Relapse
The investigators propose a placebo-controlled, randomized clinical trial that would enroll 50 postpartum women with a history of cocaine abuse or dependence to assess whether progesterone (100mgs twice daily) decreases…
- Trial name
- NCT01249274
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Cocaine-Related Disorders, HIV
Diversion to Treatment for Injection Drug Users Arrested for Possession of Heroin
More Americans are arrested for drug offenses than for any other crime. In 2009, over 294,000 arrests were made for possession of cocaine or heroin.
- Conditions
- Cocaine-Related Disorders, HIV, Heroin Dependence
- Trial name
- NCT01723527
- Testing
- Methadone, Buprenorphine, Employment-based drug abstinence reinforcement
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University