Clinical trials: Cocaine Dependency
Cocaine Dependence
An fMRI Study of SYN115 in Cocaine Dependent Subjects
The dopamine system is critical in modulation of reward and has been implicated in the initiation and maintenance of addiction (Volkow et al 2004).
- Trial name
- NCT00783276
- Testing
- SYN115
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Virginia Commonwealth University
Cocaine-Related Disorders
Selegiline Transdermal System for the Treatment of Cocaine Dependence - 1
The purpose of this study is to evaluate the Selegiline Transdermal System for the treatment of cocaine dependence.
- Trial name
- NCT00032929
- Testing
- Selegiline
- Where
- 16 sites in United States
- Volunteers
- 269 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Substance-Related Disorders
Nefazodone in the Treatment of Cocaine Dependence and Depression - 4
The purpose of this study is the use of Nefazodone in the treatment of cocaine dependence and depression comorbidity.
- Trial name
- NCT00015210
- Testing
- Nefazodone, Psychosocial Treatment
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Boston Medical Center
Cocaine Dependence
Study of the Effect of Magnetic Stimulation Repetitive Transcranial on Impulsivity in Cocaine Dependence
In a randomized, double-blind controlled trial the investigators will evaluate the efficacy of rTMS in reducing impulsivity for cocaine addicts through - Quantitative and qualitative analysis - such behavior and possible…
- Trial name
- TMSCOCAINE (NCT01397266)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Cocaine Dependence, Cocaine Abuse
Long Term Maintenance of Drug Abstinence
The purpose of this study is to develop a model for long-term maintenance of behavior change by examining the effects of extending the duration of contingency management (CM) for drug abuse on long-term abstinence outcomes.
- Trial name
- NCT00842517
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Treatment Research Institute
Cocaine-Related Disorders
Infusion Laboratory: Protocol 3 (Risperidone) - 4
The purpose of this study is to evaluate clinical safety issues pertaining to risperidone, to cocaine and to its interaction, and to determine how pretreatment with risperidone modifies the subjective as well as physiological…
- Trial name
- NCT00000339
- Testing
- Risperidone
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Cocaine Abuse
A Pilot Study of Cabergoline for the Treatment of Cocaine Dependence
The purpose of this study is to determine the effects of treatment with cabergoline, compared to treatment with placebo, on cocaine induced craving and subjective effects in cocaine-dependent human volunteers.
- Conditions
- Cocaine Dependence, Cocaine Abuse, Cocaine Addiction, Substance Abuse
- Trial name
- NCT01651364
- Testing
- Cabergoline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Baylor College of Medicine
Cocaine-Related Disorders
Tiagabine, Sertraline, or Donepezil for the Treatment of Cocaine Dependence - 9
The purpose of this CREST (Clinical Rapid Evaluation Screening Trial) study is the use of tiagabine, sertraline, or donepezil for the treatment of cocaine dependence using a modified placebo-controlled experimental design.
- Trial name
- NCT00015132
- Testing
- Sertraline
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
A Phase II Trial of Varenicline for the Treatment of Cocaine Dependence
This is a double-blind placebo-controlled clinical trial (n = 156) of varenicline for the treatment of cocaine dependence that utilizes contingency management to promote treatment attendance.
- Trial name
- NCT01680887
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence
Clinical Neurobiology of Serotonin and Addiction
The purpose of this study is to examine the relationship between 5-HT2R function, impulsivity and cue reactivity in cocaine dependent subjects and healthy controls and examine specific effects of escitalopram and mirtazapine on…
- Trial name
- NCT00732901
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cocaine Use Disorder, Cocaine Dependence
Low-Intensity Focused Ultrasound for Cocaine Use Disorder
This study aims to understand the role of Low-Intensity Focused Ultrasound on craving levels for cocaine as evidenced by diagnostic imaging of the dorsal anterior insula (dAI) and subjective ratings.
- Conditions
- Cocaine Use Disorder, Cocaine Dependence, Cocaine Abuse, Ultrasound
- Trial name
- NCT05857852
- Testing
- Low-Intensity Focused Ultrasound
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Cocaine Dependence, Opioid Dependency
Disulfiram for Cocaine Abuse in Buprenorphine Treatment
The investigators are proposing a placebo-controlled clinical trial to evaluate the efficacy and potential mechanisms of action of disulfiram (versus placebo) for treating cocaine abuse in subjects with concurrent opiate…
- Trial name
- NCT00913484
- Testing
- Disulfiram
- Where
- 2 sites in United States
- Volunteers
- 177 people
- Sponsor
- Yale University
Adult Attention Deficit Hyperactivity Disorder, Cocaine Dependence
Study of Adderall-XR for the Treatment of Adult Attention Deficit Hyperactivity Disorder and Cocaine Dependence
The proposed protocol is a 3 group double-blind, placebo-controlled outpatient study of the safety and efficacy of Adderall-XR (ER-MAS) in the treatment of comorbid ADHD and cocaine dependence.
- Trial name
- CAMP (NCT00553319)
- Testing
- Adderall-XR
- Where
- 2 sites in United States
- Volunteers
- 139 people
- Sponsor
- New York State Psychiatric Institute
Cocaine-Related Disorders
Modafinil Treatment for Cocaine-Dependent Individuals
Despite years of active research, there are still no approved medications for the treatment of cocaine dependence. The purpose of this study is to determine the effectiveness of modafinil in treating cocaine-dependent individuals.
- Trial name
- NCT00129285
- Testing
- Low Dose Modafinil, High Dose Modafinil
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- University of Pennsylvania
Cocaine-Related Disorders
Topiramate to Reduce Cocaine Dependence
Cocaine addiction is a serious health problem with no available medical treatment for preventing relapse. Topiramate, a medication which lowers dopamine levels, may have the ability to diminish cocaine cravings in addicts.
- Trial name
- NCT00223626
- Testing
- Topiramate
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Bankole Johnson
Cocaine-Related Disorders
Effect of Nefazodone on Relapse in Females With Cocaine Abuse - 10
The purpose of this study is to determine the effect of nefazodone on relapse to cocaine use in depressed and non-depressed females with cocaine abuse/dependence.
- Trial name
- NCT00000293
- Testing
- Nefazodone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Effects of Vigabatrin on Cocaine Self-Administration
The objective of this study is to determine if vigabatrin will decrease cocaine self-administration, cardiovascular effects, subjective effects and craving compared to placebo.
- Trial name
- NCT00373581
- Testing
- Vigabatrin, Cocaine
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Disulfiram for Cocaine Abuse
This study examines the influence of dopamine beta-hydroxylase enzyme activity on the clinical efficacy of the novel pharmacotherapy, disulfiram, for treating cocaine dependence in cocaine-dependent patients, some of whom are…
- Trial name
- NCT00395850
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Cocaine Dependence
Modafinil Treatment for Cocaine Dependence and HIV High-Risk Behavior
The purpose of study is to determine if modafinil promotes cocaine abstinence and reduces high risk behavior in cocaine dependent subjects.
- Trial name
- MOD6 (NCT00368290)
- Testing
- Modafinil, Cognitive Behavioral Therapy (CBT)
- Volunteers
- 94 people
- Sponsor
- Kyle Kampman
Cocaine Dependence, Cocaine Use Disorder
Predicting Relapse After Cocaine Inpatient Cessation
Can brain MRI at entry of cocaine inpatient cessation attempt predict relapse during a three month follow-up ? Hypothesis : White matter losses in the prefrontal cortex are associated with relapse to cocaine use.
- Trial name
- QUIT-COC (NCT02416050)
- Testing
- Brain MRI imagery
- Where
- France
- Volunteers
- 87 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris