Clinical trials: Cognition Disorders in Old Age
Insulin Resistance, Obesity
Metformin Effect on Brain Function in Insulin Resistant Elderly People
Alzheimer's disease (AD) and other forms of dementia are rapidly increasing with the aging of the population, and show a clear preponderance among people with insulin resistance.
- Conditions
- Insulin Resistance, Obesity, Obesity, Abdominal
- Trial name
- NCT03733132
- Testing
- Metformin Hydrochloride
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Mild Cognitive Impairment
Effects of Bidomain Cognitive and Aerobic Training on Cognitive Functioning in Mild Cognitive Impairment.
The study aims to assess the effects of Bidomain cognitive and aerobic training on both cognitive functioning and quality of life in individuals with mild cognitive impairment.
- Trial name
- NCT06867016
- Testing
- Combined Cognitive & Aerobics Training, Cognitive Training
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Bipolar II Disorder
add-on Low Dose Memantine in Middle-to-old Aged Bipolar II Disorder Patients
The investigators hypothesized that add-on memantine (MM) 5 mg/day may reduce chronic inflammation, and subsequently improve neuro-progression process and cognitive function in middle-to-old aged bipolar II disorder (BP-II)…
- Trial name
- NCT04035798
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Cheng-Kung University Hospital
Cognitive Impairment, Dementia
Determinants of Cognitive Impairment Among Geriatrics
This study aims to explore the determinants of cognitive impairment among Indonesian geriatrics in an Old Age Home.
- Conditions
- Cognitive Impairment, Dementia, Hearing Impairment, Vision Impairment and Blindness
- Trial name
- NCT03669536
- Where
- Indonesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tarumanagara University
Cognitive Decline, Cognitive Impairment
Preoperative Cognitive Training for Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction (POCD) is a state of decline in cognitive ability after surgery and is frequently seen among our elderly population.
- Conditions
- Cognitive Decline, Cognitive Impairment, Cognitive Deterioration
- Trial name
- CogniTrain (NCT03353987)
- Testing
- Cognitive training
- Where
- Malaysia
- Volunteers
- 17 people
- Sponsor
- University of Malaya
Neurocognitive Disorders, Dementia
Major Memory 2: A Long-term Group Cognitive Stimulation Program
This study aims to evaluate the effect of a long-term group cognitive stimulation (CS) program on the cognitive function of institutionalized elderly people with neurocognitive disorders.
- Conditions
- Neurocognitive Disorders, Dementia, Cognitive Impairment, Cognitive Decline
- Trial name
- NCT04178564
- Testing
- Cognitive Stimulation
- Where
- 8 sites in Portugal
- Volunteers
- 70 people
- Sponsor
- Rsocialform - Geriatria, Lda
Parkinson Disease
The Role of DLOTCA-G in the Cognitive Function Evaluation of Parkinson's Patients
The purpose of this study is to evaluate the usefulness of Dynamic Loewenstein's Occupational Therapy and Cognitive Assessment Scale for Geriatrics (DLOTCA-G) in parkinson patients.
- Trial name
- NCT06131619
- Testing
- assesment of cognitive parameters with DLOTCA-G
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Cognitive Impairment
Geriatric Inclusive Art: Effects of Painting Sessions on Older In-patients With Cognitive Decline
Geriatric Inclusive Art (GIA) painting activity is a new form of art therapy, which has been adapted for older adults hospitalized in medical wards.
- Trial name
- GIA (NCT03624387)
- Testing
- Painting Sessions
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Jewish General Hospital
Elective Surgery, Postoperative Cognitive Dysfunction
Effect Of Aspirin Preoperative on Postoperative Cognitive Dysfunction In Elderly Patients Undergoing Knee Arthroplasty
Studies have shown that the lifetime risk of developing symptomatic knee osteoarthritis is 40% in men and 47% in women; and the risk can be increased to 60% when the patient's BMI reaches 30 kg/m2.
- Conditions
- Elective Surgery, Postoperative Cognitive Dysfunction, Knee Arthroplasty
- Trial name
- NCT04225702
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Xuzhou Medical University
Alzheimer Disease, Cognitive Decline
Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease
The investigators will study performance on computerized cognitive tasks in healthy participants of different ages to gather normative data for newly developed computerized cognitive tests.
- Conditions
- Alzheimer Disease, Cognitive Decline, Aging
- Trial name
- NCT04800588
- Testing
- California Cognitive Assessment Battery
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Neurobehavioral Systems, Inc.
Alzheimer Disease, Neurodegenerative Diseases
Cognitive Impairment Cohort Study of the Elderly Population in YuGarden
The goal of this prospective observational research with an 8-year follow-up is to study the cognitive changes in the elderly in YuGarden community, Shanghai, China.
- Conditions
- Alzheimer Disease, Neurodegenerative Diseases, Cognitive Impairment, Mild Cognitive Impairment
- Trial name
- NCT06325527
- Where
- China
- Volunteers
- 1,872 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Spatial Navigation
Exploring to Remediate Behavioral Disturbances of Spatial Cognition
Spatial navigation (SN) has been reported to be one of the first cognitive domains to be affected in Alzheimer's disease (AD), which occurs as a result of progressive neuropathology involving specific brain areas.
- Trial name
- BDSC-MCI (NCT05944601)
- Testing
- Virtual and computer-based cognitive remediation training
- Where
- Italy
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Mild Cognitive Impairment (MCI), Aging
Elderberry Functional Gum and Cognitive & Oral Health in Older Adults
Globally, the aging population is increasing rapidly, leading to a dramatic rise in the prevalence of Alzheimer's disease and other types of dementia.
- Conditions
- Mild Cognitive Impairment (MCI), Aging, Oral Microbiome
- Trial name
- NCT07054645
- Testing
- Elderberry Anthocyanin Chewing Gum
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Burdur Mehmet Akif Ersoy University
Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction in Elderly and it's Relation With Sleep Disorders and Melanin Concentrating Hormone
The aim of this study is to explore the relationship between preoperative sleep disorders, melanin-concentrating hormone (MCH), and delayed neurocognitive recovery early after surgery in older adult patients undergoing spinal…
- Trial name
- NCT07392840
- Volunteers
- 50 people
- Sponsor
- Minia University
Dementia, Neurocognitive Disorders
Prefrontal Cortex Dynamics of the Elderly During a Cognitive Stimulation Programme
This research aims to evaluate the effect of cognitive stimulation (CS) on the functioning of the prefrontal cortex (PFC), seeking an analysis of both cerebral hemodynamics in neuroplasticity and aspects related to the initiation…
- Conditions
- Dementia, Neurocognitive Disorders, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT04693611
- Testing
- Individual cognitive stimulation therapy (iCST), Functional near-infrared spectroscopy (fNIRS)
- Where
- Portugal
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas
Delirium, Postoperative, Delirium in Old Age
The SCOPE Trial: Sleep, Cognition, and Pain Bundle vs. ERAS-cardiac for Postoperative Delirium
Sleep disturbances, cognitive reserve, and continuing pain and inflammation are other risk factors contributing to delirium (confusion and agitation) and neurocognitive decline (in the long term) following heart surgery.
- Trial name
- SCOPE (NCT06721819)
- Testing
- Sleep Hygiene, Brain Game, and IV Acetaminophen Intervention, Control
- Where
- 3 sites in United States
- Volunteers
- 406 people
- Sponsor
- Beth Israel Deaconess Medical Center
Fall, Frailty
Combined Exercise and Cognitive Stimulation for Falls Prevention
Randomized clinical trial of 310 older adults over 75 years old recruited from the Falls Units of Geriatric Departments in 4 three University Hospitals in Spain (Pamplona, San Sebastián, Albacete and Barcelona).
- Conditions
- Fall, Frailty, Cognition Disorders in Old Age, Exercise
- Trial name
- Vivifrailcogn (NCT04911179)
- Testing
- Vivfrail-Cog combined multicomponent physical exercise and cognitive stimulation.
- Where
- Spain
- Volunteers
- 310 people
- Sponsor
- Fundacion Miguel Servet
Mild Cognitive Impairment
Efficiency of CogniPlat on Cognitive Functions in Older Adults
Mild cognitive impairment is a common intermediate stage between normal aging and dementia, affecting memory and other cognitive domains in older adults.
- Trial name
- NCT07130591
- Testing
- Cogniplat game platform, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Izmir Democracy University
Dementia, Alzheimer Disease
Evaluation of Alteration by Magnetic Resonance Imaging (MRI) in Dementia Among Elderly Subjects
Capturing the earliest stages of Dementia especially Alzheimer's Disease (AD) is a great challenge. Until now the NINCDS-ADRDA and the DSM criteria for AD were largely used as diagnostic standards in research.
- Trial name
- AMIMAGE (NCT00951197)
- Testing
- Neuroimaging
- Where
- France
- Volunteers
- 318 people
- Sponsor
- University Hospital, Bordeaux
Healthy, Alzheimer Disease
A Study to Measure CSF Proteins in Elderly Healthy Volunteers and Volunteers With Mild Cognitive Impairment or Alzheimer's Disease
The purpose of this study is to investigate changes of cerebral spinal fluid (CSF) proteins over time using continuous CSF sampling for 36 hours in elderly healthy volunteers and volunteers with mild cognitive impairment or…
- Trial name
- NCT01436188
- Testing
- Standard CSR sampling procedure, Alternate frequency CSR sampling procedure, Standard frequent CSR sampling procedure with 800 mg ibuprofen
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC